• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.102-110
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• 2010

This study was designed to investigate the hyperlipidemia-healing effect of aqueous extract from Mahwangimun-tang(麻黃二門湯) and it was performed on the hyperlipidemia of rats induced by high cholesterol diet and Triton WR-1339. We prepared two types of hyperlipidemia model in rats induced by high cholesterol diet and Triton WR-1339. The amount of total cholesterol, HDL-cholesterol, LDL -cholesterol, triglyceride, phospholipid, free fatty acid, the activity of superoxide dismutase and glutathione were measured. The aqueous extract from Mahwangimun-tang showed significant decreasing effects on total cholesterol, LDL- cholesterol, triglyceride in the both model. And it showed significant increasing effects on HDL-cholesterol, the activity of SOD in both model. These results suggest that aqueous extract from Mahwangimun-tang has healing efficacy on hyperlipidemia induced by high cholesterol diet and Triton WR-1339.

• Nutrition Research and Practice
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• v.4 no.6
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• pp.492-498
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• 2010

Both metabolic syndrome (MetS) and elevated LDL cholesterol (LDL-C) increase the risk for cardiovascular disease (CVD). We hypothesized that low HDL cholesterol (HDL-C) would further increase CVD risk in women having both conditions. To assess this, we recruited 89 women with MetS (25-72 y) and LDL-C ${\geq}$ 2.6 mmol/L. To determine whether plasma HDL-C concentrations were associated with dietary components, circulating atherogenic particles, and other risk factors for CVD, we divided the subjects into two groups: high HDL-C (H-HDL) (${\geq}$ 1.3 mmol/L, n=32) and low HDL-C (L-HDL) (< 1.3 mmol/L, n=57). Plasma lipids, insulin, adiponectin, apolipoproteins, oxidized LDL, Lipoprotein(a), and lipoprotein size and subfractions were measured, and 3-d dietary records were used to assess macronutrient intake. Women with L-HDL had higher sugar intake and glycemic load (P< 0.05), higher plasma insulin (P< 0.01), lower adiponectin (P< 0.05), and higher numbers of atherogenic lipoproteins such as large VLDL (P < 0.01) and small LDL (P<0.001) than the H-HDL group. Women with L-HDL also had larger VLDL and both smaller LDL and HDL particle diameters (P<0.001). HDL-C was positively correlated with LDL size (r=0.691, P<0.0001) and HDL size (r=0.606, P<0.001), and inversely correlated with VLDL size (r=-0.327, P<0.01). We concluded that L-HDL could be used as a marker for increased numbers of circulating atherogenic lipoproteins as well as increased insulin resistance in women who are already at risk for CVD.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.5 no.6
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• pp.546-551
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• 2004

Effect of fried beancurd containing powered green tea on the serum lipid metabolism in rats were investigated. HPLC analysis of green tea-fried beancurd showed that epigallocatechin, epicatechin, epicatechin gallate and epigallocatechin gallate were intact without degradation during manufacturing process. Serum HDL-cholesterol, LDL-cholesterol, triglyceride and glucose concentrations were measured in rats fed experimental diet containing green tea-fried beancurd. Serum LDL-cholesterol contents and blood glucose were significantly decreased with treatment of green tea-fried beancurd comparing to control.

• The Journal of Internal Korean Medicine
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• v.27 no.2
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• pp.488-499
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• 2006

Objectives : This study was executed in order to examine relationship between Sasang constitution and serum lipids in CVA patients. Method and Results : This study was done with 104 cases of stroke patients who admitted to department of the internal medicine Wonkwang university oriental hospital from September in 2004 to August in 2005. A study on the relationship among serum lipids : In T-cholesterol and triglyceride, T-cholesterol and HDL-cholesterol, LDL-cholesterol and HDL-cholesterol. T-cholesterol and LDL-cholesterol, they had positive correlation each other. Between triglyceride and HDL-cholesterol, they had negative correlation each other. Distribution of serum lipids which it follows in stroke type : T-cholesterol, HDL-cholesterol and LDL-cholesterol average of cerebral hemorrhage is higher than cerebral infarction. Distribution of serum lipids which it follows in Sasang constitution : T-cholesterol, triglyceride and LDL-cholesterol average of Taeyumin was higher than different types of Sasang constitution But it didn't have no statistically consideration Conclusions : The relationship between Sasang constitution and Serum lipids was not proven.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.2
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• pp.319-327
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• 2010

This study was designed to investigate the hyperlipidemia-healing effect of liquid extract from Mageum-tang(麻芩湯), it was performed on the hyperlipidemia of rats induced by high cholesterol diet and Triton WR-1339. We prepared two types of hyperlipidemia model in rats induced by high cholesterol diet and Triton WR-1339. The amount of total cholesterol, HDL-cholesterol, LDL -cholesterol, triglyceride, phospholipid, free fatty acid, the activity of superoxide dismutase(SOD), and glutathione were measured. The liquid extract from Mageum-tang showed significant decreasing effects on total cholesterol, LDL- cholesterol, triglyceride, phospholipid, free fatty acid in the both model. And it showed significant increasing effects on HDL-cholesterol, the activity of SOD in both model and amount of glutathione in Triton WR-1339 model. These results suggest that liquid extract from Mageum-tang has healing efficacy on hyperlipidemia induced by high cholesterol diet and Triton WR-1339.

