• Title/Summary/Keyword: LMP

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Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma: is it different between Over and Under 50 Years of Age?

  • Monabati, Ahmad;Vahedi, Amir;Safaei, Akbar;Noori, Sadat;Mokhtari, Maral;Vahedi, Leila;Zamani, Mehdi
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.4
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    • pp.2285-2289
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    • 2016
  • Background: Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) of the elderly is an entity introduced in the latest WHO classification of lymphoid tumors and defined in patients older than 50 years without prior lymphoma or immunodeficiency. However, recently it has also been seen in patients under 50. There is thus debate as to whether these are separate entities. Materials and Methods: In this retrospective study, we analyzed de novo DLBCL admitted to our institute over a period of two years. Clinical data included age, sex, nodal and extranodal presentation. The results of an immunohistochemistry (IHC) panel were also reviewed. IHC findings were mainly used to sub-classify DLBCL as germinal center vs. non germinal center types. IHC for identification of LMP-1 (latent membrane protein) and in situ hybridization for detection of EBV-encoded RNA (EBER) was performed. EBV prevalence, clinical data and IHC findings were compared between patients under and over 50 years of age. Results: Out of 95 DLBCL, 11.6% were EBV positive (7.5% and 14.5% in the young and old groups). We did not find any significant differences in IHC subclasses and clinical data between EBV positive DLBCL (EBV+DLBCL) of young and old groups. Conclusions: EBV+DLBCL are not exclusive to patients older than 50 years. With regard to clinical data as well as IHC subclasses, no differences were evident between EBV+DLBCL of young and old groups. Our suggestion is to eliminate any cut off age for EBV+DLBCL.

The Study of Zinc Nutritional Status of Pregnant Women Visiting in Public Health Centers in Ulsan (울산 지역 보건소 이용 임신부의 아연 영양상태에 관한 연구)

  • 유경희
    • Journal of Nutrition and Health
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    • v.33 no.8
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    • pp.848-856
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    • 2000
  • The study was designed to assess the zinc nutritional status by gestational age of pregnant women visiting in public health centers in Ulsan. The subjects were divided into 3 trimester by last menstrual period(LMP). Interview for dietary zinc intake and general characteristics of each subjects was given and biochemical analysis of blood and urine was performed. Serum zinc concentration and urinary zinc excretion were analyzed by Flame Atomic Absorption Spectrophotometer, and alkaline phosphatase(ALP) activity was analyzed by Bowers & McComb\\`s method with Schimadzu automatic analyser. Also urinary creatinine was analyzed by Hawk\\`s method. Mean intake of zinc was 6.61${\pm}$1.57mg and did not meet the RDA(44.1% of RDA) for pregnant women by gestational age. Zn intake of 3rd trimester was significantly increased but dietary zinc was almost supplied with cereal and grain (47.30%) which were reported with low zinc availability due to phytate. Mean concentration of serum Zn in 1st trimester was 86.4${\pm}$10.5$\mu\textrm{g}$/dl, was 72.4${\pm}$10.3$\mu\textrm{g}$/dl in trimester and 65.1${\pm}$10.8$\mu\textrm{g}$/dl in 3rd trimester and was declined significantly by gestational age during pregnancy. In was concluded that a decline in serum Zn by gestional age was not influenced by amount of Zn intake. However ALP activity and urinary zinc excretion increased significantly by gestational age. Zinc nutritional status of pregnant women was not confirmed yet due to the physiological changes during pregnancy. However, the pregnant woman may be in a marginal zinc deficient status because of low amount of Zn intake and low bioavailability of Zn from dietary sources. (Korean J Nutrition 33(8) : 848-856, 2000)

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High Prevalence of the China 1 Strain of Epstein-Barr Virus in Korea as Determined by Sequence Polymorphisms in the Carboxy-Terminal Tail of LMP1

  • Cho, Sung-Gyu;Lee, Won-Keun
    • Journal of Microbiology
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    • v.41 no.2
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    • pp.129-136
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    • 2003
  • The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMPI) exhibits considerable sequence heterogeneity among EBV isolates. Seven distinct EBV strains have been defined based on sequence polymorphisms in the LMPI gene, which are designated China 1, China 2, China 3, Alaskan, Mediterranean, NC, and the B95-8 strains. In this study, we analyzed a 30-bp deletion and sequence variations in the carboxy-terminal region of the LMPl gene in 12 EBV isolates from spontaneous lym-phoblastoid cell lines derived from individuals with non-EBV associated cancers in Korea. Eleven of the 12 isolates showed a 30-bp deletion spanning LMPI amino acids 342 to 353, suggesting a high prevalence of the LMPI 30-bp deletion variant among EBV isolates in Korea. In addition, all 12 isolates had a 15-bp common deletion in the 33-bp repeat region and multiple base-pair changes relative to the prototype B95-8 EBV strain along with variations in the number of the 33-bp repeats. The bp changes at positions 168746, 168694, 168687, 168395, 168357, 168355, 168631, 168320, 168308, 168295, and 168225 were highly conserved among the isolates. Comparative analysis of sequence change patterns in the LMPI carboxy-terminal coding region identified nine 30-bp deletion variants as China 1, two deletion variants as a possible interstrain between the Alaskan and China 1 strains, and a single undeleted variant as a possible variant of the Alaskan strain. These results suggest the predominance of the China 1 EBV strain in the Korean population.

