• Asian-Australasian Journal of Animal Sciences
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• 제31권6호
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• pp.798-803
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• 2018

Objective: The objective of this study was to estimate the genetic parameters for milk ${\beta}$-hydroxybutyrate (BHBA), acetone (Ac), fat protein ratio (FPR), and energy balance (EB) using milk test day records and investigate the effect of early lactation FPR and EB on milk ketone body concentrations. Methods: Total 262,940 test-day records collected from Korea Animal Improvement Association during the period of 2012 to 2016 were used in this study. BHBA and Ac concentrations in milk were measured by Fourier transform infrared spectroscopy (FTIR). FPR values were obtained using test day records of fat and protein percentage. EB was calculated using previously developed equation based on parity, lactation week, and milk composition data. Genetic parameters were estimated by restricted maximum likelihood procedure based on repeatability model using Wombat program. Results: Elevated milk BHBA and Ac concentrations were observed during the early lactation under the negative energy balance. Milk FPR tends to decrease with the decreasing ketone body concentrations. Heritability estimates for milk BHBA, Ac, EB, and FPR ranged from 0.09 to 0.14, 0.23 to 0.31, 0.19 to 0.52, and 0.16 to 0.42 respectively at parity 1, 2, 3, and 4. The overall heritability for BHBA, Ac, EB and FPR were 0.29, 0.32, 0.58, and 0.38 respectively. A common pattern was observed in heritability of EB and FPR along with parities. Conclusion: FPR and EB can be suggested as potential predictors for risk of hyperketonemia. The heritability estimates of milk BHBA, Ac, EB, and FPR indicate that the selective breeding may contribute to maintaining the milk ketone bodies at optimum level during early lactation.

• 한국환경보건학회지
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• 제30권2호
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• pp.71-78
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• 2004

This study was performed to evaluate developmental and estrogenic activity of bisphenol A (BPA) and butyl benzyl phthalate (BBP) to the second generation of Sprague-Dawley rats ingested during gestational or lactational periods. Rats were given BPA 20$\mu\textrm{g}$/kg BBP 100mg/kg of pregnancy or lactation periods. Maternal body weight and neonatal body weight were recorded. The rats were sacrificed on day 21 after birth. Reproductive organs of dam and neonate were utilized for receptor binding assay. The plasma concentrations of BPA and MBep, one of the major metabolites of BBP were analyzed with HPLC. The co-administration of BPA and BBP induced slow weight gain compared with single administration in dams. Also, such mixture induced low neonatal body weights in next generation. The dams treated with BPA and BBP during lactational periods showed significant organ weight changes in liver and spleen. The dams exposed during lactational periods showed significant organ weight changes not only in liver and spleen but also in kidney, uterus and ovary. The F1 female rats exposed during lactation periods showed significant organ weight changes in liver, spleen, ovary. The F1 male rats showed significant organ weight changes in liver, kidney, epididymis, vesicular glands, prostate. However, no clear synergistic effects of BPA and BBP were noted. There was no significantly different ER$\alpha$ expression pattern between control and treated groups. However, ER$\alpha$ expression were increased in F1 male testis and female uterus. PI male showed distinct ER$\alpha$ expression, especially in the group of lactational combined exposure. Synergistic ER$\alpha$ expression was found by combined treatment of BPA and BBP. We could not find any evidences of synergistic effects on BPA and/or BBP combined administration on dams and their fetuses, except in ER$\alpha$ expression of F1 male.

• Journal of Animal Science and Technology
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• 제48권6호
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• pp.767-776
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• 2006

