• Title/Summary/Keyword: KpA

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The Inhibitory Effects of Intestine-oriented Lactobacillus sp. KP-3 on the Accumulation of Heavy Metals in Sprague Dawley rats (Sprague Dawley 쥐에서 장내 유래 Lactobacillus sp. KP-3의 중금속 축적 저해 효과)

  • Kim, Shin Yeon;Kim, Hyun Pyo
    • Journal of Life Science
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    • v.25 no.2
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    • pp.164-173
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    • 2015
  • To investigate the effect of lactic acid bacteria on the heavy metal adsorption from internal organs and blood, lactic acid bacteria were isolated from human feces. Some strains resistant to heavy metals were selected by incubation in agar media containing each of chrome and cadmium salts. Among them, a strain named KP-3 was ultimately chosen due to its higher growth rate in selective broth medium containing the heavy metals at the concentration of 0.01%. The strain was identified as Lactobacillus sp. based on its morphological, cultural and physiological characteristics. For evaluating the ability to prevent accumulation of heavy metals by selected Lactobacillus sp. strain in vivo, Sprague Dawley rats were fed with heavy metal salts (cadmium, chrome and lead) with or without cultured whole cells for 7 days. The amounts of heavy metals accumulated in liver, kidney and blood were analyzed. As a result, chrome was accumulated to kidney mostly, and lead was frequently found in liver and kidney. Experimental group (rats fed with lactic acid bacteria) showed less accumulation of heavy metal than control group (rats fed with saline solution). The inhibition rates of heavy metal accumulation were calculated to 41.8% (Cd), 33.4% (Cr) and 44.2% (Pb). Especially, feeding lactic acid bacteria strongly reduced accumulation of cadmium in blood. The results showed that feeding Lactobacillus sp. KP-3 could prevent the bioaccumulation of heavy metals in the living body.

Gastric cancer and adenomatous colorectal polyp concomitant with pyogenic liver abscess and bacteremia

  • Kang, Min Kyu;Kwon, Hee Jung;Kim, Min Cheol
    • Journal of Yeungnam Medical Science
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    • v.37 no.3
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    • pp.246-249
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    • 2020
  • Synchronous gastric cancer and adenomatous colorectal polyp in patients with Klebsiella pneumoniae-induced pyogenic liver abscess (KP-PLA) and bacteremia is a rare presentation. A 58-year-old man with a 6-month history of diabetes mellitus (DM) presented with febrile sensation and dull abdominal pain in the right upper quadrant of the abdomen. Subsequent to laboratory test results and abdominal computed tomography findings, KP-PLA with bacteremia was diagnosed. After intravenous antibiotic administration, his symptoms improved, and upper endoscopy and colonoscopy were performed to evaluate the cause of KP-PLA. Biopsy specimens of the prepyloric anterior wall revealed a moderately differentiated adenocarcinoma. Endoscopic mucosal resection of the colon revealed high-grade dysplasia. Early gastric cancer (EGC) and adenomatous colorectal polyps with high-grade dysplasia concomitant with KP-PLA and bacteremia were diagnosed in our patient who had DM. Intravenous antibiotic treatment for KP-PLA, subtotal gastrectomy for EGC, and colonoscopic mucosal resection for the colon polyp were performed. After 25 days of hospitalization, subtotal gastrectomy with adjacent lymph node dissection was performed. Follow-up ultrasound imaging showed resolution of the abscess 5 weeks post-antibiotic treatment, as well as no tumor metastasis. Upper gastrointestinal endoscopy and colonoscopy should be performed to evaluate gastric cancer in patients with PLA or bacteremia, accompanied with DM or an immunocompromised condition.

Effect of Kp, an Antitumor Protein-Polysaccharide from Mycelial Culture of Phellinus Linteus on the Humoral lammune Response of Tumor-Bearing ICR Mice to Sheep Red Blood Cells

  • Chung, Kyeong-Soo;Kim, Shin-Sook;Kim, Hee-Soo;Kim, Kye-Yang;Han, Man-Woo;Kim, Kil-Hyun
    • Archives of Pharmacal Research
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    • v.16 no.4
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    • pp.336-338
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    • 1993
  • The immunomodulating activity of Kp, an antitumor protein-polysacchanide preparation from the shake-cultured mycelia of Phellinus linteus, was investigated in ICR mice subcutaneously implanted wit $1\times10^6$ cells of sarcoma 180. The mice were intraperitoneally administered with Kp at a does of 100 mg/kg once daily for five consecutive days starting from 24 hrs after the tumor implantation. Ten days after the last injection, the mice were immunized with $1\times10^7$ or $4\times10^8$ sheep red blood cells (SRBC) and five days later, the antibody-forming immune response were assessed by direct hemolytic plaque assay. To an immunization does of $1\times10^7$ SRBC, the Kp-treated mice elicied a successful humoral immune response despite the turmor-burden and produced $259\times10^3$ plaque-forming cells (PFC)/spleen, while the corresponding tumor-bearing control mice showed virtually no reponse $(2.0\times10^3$ PFC/spleen) (the stimulation index=129.5). However, to an immunization dose of $4\times10^8$ SRBC, both of the control mice and Kp-treated mice showed almost the same level of strong humoral immune response. From these data it is clear that Kp effectively restores the humoral immune response of the turmor-bearing ICR mice.

