• 한국식품저장유통학회지
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• 제18권6호
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• pp.923-929
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• 2011

본 연구는 당뇨처방을 근거로 구성된 생약재 복합물의 항당뇨 효능을 조사하기 위하여 복합물의 인슐린성 물질을 탐색하고 ${\alpha}$-amylase 및 ${\alpha}$-glucosidase 저해활성을 평가하였다. 3T3-L1 세포에 복합 생약재 추출물을 $10{\mu}g/mL$의 농도로 처리하였을 때 지방세포로의 분화능은 151.7%로 인슐린의 작용을 향상시키는 것으로 확인되었다. 혈당저하제로서 생약재 복합 추출물의 ${\alpha}$-amylase에 대한 저해활성은 생약재 복합 추출물 10.0, 1.0 및 0.1 mg/mL의 농도에서 각각 38.4, 31.5 및 16.6%이었으며, ${\alpha}$-glucosidase에 대한 생약재 복합 추출물의 저해활성은 같은 농도에서 각각 81.3, 35.8 및 26.7%였다. 열수 추출물과 80% ethanol 추출물의 각종 용매 분획물에 대한 ${\alpha}$-glucosidase 저해활성은 다양한 용매 분획물 가운데 ethyl acetate층에서 66.9%와 55.1%로 가장 높은 활성을 나타내었다.

• 정신신체의학
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• 제24권2호
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• pp.217-226
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• 2016

연구목적 본 연구는 대사증후군의 예방과 회복을 위해 5년 동안 추적이 가능한 만성 조현병 환자에서 대사증후군의 변화와 예측인자를 조사하였다. 방 법 2011년부터 2016년까지 추적이 가능하며 동의서에 동의한 107명의 환자가 본 연구에 포함되었다. Revised National Cholesterol Education Program-Adult Treatment Panel III(NCEP-ATP III)를 이용하여 대사증후군을 정의하였다. 결 과 추적 관찰 기간 동안 22명(20.5%)의 환자가 새롭게 대사증후군에 진단되었고 14명(13.1%)는 대사증후군에서 회복되었다. 77명(66.4%)은 변화가 없었다(대사증후군이 있는 환자:34명[31.8%], 대사증후군이 없는 환자 : 37명[34.6%]). 복부둘레와 중성 지방이 대사증후군의 유무가 변화된 환자들에서 중요한 인자였다. 다른 변수를 통제한 다변량 회귀분석에서 여성(OR=2.846, 95% C.I. 1.020-7.942), 1달에 1회 이상 외래 방문(OR=3.155, 95% C.I. 1.188-8.379), 항우울제 병합치료(OR=3.991, 95% C.I. 1.048-15.205)가 대사증후군의 유병률에 유의한 영향을 주었다. 반면에 항정신병 약물의 종류나 용량은 대사증후군의 유병률에 영향을 주지 못했다. 결 론 만성 조현병 환자에서 약제의 변경 및 용량조절보다 증상에서의 회복과 건강한 생활 습관이 대사증후군에 중요하다.

• 말소리와 음성과학
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• 제11권3호
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• pp.77-87
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• 2019

