• Biomolecules & Therapeutics
• /
• v.15 no.3
• /
• pp.199-204
• /
• 2007

Carbamates have excellent insecticidal activities against a broad spectrum of insects. They possess knocking-down, fast-killing, and systemic effects, however, they are toxic to mammals. In this study, we have carried out in vitro genetic toxicity test of methylcarbamate and microarray analysis of differentially expressed genes in response to methylcarbamate. Methylcarbamate did not show mutations in base substitution strain TA1535 both with and without exogenous metabolic activation. Methylcarbamate did not show mutations in frame shift TA98 both with and without exogenous metabolic activation. Methylcarbamate showed DNA damage based on single cell gel/comet assay in L5178Y cells both with and without exogenous metabolic activation. Methylcarbamate did not increase micronuclei in CHO cells both with and without exogenous metabolic activation. Microarray analysis of gene expression profiles in L5178Y cells in response to methylcarbamate selected differentially expressed 132 genes that could be candidate biomarkers of genetic toxic action of methylcarbamate.

• Journal of the Korean Society of Tobacco Science
• /
• v.18 no.2
• /
• pp.132-137
• /
• 1996

This experiment was conducted to investigate varietal responses to cool temperature (18℃) and short photoperiod (8 hours a day) in a controlled room of phytotron. Five burley tobacco varieties (Nicotiana tabacum L.), Awelius (very early flowering type), Burley 21 and KB 103 (medium), Banket Al and MB 1 (slightly late) and TC 681 (late) were compared in number of leaves per plant and day to flower in different treatment periods (10, 15, 20, 25 and 30 days). The days to flower decreased significantly than the control (in the phytoron with 14hr photoperiods and a minimum temperature 20'c) when the treatment periods were over 15 days for the varieties Aurelius, Burley 21 and KB 103, and 20 days for TC 681, and 30 days for Banket Al, respectively. And also the number of leaves decreased significantly than that of the control when the periods of treatment were over 10 days for Burley 21 and Aurelius, 15 days form 103, and 20 days for TC 681 and Banket Al, and 30 days for MB 1, respectively. The decreasing ratio in the number of leaves per plant under cool temperature and short photoperiod treatments was the lowest in Banket Al and MB 1. Key words : Nicotiana tabacum, cool temperature, short photoperiod.

• International Journal of Oral Biology
• /
• v.43 no.3
• /
• pp.129-132
• /
• 2018

Enterococcus faecalis is a major causative agent of endodontic treatment failure. The purpose of this study was to investigate bactericidal effects of ethanol extract of Garcinia mangostana L. (mangosteen extract) on five strains of E. faecalis that were isolated from human oral cavities. The bactericidal effects of mangosteen extract were assessed by measurement of minimum bactericidal concentration (MBC) value. The cytotoxicity of mangosteen extract on immortalized human gingival fibroblasts, hTERT-hNOF, was determined based on cell counting method. The data revealed the MBC value of mangosteen extract against the E. faecalis strains was $4{\mu}g/ml$. Additionally, the cell viability of mangosteen extract on hTERT-hNOF was 83.7-89.1% at the 1 to $16{\mu}g/ml$. These findings indicated that mangosteen extract could be used as a root canal cleaner during management of endodontic treatment failure caused by E. faecalis.

• Journal of IKEEE
• /
• v.19 no.2
• /
• pp.124-132
• /
• 2015

In this paper, we proposed a multiband internal antenna for LTE mobile handset that could be used for mobile devices. The proposed antenna has a volume of $50mm(W){\times}21mm(L){\times}5mm(H)$, ground plane size is $60mm(W){\times}100mm(L)$, and covers 9 service frequency bands including LTE(Long Term Evolution) band with VSWR(Vlotage Standing Wave Ratio) less than 3. With rapid change of technologies, people wants to include more function into one device. In addition, each country uses different frequency band for traffic service, it is necessary to design multiband antenna for mobile phone since traveling foreign country needs roaming. And if we can cover several services with one antenna, cost and volume needed for antennas are minimized. A HFSS (High Frequency Structure Simulator) of the Ansoft Corporation based on a finite element method is employed to analyze the proposed antenna in the design process and to compare the simulation and experimental results.

• Journal of Environmental Health Sciences
• /
• v.23 no.4
• /
• pp.127-132
• /
• 1997

The characteristics of the ozone treatments of phenol were studied in a laboratory scale wastewater treatment system. The ozone treatment of wastewater was carried out in a batch-type reactor. The initial pH of wastewater(7-10), volumetric flow rate(1-2l/min) and ozone concentration(20~30 mg/l) of aerating gas were considereal as experimental variables in the ozone treatment. Phenol was decomposed easily by the ozone in a batch treatment, where the rate determining step was the COD removal that is decomposition of intermediates formed by the ozonation of phenol. Phenol decomposition and COD removal could be expressed by the first order reaction for the phenol concentration and COD, respectively. Rate constants of phenol decomposition and COD removal increased with the initial pH, volumetric flow rate and ozone concentration of aeration gas. Under the present experimental condition, their relationships could be given by for the phenol decomposition $k'=4.46\times 10^{-9}[pH]_o ^{3.94}[O_3]^{1.42}Q_{O3}^{1.57}$ for the COD removal $k=2.46\times 10^{-10}[pH]_o ^{5.19}[O_3]^{1.15}Q_{O3}^{1.19}$