The Analysis of Creep characteristics for Turbine blade using Theta projection method (θ 투영법을 이용한 터빈 블레이드의 크리프 특성 분석)

  • Lee, Mu-Hyoung;Han, Won-Jae;Jang, Byung-Wook;Lee, Bok-Won;Park, Jung-Sun
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.39 no.4
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    • pp.321-331
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    • 2011
  • The present work is aimed to analyze the creep characteristics of a turbojet engine turbine blade using the theta projection method. The theta projection method has been widely used due to its advantages and flexibility. For the creep characteristic analysis of the turbine blade, tests are performed considering the operating conditions and the non-linear material properties. Results from the creep test are fitted using the four theta model. The predicted proprieties using the four theta model are compared with the prediction model and creep test results. To obtain an optimum value of the four theta parameters in non-linear square method, a number of computing processes in the non-linear least square method were carried out to obtain full creep curves. Results using the theta model has more than 0.95 value of $R^2$. The results between the experimental values and predicted four theta model has about 90.0% accuracy. The theta projection method can be utilized for a design purpose to predict the creep behavior.

The Development of Material Separation Technique for Recycling of Waste Car Tail Lamp (폐자동차(廢自動車) Tail Lamp의 재활용(再活用)을 위한 재질분리(材質分離) 기술개발(技術開發))

  • Jeon, Ho-Seok;Park, Chul-Hyun;Baek, Sang-Ho;Park, Jai-Koo
    • Resources Recycling
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    • v.15 no.6 s.74
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    • pp.25-32
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    • 2006
  • In this study, waste car tau lamps that usually gets incinerated or buried has been recovered during the dispose process in order to increase the recycling rate of waste cars and the material separation research was performed by applying triboelectrostatic separation method. After a series of charging characteristic test, PMMA materials was confirmed of being an effective charging material for waste car tail lamp material separation, a cyclone charger using PMMA material for continuous process was developed. In optimum test conditions using triboelectrostatic separator developed in this study, high quality PMMA material with recovery rate of 99.0% and 90.2% was achieved from the waste car tail lamp. Therefore, a material separation technology that can recycle tail lamps of waste cars has been established.

The Design Status of the Irradiation Facility for Fuel Test (핵연료 시험용 노내조사시험설비의 설계 현황)

  • Park, Kook-Nam;Sim, Bong-Shick;Ahn, Sung-Ho;Yoo, Seong-Yeon
    • Proceedings of the SAREK Conference
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    • 2007.11a
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    • pp.310-315
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    • 2007
  • The FTL has been developed to be able to irradiate test fuels at the irradiation hole(IR1 hole) by considering its utility and user's irradiation requirements. FTL consists of In-Pile Test Section (IPS) and Out-of-Pile System (OPS). Test condition in IPS such as pressure, temperature and the water quality, can be controlled by OPS. For safety assurance IPS is designed to have dual stainless steel pressure vessel and OPS is composed of main cooling water system, emergency cooling water system, LMP(letdown, make-up, purification) system, etc. FTL Conceptual design was set up in 2001, basic design had completed including a design requirement, basic piping & instrument diagram (P&ID), and the detail design in 2004. In 2005, the development team carried out purchase and manufacture hardware and make a contract for construction work. FTL construction work began on August, 2006 and ended on March, 2007. After FTL development which is expected to be finished by 2008, FTL will be used for the irradiation test of the new PWR-type fuel and can maximize the usage of HANARO.

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Decision-Making of Determining the Start Time of Charging / Discharging of Electrical Vehicle Based on Prospect Theory

  • Liu, Lian;Lyu, Xiang;Jiang, Chuanwen;Xie, Da
    • Journal of Electrical Engineering and Technology
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    • v.9 no.3
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    • pp.803-811
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    • 2014
  • The moment when Electrical Vehicle (EV) starts charging or discharging is one of the most important parameters in estimating the impact of EV load on the grid. In this paper, a decision-making problem of determining the start time of charging and discharging during allowed period is proposed and studied under the uncertainty of real-time price. Prospect theory is utilized in the decision-making problem of this paper for it describes a kind of decision making behaviors under uncertainty. The case study uses the parameters of Springo SGM7001EV and adopts the historical realtime locational marginal pricing (LMP) data of PJM market for scenario reduction. Prospect values are calculated for every possible start time in the allowed charging or discharging period. By comparing the calculated prospect values, the optimal decisions are obtained accordingly and the results are compared with those based on Expected Utility Theory. Results show that with different initial State-of-Charge ($SoC_0$) and different reference points, the optimal start time of charging can be the one between 12 a.m. to 3 a.m. and optimal discharging starts at 2 p.m. or 3p.m. Moreover, the decision results of Prospect Theory may differ from that of the Expected Utility Theory with the reference points changing.