• Journal of Preventive Medicine and Public Health
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• v.25 no.1 s.37
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• pp.44-52
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• 1992

This study was conducted to evaluate the relations between alcohol intake and blood lipid level in a group of 1,138 Korean adult men, ages 20 to 69 years. Total number of each of a variety of drinks in the previous two weeks was obtained by questionnaire and converted into grams of alcohol consumed in a week. The levels of blood lipid such as Cholesterol, HDL-Cholesterol, Triglyceride and LDL-Cholesterol were examined by enzyme method. We also observed the effects of various variables such as age, body mass index, smoking, exercise and blood pressure on blood lipid level. The results obtained were as follows : 1. Average weekly alcohol intake was $129.0{\pm}167.4gm$ and that of 30-39 age group was the highest as $149.3{\pm}170.4gm$. 2. Levels of Cholesterol Triglyceride and LDL-Cholesterol tended to increase with increasing age, but level of HDL-Cholesterol showed no significant relationship with age. 3. The positive linear regressions of alcohol intake on HDL-Cholesterol and Triglyceride were noted statistically significant. 4. Multiple regression analysis demonstrated that the effect of alcohol on HDL-Cholesterol and Triglyceride was statistically significant and the contribution rates were 5.0% and 0.8%, respectively. And, in the case of HDL-Cholesterol, the alcohol intake was the most significant independent variable.

• Journal of the Korean Society of Food Science and Nutrition
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• v.21 no.2
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• pp.131-135
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• 1992

For the investigation of the effects of mushrooms on prevention of hypercholesterolemia, dietary hyperc-holesterolemic rats were fed for 2 weeks with basal diet containing 5% G. lucidum, 5% L. edodes, 5% A. judae and 10% G. lucidum, 10% L. ededos or 10% A. judae mushroom. Concentrations of total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, phospholipid, free-cholesterol, cholesteryl ester, VLDL and chylomicron in serum were analyzed. The result obtained are as follows : Concentrations of total cholesterol, LDL, LDL-cholesterol in serum were lowest in the group 6 (10% L. edodes mushroom) and HDL-cholesterol concentration in serum was significantly higher than the concentrations of the control group. Concentrations of triglyceride, phospholipid, free-cholesterol, cholesteryl ester in serum were lower than the concentration of the control group, and the concentrations of triglyceride, cholesteryl ester in group 6 were lower than those of the other groups. Concentrations of phospholipid and free-cholesterol in group 3 were lower than those of the other groups.

• Journal of Nutrition and Health
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• v.28 no.8
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• pp.697-705
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• 1995

This study was conducted to investigate the effect of increasing dietary fat on plasma lipoprotein in young Korean women. During the three weeks of experimental periods, 8 healthy college women consumed a regular diet, a medium fat diet and a high fat diet for one week, consecutively. The percentages of fat from energy intake in the subjects on the regular, medium, and high fat diets were 20, 29 and 38%, respectively. Our data showed that the dietary intakes of fat and cholesterol had an influence on the plasma lipoprotein. The medium fat diet enhanced the blood glucose concentration and the plasma HDL, and the high fat diet resulted in increases in the blood glucose concentration and the plasma LDL as well as HDL. Also the type of diets led to changes in the composition of lipoprotein. When on the medium fat diet, HDL and LDL had higher phospholipid content. On the high fat diet, LDL had higher phospholipid, cholesterol and triglyceride contents, and HDL included higher cholesterol content.

• Korean Journal of Plant Resources
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• v.27 no.4
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• pp.271-278
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• 2014

Rubus coreanus has been used as a traditional medicine in Asia because of its various pharmacological properties. This study examined the effects of protocatechuic acid (PCA), one of phenolic compounds derived from R. coreanus on the lipid metabolism in high cholesterol diet-induced mice. A total of 30 male C57BL/6 mice were divided into 5 groups with 6 mice in each group as follows: (1) Control mice received normal diet (ND). (2) Mice received high-cholesterol diet (HCD) plus water, 10% sucrose solution and treated daily oral phosphate-buffered-saline (PBS) of equal volumes through gavage. (3) Mice received HCD and treated daily with 25 mg/kg b.w./day of PCA (4) with 50 mg/kg b.w./day or (5) with 10 mg/kg b.w./day of simvastatin via oral gavage for 12 weeks. Body weights were measured weekly for a period of experiment. After treatment, liver, thymus, spleen and kidney were harvested and weighed, and the lipid metabolite profiles (total cholesterol, triglyceride (TG), HDL-cholesterol (HDL-c), LDL-cholesterol (LDL-c) and liver-damaging markers (GOT and GPT) in serum were examined. PCA significantly reduced the total cholesterol, TG, LDL-c level and increased the HDL-c level. PCA administration also significantly reduced the levels of GOT and GPT. These results indicate that the PCA could be used as a functional material for lowering lipid and an adjuvant for the treatment of hyperlipemia.

• Journal of Acupuncture Research
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• v.24 no.5
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• pp.67-88
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• 2007

Objectives : To present proper protocol as global standard- clinical study about acupuncture treatment, and to demonstrate effectiveness of Sa-am Acupuncture treatment for obesity. Methods : We randomly allocated participants to treatment group 1 and 2. The group 1 is treated by real acupuncture and the group 2 is treated by Kim Sham Acupuncture. We treated Bi-jang seung-gyeok (脾臟勝格) ; Daedon(LR1), EunBaek(SP1) Gyoung-geo(LU8) Sang-gu(SP5), to both group. Primary outcomes were measured by the Body Composition Analysis(Inbody. Korea). Secondary outcomes were measured by Blood Cholesterol, Triglyceride, HDL, LDL Cholesterol. Results : After treatment, the group 1 shown significant weight loss that analysed by Kruskal-Wallis certification, but didn't show notable change in body fat, total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol. Group 2 didn't show significant change in body weight, body fat, triglyceride, HDL cholesterol, LDL cholesterol, but total cholesterol was notably decreased. Controled group was not changed in body weight, body fat. Aftter treatment, 3 groups didn't show significant change in body weight, body fat, triglyceride, HDL cholesterol, LDL cholesterol, total cholesterol.