• Journal of Preventive Medicine and Public Health
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• 제43권4호
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• pp.319-329
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• 2010

Objectives: This study was performed to determine the levels of quality of life (QOL) according to the grade of long-term care service for the elderly people who were admitted from long-term care insurance, and to reveal its association with the physical and mental functioning such as the Activity of Daily Living (ADL), the Instrumental Activity of Daily Living (IADL), the Center for Epidemiologic Studies Depression Scale (CES-D), and the Mini-Mental State Examination-Korean version (MMSE-K). Methods: The interviews were performed during the period from March 1 to May 31, 2009, for 958 elderly people in urban and rural areas. The questionnaire items included various indices such as the ADL, IADL, CES-D, and MMSE-K, as independent variables and the index of QOL, as the dependent ones. For statistical analysis, t-tests were used for the mean scores of QOL according to gender and the grade of long-term care services, and Spearman's correlation was used for each variable. The effects of physical and mental functioning for QOL were assessed by covariance structure analysis. The statistical significance was set at p<0.05. Results: The mean scores of QOL among all the subjects was $55.4{\pm}15.62$ (Grade I: $49.7{\pm}14.17$, Grade II: $56.8{\pm}14.62$, Grade III: $59.4{\pm}16.36$), and it was lower according to the higher grade of long-term care insurance. In terms of the correlation matrix of the QOL and the physical and mental function factors, the QOL showed positive correlation with the ADL, IADL and MMSE-K, while it had negative correlation with depression. On the analysis of covariance, mental functioning (depression and the MMSE-K) had a greater influence on the level of QOL than the physical functioning (ADL and IADL). Conclusions: The level of the QOL in the elderly people who were admitted from long-term care insurance was lower according to higher the grade of long-term care insurance. Also, the mental functioning (depression and MMSE-K) was more influential on the level of the QOL than the physical functioning (ADL and IADL).

• 한국환경보건학회지
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• 제48권6호
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• pp.306-314
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• 2022

Background: Due to the rapid aging of the South Korean population, neurological diseases such as dementia are increasing. Many studies have reported that the incidence of dementia is associated with environmental factors along with age. Objectives: This study analyzed the association between cognitive function and ten heavy metals in the body: arsenic, aluminum, chromium, manganese, cobalt, nickel, iron, copper, zinc, and lead. Methods: From 2018 to 2019, a total of 120 participants who suffered from cognitive impairment were recruited for this study. Blood and urine samples were collected and analyzed for heavy metal concentrations using an inductively coupled plasma mass spectrometer. Demographic information was obtained through face-to-face questionnaires completed by a trained investigator. Cognitive function was evaluated with the Korean version of the Mini-Mental State Examination and the Korean version of the Boston Name Waiting Test. The associations between cognitive function scores and heavy metal concentrations were analyzed using multiple logistic regression analysis. Results: The average age of the 120 participants was 72.7 years, and 69.2% were female. The mean of the MMSE-K and K-BNT scores were 22.9 and 37.9, respectively. The geometric mean of aluminum (Al) was 8.42 ㎍/L. MMSE-K was associated with iron (Fe), but the significance was removed in the logistic regression based on 24 points. K-BNT was significantly associated with aluminum and the odds ratio for K-BNT above 38 decreased by 45% as the aluminum concentration increased. Conclusions: The association between aluminum and the K-BNT score indicated that aluminum is associated with language-related cognitive decline. Based on this result, further study will be conducted by considering co-exposure effects of heavy metals including aluminum.

• 동의생리병리학회지
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• 제25권1호
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• pp.144-148
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• 2011

The purpose of this case series was to investigate the effectiveness of Bojungikki-tang-gamibang for vascular dementia. The case subjects were nine patients who were diagnosed as vascular dementia by Mini-Mental State Examination-Korean (MMSE-K) and Hachinski's ischemic score. They were inpatients at the Kumi Oriental Medical Hospitalof Daegu Haany University from February in 2008 to Aprile in 2009. They were treated with Bojungikki-tang-gamibang. Results of before and after therapy were evaluated and scored using Korean-version Dementia Rating Scale (K-DRS). The results were analyzed using statistical methods, such as Wilcoxon signed rank test and Mann-Whitney U test. The study showed that the K-DRS score significantly increased after treatment (P<0.05). In summary, this cases report suggests that Bojungikki-tang-gamibang appears to be effective in the treatment of vascular dementia.