A Cross-Sectional Study of Nutrient Intakes by Gestational Age and Pregnancy Outcome(I) (우리나라 임신부의 임신 시기별 영양 섭취상태 및 임신결과에 대한 횡적 조사 연구(I))

  • 유경희
    • Journal of Nutrition and Health
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    • v.32 no.8
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    • pp.877-886
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    • 1999
  • To assess the effect of an antenatal nutritional status on pregnancy outcome, especially neonatal birty weight, one-day 24hr-recall and two-day recording methods for dietary survey and interview for general and obstetric characteristics of each subject were completed and pregnancy outcome was recorded by phone after delivery. 147 pregnant women attending routinely public health centers in Ulsan were divided into 1st trimester(n=36), 2nd trimester(n=102), 3rd trimester(n=71) by LMP(Last Menstrual Period) because some subjects attended repeatedly in different trimester. The subjects were aged 27.9$\pm$2.9 as mean and the level of education was senior high school and more. 20.4% of subjects experienced spontaneous abortion and 30.0% experienced induced abortion in previous pregnancy. Mean intakes of all nutrients except ascorbic acid were significantly different but dietary composition of energy intakes was not different between trimester. Mineral of calcium, iron and zinc did not meet the RDA for pregnancy outcome was about 20%, which consists of spontaneous abortion (3.4%), caesarian section(15.6%), premature delivery(0.7%) and still births(0.7%). The mean birth weight of neonates is 3.31kg the rate of neonatal birth weight below 10th percentile was 8.4% and the rate of low birth weight(<2.5kg) was 3.1%. By analysis of nutrient factors that influence on the neonatal birth weight (NBW), iron intake correlated negatively and zinc intake correlated positively with NBW in 1st trimester but fat and iron intakes correlated with NBW positively in 3rd trimester. Prepregnancy weight, gestational age at delivery and No. of induced abortion had a positive effects on NBW and No. of spontaneous abortion and te severity of morning sickness had a negative effects on NBW.

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Reliability Prediction of Long-term Creep Strength of Gr. 91 Steel for Next Generation Reactor Structure Materials (미래형 원자로 구조 재료용 Gr. 91 강의 장시간 크리프 강도의 신뢰성 예측)

  • Kim, Woo-Gon;Park, Jae-Young;Yin, Song-Nan;Kim, Dae-Whan;Park, Ji-Yeon;Kim, Seon-Jin
    • Korean Journal of Metals and Materials
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    • v.49 no.4
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    • pp.275-280
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    • 2011
  • This paper focuses on reliability prediction of long-term creep strength for Modified 9Cr-1Mo steel (Gr. 91) which is considered as one of the structural materials of next generation reactor systems. A "Z-parameter" method was introduced to describe the magnitude of standard deviation of creep rupture data to the master curve which can be plotted by log stress vs. The larson-Miller parameter (LMP). Statistical analysis showed that the scattering of the Z-parameter for the Gr. 91 steel well followed normal distribution. Using this normal distribution of the Z-parameter, the various reliability curves for creep strength design, such as stress-time temperature parameter reliability curves (${\sigma}$-TTP-R curves), stress-rupture time-reliability curves (${\sigma}-t_{r}-R$ curves), and allowable stress-temperature- reliability curves ([${\sigma}$]-T-R curves) were reasonably drawn, and their results are discussed.

Luminescence Characteristics of Sr3MgSi2O8:Eu Blue Phosphor for Light Emitting Diodes (LED용 Sr3MgSi2O8:Eu청색 형광체의 발광특성)

  • 최경재;박정규;김경남;김창해;김호건
    • Journal of the Korean Ceramic Society
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    • v.41 no.8
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    • pp.573-577
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    • 2004
  • We have synthesized a Eu$^{2+}$-activated Sr$_3$MgSi$_2$ $O_{8}$ blue phosphor and investigated an attempt to develop blue LEDs by combining it with a InGaN blue LED chip (Len=405 nm). The InGaN-based Sr$_3$MgSi$_2$ $O_{8}$:Eu LED Lamp shows two bands at 405 nm and 460 nm. The 405 nm emission band is due to a radiative recombination from a InGaN active layer. This 405 nm emission was used as an optical transition of the Sr$_3$MgSi$_2$ $O_{8}$:Eu phosphor. The 460 m emission band is ascribed to a radiative recombination of Eu$^{2+}$ impurity ions in the Sr$_3$MgSi$_2$ $O_{8}$ host matrix. As a consequence of a preparation of W blue LED Lamp using the Sr$_3$MgSi$_2$ $O_{8}$:Eu blue phosphor, the highest luminescence efficiency was obtained at the ration of epoxy/blue phosphor(1/0,202). At this time, the CIE chromaticity was x=0.1417 and y=0.0683.