• Biomolecules & Therapeutics
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• v.17 no.1
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• pp.86-91
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• 2009

In our ongoing search for biological components from the Korea endemic plants, the MeOH extract of Ailanthus altissima leaves (Simaroubaceae) showed cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) dual inhibitory activity by assessing their effects on the production of prostaglandin $D_2$ ($PGD_2$) and leukotriene $C_4$ ($LTC_4$) in mouse bone marrow-derived mast cells (BMMCs). In further study, eight compounds, squalene (1), ${\beta}$-sitosterol (2), scopoletin (3), quercetin (4), luteolin (5), astragalin (6), scopolin (7), and daucosterol (8) were isolated, the chemical structures were elucidated on the basis of physicochemical and spectroscopic data and by comparison with those of published literatures. Among the compounds, 2, 4, and 5 strongly inhibited both the COX-2-dependent PGD2 generation with $IC_{50}$ values of 2.6, 7.3 and 2.5 ${\mu}M$, respectively and the generation of $LTC_4$ in the 5-LOX dependent phase with $IC_{50}$ values of 2.0, 5.1 and 1.8 ${\mu}M$, respectively, which suggest that the anti-inflammatory activity of A. altissima might occur in part via the inhibition of both $PGD_2$ and $LTC_4$ generation by 2, 4 and 5.

• Journal of the Korean Society of Propulsion Engineers
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• v.12 no.5
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• pp.18-25
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• 2008

A performance analysis program has been developed for the gas generator cycle liquid rocket engine. This program predicts the system performance with the performances of subsystems which are evaluated by the models based on another analyses or experiments. The analysis method has been validated by comparing the engine performance against the published conceptual design. The performance models of the subsystems have been verified to give reasonable results by comparing with the MC-1 engine design and the system analysis of 10 ton thrust engine. The system performance of the 30 ton thrust rocket engine using LOx/Jet-A1 has been presented as an application example.

• Journal of the Korean Society of Propulsion Engineers
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• v.13 no.6
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• pp.48-55
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• 2009

The purpose of using Gas Generator Oxidizer On/Off Valve(GOV) is to control opening and closing of oxidizer mass flow. This paper describes analytical results of flow and structural properties for four different GOV models, using commercial software such as Fluent(Ver. 6.3.26) and NASTRAN(2005 r.2), PATRAN(2005 r.2). Analytical results show that GOVs could generate 2.3~3.8 kg/s of oxidizer mass flow rate and come up with 1.09~1.42 of safety factor.

• Aerospace Engineering and Technology
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• v.9 no.1
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• pp.93-97
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• 2010

The analysis of specific impulse of the liquid rocket engine employing gas generator cycle with LOx/kerosene as propellant has been performed. The relative error of performance of 300 ton level engine is 0.1%s for specific impulse and 12% for optimal combustion pressure comparing with the published data. The difference of the performance model and the material property models of gas generator product gas are the presumed major reason of discrepancy. The optimal condition of 30 ton level engine is combustion pressure of 68 bar and mixture ratio of 2.2 for maximum specific impulse. This optimal condition can be changed by performance models.

• Natural Product Sciences
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• v.22 no.4
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• pp.225-230
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• 2016

Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin (1), (+)-sesartemin (2), (+)-excelsin (3), (+)-sesamin (4), and (+)-syringaresinol (5), together with lupeol (6), lupenone (7), ${\beta}-sitosterol$ (8), and ${\beta}-sitostenone$ (9). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. The isolated lignans were tested for their anticholinesterase (AChE: acetylcholine esterase and BChE: butyryl cholineesterase) and anti-inflammatory (COX-2: cyclooxygenase-2 and LOX: lipoxygenase) activities. All the isolated lignans (1 - 5) exhibited significant inhibition activities in AChE/BChE and COX-2/LOX assays with $IC_{50}$ values ranging from $168.8-504.2{\mu}M$ and $21.0-59.4{\mu}M$, respectively.

• Bulletin of the Korean Space Science Society
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• 2003.10a
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• pp.90-90
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• 2003

