• Archives of Pharmacal Research
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• v.26 no.5
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• pp.421-425
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• 2003

The aim of the present study was to evaluate the effects of two phospholipid permeation enhancers, lysophosphatidylcholine (LPC) and didecanoylphosphatidylcholine (DDPC), along with a fusidic acid derivative, sodium taurodihydrofusidate (STDHF) and ethanol (EtOH) on the buccal transport of propranolol hydrochloride (PPL) using an ex vivo buccal diffusion model. The permeation rate of [$^3 H$]PPL as measured by steady-state fluxes increased with increasing EtOH concentration. A significant flux enhancement (P＜0.05) was achieved by EtOH at 20 and 30 %v/v concentrations. At a 0.5 %w/v permeation enhancer concentration, the buccal permeation of [$^3 H$]PPL was significantly enhanced by all the enhancers studied (i.e., LPC, DDPC and STDHF) compared to the control (phosphate-buffered saline pH 7.4, PBS). LPC and DDPC displayed a greater degree of permeation enhancement compared with STDHF and EtOH-PBS mixtures with an enhancement ratio of 3.2 and 2.9 for LPC and DDPC, respectively compared with 2.0 and 1.5 for STDHF and EtOH:PBS 30:70 %v/v mixture, respectively. There was no significant difference between LPC and DDPC for the flux values and apparent permeability coefficients of [$^3$H]PPL. These results suggest that phospholipids are suitable as permeation enhancers for the buccal delivery of drugs.

• Korean Journal of Food Science and Technology
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• v.2 no.2
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• pp.17-25
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• 1970

Juice were extracted from fresh leaves of 70 species of plants growing in Korea by mincing and pressing the resulting pulp through a cotton cloth. Leaf protein concentrates could be prepared from many species of land and water plants that are at present economically unimportant. The choice of plants is of considerable important. Total-N, protein-N and pH determinations were made on the extracts, and total-N remaining in the fibre were calculated. Leaf protein concentrates were precipitated from the extracts at $75{\sim}80^{\circ}C$, and analysed total-N as protein-N of products. The present paper deals with the calculated yields of leaf protein concentrates from various plants, relations between yield of leaf protein concentrates and total-N of leaves, or pH of extracts, and the amino acid compositions of leaf protein concentrates. Results are summarized as follows. 1. Spinach and radish were the best sources of easily extractable, but good results were also obtained with indian mustard, kail, chenopod, red bean, cucumber, squash, houndberry, white flowered gourd, potato, Humulus japonicus, arrowroot and soybean as a good resources for the production of leaf protein concentrates. 2. In general, the greater the protein content of leaves the greater the yield of leaf protein concentrates. However, there are some plants difficult to make a adequate protein extraction by a simple mechanical process. 3. It was to be expected that leaf protein concentrates would be more extractable with the higher pH of extracts. There were a poor yield of the leaf protein concentrate in the pH values lower than 5.50 of the first extracts. 4. Protein content of the leaf protein concentrate shows marked differences, depending on species and season. It ranged between 29 to 80% of protein contents. However, the majority of plants yielded products containing more than 50% of protein. Products containing more than 75% of protein were obtained from two species of radish and indian mustard. Cabbage and Digitaria sanguinalis cilialis (summer) made products containing 29 to 32% of protein. 5. The amino acid composition of leaf protein concentrates was not greatly altered by species of plants. On an amino acid compositional basis, the leaf protein concentrate has a favorable balance of essential and non-essential amino acids, the only exception being methionine, which was usually low in all cases.

• Proceedings of the Acoustical Society of Korea Conference
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• 1994.06c
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• pp.205-209
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• 1994

This paper presents a variable rate speech coding method with phonetic segmentation, called for PSVXC. Multiple access techniques that require efficient encoding of speech to achieve capacity improvements are currently emerging in the cellular telephone system. The variable rate speech coder have the reduced average data rate required to transmit conversational speech. Each frame of active speech is classified into one of four phonetic classes. A distinct coding configuration and bit-rate is applied to each category. And also a split vector quantization is used to accurately quantize the LPC information using LSP parameters.

