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A Normative Review on Non-Invasive Prenatal Diagnosis (NIPD): Focusing on the German Discussion on PrenaTest®

  • Kim, Na-Kyoung
    • Development and Reproduction
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    • v.25 no.2
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    • pp.113-121
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    • 2021
  • This article aims to introduce German discussion on the approval of the non-invasive prenatal diagnosis (NIPD), which started with the development of PrenaTest® by LifeCodexx AG. The discussion started with the concern that the non-invasive nature of NIPD, such as PrenaTest®, may rapidly expand the use and scope of similar tests, thus leading to a new era of eugenics. Based on this concern, the need for clear clinical guidelines on specific indications for NIPD has been suggested. Along the same line, it was discussed whether PrenaTest® is against the Basic Law prohibiting discrimination on grounds of disability and whether the test is outside the scope of the purpose of gene testing limited by Genetic Diagnosis Act. Through such discussion, the Federal Ministry of Health of Germany established the preconditions for inclusion of NIPD in the German public health insurance system. For this, the German motherhood guideline was amended and the information for the insured persons provided to pregnant women was included in the amended guideline. Such discussion made in Germany provides insight on which points should be considered when various gene testings are accepted in Korea, in which genetic communication has not been systematized yet. In particular, German counseling system for pregnant women will provide valuable insights for Korea where the direction for regulations on abortion has not been established even after the ruling by the Constitutional Court that charges for abortion are against the constitution.

Comparison of Environmental Economic Performance In South Korea and Germany

  • Choi, Jung-Su;Schoer, Karl;Schweinert, Stefan
    • Journal of Environmental Policy
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    • v.2 no.2
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    • pp.81-103
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    • 2003
  • This paper compares the environmental economic performance of the South Korean and the German economy during the last decade. The analysis is based on comparable data from the Environmental Economic Accounts (EEA). The EEA is a satellite account to the National Accounts which enhances the conventional economic accounts by a description of the interactions between the economy and the environment. The data from the EEA and the national accounts are fully compatible. In absolute terms the environmental pressures caused by economic activities were with regards to the environmental factors used for the analysis generally lower in South Korea than in Germany. If the use of environmental factors is related to each country's gross domestic product (environmental productivities) a lower level of environmental productivity can be observed for most of the environmental factors in South Korea compared to Germany. For example in 1999 energy and $CO_2$ productivity were about two fifths of the German level. This corresponds to the relation regarding labour productivity (Gross domestic product per employment).

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Hemangiosarcoma in a German Shepherd Dog (German Shepherd견의 혈관육종례)

  • 윤정희;권오경;성재기
    • Journal of Veterinary Clinics
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    • v.13 no.1
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    • pp.87-92
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    • 1996
  • A hemangiosarcoma in a 30 kg, 6-year-old German Shepherd dog showing signs of abdominal distension, anorexia and depression was diagnosed with clinicopathologic examination, abdominal radiographs and ultrasonographic assessmint. In abdominal radiographs, overall abdominal distension was seen. Stomach and some parts of small intestines were deviated caudo-ventrally by enlarged liver. The splenomegaly was also identified and descending colon was dislocated laterally by splenic mass. In ultrasonographic findings, abdominal fluid was identified. Hepatomegaly was seen and it was consisted of multiple, anechoic cysts. The spleen was enlarged and a large round mass with mixed echo pattern at the mid to tail portion of spleen was identified. Grossly, at necropsy, multi-sized cysts in which contained blood and fibrpus materials and some blood were seen in the cross section and it showed hard consistency. Also, lots of small red tumor nodules were dispersed on the serosal surface of the bladder, omentum, mesentery, diaphragm and peritoneum. In abdominal paracentesis, fluid having almost the same properties as circulating blood was identified. The hemoperitoneum was thought to be resulted from the bleeding into peritoneum owing to the rupture of cystic lesions located on the superficial liver area.