본 연구는 발화범위 프로파일(Speech Range Profile, SRP) 과제를 개발하고, 개발된 SRP 과제가 최대발화범위를 측정하기에 적합한지 살펴보기 위해 45명의 18-29세 정상음성군을 대상으로 음성범위 프로파일(Voice Range Profile, VRP) 과제와 비교하였다. 이를 위해 한국어의 모든 말소리와 문장 유형을 포함하는 14개 문장으로 구성된 "불이야"문단을 개발하였다. SRP와 VRP 간의 차이를 비교하기 위해 SRP 과제로는 새롭게 개발된 문단으로 문단읽기와 21-30까지 숫자세기를 사용하였고, VRP 과제는 /a/ 모음을 낮은 음도부터 높은 음도까지 활창하기와 축약된 VRP를 사용하였다. SRP와 VRP의 변수로 최고기본주파수($F0_{max}$), 최저기본주파수($F0_{min}$), 기본주파수범위($F0_{range}$), 최대음성강도($I_{max}$), 최소음성강도($I_{min}$) 및 음성강도범위($I_{range}$)를 측정한 후 과제 간 차이를 비교하였다. 그 결과, $F0_{max}$, $F0_{min}$, $F0_{range}$, $I_{max}$ 및 $I_{range}$는 모두 문단읽기의 SRP와 활창하기의 VRP 간에 차이가 없었고, $I_{min}$은 숫자세기의 SRP가 가장 낮은 평균값을 보였다. 즉 새롭게 개발된 SRP 과제인 "불이야" 문단은 정상 음성 산출 화자에서 모음만을 통해 측정된 VRP의 음역대와 유사한 수준의 음역대를 산출할 수 있음을 알 수 있다. 이에 오랜 시간이 소요되거나 중증도의 음성장애에서 측정이 어려울 수 있는 VRP를 대신하여 기능적 말산출 과제인 SRP를 적용함으로써 국내 임상환경에서 비교적 짧은 시간 내에 음성평가를 효과적으로 실시할 수 있을 것으로 본다.

• 생명과학회지
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• 제29권5호
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• pp.524-529
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• 2019

엉겅퀴는 대표적인 다년생의 약용식물이다. 최근 국제적 추세에 따라 자국의 유전자원의 발굴, 보존 등이 강화 됨에 따라 인접국가와 국내 자생 엉겅퀴 계통을 판별 할 수 있는 기준 설정에 관한 연구의 필요성이 대두되고 있지만, 분자생물학적 판별 기술의 개발은 아직 미흡한 실정이다. 본 연구에서는 국내 토종과 해외 유래 엉겅퀴종의 기원을 판별하기 위해 엽록체에 존재하는 trnL-trnF와 MatK 유전자단편에서 SNP를 이용한 판별 프라이머를 확보하였으며 이를 보완하여 보다 신속하게 판별하기 위하여 HRM 분석 기술을 이용한 판별 마커와 그 조건을 확립하였다. 그러므로, 본 연구에서 개발된 SNP 마커는 다양한 지역 또는 국가에서 서식하는 엉겅퀴 종들의 신속한 확인을 위해 매우 유용하게 이용될 것으로 생각된다.

• 한국학교ㆍ지역보건교육학회지
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• 제22권4호
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• pp.49-60
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• 2021

Objectives: Laboratories have various latent physical, chemical, biological, and ergonomical factors according to the diversification and fusion of research and development activities. This study aims to investigate the chemical exposure concentrations of college laboratories and evaluate their health risks, and use them as basic data to promote the health of college students. Methods: The sampling and analysis of harmful chemicals in the air in laboratories were performed using Method 1500 of the U.S. National Institute for Occupational Safety and Health (NIOSH)의 Method 1500. The harmful chemicals in the laboratories were divided into carcinogenic and non-carcinogenic chemicals. Risk assessment was performed using the cancer risk (CR) for carcinogenic chemicals and using the hazard index (HI) for non-carcinogenic chemicals. Results: The harmful chemicals in college laboratories consisted of acetone, diethyl ether, methylene chloride, n-hexane, ethyl acetate, chloroform, tetrahydrofuran, toluene, and xylenes. They showed the highest concentrations in laboratories A (acetone 0.001~2.34ppm), B (chloroform 0.95~6.35ppm), C (diethyl ether 0.08~8.68ppm), and D (acetone 0.07~14.96ppm). The risk assessment result for non-carcinogenic chemicals showed that the HI of methylene chloride was 2.052 for men and 2.333 for women, the HI of N-hexane was 4.442 for men and 5.05 for women. Thus, the HI values were higher than 1. The risk of carcinogenic chemicals is determined by an excess cancer risk (ECR) value of 1.0×10^-5, which means that one in 100,000 people has a cancer risk. The ECRs of chloroform exceeded 1.0×10^-5 for both men and women, indicating the possibility of cancer risk. Conclusion: College laboratories showed the possibility of non-carcinogenic health risks for methylene chloride, n-hexane, tetrahydrofuran (THF), toluene, and xylenes, and carcinogenic health risks for chloroform, methylene chloride. However, this study used the maximum values of measurements to determine the worst case, and assumed that the subjects were exposed to the corresponding concentrations continuously for 8 hours per day for 300 days per year. In consideration of the nature of laboratory environment in which people are intermittently exposed, rather than continuously, to the chemicals, the results of this study has an element of overestimation.

