• International Journal of Computer Science & Network Security
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• v.21 no.6
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• pp.319-328
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• 2021

Parallel administration of numerous drugs increases Drug-Drug Interaction (DDI) because one drug might affect the activity of other drugs. DDI causes negative or positive impacts on therapeutic output. So there is a need to discover DDI to enhance the safety of consuming drugs. Though there are several DDI system exist to predict an interaction but nowadays it becomes impossible to maintain with a large number of biomedical texts which is getting increased rapidly. Mostly the existing DDI system address classification issues, and especially rely on handcrafted features, and some features which are based on particular domain tools. The objective of this paper to predict DDI in a way to avoid adverse effects caused by the consumed drugs, to predict similarities among the drug, Drug pair similarity calculation is performed. The best optimal weight is obtained with the support of KHA. LSTM function with weight obtained from KHA and makes bets prediction of DDI. Our methodology depends on (LSTM-KHA) for the detection of DDI. Similarities among the drugs are measured with the help of drug pair similarity calculation. KHA is used to find the best optimal weight which is used by LSTM to predict DDI. The experimental result was conducted on three kinds of dataset DS1 (CYP), DS2 (NCYP), and DS3 taken from the DrugBank database. To evaluate the performance of proposed work in terms of performance metrics like accuracy, recall, precision, F-measures, AUPR, AUC, and AUROC. Experimental results express that the proposed method outperforms other existing methods for predicting DDI. LSTMKHA produces reasonable performance metrics when compared to the existing DDI prediction model.

• Journal of Applied Biological Chemistry
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• v.66
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• pp.359-368
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• 2023

This study aims to explore the impact of Krill Oil (KO, Superba^TM Boost) on skin moisturization regulation. The research involved five groups: an intact control, a reference group (L-AA 100 mg/kg), and KO groups (400, 200, and 100 mg/kg), each comprising ten mice. Oral administration was conducted for 8 weeks (56 days), during which changes in body weight, hyaluronan, collagen type 1 (COL1), transforming growth factor-β1 (TGF-β1), ceramide, and water contents were analyzed in dorsal back skin tissue. Real-time PCR was employed to assess gene expression related to hyaluronic acid synthesis (HAS1, HAS2, HAS3), COL1 synthesis (COL1A1 and COL1A2), and TGF-β1. Results demonstrated that KO administration significantly increased hyaluronan content, hyaluronic acid synthesis (HAS1, HAS2, HAS3), COL1 content, COL1 synthesis (COL1A1 and COL1A2), TGF-β1 content, TGF-β1 mRNA expression, ceramide content, and water content in a concentration-dependent manner compared to the intact control. Importantly, no discernible disparities were noted between the KO and L-AA groups, even though they received equivalent oral dosages. This study accentuates the potential utility of exogenous KO in the regulation of skin moisture, thus positioning it as a promising avenue for the development of nutricosmetics. Future research endeavors should delve into the role of KO in safeguarding against both intrinsic and extrinsic aging-related skin manifestations, as well as its potential to ameliorate skin wrinkles, in conjunction with its moisturizing attributes.

• Journal of the korean society of oceanography
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• v.33 no.3
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• pp.123-135
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• 1998

Cooperative scientific research in Antarctic has been successful since the International Geophysical Year 1957/1958. Presently, 43 nations have joined the Antarctic Treaty as consultative parties or acceding states, and other treaties and agreements have evolved to conserve the integrity and to manage the resources of the Antarctic ecosystem. Although yet to be designated, tourism areas in Antarctica are under consideration. Due to its remoteness and vast magnitude, Antarctica's science is slowly emerging. Satellite technology has enabled observation of the progression of the ozone hole above Antarctica. Mineral exploitation has yet to take place, as has the transport of Antarctic icebergs to some arid nations. On the other hand, both seal and whale exploitations have occurred, devastating these populations. The lessons learned from past human greed are used to design krill and squid fisheries, though the life histories of these organisms are yet to be adequately understood. An ecosystem approach to managing Antarctic resource exploitation is essential. Procuring the needed logistics to do so is daunting, requiring the highest degree of international cooperation and educational outreach to nurture the needed effective scientific and engineering talent, both natural and social.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.15 no.1
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• pp.43-48
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• 1979