젖소의 강건성 및 생산수명과 밀접한 관련성이 있는 선형심사형질들에 대한 여러가지 환경요인들의 효과를 알아보고 측정치에 영향하는 환경요인들에 대한 효과를 추정함으로써 통계적 유전분석을 위한 기초자료를 제공하고자 한국종축개량협회에서 2000년부터 2004년까지 국 Holstein 젖소 115,646두를 대상으로 측정한 15개의 선형심사 1차형질과 5개의 선형심사 2차형질에 대한 통계분석모형을 찾고 해당요인들에 대한 효과를 제시하였다. 모형설정을 위한 1차 연구로써 농가(H), 심사년도(Y), 심사월(M) 심사자(A)에 따라 분석에 고려된 대분분의 형질에서 고도의 유의적인 차이가 있었기 때문에 해당요인들을 결합한 HYMA 효과를 고려하고 산차, 비유기간, 등록구분 및 착유개시 후 심사시까지의 시간을 주 요인으로 하는 분산분석을 실시하였다. HYMA 효과에 대한 보정을 실시한 후 산차 및 비유기간은 분석에 고려된 1차 심사형질 및 2차 심사형질 전체에 있어서 고도의 유의적인 차이가 있는 것으로 분석되었고 등록구분은 유방부위의 심사점수 등 일부의 형질에서 유의적인 차이가 있는 것으로 분석된 반면에 심사시간은 대부분의 형질에서 유의적인 차이를 보이지 않았다. 유방부위의 심사점수, 유두배열 및 발굽각도 등은 산차가 증가할수록 심사점수가 감소하는 경향을 보인 반면에 기타 형질들은 산차가 증가할수록 점차 증가하는 경향을 보였다. 2～3산에서 최대의 최종심사점수를 보였는데 이는 우리나라 착유우의 생산수명이 짧고 다산우가 적은 것과 관련이 있는 것으로 추론된다. 비유기간에 따라 예각성, 뒷유방의 부착높이, 뒷유방의 너비 및 최종점수는 비유곡선과 유사한 경향치를 보이는 것으로 평가되었다. 2차 선형심사형질에 있어서는 산차가 증가하거나 비유기간이 증가할수록 지제 및 비유기관의 점수가 낮아지고 있는 경향을 보였으며 유용특질은 비유기간에 따라 비유곡선과 유사한 경향치를 보였다. 따라서 최종심사점수는 비유기간에 따른 보정을 실시함이 바람직할 것으로 사료된다.

• Asian-Australasian Journal of Animal Sciences
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• 제14권6호
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• pp.765-770
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• 2001

Thirty second parity sows of the synthetic Nepalese Pakhribas genotype were used to investigate factors which might improve the occurrence and expression of estrus. The experiment had two sequential elements. In part 1, a change in suckling pattern was applied during lactation, and in part 2, different estrus detection methods were evaluated after weaning. All sows received the same pattern of weaning, which imitated the progressive weaning system used in Nepalese villages. Piglets from each litter were weaned at three ages (6, 7 and 8 weeks of age) in the proportion of 0.5 at 6 weeks followed by 0.25 at each of the subsequent weanings. In the first lactation treatment, the suckling pattern was left undisturbed, similar to the practice used in the villages in which the remaining piglets after first weaning are allowed continuous suckling. In the other treatment, the remaining piglets after first weaning were allowed to suckle their sows only during the night, whilst in the day time (09:00-16:00) they were excluded from the sow but left free to roam around. After weaning, estrus detection procedures were carried out in the absence or presence of two different boar stimuli: a synthetic boar pheromone spray or fresh boar urine. These were applied sequentially in a sequence of testing that alternated for each sow on a daily basis. The weaning to re-mating interval was significantly longer for the unrestricted suckling treatment. All sows were re-mated within 30 days after first weaning in the restricted suckling treatment groups, whereas only 71% of sows were re-mated within 30 days after weaning in the unrestricted suckling treatment groups ($x^2=3.877$, 1df, p<0.05). Both boar pheromone spray and boar urine increased the estrus detection probability, with no significant differences between the two stimuli treatments.

• 한국식품영양과학회지
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• 제14권1호
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• pp.39-46
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• 1985

수유 기간의 경과에 따른 인유의 트리글리세리드조성의 변화를 자유 섭취하는 수유부들로부터 분만 후 70일까지 채취한 인유 69시료에 대하여 가스 크로마토그래피와 TLC-FID 법 등을 사용하여 살펴 보았다. 트리글리세리드의 포화 지방산 중에서 유선의 alveolar cell에서 합성되는 지방산들(8:0, 10:0, 12:0, 14:0)은 수유 기간이 경과함에 따라 점차 유의하게 증가하였다. 혈액으로부터 유래되는 포화 지방산들 중 16:0, 22:0, 24:0 등의 지방산들은 초유에서 유의하게 높았다. 18:2w6과 18:3w3은 수유 기간이 경과함에 따라 증가한 반면 18:1w9와 w6 및 w3계의 장쇄 고도 불포화 지방산의 대사 산물들은 유의하게 감소하여 갔다. 트리글리세리드의 아실 탄소수의 범위는 30-60으로서 주요 글리세리드는 아실탄소수 44-52개를 가진 것이었는데 수유 기간의 경과에 따라 탄소수 46이하일 때는 유의한 증가의 경향을 띄었고, 50 이상일 때는 감소의 경향을 나타내었다. 트리글리세리드의 종 중에서 saturates는 수유기간이 경과함에 따라 유의한 증가치를 보인 반면 dienes는 감소의 양상을 띄었다.