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Taking over process of the East Germany People's Police by the West Germany (동서독 경찰통합 과정에서의 동독 인민경찰의 흡수.활용)

  • Hwang, Mungyu;Park, HyungSik
    • Convergence Security Journal
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    • v.13 no.5
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    • pp.157-165
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    • 2013
  • This study examines how East German police was absorbed into the Unified Germany Police. The experience of Germany suggests a few implications and preview points when the two Koreas unify how North Korean police to absorb and utilize, which is the purpose of this study. According to a study, in a unified transition in North Korea, 110,000 police forces is needed in order to cope with an outbreak of rioting and public disorder in North Korea. It is never easy, in an imminent unification, to secure a large number of police forces in a short time. We cannot help making the best use of North Korean police. At this point, the German case would be nice for us to see the implications presented. Because West German police led the integration of East Germany in the People's Police, and reemployed them under certain conditions. As a result, by taking over the People's Police of North Korea without friction with the security of the high security demand required by the unification process in the future, it is necessary to achieve seamless integration of the North-South police.

Analysis of Informatics Curriculum in Germany(Bayern) (독일 바이에른 주의 정보 교육과정 분석)

  • Choi, HeeJeong;Lee, WonGyu;Kim, JaMee
    • The Journal of Korean Association of Computer Education
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    • v.22 no.1
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    • pp.1-10
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    • 2019
  • With the advent of the age of the 4th Industrial Revolution, countries around the world are reinforcing informatics education to cope with changing society. The purpose of this study is to analyze the trends in German informatics education through the analysis of the German informatics curriculum, and provide implications for the informatics education of Korea. The analysis of German informatics education focused on the contents and changes of the informatics education of Bayern, which can be said to be the center of German education. As a result of this analysis, first, elementary education approaches 'informatics' from the viewpoint of integrated curriculums. Second, secondary education provides education that makes it possible to experience theory and practice by securing sufficient credit hours. Third, they reflected informatics subjects in entrance examinations, and sufficiently ensured links to higher education. This analysis confirmed that systematic informatics education requires many credit hours from elementary education, and links with secondary and higher education must be taken into consideration.

A Case of Max Planck as a Model of Engineering Literacy Education (공학소양교육 모델로서의 막스 플랑크)

  • Nam, Young
    • Journal of Engineering Education Research
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    • v.24 no.6
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    • pp.67-78
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    • 2021
  • This study is an analysis of the life of Max Planck (1858-1947), the in view of engineering literacy education. Some expressions describing Planck include "the father of German science", "the namer of Quantum". Furthermore, he is the scientist who permanently engraved his name in a scientific invariant called the Planck Constant. Planck had already made remarkable scientific achievements in his mid-ages, which became the springboard of quantum mechanics, but he went on to achieve much more in his old age. Between 1910s and 1930s, he was the director of the Kaiser-Wilhelm Gesellschaft, the Berlin Academy, and the German Physics Society, which is the German core research group. In the 1910s, he endured the terrible personal suffering of losing his three children and then succeeded in rebuilding German science in the 1920s in his golden age of 70s. His achievement was great not only as a scientist but also as a science administrator. His life was contradictory in several ways. While fundamentally being a conservative, he initiated a great scientific revolution. While making efforts to preserve traditional values, he was in the center of great many upheavals and destruction. While being the incarnation of honesty, he was also given to extremely delicate political positions. In his long career, Planck lived with all his might as a leader of the German science organizations and permanently left his name on the institute representing Germany. Planck succeeded in his work for the institutional development of science, philosophical understanding of science, and as a role model of exemplary scientist. His long life was accompanied by both achievements and failures, intangible and difficult to judge. Today, as research and development management and scientific leadership have become increasingly important, Planck's life may be a good example of engineering literacy education.

Improving the Competitiveness of Korean Exhibition Industry - Comparison of Korean Exhibition Industry with German Exhibition Industry - (한국전시산업의 경쟁력 강화 방안을 위한 독일과 한국의 전시산업 비교)

  • Yoo, Hwa-Sook;Park, Kwang-Hee;Kim, Mun-Young
    • Fashion & Textile Research Journal
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    • v.11 no.1
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    • pp.84-92
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    • 2009
  • The purpose of this study was to examine the facilities, the current status, and the problems of Korean Exhibition Industry and to provide its future direction based on analysis of the characteristics and the recent trend of German Exhibition Industry. Data were obtained from previous research papers, periodicals, magazines, and newspapers. Also, statistical data provided by AUMA(Ausstellungs- und Messe- Ausschuss der Deutschen Wirtschaft e.V.), Association of Korean Exhibition Industries, and Global Exhibition Portal were used. In the result part of this study, various issues such as similarities and differences between Korean and German Exhibition Industry and problems of Korean Exhibition Industry were discussed. The strategies to improve the competitiveness of Korean Exhibition Industry were suggested. They are as follows ; development of global and specialized exhibitions, training of professional human resources for exhibition, formulating of aggressive and powerful oversee marketing, formation of oversee network, improving of laws, regulation and system in such a way to meet the realistic needs of exhibition, building of infrastructure such as roads, traffic networks and accomodations, raise of the Korea image and strengthen of quality of exhibition service.