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Genetic structure of apical membrane antigen-1 in Plasmodium falciparum isolates from Pakistan

  • Komal Zaib;Asifullah Khan;Muhammad Umair Khan;Ibrar Ullah;Tuan Cuong Vo;Jung-Mi Kang;Huong Giang Le;Byoung-Kuk Na;Sahib Gul Afridi
    • Parasites, Hosts and Diseases
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    • v.62 no.3
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    • pp.302-312
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    • 2024
  • Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) is a major candidate for the blood-stage malaria vaccine. Genetic polymorphisms of global pfama-1suggest that the genetic diversity of the gene can disturb effective vaccine development targeting this antigen. This study was conducted to explore the genetic diversity and gene structure of pfama-1 among P. falciparum isolates collected in the Khyber Pakhtunkhwa (KP) province of Pakistan. A total of 19 full-length pfama-1 sequences were obtained from KP-Pakistan P. falciparum isolates, and genetic polymorphism and natural selection were investigated. KP-Pakistan pfama-1 exhibited genetic diversity, wherein 58 amino acid changes were identified, most of which were located in ectodomains, and domains I, II, and III. The amino acid changes commonly found in the ectodomain of global pfama-1 were also detected in KP-Pakistan pfama-1. Interestingly, 13 novel amino acid changes not reported in the global population were identified in KP-Pakistan pfama-1. KP-Pakistan pfama-1 shared similar levels of genetic diversity with global pfama-1. Evidence of natural selection and recombination events were also detected in KP-Pakistan pfama-1.

Ketoprofen-Polyethylene Glycol Conjugate: Pharmacokinetics. anti-inflammatory and analgesic activity

  • Jang, Mi-Hee;Kim, Soo-Yeon;Jeong, Choon-Sik;Oh, Seaung-Youl
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.410.2-411
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    • 2002
  • Ketoprofen (KP), a potent analgesic and non-steroidal anti-inflammatory drug, has some disadvantages such as gastro-intestinal irritation. short half-life (1.5-4 hour) in plasma and low solubility in aqueous solution. In order to minimize these disadvantages. we have recently prepared a KP prodrug, KP-polyethylene glycol conjugate (KPEG750, PEG Mw=750), and investigated its pharmacokinetic behavior. anti-inflammatory and analgesic effect. (omitted)

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Effect of Calcining Temperature on Planr Coupling Factor and Resonance Characteristics of PZT (하소온도가 PZT의 Kp와 공진특성에 미치는 영향)

  • 정수태;이우일;조상희
    • Journal of the Korean Ceramic Society
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    • v.22 no.1
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    • pp.47-52
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    • 1985
  • The effect of calcining temperature on planar coupling factor Kp resonance and antiresonance frequency of $Pb(Z_{0.53}Ti_{0.47})O_3$ doped with $Nb_2O_5$ has been investigated. The calcining temperature ranged from $700^{\circ}C$ to 110$0^{\circ}C$ The calcining temperature affected on antiresonance frequency more strongly than the resonance frequency. Therefore the Kp was almost entirely dependent upon the antiresonance frequency. The p and antiresonance frequency of the sample in creased with the calcining temperature reaching a maximum at about 90$0^{\circ}C$ When a poling electric field of 35KV/cm was applied to the sample calcined at 90$0^{\circ}C$ and sintered for two hours at 120$0^{\circ}C$ Kp attained a maximum value of 0.64 which is in good agreement with the results of other investigators.

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A Study on the System Principle of PID Module Implementation (PID Module 구현 원리 시스템에 대한 연구)

  • 위성동;김태성;최창주;권병무
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1999.05a
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    • pp.183-192
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    • 1999
  • The derivative equation measured of a ${\Delta}MV=Kp*{(EVn-EVn-1)+\frac{1}{Ki/S}* EVn+(Kd/S)*(2PVn-1-PVn-PVn-1)}$ is used on the machine apparatus of industrial field, but this par doesn\`t able to educate now, because we didn\`t have the implementation device of PID module, so the principle implementation system of the PID Module is manufactured and developed. Through this system, the implementation system of PID Module is practiced with that the SV and the set of P, I, D is set on the derivative equation measured of PID. A things to be known of this experiment result is flow. 1)PID module is known that had to be used with the module of A/D and D/A. 2) In process of PV is approached to the SV to follow Kp, Ti and Td to cause a constant of set value on the $MVp=Kp*EV, MV=\frac{1}{Ki}{\int}EVdt, MVd=Td\frac{d}{dt}EV$, the variable rate of E and Kp, Td, Ti in that table 1 is analysed, is same as flow. (1)If Kp is high, PV is near fast to the SV, but Kp is small, PV is near slowly to the SV. (2)If Ki is shot, PV is close fast to the SV, but Ti is high, PV is close slowly to the SV (3)If Td is high, the variable rate of E press hardly when because it doesn\`t increase, but Td is small, the variable rate of E press not hardly, upper with 1), 2), PID module is supposed that be able to do the A/S and an implementation of that apparatus, and getting a success of aim that an engineer want, on control of temperature, tension, velocity, amount of flow, power of wind end so on, to get the principle of automatic implementation in industrial field with cooperation of A/D and D/A module.