• Proceedings of the Acoustical Society of Korea Conference
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• 1984.12a
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• pp.63-65
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• 1984

In this paper, the implementation of the real time LPC synthesizer using NEC 77p20, the DSP (Digital Signal Processor) chip which facilitates and simplifies the digital hardware, is considered. This method shows the good quality with the low bit rate below 9.6kbps and has the advantage of the flexibility and the simplicity.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.10a
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• pp.63-65
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• 2012

본 논문에서는 입력된 음성이 남성화자인지 여성화자인지를 구분하는 FFT 스펙트럼 및 LPC 켑스트럼 입력에 의한 성별인식 알고리즘을 제안한다. 본 논문에서는 특히 남성화자와 여성화자의 특징벡터를 비교 분석하여, 이러한 남녀의 음향학적인 특징벡터의 차이점을 이용하여 신경회로망에 의한 성별 인식에 대한 실험을 수행한다. 특히 12차의 LPC 켑스트럼 및 8차의 저역 FFT 스펙트럼의 특징벡터를 사용한 경우에, 남성화자 및 여성화자에 대해서 양호한 남녀 성별인식률이 구해졌다.

• Speech Sciences
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• v.3
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• pp.93-108
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• 1998

This paper attempts to acoustically examine the place of articulation of Korean affricates. In order to pursue an acoustic analysis of where Korean affricates are articulated, we resort to LPC spectra of the Korean plain affricate /c/ in intervocalic position, based on theoretical assumptions (e.g., Stevens 1993a), and compare the data to that of the Korean alveolar consonants /t, s/ in the same context. Our phonetic results show that in intervocalic position, the Korean plain affricate is alveolar just like the Korean alveolar consonants /t, s/, supporting the articulatory studies of $Skali{\check{c}}kov{\acute{a}}$ (1960) and Kim (1997).

• The Journal of the Acoustical Society of Korea
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• v.1 no.1
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• pp.54-59
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• 1982

We present an improved 4800 bps LPC vocoder system that virtually eleminates the buzzy effect from synthetic speech. Excitation signal in the new system is formed by adding high-pass filtered pitch pulses or random noise to a baseband residual signal that has been coded by pitch predictive PCM. Since the baseband residual is used as a part of excitation, the system is also robust to V/UV and pitch errors. According to our informal listening tests, the synthetic speech of the new system does not have the buzzy effect. As a result the vocoder speech quality is more natural than that of a conventioinal LPC vocoder.

• Proceedings of the Acoustical Society of Korea Conference
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• 1994.06a
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• pp.1092-1097
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• 1994

To solve the frequency variation of speech patterns which consist of LPC sequences, a new membership function made by the relation between order of LPC and spectrum is proposed in this paper. To reduce errors, fuzzy inference is executed using the proposed membership function. The computer simulation shows the effectiveness of the word recognition.

• Proceedings of the Acoustical Society of Korea Conference
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• 1994.06c
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• pp.364-367
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• 1994

In this paper, we carried out some experiments on the Korean vowel recognition using the fractal dimension of the speech signals. We chose the Mincowski-Bouligand dimensioni as the fractal dimension, and computed it using the morphological covering method. For our experiments, we used both the fractal dimension and the LPC cepstrum which is conventionally known to be one of the best parameters for speech recognition, and examined the usefulness of the fractal dimension. From the vowel recognition experiments under various consonant contexts, we achieved the vowel recognition error rats of 5.6% and 3.2% for the case with only LPC cepstrum and that with both LPC cepstrum and the fractal dimension, respectively. The results indicate that the incorporation of the fractal dimension with LPC cepstrum gies more than 40% reduction in recognition errors, and indicates that the fractal dimension is a useful feature parameter for speech recognition.

• The Journal of the Acoustical Society of Korea
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• v.31 no.3
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• pp.179-187
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• 2012

This paper presents a novel method for estimating reliable noise spectral magnitude for acoustic background noise suppression where only a single microphone recording is available. The proposed method finds noise estimates from spectral magnitudes measured at line spectral frequencies (LSFs), under the observation that adjacent LSFs are near the peak frequencies and isolated LSFs are close to the relatively flattened valleys of LPC spectra. The parameters used in the proposed method are LPC coefficients, their corresponding LSFs, and the gain of LPC residual signals, so it suits well to LPC-based speech coders.