• Korean Journal of Pharmacognosy
• /
• v.46 no.2
• /
• pp.123-132
• /
• 2015

In this study, we carried out quantification analysis of the six marker components, geniposidic acid, chlorogenic acid, geniposide, pinoresinol diglucoside, liriodendrin, and genipin in the 70% ethanol extracts of non-processed Eucommiae Cortex and processed Eucommiae Cortex using a high-performance liquid chromatography coupled with photodiode array detector. The six components were separated on Gemini C₁₈ column (5 μm, 4.6×250 mm) by the gradient elution with 1.0% (v/v) acetic acid in water and 1.0% (v/v) acetic acid in acetonitrile as mobile phase. The flow rate was 1.0 mL/min and the injection volume was 10 mL. The amount of geniposidic acid, chlorogenic acid, geniposide, pinoresinol diglucoside, liriodendrin, and genipin in non-processed Eucommiae Cortex were 1.31, 0.31, 0.66, 0.46, 0.46, and 0.03%, respectively, while the amount of the six compounds in non-processed Eucommiae Cortex were 0.04-0.78, 0.01-0.14%, 0.05-0.63%, 0.01-0.37%, 0.15-0.42%, and not detected, respectively. After processing treatment, the contents of three iridoids, two lingnan, and one phenylpropanoid decreased in Eucommiae Cortex.

• Natural Product Sciences
• /
• v.16 no.2
• /
• pp.123-132
• /
• 2010

The aim of the present study was to investigate whether self-fermented pine extract for 2 years (SFPE2) and ethyl acetate (EtOAc) fraction from self-fermented pine needle extract may affect the contractility of the isolated aortic strips and blood pressure of normotensive rats. SFPE2 ($360-1440\;{\mu}g/mL$) significantly depressed both phenylephrine ($10\;{\mu}M$)- and high potassium (56 mM)-induced contractile responses of the isolated rat aortic strips in dose-dependent fashion. The EtOAc-fraction ($400\;{\mu}g/mL$) also inhibited both phenylephrine ($10\;{\mu}M$)- and high potassium (56 mM)-induced contractile responses. Also, in anesthetized normotensive rats, intravenous injection of the EtOAc fraction (1.0~10.0 mg/kg) dose-dependently elicited hypotensive responses. The EtOAc fractions (1.0 and 3.0 mg/kg/30 min) inhibited norepinehrine-induced pressor responses. Intravenous infusion of SFPE2 fraction (3.0 and 10.0 mg/kg/30 min) also inhibited norepinehrine-induced pressor responses in both anesthetized spontaneously hypertensive rats (SHRs) and normotensive rats. In conclusion, these results suggest that both SFPE2 and the EtOAc fraction cause vascular relaxation in the aortic strips isolated from normotensive rats and SHRs as well as vasodepressor responses. Based on these experimental data, it seems that SFPE2 or the EtOAc fraction possesses active antihypertensive components, which are available to prevent or treat hypertension in future.

• Korean Linguistics
• /
• v.63
• /
• pp.103-132
• /
• 2014

This study compares various speech rates of Korean learners with those of native Korean. Speech data were collected from 34 native Koreans and 33 Korean learners (19 Chinese and 14 Japanese). Each participant recorded a 9 syllabled Korean sentence at three different speech rate types. A total of 603 speech samples were analyzed by speech rate types (normal, slow, and fast), native languages (Korean, Chinese, Japanese), and learners' proficiency levels (beginner, intermediate, and advanced). We found that learners' L1 background plays a role in categorizing different speech rates in the L2 (Korean), and also that the leaners' proficiency correlates with the increase of speaking rate regardless of speech rate categories. More importantly, faster speech rate values found in the advanced level of learners do not necessarily match to the native speakers' speech rate categories. This means that learning speech rate categories can be more complex than we think of proficiency or fluency. That is, speech rate categories may not be acquired automatically during the course of second language learning, and implicit or explicit exposures to various rate types are necessary for second language learners to acquire a high level of communicative skills including speech rate variation. This paper discusses several pedagogical implications in terms of teaching pronunciation to second language learners.

• The Korean Journal of Food And Nutrition
• /
• v.35 no.2
• /
• pp.137-149
• /
• 2022

The purpose of this paper was to analyze domestic patents for food using edible insects. From January 1, 1980 to December 31, 2021, patents filed with the Korean Intellectual Property Office were searched, and a total of 242 valid patents were selected. The trend of Korean patent applications for edible insect food has increased since 2015, with 57 cases (the highest number) in 2017. As for the edible insects used in food, Bombyx mori L. were the most common with 127 cases, followed by Tenebrio molitor L. with 118 cases. By type of applicant, individuals accounted for the most, with 132 cases. As a result of grouping patents by food classification, 67 cases of edible insects were used in snacks, breads, and rice cakes. As a result of patent analysis, an effort was made to supplement insufficient nutrients by adding nutritionally excellent edible insects to existing foods, and efforts were made to improve the sensory properties of insect foods. It is expected that this study will contribute to establishing future R&D directions and patent application strategies related to edible insect food.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2023.05a
• /
• pp.131-132
• /
• 2023

Recently, the construction industry has seen the emergence of interior and exterior finishes using ultra-high performance concrete (UHPC) and colored concrete products using precast concrete (PC). However, the excessive amount of pigment used for coloring reduces the strength of the concrete. There is a need to improve the durability and chromaticity of colored concrete, and further analytical studies on the properties of colored concrete are also required. Therefore, in this paper, colored ultra-high strength cement composites (C-UHSCC) containing red and green inorganic pigments were prepared, and the compressive strength and color of the specimens were measured according to the age, and the correlation between strength and color was analyzed by simple linear regression analysis using R² value. The results showed that the red color was highly correlated with L^* and a^*, and the green color was highly correlated with a^*. These results can be considered for various concrete formulations, but research is needed to suggest the optimal pigment mixing ratio for proper strength and color development.