• 한국체육학회지인문사회과학편
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• 제51권2호
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• pp.305-314
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• 2012

본 연구의 여가제약 수준에 따른 여가정체성 현출성, 여가제약 협상전략 및 여가활동 참가의도간의 인과관계를 검증하는데 있다. 이를 위하여 서울, 경기지역에 소재한 4년제 대학재학생 296명을 대상으로 SPSS 18.0과 AMOS 18.0을 이용하여 구조방정식 모형분석을 실시하여 다음과 같은 결론을 얻었다. 여가제약의 수준에 따라 여가정체성 현출성, 여가제약 협상전략, 여가활동 참가의도의 인과관계를 검증한 결과 첫째, 여가제약 수준이 높은 집단과 낮은 집단 모두에서 여가정체성 현출성은 협상전략에 정적인 영향을 미치고 있었다. 다만, 여가제약 수준이 높은 집단의 경우, 정체성 현출성의 발현 정도가 더 높게 나타났다. 둘째, 여가제약 수준이 낮은 집단의 경우에는 여가정체성 현출성이 높아지면 여가활동 참가의도에 긍정적(+) 관계가 직접적으로 나타났다. 셋째, 여가제약 수준이 높은 집단에서는 여가정체성 현출성이 여가활동 참가의도에 직접적인 영향관계를 주지 못하고, 여가제약 협상전략을 적극적으로 수용함으로써 궁극적으로 여가활동 참가의도에 영향을 미치는 것으로 드러났다. 이러한 결과를 통해 제약이 높게 인지되는 경우일수록, 여가참가 의도에 대한 제약협상전략의 매개적 역할이 중요해 짐을 유추할 수 있다. 또한 본 연구를 통해 여가제약 협상전략의 과정에서 여가정체성 현출성의 중요성에 대해서도 검증할 수 있었다.

• 한국통신학회:학술대회논문집
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• 한국통신학회 1993년도 추계종합학술발표회 논문집
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• pp.62-66
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• 1993

• 융합정보논문지
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• 제11권9호
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• pp.50-57
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• 2021

본 연구는 지역사회 거주 노인들의 통합돌봄욕구를 유형화하여 각 유형이 우울에 미치는 영향을 검증하고, 동시에 각 유형의 인구사회학적 특징을 파악하기 위해 실시되었다. 2017년 노인실태조사 자료로 65세 이상 노인 10,300명을 대상으로 분석한 결과는 다음과 같다. 첫째, 만성질환 수, ADL/IADL, 거주환경 만족도, 사회활동/사회적 지지망으로 노인들의 돌봄욕구 수준을 유형화한 결과, '전반적 돌봄욕구 저집단', '사회적욕구 고집단', '복합 돌봄욕구집단'의 세 개 군집이 도출되었다. 둘째, '사회적욕구 고집단'에 비해 '복합돌봄욕구집단'은 고연령, 여성, 낮은 교육수준, 도시 거주라는 특성이, '전반적 돌봄욕구 저집단'은 저연령, 여성, 높은 교육수준, 가족동거라는 특성이 제시되었다. 셋째, '전반적 돌봄욕구 저집단'의 우울 수준은 '사회적욕구 고집단'에 비해 더 낮았고, '복합돌봄 욕구집단'의 우울 수준은 더 높은 것으로 나타났다. 분석 결과에 따른 실천적, 정책적 함의를 논하였다.

• Biomolecules & Therapeutics
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• 제29권2호
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• pp.135-143
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• 2021