A Compartive Study on the Overseas Business Activity of Insurance Companies in Korea and Germany - a Case of German Legal Expenses Insurance Company - (한국 및 독일 보험회사의 해외 진출 모델 비교 연구 -독일 법률비용보험회사의 사례를 중심으로-)

  • Shin, Dong-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.11 no.8
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    • pp.2876-2881
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    • 2010
  • This paper attempts to find out implications based on the comparative analysis of overseas expansion model between the Korean insurance companies and the German one. There are three types of the strategies of the overseas-expansion-model of insurer, i.e. customer-oriented localized strategy, niche market-oriented strategy, and growing market-oriented strategy. From the review of related literatures and through an interview conducted by the insurance specialist, the findings are some differences between Korean and German insurance companies, when they go into foreign insurance markets. Th significant differences between Korean and German insurers are a customer oriented localized strategy and niche market oriented strategy. The Korean insurer shows a strength on the overseas-expansion-strategy, but the most clients of the Korean insurer on overseas markets are also Korean companies and Korean immigrants. The Korean legal expenses insurance market is yet in its embryonic stage, while the German legal expenses insurance company is pushing ahead with a strategy focused on localization and niche market on the legal expenses insurance product. In conclusion, like a case of the German legal expenses insurance company, the Korean insurer needs a customer oriented localized strategy as well as a niche market oriented strategy on the overseas insurance market.

A Study on the German Mandatory Prescription System : Implications for the Korean System (독일 의약분업제도 운영에 관한 연구 : 한국 의약분업제도에의 함의)

  • Lee, Jun-Young
    • Korean Journal of Social Welfare
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    • v.46
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    • pp.349-376
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    • 2001
  • The objectives of this study is to examine the German mandatory prescription system in terms of the applicability and restriction of the pharmaceutical policy in order to obtain some useful implications for solving the problems in Korean prescription system. Recently, in Germany, an issue about the security of the prescription, the price control of the pharmaceuticals and the containment of the increasing prescription expenditure has been intensively discussed. Similar problems are also occurred in Korea. So, the policy measurements of Germany could be used in Korea. But it could not easy to introduce the German policy measurements in Korea because of the social-institutional differences between the two countries, which are following; (1) Korea has a short experience with the mandatory prescription system, (2) the German concept of the management differs from that of the Korea, (3) the subscribers and the patients are excluded from the decision making process, (4) the medical service providers often resist against reform plans. For the stable development of the Korean prescription system the principle of self-government, the collective bargaining concept for cost containment, and social consensus about optimal expenditure of the pharmaceuticals are expected to be needed.

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Structural Identification of Modified Amino Acids on the Interface between EPO and Its Receptor from EPO BRP, Human Recombinant Erythropoietin by LC/MS Analysis

  • Song, Kwang-Eun;Byeon, Jaehee;Moon, Dae-Bong;Kim, Hyong-Ha;Choi, Yoo-Joo;Suh, Jung-Keun
    • Molecules and Cells
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    • v.37 no.11
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    • pp.819-826
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    • 2014
  • Protein modifications of recombinant pharmaceuticals have been observed both in vitro and in vivo. These modifications may result in lower efficacy, as well as bioavailability changes and antigenicity among the protein pharmaceuticals. Therefore, the contents of modification should be monitored for the quality and efficacy of protein pharmaceuticals. The interface of EPO and its receptor was visualized, and potential amino acids interacting on the interface were also listed. Two different types of modifications on the interface were identified in the preparation of rHu-EPO BRP. A UPLC/Q-TOF MS method was used to evaluate the modification at those variants. The modification of the oxidized variant was localized on the Met54 and the deamidated variants were localized on the Asn47 and Asn147. The extent of oxidation at Met54 was 3.0% and those of deamidation at Asn47 and Asn147 were 2.9% and 4.8%, respectively.