南大洋의 크릴(krill)資源에 關한 本格的인 調査는 1961年 소련이 처음 着手한 以後 日本을 위시한 各國이 參與하고 있다. 1968年 現在 南大洋의 調査에 參與하고 있는 國家는 漁業에는 日本 소련 서독 프랑스 臺灣 칠레 폴란드等 7 個국이, 處理加工 誠驗에는 노르웨이 덴마크 모나코 남아프리카等 4 個國이고, 그외 美國 알젠티나等이 資源硏究所 設立計劃과 資源評價및 技術練修등을 計劃함으로써 모두 13 個國이다. 그 중 日本 1961年에 東京수산대학의 “우미다까마루”로써 南大洋의 綜合的인 海洋觀測과 調査를 實施한 것이 시초이나. 本格的인 調査는 1972年 海洋水産資原開發센터에 의하여 着手되어 現在까지 6年째에 이르렀다. 1972~75年間은 試驗 및 漁場開發段階에 不過했으나, 1976年~1977年은 企業化로써 採算面에서 收支가 맞는 企業漁業으로 成長하였다. 試驗 및 漁場開發段階에 不過했으나, 1976年~1977年은 企業化로써 採算面에서 收支가 맞는 企業漁業으로 成長하였다.

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2001.10a
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• pp.183-184
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• 2001

Angiotensin I converting enzyme (ACE) in renin-angiotensin system is a cause of essential hypertension, which covers most hypertension, one of the major adult diseases. Thus, the inhibition of ACE would be indispensable for the prevention and cure of hypertension. Therefore, a lot of studies on the ACE inhibitor have been conducted. Peptides from the protein hydrolysate have been reported as an remarkable inhibitor. Especially, various ACE inhibitory peptides were isolated and identified from marine products for their utilization as value added products. (omitted)

• Information and Communications Magazine
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• v.31 no.1
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• pp.53-62
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• 2013

생태계를 구성하고 있는 각 생물체들은 외부에서의 제어 개체 없이 독자적이면서 매우 단순하고 적은 수의 행동 규칙의 준수를 통하여 해당 생태계의 유지, 관리 및 동기화 등의 기능을 수행하고 있음을 관찰 할 수 있다. 이처럼 지구상의 다양한 생물체의 행동 원리를 관찰하고 이를 기반으로 모델링한 알고리듬을 생체모방 알고리듬 (biologically inspired or bio-inspired algorithm)이라 한다. 생체모방 알고리즘은 동종 혹은 이종의 다수의 개체가 존재하고, 주변 환경이 동적으로 변하며, 사용가능한 자원의 제약이 정해져 있을 때, 각 개체들이 분산 및 자율적으로 움직이는 환경에서 안정성, 확장성, 적응성과 같은 특징을 보여주는데, 이는 통신 네트워크 환경 및 서비스 요구사항과 유사성을 갖는다. 본 논문에서는 최근에 발표된 생체모방 알고리즘으로 통신 및 네트워킹 기술로 적용 가능한 Huddling Penguins 알고리즘, Krill Herd알고리즘, Cuckoo 알고리즘에 대해 살펴보고, 관련 프로젝트 및 연구 동향을 정리한다.

• Journal of Medicine and Life Science
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• v.18 no.1
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• pp.1-10
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• 2021

Omega-3 fatty acids (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) may be beneficial for the primary and secondary prevention of cardiovascular events (CVEs), especially in patients with myocardial infarction or heart failure with reduced ejection fraction. For this purpose, one to two seafood meals per week is preferentially recommended. Omega-3 fatty acids with a high-dose EPA formula (4 g/day) may be more effective than EPA+DHA mixed supplements for the secondary prevention of CVE. Krill oil also contains omega-3 fatty acids, but at a much lower dose compared to fish oil. Supplemental vitamins and minerals have not shown the preventive effects on CVE in prospective, and randomized clinical trials, except for one Chinese study showing the stroke prevention effects of folic acid. The clinical benefit of chelation therapy in reducing CVEs is uncertain.

• Coupled systems mechanics
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• v.13 no.1
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• pp.1-19
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• 2024

The effectiveness of coupling with a bolted rim is assessed in this research using a newly designed optimization algorithm. The current study, which is provided here, evaluates 10 contemporary metaheuristic approaches for enhancing the coupling with bolted rim design problem. The algorithms used are particle swarm optimization (PSO), crow search algorithm (CSA), enhanced honeybee mating optimization (EHBMO), Harmony search algorithm (HSA), Krill heard algorithm (KHA), Pattern search algorithm (PSA), Charged system search algorithm (CSSA), Salp swarm algorithm (SSA), Big bang big crunch optimization (B-BBBCO), Gradient based Algorithm (GBA). The contribution of the paper isto optimize the coupling with bolted rim problem by comparing these 10 algorithms and to find which algorithm gives the best optimized result. These algorithm's performance is evaluated statistically and subjectively.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.26 no.2
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• pp.125-132
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• 1990