• Asian-Australasian Journal of Animal Sciences
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• 제26권9호
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• pp.1237-1246
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• 2013

The objective of this study was to estimate variance components and genetic parameters for lactation milk yield (LY), lactation length (LL), average milk yield per day (YD), initial milk yield (IY), peak milk yield (PY), days to peak (DP) and parameters (ln(a) and c) of the modified incomplete gamma function (MIG) in an Ethiopian multibreed dairy cattle population. The dataset was composed of 5,507 lactation records collected from 1,639 cows in three locations (Bako, Debre Zeit and Holetta) in Ethiopia from 1977 to 2010. Parameters for MIG were obtained from regression analysis of monthly test-day milk data on days in milk. The cows were purebred (Bos indicus) Boran (B) and Horro (H) and their crosses with different fractions of Friesian (F), Jersey (J) and Simmental (S). There were 23 breed groups (B, H, and their crossbreds with F, J, and S) in the population. Fixed and mixed models were used to analyse the data. The fixed model considered herd-year-season, parity and breed group as fixed effects, and residual as random. The single and two-traits mixed animal repeatability models, considered the fixed effects of herd-year-season and parity subclasses, breed as a function of cow H, F, J, and S breed fractions and general heterosis as a function of heterozygosity, and the random additive animal, permanent environment, and residual effects. For the analysis of LY, LL was added as a fixed covariate to all models. Variance components and genetic parameters were estimated using average information restricted maximum likelihood procedures. The results indicated that all traits were affected (p<0.001) by the considered fixed effects. High grade $B{\times}F$ cows (3/16B 13/16F) had the highest least squares means (LSM) for LY ($2,490{\pm}178.9kg$), IY ($10.5{\pm}0.8kg$), PY ($12.7{\pm}0.9kg$), YD ($7.6{\pm}0.55kg$) and LL ($361.4{\pm}31.2d$), while B cows had the lowest LSM values for these traits. The LSM of LY, IY, YD, and PY tended to increase from the first to the fifth parity. Single-trait analyses yielded low heritability ($0.03{\pm}0.03$ and $0.08{\pm}0.02$) and repeatability ($0.14{\pm}0.01$ to $0.24{\pm}0.02$) estimates for LL, DP and parameter c. Medium heritability ($0.21{\pm}0.03$ to $0.33{\pm}0.04$) and repeatability ($0.27{\pm}0.02$ to $0.53{\pm}0.01$) estimates were obtained for LY, IY, PY, YD and ln(a). Genetic correlations between LY, IY, PY, YD, ln(a), and LL ranged from 0.59 to 0.99. Spearman's rank correlations between sire estimated breeding values for LY, LL, IY, PY, YD, ln(a) and c were positive (0.67 to 0.99, p<0.001). These results suggested that selection for IY, PY, YD, or LY would genetically improve lactation milk yield in this Ethiopian dairy cattle population.

• Asian-Australasian Journal of Animal Sciences
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• 제14권12호
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• pp.1712-1718
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• 2001

An experiment was carried out to study the effect of monensin administration on mammary functions in crossbred Holstein cattle. Fourteen non-pregnant late lactating crossbred Holstein cattle, approximately 270 days postpartum, were selected for the experiment. They were divided into two groups of 7 animals each. Seven animals in the treated group were given sodium monensin orally in a slow-release capsule. Animals in both control and treated groups were fed the similar diet to maintain milk production and body score at 2.5. Rice straw was fed as a source of dietary fiber throughout the experimental period. After monensin administration, a significant increase in the molar percent of ruminal propionate (p<0.05) and a significant decrease in the molar percent of ruminal acetate (p<0.05) were apparent in comparison to the pretreated period. The ratio of acetate to propionate concentration decreased significantly after monensin administration (p<0.05), while it was maintained at the similar level throughout the period of experiment in the control group. Monensin did not affect the molar percent of ruminal butyrate and valerate. The concentration of milk allantoin between the control group and monensin treated group was not different. An excretion rate of allantoin in milk decreased in animals treated with monensin (p<0.05). Mammary blood flow did not show significant difference between control and monensin treated groups. The plasma glucose concentration, arteriovenous concentration difference and mammary gland uptake of glucose remained constant in both groups. Milk yield of the later stage of lactation in the control group declined during lactation advance while a tendency to increase in the milk yield was apparent after 21 days monensin administration. Milk compositions for concentration of lactose, fat and protein in both control group and monensin treated group did not change throughout the experimental periods. From these results, it can be concluded that the action of monensin could affect the ruminal fermentation pattern. Monensin could not increase milk yield in the late lactating period.