• 정신신체의학
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• 제31권2호
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• pp.72-78
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• 2023

연구목적 코로나19 감염으로 인한 다양한 정신과적 증상, 정신신체증상을 파악하고 장기적 영향을 조사하였다. 방 법 체계적 문헌고찰을 통해 국내외 데이터베이스에서 논문을 선정하고, "COVID-19", "psychosomatic" 등의 검색어를 활용하였다. 정신신체증상에 대한 구조화된 측정도구를 사용한 연구를 포함하여, 총 16편의 논문이 최종 분석 대상으로 포함되었다. 결 과 코로나19 급성 감염과 관련된 정신증상으로는 불안, 우울, 신체증상 등이 보고되고 있다. 장기간 지속되는 포스트 코로나증후군의 증상으로는 흉통, 피로 등이 보고되었고, 이와 관련된 정신신체증상의 발생 빈도는 10%-20%로 파악되었다. 감염병으로 인한 심리사회적 스트레스, 여성, 노인, 정신과적 기왕력이나 동반 정신질환 등의 요인이 관련을 미친다. 전신염증, 자가면역, 자율신경계의 이상반응 등이 관련이 있을 것으로 생각되고 있다. 결 론 코로나19 감염 이후 발생하는 정신신체증상은 삶의 질과 심리사회적 기능에 부정적인 영향을 미칠 뿐 아니라 증상에 대한 정신과적 이해와 접근은 예방과 치료에도 중요하다.

• 성인간호학회지
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• 제22권6호
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• pp.644-652
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• 2010

Purpose: The purpose of this study was to analyze the relationship among life style, body composition and Bone Mineral Density (BMD) in community dwelling Korean adults. Methods: Data were collected from 140 adults who participated in a health check-up program at community health departments in D city, Choong-chung providence. Subjects' life style was assessed with a structured interview survey. Body composition analyses were performed by the bioimpedence method and BMD was measured by peripheral dual energy X-ray absorptionmetry. Results: Among the subjects, 39.3% showed normal BMD values, 50.7% were osteopenic and 10% were assessed as osteoporotic. BMD was significantly different by gender, age, education, economic status and BMI. Subjects who had three or more meals/day had higher BMD then who had less than three meals (t=-2.273, p=.026). BMD was not influenced by regular exercise, alcohol consumption, or smoking. In terms of body composition, there was a significant relationship between fat free mass and BMD (r=.172, p=.043). Conclusion: Implementing an osteoporosis prevention program would be warrented considering the significant proportion of osteopenic or osteoporotic subjects. Regular eating habit with three meals for adequate nutrition need to be emphasized to prevent further bone loss in this population. Among the body composition, fat free mass seem to be the mostly predicting factor for BMD.

• 대한간호학회지
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• 제27권4호
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• pp.961-974
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• 1997