• Journal of Korean Biological Nursing Science
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• 제12권3호
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• pp.140-147
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• 2010

Purpose: The purpose of this study was to identify the effects of the cognitive training program on cognitive function, stress and depression in geriatric hospitals. Methods: The subjects of the experimental group were 17 elderly patients who attended the cognitive training program in Geriatric Hospitals and the subjects of the control group were 15 elderly patients who attended in geriatric hospitals. The persons in training group must take cognitive training program for 4 weeks by 3 times a week. The Mini-mental State Examination Korea version (MMSE-K), Geriatric depression Scaleshort form-Korea version (GDS-K) and Korean Computerized Neurobehavioral Test (KCNT) were utilized to determine cognitive function, stress and depression. The collected data were analyzed by descriptive statistics, t-test and ANOVA using SPSS/PC 12.0 program. Results: Cognitive function (t=-7.625, p=.000) in the elderly after receiving the cognitive training program was significantly more improved than before intervention. Also, Stress and depression (t=2.73, p=.004) was significantly more reduced than before the intervention. Conclusion: This cognitive training program was partially effective in improving cognitive function, neurobehavioral performance and reduce stress and depression. Therefore, it is recommended that this program be used in clinical practice as an effective nursing intervention in geriatric hospitals.

• Journal of Korean Academy of Oral Health
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• 제41권2호
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• pp.96-101
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• 2017

Objectives: The aim of this study was to investigate the relationship between cognitive function and occlusal status in elderly individuals. Methods: A total of 162 individuals aged 65 years and older, who attended the senior citizen center in Daegu city, were included after consent for participation in the study was obtained. The Korean version of the Mini-Mental State Examination (MMSE-K) was used to evaluate the level of cognitive function. Occlusal status was determined using the T-scan $III^{(R)}$ system. All collected data were analyzed by ${\chi}^2$ test, t-test, one way ANOVA, and linear regression analysis using SPSS version 23.0 for Windows. Results: There was a significant relationship between the cognitive function and the use of dentures. Individuals with posterior occlusal status had higher MMSE-K scores than those with anterior occlusal status. There was a positive correlation between the cognitive function and posterior occlusal force. Conclusions: These results suggest that occlusal status was associated with cognitive function in the elderly individuals. Active national policies to improve occlusal condition in the elderly population are needed.

• 생물정신의학
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• 제14권1호
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• pp.48-54
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• 2007

Objectives : This study aimed to examine the relationship between behavioral and psychological symptoms of dementia(BPSD) and patient and caregiver QOL in Alzheimer's disease(AD). Methods : Fifty-one AD patients and their caregivers participated. Measures about patients were Neuropsychiatric Inventory(NPI), Korean version of QOL-Alzheimer's Disease(KQOL-AD), Activities of Daily Living(ADL), Clinical Dementia Rating(CDR), and Korean version-Mini Mental State Examination(K-MMSE). Caregiver QOL was assessed with KQOL-AD and General Health Questionnaire/Quality of Life-12(GHQ/QOL-12). Results : Patient QOL-AD on patient ratings was negatively correlated with appetite/eating change and NPI scores. Patient QOL-AD on caregiver ratings was negatively correlated with hallucinations, depression/dysphoria, and NPI scores. Caregiver QOL assessed by the GHQ/QOL-12 was negatively correlated with agitation/aggression, depression/dysphoria, and NPI scores and was negatively correlated with distress related to agitation/aggression, depression/dysphoria, and NPI scores. Conclusion : BPSD of AD patients was associated with low QOL of both patients and caregivers. Thus, interventions of BPSD were needed to improve both patient and caregiver QOL.

• 대한통합의학회지
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• 제8권4호
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• pp.49-58
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• 2020

Purpose : This study examined the effect of a home visit cognitive training program that uses a tablet-based digital recognition rehabilitation application, Brain Doctor, on local elderly people's cognitive function and depression. Methods : This study featured 20 elderly people living in Busan Metropolitan City, South Korea, who received a voucher for a home visit service to prevent dementia. The subjects were evenly divided into an intervention group provided with Brain Doctor and a control group provided with a conventional cognitive training program. Korean version of Mini Mental State Examination (MMSE-K) and Korean version of Montreal Cognitive Assessment (K-MoCA) were used to assess cognitive function in each group. Patient Health Questionnaire-9 (PHQ-9) was used to evaluate the depression levels. Results : The intervention group showed a significant change in cognitive function and depression after the intervention (p<.05). There was a statistically significant change in cognitive function and depression between the intervention and control groups (p<.05). Conclusion : This study confirmed that Brain Doctor had a positive effect on the cognitive function and depression of elderly people in the local community. It is expected to become a useful home visit program for dementia prevention in the future.