• 대한간호학회지
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• 제34권7호
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• pp.1265-1276
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• 2004

Purpose: This study tries to explore mothers' stress patterns and the related factors influencing mothers' stress over time after giving birth to premature babies. Method: Eighty four mothers who had given birth to premature babies were selected from Hospitals in B city. Data was collected using a self-reporting questionnaire that the mothers' stress level. Result: The mothers' stress after giving birth to premature babies gradually diminished and the stress pattern of mothers changed over time. Mother's age, occupation, income level, gestational period of the measures baby, weight at birth, nutrition type, lactation mode, number of complications, and existence or non-existence of an operation were analyzed as the factors that affected the mother's stress. Conclusion: The stress pattern of mothers giving birth to premature babies changed overtime. Based on the study results, it is considered that the nursing intervention programs should be developed in order to reduce the stress of premature baby's mothers with time elapse.

• Asian-Australasian Journal of Animal Sciences
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• 제17권9호
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• pp.1214-1218
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• 2004

Data on 958 Karan Fries (KF) and 780 Karan Swiss (KS) cows, born during 1974 to 1992 at National Dairy Research Institute, Karnal were evaluated for causes of culling and their impact on milk performance and herd strength. Causes of culling were classified as voluntary culling (low milk yield) and involuntary culling (other than milk yield). The milk yield of cows was evaluated inretrospectively by estimating expected breeding value (EBV) on the basis of first lactation yield (FLY) and all available lactation yield (ALY). The culling rate of KF cows over the years varied from 10.89 (1988) to 33.92% (1991) with an overall average of 20.96% and in KS from 19.91 (1984) to 33.74% (1989) with an overall average of 25.01%. Reproductive disorders, teat and udder problems, low milk production, health and locomotive disorders were the major reasons of culling accounted respectively for 5.56, 4.97, 4.61, 3.18 and 2.24% of herd strength in KF cows. The corresponding causes of culling were 6.20, 6.26, 7.69, 1.49 and 2.67% of herd strength in KS cows. The involuntary culling of cows accounted for 82.4% in K F and 76.1% in KS cows of total culling. The average annual disposal rate in KF and KS was 26 and 30% whereas annual replacement rate was 24 and 26% respectively. The EBV of involuntary culled cows on the basis of FLY and ALY was 3,111 and 3,515 kg in KF; and 2,669 and 2,940 kg in KS cows respectively. The EBV of selected cows on the basis of FLY and ALY was 3,242 and 3,549 kg in KF and 2,893 and 3,245 kg in KS cows respectively. The average breeding value of involuntary culled cows was not significantly different from selected cows in both the herds. The high rate of involuntary culling of potential cows might be major factor responsible for declined performance and size in these herds. The results indicated that higher genetic gain (2.14% of herd average in KF and 3.49% of herd average in KS) could be obtained by restricting the involuntary culling (50% of total culling) through improved management practices and increasing replacement rate.

• Asian-Australasian Journal of Animal Sciences
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• 제21권8호
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• pp.1088-1096
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• 2008

Data from milk performance testing were used to analyze genetic and environmental trends for purebred Tsigai, Improved Valachian and Lacaune sheep. 103,715 (Tsigai), 212,962 (Improved Valachian) and 2,196 (Lacaune) test-day records gathered by the State Breeding Institute of the Slovak Republic entered the analyses. The respective pedigree data comprised 23,724 (Tsigai), 51,401 (Improved Valachian) and 438 (Lacaune) records. The multiple-trait, mixed model methodology was used to predict the breeding values for daily milk yield, fat and protein content and to estimate the fixed and remaining random effects assumed to affect the above mentioned traits, separately for each breed. The breeding values for daily milk yield were adjusted for 150-day standardized lactation length by multiplying with the constant 150, as the breeding goal of the selection scheme in Slovakian sheep is to increase 150-day milk production and constant heritability throughout the whole lactation is assumed. The genetic trends were expressed as changes in averages of breeding values across birth years of animals. For Tsigai and Lacaune breeds, cumulative genetic changes over the analyzed period were 3.8 and 5.1 kg for 150-day milk, 0 and -0.16% for fat content and 0 and -0.12% for protein content. For Improved Valachian breed, either a low (1.6 kg for 150-day milk yield) or zero (fat and protein content) cumulative genetic change was found. The environmental trends were calculated as averages of solutions for flock-test day effect across years and months in which measurements were taken. A distinctive cyclical pattern which reflected short-time variation in milk production traits was found. Possible explanations for this phenomenon are given and discussed.