The authors carried out an experiment to investigate the responsive behavior of sea eel, Astroconger myriaster(BREVOORT) to chemical stimuli. The experimental tank was made in doughnut type by using FRP plates. The channel of tank was divided into three concentric troughs by using perforated plastic plates. The inside trough was used as influent part, the outside one as effluent part, and the middle one as the testing trough in which testing fish may be swimmable. The influent part was radially portioned into 12 sections so as to be 30 degrees of central angle. But a basin of any section in testing trough was diverged in the range of 45 degrees of central angle. The the testing trough are radially divided into eight zones. Water is supplied at the rate of 6.3l per minute from the central water tank set as high as 50cm in the center of doughnut, passed across the influent part, testing trough, effluent part and finally discharged by overflow pipes. The chemical substance to stimulate the sea eel was extracted from mackerel, shad and krill which are used as bait for fishing. The chemical substance was injected into any one of 12 hoses which supplies water from central water tank to the influent part at the rate of 2ml per minute. Sea eels used for the experiment were caught by pot in the coast of Chung-mu and accustomed to the tanks for 5 days before applying them to the experiment. The result obtained are as follows: 1. The rate of time length of sea eel's staying in the stimulated zone, as the extracts of mackerel, shad and krill were given to it, was observed as 7.9%, 30.9% and 11.4% respectively. It means that the extract from shad was the most effective of three in attracting sea eel. 2. To compare the effect of freshness of bait fish, the extracts were prepared from shad just killed, form the 24 hour-lapsed one and from the 48 hour-lasped one after killed. The rate of time length of sea eel's staying in the stimulated zone was 30.9%, 17.1% and 11.3% respectively. It means that the freshness is much effective in attracting olfactory fishes like sea eel.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.44 no.3
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• pp.174-183
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• 2008

In order to develop the substitutive materials for natural baits of swimming crab pots, the fluorescent characteristics of the baits were analyzed, and the preference of fluorescent dyes were investigated by the mean entrapped catch number to the pots through the water tank experiments and fishing experiments. On the investigation of fluorescent characteristics by the 5 kinds of baits, mackerel, krill, manila clam, pig's fat and chicken's head which were used in substitutive baits for test in the UV long wave(365nm) area, it showed clear blue fluorescence in the skin of mackerel, shell of krill, manila clam and bill of chicken's head, and green fluorescence in the mackerel s muscle and internals, and yellow fluorescence in the pig's fat and chicken's head. On the investigation of fluorescent characteristics by the bait cages in the UV short wave(254nm) and long wave(365nm) area, it showed each green, red and blue fluorescence in the cylinderical or hexahedral red plastic bait cages which were painted each green, red and blue fluorescence dyes, but it showed yellowish green flourescence in the cylinderical or hexahedral red plastic bait cage which was painted yellow fluorescent dye. On the preference investigation of the fluorescent dyes of swimming crabs by the 5 kinds of the bait cages which were put the mackerel in the non-fluorescent red plastic cage($RF_N$), red, yellow, green and blue fluorescent plastic cages(RF, YF, GF, BF) each, nonfluorescent red plastic cage($RF_N$) was entrapped mean 2.0(6.7%), but blue fluorescent plastic cage(BF) was mean 5.0(16.7%) and it was more 2.5 times comparing to $RF_N$, and red fluorescent cage(RF) was same level and green fluorescent cage(GF) was 50% of catch number comparing to $RF_N$, and yellow fluorescent cage(YF) was entrapped nothing(F 46.324, P < 0.05). On the investigation of the entrapped catch number to the pots which were put the mackerel in the blue fluorescent hexahedral plastic cage(HP) and blue fluorescent silicon mackerel model cage(SM), HP was mean 3.4(11.3%) and it was a little more comparing to SM which was entrapped mean 3.2(10.7%)(t 0.775, P > 0.05). Fishing experiments on the preference investigation of swimming crabs by the pots which were put in the non-fluorescent red plastic cage($RF_N$) and blue fluorescent plastic cage(BF) were conducted 3 times. Mean catching number and weight of $RF_N$ were 71.7 ind.(18.3%) and 16.9kg(64.3%), and those of BF were 93.0 ind.(23.1%) and 19.8kg(64.5%), respectively.