• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.25 no.2
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• pp.21-29
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• 2019

Background: The purpose of this study is to investigate the effect of the combined exercise program on the static balance ability of the lumbar instability of adults. Methods: The experimental group was divided into two groups and randomly. The experimental group 1 (Exp 1) applied the combined exercise program for the lumbar stabilization exercise and strengthening exercises and the experimental group 2 (Exp 2) applied the combined exercises program for the lumbar stabilization exercises and active stretching exercises. Each experiment group performed exercise program for 4 weeks, 3 times a week, 30 minutes a day. Static balance ability was measured using GOOD BALANCE system. Results: As the comparing results of static balance ability, normal standing eye open was Ant-Post and Med-Lat showed significant differences in Exp 1 (p<.05). One leg left eye open was velocity moment showed significant differences in Exp 1 (p<.05). and one leg right eye open was Med-Lat showed significant differences in Exp 1 (p<.05). Conclusion: These results show that thoracic self mobilization is immediate effective on balance and gait ability. Thus, thoracic self mobilization will help recovery of balance and gait ability in acute stroke patients.

• International Journal of Oral Biology
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• v.30 no.1
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• pp.17-22
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• 2005

In the previous studies of Saccharomyces cerevisiae, Abp140p (actin binding protein 140) fused to GFP has been only a protein that can label actin cables of yeast cells so far. However, the role of Abp140p in actin dynamics was remained elusive. In this study, the function of Abp140p was investigated with a deletion mutant and overexpression of GFP fused Abp140p. The deletion mutant was slightly more susceptible to Latrunculin-A (Lat-A), an actin-monomer sequestering agent, than wild type, although no significant deformation of actin structures was caused by ABP 140 deletion. Overexpression of Abp140p-GFP retarded cell growth, and produced thick and robust actin cables. Lat-A was not able to destabilize the thick actin cables, which suggests that actin dynamics was compromised in the cells with surplus of Abp140p. Therefore, Abp140p seems to stabilize actin cables together with other bundling proteins. Recently, actin cable dynamics of budding yeast was found to have a resemblance to that of filopodial tip of cultured mammalian cells. Retrograde movement of actin cables from buds to mother cells indicated local generation of the cable at bud sites. By using Abp140p-GFP, we traced the steps in the generation of a new actin cable after elimination of old cables by sodium azide. Before the appearance of a new actin cable, Abp140p-GFP concentrated in buds and disappeared, as mother cells became abundant in actin cables. Our observations provide a direct evidence of actin cable formation at buds of budding cells.

• Progress in Medical Physics
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• v.10 no.1
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• pp.47-54
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• 1999

Purpose: To verify the BRW coordinates of target located within the limit of XKnife hardware, and to verify the successful transfer of image data, rod detection, anatomical structure when CT images are transferred into a XKnife computer. Materials and Methods: Target coordinates of 13 patients were calculated by SCS1 computer through the rod image on the console screen and film. BRW coordinates of target and landmark calculated by SCS1 computer were compared to those acquired by XKnife localizer. Results : Vertical components of BRW coordinates of target for 13 patients are larger than -50 mm, and then the vertical components of BRW coordinates of target are localized within the limit of XKnife hardware. Average differences between XKnife and SCS1 for BRW coordinates of target and landmark were within 1 mm for AP and LAT components, 0.5 mm for VERT component. Conclusion : It was verified that the SCS1 computer is adequate tool to calculate BRW coordinates of target quickly. And by the comparison between SCS1 computer and XKnife localizer, it was verified that the image transfer into the XKnife computer was performed successfully.

• Korean Journal of Veterinary Research
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• v.39 no.6
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• pp.1151-1160
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• 1999

This study was conducted to detect the toxoplasma-specific DNA in peripheral blood collected from cats experimentally infected with Toxoplasma gondii (RH strain) and from domiciled cats by B1 gene-base polymerise chain reaction(PCR). The sensitivity of oligonucleotide primer, T-1 & T-2, designed from toxoplasma B1 gene amplification method was compared with parasite detection by mouse inoculation(MI). And also, latex agglutination test(LAT) and indirect fluorescent antibody test(IFAT) were conducted to detect the fluctuation of serum antibodies compared with the detection of toxoplasma by PCR and MI. Toxoplasma B1 gene PCR was shown consistently high sensitivity and the results obtained by PCR agreed completely with those from MI. All blood samples collected before infection with T gondii gave negative results by PCR and MI. Also, toxoplasma Bl gene PCR was not cross reaction with Neospora caninum DNA and normal cat leucocyte as controls. The toxoplasma-specific DNA was detected by PCR in blood of 5 cats experimentally infected with T gondii 6 days after infection and the detection of this specific-DNA was long lasted in blood for 64 days after infection. The detection of toxoplasma-specific DNA by PCR could be identified as few as 10 tachyzoites and the isolation of T gondii by MI could be isolated as few as 1 tachyzoite from tenfold serial dilution of T gondii with normal cat blood, respectively. In healthy domiciled cats, the toxoplasma-specific DNA and the parasite were detected and isolated in blood from 3 of 56(5.3%) cats by both PCR and MI, respectively. In the results of antibody test from the total 56 heads of healthy domiciled cats, the positive rates are 15(26.7%) by LAT and 19(33.9%) by IFAT. These results suggest that PCR detection of toxoplasma can be applied as a sensitive and specific diagnostic and research tool.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.30 no.3
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• pp.337-347
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• 2020