Drug addiction influences most communities directly or indirectly. Increasing studies have reported the relationship between circadian-related genes and drug addiction. Per2 disrupted mice exhibited more vulnerable behavioral responses against some drugs including methamphetamine (METH). However, its roles and mechanisms are still not clear. Transcriptional profiling analysis in Per2 knockout (KO) mice may provide a valuable tool to identify potential genetic involvement and pathways in enhanced behavioral responses against drugs. To explore the potential genetic involvement, we examined common differentially expressed genes (DEGs) in the striatum of drug naïve Per2 KO/wild-type (WT) mice, and before/after METH treatment in Per2 KO mice, but not in WT mice. We selected 9 common DEGs (Ncald, Cpa6, Pklr, Ttc29, Cbr2, Egr2, Prg4, Lcn2, and Camsap2) based on literature research. Among the common DEGs, Ncald, Cpa6, Pklr, and Ttc29 showed higher expression levels in drug naïve Per2 KO mice than in WT mice, while they were downregulated in Per2 KO mice after METH treatment. In contrast, Cbr2, Egr2, Prg4, Lcn2, and Camsap2 exhibited lower expression levels in drug naïve Per2 KO mice than in WT mice, while they were upregulated after METH treatment in Per2 KO mice. qRT-PCR analyses validated the expression patterns of 9 target genes before/after METH treatment in Per2 KO and WT mice. Although further research is required to deeply understand the relationship and roles of the 9 target genes in drug addiction, the findings from the present study indicate that the target genes might play important roles in drug addiction.

• 디지털산업정보학회논문지
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• 제6권1호
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• pp.83-90
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• 2010

DTNs (Delay Tolerant Networks) refer to the networks that can support data transmission in the extreme networking situations such as continuous delay and no connectivity between ends. DTMNs (Delay Tolerant Networks) are a specific range of DTNs, and its chief considerations in the process of message delivery in the routing protocol are the transmission delay, improvement of reliability, and reduction of network loading. This article proposes a new LCN (Largest Common Neighbor) routing algorism to improve Spray and Wait routing protocol that prevents the generation of unnecessary packets in a network by letting mobile nodes limit the number of copies of their messages to all nodes to L. Since higher L is distributed to nodes with directivity to the destination node and the maximum number of common neighbor nodes among the mobile nodes based on the directivity information of each node and the maximum number of common neighbor nodes, more efficient node transmission can be realized. In order to verify this proposed algorism, DTN simulator was designed by using ONE simulator. According to the result of this simulation, the suggested algorism can reduce average delay and unnecessary message generation.

• 한국환경과학회지
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• 제17권3호
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• pp.335-342
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• 2008

This study based on electro-coagulation & oxidation reaction is applied to wastewater treatment. Electro-oxidation reaction is used to remove cyanide(CN) which is contained in plating wastewater. Cyanide is transferred by gases such as $NH_3,\;NO_x,\;CO_2$. Analysis result and removal efficiency of Cyanide which is contained in heavy metal wastewater of plating plant, are shown as following paragraph. In electrode arrangement experiment, removal efficiency of carbon electrode(-)/STS316L electrode(+) arrangement method is superior to carbon electrode(-)/carbon electrode(+) arrangement method. Removal efficiencies of cyanide in different HRT such as 30 min, 45 min, 60 min, 75 min and 90 min are 85.5%, 93.1%, 98.0%, 98.7% and 99.4% respectively in carbon electrode(-)/STS316L electrode(+) arrangement method. Finally we can estimate the critical point at HRT of 60 min which the variation of removal efficiency is decreased and HRT to obtain removal efficiency of less than 1 mg/LCN is minimum 90 min.

• 에너지공학
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• 제14권2호
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• pp.140-146
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• 2005

이 연구에서는 전과정평가 방법을 토대로 국내 가동중인 대표적 발전기술들의 글로벌 환경성을 평가하였다. 전과정평가 방법론은 환경영향을 평가하는데 있어 유용성이 뛰어난 도구이다. 대표적 발전원들은 국내 전력공급의 $90\%$ 정도를 차지하고 있는 원자력, 유연탄, LNC 발전소로 하였고, 여기에 더하여 재생 에너지원 중 대표 격인 풍력발전 기술로 하였다. 환경영향 평가는 지구 지역, 부지의 환경에 영향을 미치는 8개의 영향범주를 설정한 후, 발전원별 환경영향을 평가하기 위해 특성화 영향 지표를 계산하였고, 영향범주간 상대적 중요성을 비교하기 위해 정규화 영향 지표도 평가되었다.

