• Journal of Preventive Medicine and Public Health
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• v.43 no.2
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• pp.166-173
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• 2010

Objectives: On December 7, 2007, the Hebei Spirit oil tanker spilled out 12,547 kl of crude oil on the Yellow Sea 10 km away from the cost of Taean Province, Korea. As the coastline has been contaminated, local residents have been exposed to crude oil. Because the residents were showing many symptoms, we investigated the acute health effects of this oil spill on them. Methods: We conducted a cross-sectional study consisting of the heavy and moderately oil soaked area in Taean and the lightly oil soaked area in Seocheon. Ten seashore villages were selected from each area, and 10 male and female adults were selected from each village. We interviewed the subjects using a structured questionnaire on the characteristics of residents, the cleanup activities, the perception of oil hazard, depression and anxiety, and the physical symptoms. The odds ratios and 95% confidence intervals were analyzed using logistic regression analysis. The logistic regression model was adjusted for age, gender, education, smoking, the perception of oil hazard and anxiousness. Results: The more highly contaminated the area, the more likely it was for residents to be engaged in cleanup activities and have a greater chance of exposure to oil. The indexes of anxiety and depression were higher in the heavy and moderately oil soaked areas. The increased risks of headache, nausea, dizziness, fatigue, tingling of limb, hot flushing, sore throat, cough, runny nose, shortness of breath, itchy skin, rash, and sore eyes were significant. Conclusions: The results suggest that exposure to crude oil is associated with various acute physical symptoms. Long-term investigation is required to monitor the residents' health.

• BMB Reports
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• v.28 no.2
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• pp.177-183
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• 1995

The activity of aldehyde dehydrogenase (ALDH) in the cerebrum, cerebellum, striatum, and medulla oblongata was examined and mitochondrial matrix ALDH was purified prior to immunohistochemical study on the localization of ALDH isozymes in pig brain. Relatively high enzyme activity was found in the striatum and medulla oblongata when using indole-3-acetaldehyde as substrate, and in the striatum when using 3,4-dihydroxyphenylacetaldehyde (DOPAL). The main part of mitochondrial ALDH activities with both acetaldehyde and DOPAL existed in the matrix fraction. The ratio of activity of the matrix to the membrane fraction in the cerebrum was higher than in the cerebellum, suggesting that the distribution pattern of ALDH isozymes was different according to the brain regions. The 276-fold purified mitochondrial matrix ALDH from pig brain was identified to be homologous tetramers with 53 KD subunits. The enzyme showed maximal activity at pH 9.0 and was stable in the temperature range from $25^{\circ}C$ to $37^{\circ}C$. The mitochondrial matrix ALDH activity was considerably inhibited by acetaldehyde in vitro. The $K_m$ values of the enzyme for acetaldehyde and propionaldehyde were 5.8 mM and 4.9 mM, respectively, whereas $K_m$ values for indole-3-acetaldehyde and DOPAL were 44 ${\mu}M$ and 1.6 ${\mu}M$, respectively. The $V_{max}/K_{m}$ ratio was the highest with DOPAL as compared with other substrates. These results suggested that mitochondrial matrix ALDH in the present work might be a low Km isozyme involved in biogenic aldehyde oxidation in pig brain.

• Journal of Biomedical Engineering Research
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• v.38 no.4
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• pp.163-167
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• 2017

The purpose of this study is to perform integrated body temperature cooling of the arteriovenous anastomosis site. In the arteriovenous anastomosis site, heart cooling was performed using the palm of the hand, Cooling was achieved by using Peltier and copper plates to cool the palm of the hand with the heat transferred. The control range of the conducted heat is adjustable from 25 degrees to 30 degrees. The experimental environment was to place the treadmill in the house, The temperature in the house was set at 40 degrees and the experimenter treadmill at a speed of 5 Km. The subjects were exercised until the body temperature reached about $39^{\circ}C$. As a method to lower the body temperature after the experiment, the data of the body temperature was obtained by the general rest, onehand cooling, two-hand cooling. Experiment result better than normal rest when Two hands cooling and an average decrease of 0.66 degrees. if you develop a cooling glove with Peltier, it will be an epoch-making athletic assistant to achieve thermal fatigue.