The ZZimzilbang is a room where many women eagerly go due to the special meaning women give to it related to their health. It is a different type of sauna room which maintains low degree of temperature, consisting of an Ondol room(Korean under-floor heating system, hypocaust) built with mineral stone radiating ultrared rays. Even though many women mention that they utilize it for health, there is no precise evidence of the effects on their health. This ethnographic study sought to define the phenomenon from the perspective of the women who experienced the ZZimzilbang. A convenience sample of 27 women was interviewed during a 15 month period from December 1995 to July 1997 in 12 ZZimzilbangs located in Seoul, Korea. The mean ages of the women 57.3 years ; seventeen women were housekeeper and only eight women had job : twenty women were married and three women among them were widows. The main reasons women patronize the place are : for mitigation and healing of physical signs and symptoms : composure ; safe lodging and boarding : control of outward appearance : control of health ; meeting and fellowship with friends : and custom. The outcomes of the utilization of the place were : mitigation of physical signs and symptoms : psychological tranquility : cosmetic and diet ; good use of spare time : and utilization of services provided there. Most women who visited ZZimzilbang for relief of physical signs and symptoms strongly mentioned a correlation to inadequate Sanhujori, the traditional postpartal and postabortal care for woman. Some of specific kinds of services provided in that place were alternative therapy such as acupuncture, negative cupping, finger-pressure, mugwort steam and various kinds of massage including massage of blood vessels that are influenced by Oriental medicine ; health education of breathing such as abdominal breathing or Danjeon(단전호흡) : and selling of many things including health foods, drugs for osteoporosis, and eutrophics. This study suggests that professional caregivers should further study this phenomenon for the development of adequate care of women with a resulting important in their quality of life.

• 한국직업건강간호학회지
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• 제19권2호
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• pp.170-179
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• 2010

Purpose: It was to identify the relationship with the health beliefs, self-efficacy and medical care utilization in nurses in order to provide basic data for program development to actively help nurses' health practice. Methods: The subjects were 360 hospital nurses in P city, K Province. Instruments were health belief developed by Walker, Sechrist & Pender (1987), self-efficacy by Sherer, Maddux & Mercandante(1982), and medical care utilization by Korean National Health & Nutrition Examination Survey(2006). The data were analyzed as descriptive statistics, Chi-square, t-test, and ANOVA using SPSS 11.5. Results: There were significant differences in medical care utilization depending on age(p=.008), marital status(p=.019), education level(p=.005), types of work(p=.017), nursing units(p=.018), and period of work(p=.001). Use of outpatient clinic was significantly different depending on perceived susceptibility(F=2.463, p=.045). Nurses who consulted to doctor in other hospital had higher perceived severity(F=2.759, p=.028). Nurses who used complementary medicine had higher perceived barrier(F=2.278, p=.047). The score of self-efficacy was significantly different in medical care service frequency (F=3.030, p=.018) and to whom their health problems consulted(F=3.092, p=.010). Conclusion: Medical service utilization was different depending on the demographic characteristics, perceived susceptibility, severity, and barrier, and self efficacy. It is needed to give health promotion program considering these factors for nurses.

• 대한지역사회영양학회지
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• 제17권3호
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• pp.271-279
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• 2012

The prevalence of atopic dermatitis (AD) has increased recently all over the world. Several studies worldwide reported growth retardation associated with AD, but few studies were reported in Korea. Therefore, the objective of this study was to identity the differences in growth and nutrient intakes between Korean children with and without AD. The participants were 71 AD children and age, gender-matched 81 control children aged 10 to 36 months. Demographic information was gathered by questionnaires. Height and weight were measured at clinic and health centers. Height and weight for age, and weight for height were converted as deviation in Z scores using World Health Organization Standard. A 24 hour dietary recall method was performed to estimate nutrient intakes. A higher percentage of AD children had insufficient energy and intakes of calcium, phosphorus, iron, zinc and vitamin B2, defined as intakes lower than 75% of the Dietary Reference Intakes for Korean, compared to the control group (P < 0.001, P < 0.001, P = 0.003, P = 0.001, P = 0.014, P = 0.001, respectively). The percentages of children with height and weight for age Z score below than-1 (stunted) were significantly higher in the AD group (P < 0.001 and P < 0.001, respectively). Multiple food restriction, defined as ${\geq}$ 3 food elimination, was associated with insufficient energy and intakes of calcium, phosphorus, iron, zinc, vitamins A and B2. In conclusion, children with AD need regular nutrient assessment and education about alternative food choices to avoid r food elimination in order to prevent growth retardation or inadequate nutrient intakes. Further longitudinal studies for growth and nutrient intakes should be performed to understand the patterns of growth in children with AD.