• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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• pp.114-117
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• 1998

Chinese traditional drugs have a long history to be used in clinics to treat various diseases and are confirmed to be effective approach through thousands of years of medical practice. Therefore, as a common understanding, the drug development from traditional Chinese medicines could be considered as a “shortcut” way with less blindness and more saving of time and money since development of new Chinese drugs has a different approach from that of western new drugs. Firstly, Chinese new drug development can be simplified as “from men to animal” process rather than “from animal to men” in western medicines. Hence the successful rate would be higher. Secondly, the original drugs or prescriptions from which the new drugs are planned to develop have been known what symptoms they are indicated for. Therefore, the developing procedure is actually a refine process with much less blindness than that of western drugs.

• 생약학회지
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• 제42권2호
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• pp.187-194
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• 2011

Aldose reductase (AR), the key enzyme in the polyol pathway, plays an important role in the development of the diabetic complications. None of Aldose reductase Inhibitor (ARI) has achieved worldwide use because of limited efficacy or undesirable side effects. Therefore, evaluating natural sources for ARI potential may lead to the development of safer and more effective agents against diabetic complications. Fifty two Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, twelve herbal medicines, Artemisia anomala (aerial part), Centella asiatica (aerial part), Scutellaria baicalensis (root), Senecio chrysanthermoides (whole plant), Gleditsia japonica (twig), Zizyphus jujube (twig, leaf), Citrus aurantium (fruit), Hydnocarpus anthelmintica (fruit), Potaninia mongolica (aerial part), Tribulus terrestris (fruit), Artemisia apiacea (aerial part) and Eclipta prostrate (aerial part) exhibited a significant inhibitory activity against AR. Particularly, Artemisia anomala, Centella asiatica and Scutellaria baicalensis showed four times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG).

• 동의생리병리학회지
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• 제17권6호
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• pp.1528-1532
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• 2003

To investigate the antioxidant capacity of traditional Korean medicines, water extracts from 57 species were tested on their antioxidant activity using radical scavenging effects against ABTSㆍ+. Of which, Rhus javanica, Caesalpinia sappan, Rosa rugosa, Spatholobus suberectus, and Magnolia obovata showed strong antioxidant capacities at 10㎍ concentration. Therefore, antioxidant capacities of 5 traditional medicine extracts in the different concentration (1㎍, 5㎍, and 10㎍) were determined. The 5 traditional medicine extracts was detected in antioxidant capacity dose dependently. R. javanica was showed the highest antioxidant capacity, the antioxidant activity at 1 ㎍ of herbal extract being 0.85 mM TE. At the same time, the antiperoxidation effects of these 5 medicines were determined. Lipid peroxidation in brain homogenates induced by NADPH and ADP-Fe/sup 2+/ was strong inhibited by S, suberectus, R. rugosa, and M. obovata. Extract of C. sappan was showed the highest inhibition against lipid peroxidation compared with 4 herbal extracts in vitro. These traditional medicines are a potent antioxidant capacity and antiperoxidation activity, further investigation into the in vivo antioxidant therapeutic potential for treatment of human disorders such as Alzheimer's disease.

• 대한한의학방제학회지
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• 제18권1호
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• pp.43-56
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• 2010

Objective : There is a growing need to expand or adjust insurance coverage of herbal prescriptions in National Health Insurance. The purpose of this study was to provide basic data for expansions or adjustments of 56 herbal prescriptions in the National Health Insurance. Method : We surveyed lists of 56 insurance-covered herbal prescriptions, non-covered company-produced herbal medicines and self-prepared herbal medicines in 531 traditional korean medical clinics by mail from 6/1/2008 to 12/9/2008. Result : Among the 56 Prescriptions, Ojeok-san was stocked in 66.7% of clinics (1st), Samso-eum ranked 2nd, Socheongnyong-tang ranked 3rd, Gumiganghwal-tang was 4th, Hyangsapyeongwi-san ranked 5th. Among the non-covered company-produced herbal medicines, Danggwisu-san ranked 1st, Gwakyangjeonggi-san ranked 2nd, Oryeong-san was 3rd, Bangpungtongseong-san was 4th, Maengmundong-tang ranked 5th. Among the self-prepared herbal medicines, Gongjin-dan ranked 1st, Soche-hwan was 2nd, Gyejibongnyeong-hwan was 3rd, Yeongsin-hwan was 4th, Palmi-hwan ranked 5th. Conclusions : It is reasonable to select frequently used company-produced or self-prepared herbal prescriptions in this stock rate survey for improvement of National Health Insurance coverage.

• 동의생리병리학회지
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• 제21권2호
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• pp.511-513
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• 2007

The aim of this study was to confirm traditional medicine of ante-T. gondii effect. We searched 16 traditional medicines that have antiparisite effect from dongyibogam and Traditional Chinese Medicine. We have searched 3 medicines that was Quisqualis india L. var villosa Clark, Artemisia scoparia Waldstein and Loranthi Ramulus, Selectivity of these medicines was 2.9, 2.2 and 2.3, respectively, higher than spiramycin.

• Natural Product Sciences
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• 제9권4호
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• pp.205-209
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• 2003

The Korean peninsula, located between the vast Chinese mainland and Japan, has a unique cultural background that goes back five thousand years. In ancient times, the region was deeply influenced by Chinese culture, and traditional medicine in Korea was no exception. The Korean character, HAN GUL (24 alphabets), was invented at in the early 1400s by The Great King Sejong (1397-1450) of the Chosun dynasty. But few changes were made to traditional medicines for about 500 years thereafter. At the start of the 20th century, missionaries from western countries introduced new concepts and techniques of medicine. During the last century, there was enormous development in modern medical sciences. Even today, however, natural medicine -including folk medicine (or traditional Chinese medicine) - plays an important role in Korean health care. In this paper, we will review and discuss traditional Korean medicines as it has evolved over the past three thousand years.