한국항공우주연구원은 액체추진기관 시스템을 이용한 3단형과학로켓(이하 KSR-III)을 국내 최초로 개발하여 비행시험을 수행하였다. 액체추진기관 로켓의 비행시험을 위해서는 이전의 고체 추진기관을 이용한 과학로켓 1, 2와는 달리 비행시험 조건에 부합하게 액체추진제 및 가압제 등을 공급하는 지상설비가 필요하다. 이에 한국항공우주연구원은 독자적으로 비행시험에 필요한 제반 설비를 갖춘 발사장을 구축하였다. KSR-III는 압축 헬륨가스(GHe)를 이용하여 연료(Jet A-1)와 산화제(LOx)를 가압하여 추력을 얻는 액체추진기관 시스템이다. 따라서 발사장에서의 지상공급설비는 유공압 설비와 발사시나리오에 따라 해당 부품을 제어하고 자료를 저장하는 제어/계측 설비 및 기타설비들로 구성되어 있다. 지상공급설비 중 유공압 설비는 LOx의 저장 및 기체 내 산화제 탱크의 충전을 위한 산화제 공급설비, Jet A-1의 저장 및 기체 내 연료 탱크의 충전을 위한 연료 공급 설비, 지상설비용 밸브구동 및 기체 내부 퍼지 등에 필요한 질소($N_2$)를 저장/공급하는 설비, 기체내부 밸브 구동 및 가압제로 사용되는 기체헬륨(He)을 저장/공급하는 설비들로 구성되어 있다. 이러한 구축된 공급설비는 기능시험, 연계시험 등의 각종 입증시험을 통해 그 성능을 검증한 후 단인증모델(SQTM)을 이용하여 발사 시나리오에 따른 추진제 공급능력을 입증한 후 KSR-III의 비행시험을 성공적으로 수행하였다. 수행된 연구결과는 향후 건설되어질 우주센터내의 발사장 기반설비 설계의 기초 자료로 활용할 수 있을 것이다.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.32 no.5
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• pp.109-115
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• 2004

A 1-D system design program has been developed for the preliminary design of the turbopump system in liquid rocket engines, which use LOx and kerosene as propellants. Gasgenerator cycle and staged combustion cycle were considered as turbopump type liquid rocket engine systems. In the system analysis, mass flow balance, thrust, specific impulse, mixture ratios, turbopump power, and turbine expansion ratio of engine system were analyzed. Results show that most of the parameters agree well with real engine parameters except gasgenerator. Therefore, the l-D system design program developed in this study can be used to derive the preliminary design parameters of a turbopump with any thrust level liquid rocket engine.

• Aerospace Engineering and Technology
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• v.2 no.2
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• pp.151-156
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• 2003

Liquid rocket engine system is classified into an engine of pressurization and turbo pump type by the way of fuel fed-supporting system. In the KSR-III sounding rocket, an engine of pressurization type was used, but there was lots of technical problems to be solved for a use as the first stage engine of space launch vehicle. So, an engine of turbo pump type was required to be developed to overcome the technical limitation of liquid rocket engine. In this research, the analysis of propellant of Kerosine-LOX and methane-LOX which are noticed as a future propellant was carried out for the purpose of studying the basic characteristics. And to review the basic characteristics of an engine of turbo pump type, among the sizing variant of the space launch vehicle, the ways of injecting a satellite to a direct orbit and transient orbit were discussed in this paper.

• Aerospace Engineering and Technology
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• v.8 no.1
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• pp.73-81
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• 2009

Casing leak tests using three kinds of static seals are performed by simulating test section for a 75 ton thrust class turbopump under ambient and cryogenic temperature environment. As results of application of Conical, PTFE, and C static seals to leak tests, even though they all work in normal temperature condition, only the PTFE and C static seals show good sealing performance in cryogenic condition. However, the Conical static seal fails because of the different thermal expansion rates due to the use of different materials in a LOX pump. It is found that unlike the PTFE and C static seals with sealing surfaces in axial direction, the sealing surface of the Conical static seal is in radial direction that may cause leak when the casings thermally shrink in radial direction. Especially, the C static seal reveals excellent sealing performance even for a used seal.

• The Korean Journal of Food And Nutrition
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• v.9 no.1
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• pp.52-58
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• 1996

This study was carried out 19 investigate the characteristics of pectinesterase (PE), polygalacturonase (PG), lipoxygenase(LOX) and peroxidase (POD) in hot pepper to know the effect of hot pepper on food quality during food processing and storage. The results were as follows : 1. The optimum pH of PE was pH 7.5 and the activity of PE below pH 5.5 was revealed scarcely, The concentration of NaCl and $CaCl_2$ that showed the highest activity of PE were 0.2M and 0.05M, respectively. 2. The optimum pH of PG was pH 6.0 and the activity of PG in acidity was higher than that in alkalinity. The activity of PG was maximum at 0.3M NaCl and 0.2mM $CaCl_2$. Above the concentration of 0.5M NaCl and 0.5M $CaCl_2$, the activity of PG was lower than that of PG not adding these salts 3. The optimum pH of LOX was pH 7.0 and pH 8.5. 4. The optimum pH of POD was pH 6.0 and the activity of POD was higher in weak acidity and neutrality than in alkalinity. POD activity was slightly decreased by the increase of NaCl and $CaCl_2$ concentration.