• The Journal of Korean Physical Therapy
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• 제36권2호
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• pp.61-66
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• 2024

Purpose: The purpose of this study was to investigate the impact of action observation training (AOT) on the balance and cognition of the elderly with dementia. Methods: Twenty-four participants were randomly assigned to experimental and control groups (12 participants each). The 5-week intervention involved 45 minutes sessions, three times a week. Both groups did 30 minutes of general physical exercises, followed by the experimental group watching a 5 minutes video featuring functional movements and imitating them for 10 minutes. The control group watched a scenic video and did functional training for 10 minutes, mimicking the experimental group. All participants were evaluated using the Timed Up and Go (TUG) test, Functional Reaching Test (FRT), Berg's Balance Scale (BBS), and Korean version of Mini-Mental State Examination (K-MMSE) before and after the intervention. A paired t-test was conducted to compare the within-group change before and after the intervention. Two-way repeated measures ANOVA was performed to compare the between-group difference. The statistical significance level was set to p=0.05 for all variables. Results: The experimental group showed significant within-group changes in the TUG test, FRT, BBS, and K-MMSE (p<0.05). The control group showed a significant change in FRT and K-MMSE (p<0.05). A significant difference was observed between the experimental group and the control group regarding the change in the TUG test, BBS, and K-MMSE after the interventions (p<0.05). Conclusion: The findings of this study suggest that the AOT and repetition of actual movements, led to more significant improvements in balance and cognitive abilities compared to the control group that observed scenic landscapes.

• 정신신체의학
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• 제24권2호
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• pp.227-235
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• 2016

연구목적 본 연구의 목적은 자가면역 갑상선장애 환자에서 인지결함의 발생 빈도를 알아보고, 이에 영향 미치는 변인을 규명하며, 특히 갑상선 자가항체와의 연관성을 알아보기 위함이다. 방 법 여성 자가면역 갑상선장애 환자 65명을 대상으로 구조적 면담을 통해서 인구학적 정보를 얻었으며, 한국판 Mini-Mental State Examination(Korean Version of the Mini-Mental State Examination, MMSE-K)와 한국판 Montreal Cognitive Assessment(Korean Version of the Montreal Cognitive Assessment, MoCA-K)를 사용해서 인지기능을 평가하였고, 한국판 Depression Rating Scale(Korean Version of the Hamilton Depression Rating Scale, K-HDRS)를 사용해서 우울증을 평가하였다. 결 과 1) MMSE-K 총점 24점 이하는 7.69%, MoCA-K 총점 22점 이하는 10.77%였다. 인지기능 저하의 빈도는 antimicrosomal 항체 양성군(N=38, 58.46%)과 음성군(N=27) 간에 유의한 차이가 없었다. 2) Antimicrosomal 항체 양성군과 음성군의 변인별 차이를 비교한 결과, 음성군보다 양성군에서 antithyroglobulin 항체 수치, antimicrosomal 항체 수치, TSH 농도는 유의하게 높았고, free T4는 유의하게 낮았다(각각 p<0.05). 3) 자가면역 갑상선장애 환자의 인지기능과 여러 변인의 연관성을 분석한 결과, MMSE-K 검사와 MoCA-K 검사의 총점은 연령, 결혼상태, antithyroglobulin 항체 수치, K-HDRS 총점과 각각 유의한 상관관계가 있었다(각각 p<0.05). 4) 회귀분석 결과, 연령, 교육수준, 갑상선 자가항체, 갑상선기능, 우울증은 자가면역 갑상선장애 환자의 인지기능에 영향을 미치지 않았다. 결 론 본 연구의 결과는 자가면역 갑상선장애 환자의 인지기능과 갑상선 자가항체의 연관성을 지지할 수 없었다.

• 대한한방내과학회지
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• 제38권2호
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• pp.138-145
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• 2017

Objectives: The purpose of this case study is to describe the effect of Korean medicine on a patient with delirium caused by a left middle cerebral artery infarct. Methods: The patient was treated with Sopungbosimdodam-tang, acupuncture, and moxibustion. The Korean version of the Delirium Rating Scale (K-DRS), Neelon and Champagne (NEECHAM) Confusion Scale, and Korean Version of the Mini-Mental State Examination (MMSE-K) were used to evaluate the effect of the treatment. Results: After 50 days of treatment with Sopungbosimdodam-tang, the patient's K-DRS score decreased from 16 to 8. The NEECHAM Confusion Scale also improved from 17 to 23, and the MMSE-K score improved from 1 to 7. Conclusion: This clinical study suggested that Korean medicine could contribute greatly to the treatment of delirium caused by a left middle cerebral artery infarct.