• 생약학회지
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• 제40권4호
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• pp.382-387
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• 2009

Enhanced formation and accumulation of advanced glycation end products (AGEs) have been implicated as a major pathogenesis process leading to diabetic complications, normal aging, atherosclerosis and Alzheimer's disease. In our ongoing project to discover novel treatments for diabetic complications from natural sources, we have investigated on the inhibitory activity of 67 ethanol extracts from 57 Korean herbal medicines against the formation of AGEs in vitro. Of these, 22 extracts were found to have a significant AGEs inhibitory activity ($IC_{50}$<50 ${\mu}g$/ml) compared with aminoguanidine ($IC_{50}$=75.98 ${\mu}g$/ml). Particularly, 6 extracts from 3 herbal medicines, Castanea crenata (flower, leaf, bark-twig), Acer tatarium subsp. ginnala (fruit) and Sapium japonicum (leaf, twig) showed (approximately 8-17 fold) stronger inhibitory activity than that of aminoguanidine.

• 생약학회지
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• 제40권4호
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• pp.394-399
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• 2009

Aldose reductase (AR) is a critical enzyme in the development of the diabetic complications. AR, the first enzyme in the polyol pathway, catalyzes the reduction of the aldehyde form of glucose to sorbitol with concomitant conversion of NADPH to $NADP^+$. None of aldose reductase inhibitor (ARI) has achieved worldwide use because of limited efficacy or undesirable side effects. Therefore, evaluating natural sources for ARI potential may lead to the development of safer and more effective agents against diabetic complications. Forty eight Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, seven herbal medicines, Buddleja officinalis (whole plant), Lonicera japonica (leaf and flower), Polygonum aviculare (aerial part), Polygonum aviculare (whole plant), Salvia miltiorrhiza (root), Schisandra chinensis (stem), and Zanthoxylum armatum (leaf and stem) exhibited a significant inhibitory activity against AR. Particularly, L. japonica and P. aviculare showed two times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG).

• 한국한의학연구원논문집
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• 제14권3호
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• pp.173-182
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• 2008

"EuiBangShinGam" is a classic on oriental medicines written by Han Byung Lyun with the pen name Shin Oh in 1913. It was written under the base of the writer's own experience as well as in the light of 36 other classics on oriental medicines such as "DongEuiBoGam", Introduction to Medicine, and Complete Works of Jingyue. In an attempt to avoid difficult theories and list only the essential informations and formulas for clinical purposes, it attained its own characteristics of not only reorganizing DongEuiBoGam in a pragmatic way but also explaining diseases classified in western medicines in oriental medicines' point of view as well as suggesting medicine formulas regarding such explanations. As a result, it is a complete and efficient medical classic through which one can gain knowledge in both classic oriental medicines and combination of western and oriental medicines. Its special features are making a separate chapter for cholera and phthisis, which is also a contagious disease, and trying in the chapter to explain the disease s in words of oriental medicines; listing details of nine major epidemic and matching them with the diseases known in oriental medicines: and recording a case of enforcing sterilization and preventive injection against contagious diseases. Han Byung Lyun, the writ er of the book, was born in northern province of Ham Gyoung, Woong Bu, and the date of death is unknown. He is one of the eight members who conceived and started the idea of organizing the Organization of Practioners of Oriental Medicines, which was a nationwide organization under the motive of restoring Oriental Medicines against the policy under the colonial government of Japan. Living a era of Japanese Imperialism, he stressed the need to accept western medicines if its beneficial to oriental medicines in order to develop oriental medicines for progressive causes. This reflects that he was a person who tried in various ways to extend oriental medicines to another level by facing up to the reality and coming up with a measure to cope up with it. In fact, he was a oriental medicine doctor who tried to protect oriental medicines by founding academic organizations, publishing academic magazines, and writing himself many papers related to oriental medicines. EuiBangShinGam can he summarized as a classic on traditional korean medicine through which one can find out about realities of Japan Imperialism and the attempts of oriental medicine practitioners under the colonial policies of Japan to make oriental medicines more developed by adding one's own thoughts as well as keeping the old, and adjusting to such situations.

• Journal of Evidence-Based Herbal Medicine
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• 제1권2호
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• pp.27-33
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• 2008

Allergic rhinitis comes within snuffle in Chinese medicine. For generations, physicians have believed that the internal factors that cause this disease are pulmonary tuberculosis, splenic hypofunction and loss of virility, and its external factors are a cold, an uncommon atmosphere and an uncommon flavor. From the viewpoint of Chinese medicine, this symptom was fundamentally cured by "abidance by individuality, locality and seasons", on the basis of demonstration. In result, visceral function was recovered. In Chinese medicine, a disease is etiologically cured by the principles of Wholism and by discriminating among symptoms. In particular, "method for replenishing Qi and securing Exterior" has been widely used among the foregoing therapeutics. According to modern pharmacology, Astragli Radix, Atractylodis Macrocephalae Rhizoma and Ledebouriellae Radix all have antihistaminic effects and strengthen of the masticating and swallowing function of the recticuloendothelial system. This disease can be cured by controlling immunity and allergic reactions. Besides, it is necessary to take moderate exercise, to strengthen constitution, to avoid causative substances, to control ingesting flesh, meat and shrimps, to eat little, and to avoid what is cold and raw.