• Journal of Preventive Medicine and Public Health
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• v.9 no.1
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• pp.49-54
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• 1976

In order to provide bases for the control of air pollutants in Korea, the author figured out the trend on the annual increase of air pollutants emitted in the process of combustions, and estimated the amounts of air pollutants of the future years from 1975 to 1981. 1) In 1973 the consumption rate of coal was 1.2 times of that of fuel oil. The consumption rate of them would be same in 1975 and 1977. However, the rate of fuel oil would exceed that of coal in 1979. Incontrast with the rate in 1979. The one of coal would be increased faster and faster to show reverse trend of consumption in 1981. 2) The estimated amounts of air pollutant emissions in the years of 1973, 1975, 1977, 1979 ana 1981 were 1,561,800, 1,921,700, 2,253,300, 2,769,000, and 3,145,700 tons respectively. These indicated that the amount of air pollutants in 1981 would be about 2 times of that in 1973. 3) The amounts of sulfur oxides emissions in 1981 would be 2.3 times of that in 1973, nitrogen oxides 2.2 times, carbon monoxide 1.7 times, particulate 2.0 times and hydrocarbon 2.0 times. 4) The estimated amounts of air pollutant emissions per unit area($km^2$) in the years of 1965, 1971, 1975 and 1980 were 5.2, 14.5, 19.5 and 28.7 tons respectively. These indicated that the amount of air pollutant emissions per unit area would increase 5.5 times in 1980 comparing the one in 1965.

• Journal of Preventive Medicine and Public Health
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• v.52 no.6
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• pp.427-432
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• 2019

Objectives: In Indonesia, 61 million adults smoked in 2018, and 59 million were exposed to secondhand smoke at offices or restaurants in 2011. The Presidential Decree 109/2012 encouraged local governments to implement a smoke-free policy (SFP), and the city of Jayapura enacted a local bill (1/2015) to that effect in 2015. This study aimed to evaluate compliance with this bill and to explore challenges in implementing it. Methods: We conducted a mixed-methods study. Quantitatively, we assessed compliance of facilities with 6 criteria (per the bill): the presence of signage, the lack of smoking activity, the lack of sale of tobacco, the lack of tobacco advertisements, the lack of cigarette smoke, and the lack of ashtrays. We surveyed 192 facilities, including health facilities, educational facilities, places of worship, government offices, and indoor and outdoor public facilities. Qualitatively, we explored challenges in implementation by interviewing 19 informants (government officers, students, and community members). Results: The rate of compliance with all 6 criteria was 17% overall, ranging from 0% at outdoor public facilities to 50% at health facilities. Spatial patterning was absent, as shown by similar compliance rates for SFP facilities within a 1-km boundary around the provincial and city health offices compared to those outside the boundary. Implementation challenges included (1) a limited budget for enforcement, (2) a lack of support from local non-governmental organizations and universities, (3) a lack of public awareness at the facilities themselves, and (4) a lack of examples set by local leaders. Conclusions: Overall compliance was low in Jayapura due to many challenges. This information provides lessons regarding tobacco control policy in underdeveloped areas far from the central government.

• Herbal Formula Science
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• v.29 no.4
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• pp.181-189
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• 2021

Objectives : The calyx of Diospyros kaki Thunb. has usually been used to treat obstinate hiccup. This study investigated the protective effects of Diospyros kaki using C2C12 myoblasts of H₂O₂-induced oxidative stress. Methods : Cell viability and cytotoxicity were determined by MTT assay. The level of reactive oxygen species (ROS), malondialdehyde (MDA), and reduced glutathione (GSH) were measured by using optical properties. Results : The calyx of Diospyros kaki Thunb. extract showed no toxicity to C2C12 myoblasts until 20 ㎍/mL concentration and increased cell viability compared to the H₂O₂ treated group. The calyx of Diospyros kaki Thunb. extract inhibited the production of ROS and MDA at all concentrations. In addition, the calyx of Diospyros kaki Thunb. extract increased the concentration of GSH. Conclusion : This study provides that the calyx of Diospyros kaki Thunb. can be used as a potential material that exhibit antioxidative and protective effects on H₂O₂-induced oxidative stress in C2C12 Myoblasts.