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A Study on the Wear Characteristics and the Mechanism of KP-4M Steel for Plastic Molding (플라스틱성형용 KP-4M강의 마멸특성 및 이의 기구에 관한 연구)

  • 박흥식;전태옥;김동호
    • Tribology and Lubricants
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    • v.12 no.1
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    • pp.22-28
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    • 1996
  • This study was undertaken to investigate the dry wear characteristics and mechanism of KP-4M steel for plastic molding against SKD 61 hardened by heat treatment. The wear test was carried out under different conditions such as sliding speed, contact pressure, sliding distance, with frictional tester of pin on disc type. The wear loss on variation of sliding speed was little in lower speed range below 0.5 m/sec and in higher speed range above 1.5 m/sec,'but wear loss was high in intermediate speed range. The critical sliding speed, which showed the maximum value of specific wear rate, became lower with increased contact pressure. Increasing the contact pressure, the critical sliding distance Lcr which the wear mechanism changes from severe wear to mild wear was increased due to the decrease of oxidation reaction velocity. Through this study we suggested a model of generation and elimination process of wear debris of KP-4M steel for plastic molding.

Identification of Tumor Antigens in Lung Cancer Patient by SEREX (폐암 환자에서 면역항원유전자의 혈청학적 동정)

  • Min, Young-Ki;Ha, Jin-Mok;Son, Young-Ok;Park, Hae-Rim;Lee, Min-Ki;Park, Yeoung-Min;Kim, Cheol-Min;Lee, Sang-Yull
    • Journal of Life Science
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    • v.17 no.8 s.88
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    • pp.1082-1089
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    • 2007
  • Serological anlysis of recombinant cDNA expression libraries (SEREX) has led to identification of several categories of new antigens recognized by the immune system of cancer patients, which are referred to as the cancer immunome. We analyzed normal testis cDNA expression libraries with serumobtained from non-small lung cancer patient and isolated 40 distinct antigen designated KP-LuT-1 through KP-LuT-40. Among these antigens 20 antigens were previously identified by SEREX analysis of other tumor types, and 20 out of 40 antigens (50%) did not match entries in Cancer Immunome Database and were considered newly identified antigens. Sequencing analysis showed that the anti-gens comprised 26 functional known proteins and 14 noble/uncharacterized gene products. Of these, the hypothetical protein KP-LuT-6 was shown tissue-restricted. RT-PCR showed it to be expressed strongly only in normal testis. In addition to normal tissues-restricted expression, KP-LuT-6 mRNA was detected in lung tumor samples(3/l0), stomach tumor samples(3/l0), and breast tumor samples(l/5), whereas not detected in colon tumor samples(O/I2). These data suggest that KP-LuT-6 is a cancer/testis (CT)-like antigen as a potential target for cancer immunotherapies.

A Study on the Harmonic Evaluation Algorithm for Dispersed Sources in Distribution Systems (배전계통에 있어서 분산전원의 고조파 평가 알고리즘에 관한 연구)

  • Kang, Min-Kwan;Park, Jae-Ho;Rho, Dae-Seok;Oh, Yong-Taek;Hong, Sang-Eun
    • Proceedings of the KIEE Conference
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    • 2006.07a
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    • pp.543-544
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    • 2006
  • 본 논문에서는 고조파 환경 목표레벨을 유지시키기 위하여, 고조파의 발생원인 수용가가 고조파 유출에 대한 평가 알고리즘을 제시한 것이다. 이 평가 알고리즘은 단계 별로 이루어지는데, 수용가(특수/보통)의 종류판정과 고조파 유출전류 계산 및 억제대책의 여부판정 그리고 마지막으로 고조파 대책 검토 최종 단계에 의해 역율 개선과 고조파의 발생량을 저감하기 위하여 동력변압기의 2차 측에 직렬리액터가 있는 콘덴서를 설치하고, 리액턴스를 고려 해 계산하여 유출량계산 및 상한치와 비교 후, 고조파 대책을 실시한다. 각 차 고조파에 대하여 상한치 이내로 고조파가 저감되어 기준치를 만족하면 다른 조파도 동일한 방법으로 검토한다.

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