In CRYPTO 2019, Gohr presents that Deep-learning can be used for cryptanalysis. In this paper, we verify whether Deep-learning can identify the structures of S-box. To this end, we conducted two experiments. First, we use DDT and LAT of S-boxes as the learning data, whose structure is one of mainly used S-box structures including Feistel, MISTY, SPN, and multiplicative inverse. Surprisingly, our Deep-learning algorithms can identify not only the structures but also the number of used rounds. The second application verifies the pseudo-randomness of and structures by increasing the nuber of rounds in each structure. Our Deep-learning algorithms outperform the theoretical distinguisher in terms of the number of rounds. In general, the design rationale of ciphers used for high level of confidentiality, such as for military purposes, tends to be concealed in order to interfere cryptanalysis. The methods presented in this paper show that Deep-learning can be utilized as a tool for analyzing such undisclosed design rationale.

• Journal of Yeungnam Medical Science
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• v.7 no.1
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• pp.113-119
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• 1990

The stereotactic radiosurgery using ionizing radiation of high energy is a technique for exadicating intracranial small tumors, which are inaccessible or unsuitable for open surgical technique. For such a small field radiosurgery. TLD or film dosimetry is essential. The three dimensional dose planning of radiosurgery was performed with dose planning computer system (Therac 2300). The target dose distribution and its error according to patient position were discussed. And were measured of circular cone which specially designed in our Hospital. The position error of Rando Phantom compared with CT were O.4mm in the AP-LAT section and in the AP-VERT section, 1.0mm in the AP-VERT $45^{\circ}$section. The ratio of accuracy of the gantry and couch rotation were 1.5mm diamteter for centeral axis of I8MeV linear accelerator. Our study suggested that radiosurgery of small field in our department will be appropriate for clinical application.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.465-465
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• 2016

관거시설은 관거, 맨홀(manhole), 우수토실, 물받이, 연결관, 침투시설, 저류시설, 펌프장 등을 포함하는 시설들로 구성되어 있다. 여기서 맨홀은 배수시설의 유지와 관리를 위하여 일정거리마다 설치되고 있으며, 관거의 기점, 방향, 경사 및 관경이 변하는 곳, 단차가 발생하는 곳, 관거가 합류하는 곳에는 반드시 설치한다(환경부, 2011). 그러나 하수도시설기준(환경부, 2011)에서 합류맨홀의 설치에 관한 사항은 T형 합류맨홀에 관한 개략적인 표만 제시되어 있을 뿐, 4방향 합류맨홀에 대한 구체적인 설치 기준이 제시되어 있지 않은 실정이다. 또한 에너지 손실의 저감 및 배수능력을 증대시키기 위하여 맨홀내 설치되는 인버트는 미국의 형태 및 기준을 그대로 적용하고 있으므로 관거시설의 시설의 합리적인 설계기준을 제시하기 위하여 인버트가 설치된 4방향 합류맨홀에서의 흐름특성 및 수두 손실을 분석할 필요가 있다. 본 연구에서는 인버트가 설치된 4방향 합류맨홀 손실계수 산정 및 흐름특성을 분석하기 위하여 문헌조사 및 현장조사를 실시하여 수리실험 장치를 제작하였다. 실험에 사용된 맨홀은 하수도시설기준(환경부, 2011)의 표준 1호 맨홀을 1/5로 축소하였고, 인버트는 설치되지 않은 조건(CASE A), 반원형 인버트(CASE B), U형 인버트(CASE C)를 각각 실험하였으며, 실험유량으로 총 유출량 (Qout)은 $2{\sim}5{\ell}/sec$, 총 유출량에 대한 측면 유입량($Q_{Lat}$)의 비($Q_{Lat}/Q_{out}$)는 0~1 조건으로 변화시키면서 흐름특성 및 손실계수를 산정하였다. 실험결과 측면유량비가 증가함에 따라 CASE B와 CASE C는 CASE A보다 맨홀 내 수심이 약 3~7%정도 증가되는 경향을 나타내고 있었으며, 측면유량비의 증가에 따른 손실계수 산정 결과, CASE B는 CASE A 보다 약 30%정도 손실계수가 증가하였으며, CASE C는 CASE A보다 약 35%정도 손실계수가 증가하는 것으로 나타났다. 이는 기존에 사용되고 있는 인버트의 형상이 4방향 합류맨홀에서의 손실 저감 및 배수능력을 증대시키기 보다는 오히려 맨홀 내 통수능력을 저하시켜 4방향 합류맨홀에서의 배수능력을 저감시키는 것으로 분석되었다. 그러므로 기 사용되는 인버트의 개선이 필요하며 관거시설의 배수능력을 증대하기 위하여 지속적인 연구를 통한 개선된 인버트의 형상 제시가 필요할 것으로 판단된다.

