• Title/Summary/Keyword: Kyoto

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RUNX1-Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors

  • Masamitsu, Mikami;Tatsuya, Masuda;Takuya, Kanatani;Mina, Noura;Katsutsugu, Umeda;Hidefumi, Hiramatsu;Hirohito, Kubota;Tomoo, Daifu;Atsushi, Iwai;Etsuko Yamamoto, Hattori;Kana, Furuichi;Saho, Takasaki;Sunao, Tanaka;Yasuzumi, Matsui;Hidemasa, Matsuo;Masahiro, Hirata;Tatsuki R., Kataoka;Tatsutoshi, Nakahata;Yasumichi, Kuwahara;Tomoko, Iehara;Hajime, Hosoi;Yoichi, Imai;Junko, Takita;Hiroshi, Sugiyama;Souichi, Adachi;Yasuhiko, Kamikubo
    • Molecules and Cells
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    • v.45 no.12
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    • pp.886-895
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    • 2022

  • Malignant rhabdoid tumor (MRT) is a highly aggressive pediatric malignancy with no effective therapy. Therefore, it is necessary to identify a target for the development of novel molecule-targeting therapeutic agents. In this study, we report the importance of the runt-related transcription factor 1 (RUNX1) and RUNX1-Baculoviral IAP (inhibitor of apoptosis) Repeat-Containing 5 (BIRC5/survivin) axis in the proliferation of MRT cells, as it can be used as an ideal target for anti-tumor strategies. The mechanism of this reaction can be explained by the interaction of RUNX1 with the RUNX1-binding DNA sequence located in the survivin promoter and its positive regulation. Specific knockdown of RUNX1 led to decreased expression of survivin, which subsequently suppressed the proliferation of MRT cells in vitro and in vivo. We also found that our novel RUNX inhibitor, Chb-M, which switches off RUNX1 using alkylating agent-conjugated pyrrole-imidazole polyamides designed to specifically bind to consensus RUNX-binding sequences (5'-TGTGGT-3'), inhibited survivin expression in vivo. Taken together, we identified a novel interaction between RUNX1 and survivin in MRT. Therefore the negative regulation of RUNX1 activity may be a novel strategy for MRT treatment.

  • https://doi.org/10.14348/molcells.2022.2031 인용 PDF KSCI

THE KYOTO 3D SPECTROGRAPH

  • OHTANI H.;ISHIGAKI T.;HAYASHI T.;OZAKI S.;HATTORI T.;SASAK M.;AOKI K.
    • Journal of The Korean Astronomical Society
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    • v.29 no.spc1
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    • pp.405-406
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    • 1996

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Implications for man-machine interface designing from the findings of basic laboratory experiments of human cognitives

  • Yoshikawa, Hidekazu;Shimoda, Hiroshi;Kojima, Shin-ichi;Nagai, Youshinori;Nishio, Takehiko
    • 제어로봇시스템학회:학술대회논문집
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    • 1990.10b
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    • pp.1430-1435
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    • 1990

  • Using eye mark recorder and polygraph, basic laboratory experiments have been conducted to investigate the validity of psycho-physiological measures to the analysis of on-line cognitive information characteristics at man-machine interface (MMI). It is concluded that various psycho-physiological measures are useful to estimate various aspects of human cognitive characteristics and thus to the evaluation of MMI designing from the viewpoint of its harmony to the human cognitives.

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