• Molecular & Cellular Toxicology
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• 제2권3호
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• pp.193-201
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• 2006

Cephalexin, one of most widely prescribed cephalosporin, has been reported to cause acute renal failure as a side effect in human and experimental animals. Although numerous animal studies have been reported for the cephalosporin nephrotoxicity, the molecular and cellular nephrotoxic mechanisms of cephalexin are still unknown. This investigation evaluated the time-dependent gene expression profile of kidney in mouse during cephalexin induced nephrotoxicity. C57BL/6 female mice were administered either saline or 1,000 mg/kg cephalexin intraperitoneally. Mice were sacrificed at 3, 6, and 24 hr after administration. Blood biochemical and histopathological results indicated cephalexin induced nephrotoxicity. Microarray experiment carried out using Affymetrix $GeneChip^{(R)}$. There were 198 informative genes that were significantly expressed >5-fold versus control at 3, 6, and 24 hr (p<0.01), of which 156 and 42 were up-and down-regulated, respectively. Major classes of up-regulated genes at 3, 6 hr included those involved in MAPK/Jak-STAT signaling pathway and immune response such as cytokine-cytokine receptor interaction and complement and coagulation cascades. At 24 hr, up-regulated genes were mainly involved in regeneration/repair and immune response; down-regulated genes were generally associated with transporters and intermediary metabolism. Among the up-regulated genes at 24 hr, several potential biomarkers on nephrotoxicity such as Kim-1, Fga, Timp1, and Slc34a2 were clustered in a same category. In addition, Tnfrsf12a and Lcn2 which were consistently up-regulated (>5 fold) were also included as potential biomarkers. These results may provide clues for elucidating the mechanism of cephalexin induced nephrotoxicity and evaluating potential biomarkers to assess nephrotoxicity.

• 한국ITS학회 논문지
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• 제11권6호
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• pp.103-110
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• 2012

VANET의 대표적 응용인 차량 안전 통신에서는 차량 운행 중 긴급 상황에 대처하기 위하여 차량 간 통신을 통해서 EWM (Emergency Warning Message)을 브로드캐스트하게 된다. 그러나 차량의 수가 증가하게 되면 다수의 중복된 EWM의 송수신으로 인하여 Broadcast Storm Problem이 발생한다. Broadcast Storm Problem을 해결하기 위한 여러 가지 방안들이 제시되었으나 대부분의 경우, 사전에 주변 차량들과의 주기적인 Beacon 메시지의 송수신을 통하여 이웃관계를 설정하거나 이동성에 따른 토폴로지 변화로 이웃관계를 재설정해야 하는 과정이 필요하며 동시에 Beacon 메시지 교환에 따라 통신부하를 가중시키게 된다. 본 논문에서는 이웃관계 설정을 위한 Beacon 메시지 교환과정을 생략하고 Broadcast Storm Problem을 효율적으로 해결할 수 있는 LLR (Longest Leaping Relay) 기법을 제안하여 컴퓨터 시뮬레이션을 통해 성능을 검증하였다.

• Journal of Ginseng Research
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• 제43권4호
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• pp.666-675
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• 2019

Background: Korean Red Ginseng (KRG) has been widely used as an herbal medicine to normalize and strengthen body functions. Although many researchers have focused on the biological effects of KRG, more studies on the action mechanism of red ginseng are still needed. Previously, we investigated the proteomic changes of the rat spleen while searching for molecular signatures and the action mechanism of KRG. The proteomic analysis revealed that differentially expressed proteins (DEPs) were involved in the increased immune response and phagocytosis. The aim of this study was to evaluate the biological activities of KRG, especially the immune-enhancing response of KRG. Methods: Rats were divided into 4 groups: 0 (control group), 500, 1000, and 2000 mg/kg administration of KRG powder for 6 weeks, respectively. Isobaric tags for relative and absolute quantitation was performed with Q-Exactive LC-MS/MS to compare associated proteins between the groups. The putative DEPs were identified by a current UniProt rat protein database search and by the Gene Ontology annotations. Results: The DEPs appear to increase the innate and acquired immunity as well as immune cell movement. These results suggest that KRG can stimulate immune responses. This analysis refined our targets of interest to include the potential functions of KRG. Furthermore, we validated the potential molecular targets of the functions, representatively LCN2, CRAMP, and HLA-DQB1, by Western blotting. Conclusion: These results may provide molecular signature candidates to elucidate the mechanisms of the immune response by KRG. Here, we demonstrate a strategy of tissue proteomics for the discovery of the molecular function of KRG.