• Biomolecules & Therapeutics
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• v.30 no.6
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• pp.520-528
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• 2022

Mast cells are an effector cell that plays a pivotal role in type I hypersensitive immune responses. Mast cells exist in connective tissues, such as skin and mucosal tissue, and contain granules which contain bioactive substances such as histamine and heparin in cells. The granules of mast cells are secreted by antigen stimulation to cause the type I allergic hypersensitivity. In addition, stimulated by antigen, mast cells synthesize and secrete various eicosanoids and cytokines. While AT9283 is known to have anticancer effects, the therapeutic effect of AT9283 on allergic disorders is completely unknown. In this study, it was found that AT9283 reversibly inhibited antigen-IgE binding-induced degranulation in mast cells (IC₅₀, approx. 0.58 μM) and suppressed the secretion of the inflammatory cytokines IL-4 (IC₅₀, approx. 0.09 μM) and TNF-α (IC₅₀, approx. 0.19 μM). For a mechanism of mast cell inhibition, while not inhibiting Syk phosphorylation, AT9283 suppressed the activation of LAT, a downstream substrate protein of Syk, in a dose-dependent manner. As expected, AT9283 also inhibited the activation of PLCγ1 and Akt, downstream signaling molecules of Syk/LAT, and MAP kinases such as JNK, Erk1/2, and P38. In an in vitro protein tyrosine kinase assay, AT9283 directly inhibited Syk activity. Next, AT9283 dose-dependently inhibited passive cutaneous anaphylaxis (PCA), an IgE-mediated allergic acute response, in mice (ED50, approx. 34 mg/kg, p.o.). These findings suggest that AT9283 has potential to use as a new drug for alleviating the symptoms of IgE-mediated allergic disorders.

• Journal of the Korea Society of Computer and Information
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• v.28 no.11
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• pp.65-71
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• 2023

In this paper, we design and implement the Walking Life Festival application, which is based on the Android platform and provides information about domestic travel destinations and regional festivals in South Korea. This application utilizes various sensors found in smartphones, including the Step Counter sensor, Step Detector sensor, Acceleration sensor, and GPS sensor. Additionally, it makes use of Google Map API and Public Open API to offer information about domestic travel destinations and local festivals. The application also incorporates an automatic login feature using the Shared Preference API. When storing login information in the database, it encrypts the input plaintext data using a hash algorithm. For Google Maps integration, it creates objects using the Google.maps.LatLngBounds() method and extends the location information through the extends method. Furthermore, this application contributes to the activation of the domestic tourism industry by notifying users about the timing of local festivals related to domestic travel destinations, thus increasing their opportunities to participate in these festivals.

• The Journal of Korean Society for Radiation Therapy
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• v.29 no.2
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• pp.43-51
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• 2017

Purpose: The purpose of this study is to evaluate the dosimetric effects of couch attenuation and air gaps using 3D phantom for prone breast radiation therapy. Materials and method: A 3D printer(Builder Extreme 1000) and computed tomography (CT) images of a breast cancer patient were used to manufacture the customized breast phantom. Eclipse External Beam Planning 13.6 (Varian Medical Systems Palo Alto, CA, USA) was used to create the treatment plan with a dose of 200 cGy per fraction with 6 MV energy. The Optically Stimulated Luminescence Detector(OSLD) was used to measure the skin dose at four points (Med 1, Med 2, Lat 1, Lat 2) on the 3D phantom and ion-chamber (FC65-G) were used to perform the in-vivo dosimetry at the two points (Anterior, Posterior). The Skin dose and in-vivo dosimetry were measured with reference air gap (3 cm) and increased air gaps (1, 2, 3, 4, 5, 6 cm) from reference distance between the couch and 3D phantom. Results: As a result, measurement for the skin dose at lateral point showed a similar value within ${\pm}4%$ compared to the plan. While the air gap increased, skin dose at medial 1 was reduced. And it was also reduced over 7 % when the air gap was more than 3 cm compared to radiation therapy plan. At medial 2 it was reduced over 4 % as well. The changes of dose from variety of the air gap showed similar value within ${\pm}1%$ at posterior. As the air gap was increased, the dose at anterior was also increased and it was increased by 1 % from the air gap distance more than 3 cm. Conclusion: Dosimetrical measurement using 3D phantom is very useful to evaluate the dosimetric effects of couch attenuation and air gaps for prone breast radiation therapy. And it is possible to reduce the skin dose and increase the accuracy of the radiation dose delivery by appling the optimized air gap.