• Korean Journal of Acupuncture
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• v.39 no.3
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• pp.84-90
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• 2022

Objectives : Acupoints are divided into three categories: classical acupoints, extra-acupoints, and Ashi points. The aim of this study was to understand the meaning and features of Ashi points. Methods : We examined the original meaning of Ashi points from the classical medical texts, including the Beijiqianjinyaofang, the Essential Prescriptions Worth a Thousand Gold for Emergencies, and the Huangdi Neijing, the Yellow Emperor's Canon of Internal Medicine. Results : First, the Ashi method is to locate the points for the acupuncture and moxibustion based on the patients' reactions mainly manifested by sensations of comfort and pain, which can help identify not only Ashi points but also classical and extra-acupoints. Thus, Ashi points may or may not match to classical or extra-acupoints, and we propose that Ashi points should not be classified mutually exclusive to classical or extra-acupoints. Second, there are several similarities between Ashi points and myofascial trigger points. They are located by palpation and have no fixed anatomical positions. Patients experience painful but pleasant feeling when Ashi and myofascial trigger points are pressed, and stimulation of these points have treatment effects. Conclusions : We suggest that Ashi method be used to identify the acupoints based on how patients react when these points are pressed. Ashi points may or may not correspond to classical or extra-acupoints, and share traits with myofascial trigger points.

• Korean Journal of Exercise Nutrition
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• v.25 no.4
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• pp.54-58
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• 2021

[Purpose] Deleted in breast cancer 1 (DBC1) ablation causes obesity, and stearoyl-CoA desaturase 1 (SCD1) induces the biosynthesis of monounsaturated fatty acids. This study examined whether voluntary wheel running (VWR) alters SCD-1 and DBC1 protein levels in the liver of leptin-deficient ob/ob mice. [Methods] Twenty-five Ob/Ob mice were divided into two groups (ob/ob-Sed and ob/ob-Ex). The expression of DBC1 and SCD1 in the mouse liver was determined using western blotting. [Results] After 10 weeks, VWR significantly reduced body weight without affecting the fatty acid synthase and CD36 protein levels. The average daily running distance was 4.0±1.0 km/day. This improvement was associated with changes in the hepatic SCD1 and DBC1 levels. Hepatic SCD-1 protein levels increased significantly, and DBC1 protein levels decreased in ob/ob-Sed animals. On the other hand, VWR inhibited the obesity-induced increase in SCD1 expression and impaired the obesity-induced decrease in DBC1 expression in the liver of leptin-deficient ob/ob mice. [Conclusion] This is the first study showing that VWR has strong effects on hepatic SCD1 and DBC1 in ob/ob mice, and provides key insights into the effects of exercise on obesity.

• Nuclear Engineering and Technology
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• v.55 no.10
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• pp.3907-3912
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• 2023

Radiation portal monitors (RPMs) installed at airports and harbors to prevent illicit trafficking of radioactive materials generally use large plastic scintillators. However, their energy resolution is poor and radionuclide identification is nearly unfeasible. In this study, to improve isotope identification, a RPM system based on a multi-array plastic scintillator and convolutional neural network (CNN) was evaluated by measuring the spectra of radioactive sources. A multi-array plastic scintillator comprising an assembly of 14 hexagonal scintillators was fabricated within an area of 50 × 100 cm². The energy spectra of ¹³⁷Cs, ⁶⁰Co, ²²⁶Ra, and ⁴K (KCl) were measured at speeds of 10-30 km/h, respectively, and an energy-weighted algorithm was applied. For the CNN, 700 and 300 spectral images were used as training and testing images, respectively. Compared to the conventional plastic scintillator, the multi-arrayed detector showed a high collection probability of the optical photons generated inside. A Compton maximum peak was observed for four moving radiation sources, and the CNN-based classification results showed that at least 70% was discriminated. Under the speed condition, the spectral fluctuations were higher than those under dwelling condition. However, the machine learning results demonstrated that a considerably high level of nuclide discrimination was possible under source movement conditions.

• Journal of Preventive Medicine and Public Health
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• v.23 no.1 s.29
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• pp.98-105
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• 1990

In order to fine out the relationship between traffic accidents and atmospheric phenomena, we have analyzed 2,562 cases, one tenth of the total traffic accidents occurred in Taegu city for a year in 1988. The meteorological elements observed by Taegu Weather Bureau were used. It was divided into two largy categories : the patterns of accident as human injuries and destructions of car. When the accidents were overlapped in each other, it was considered as human injury. Human injuries were subdivided into three parts : death, severe wound and slight in, when more then two cases were overlapped, we choiced severe damage. The average number of daily traffic accidents including human injuries were lowest in winter of four seasons. The accident patterns in accordance with the seasons showed statistically significant difference. The frequency was the highest as 3.3 cases in an hour at $25.1-30.0^{\circ}C$ of atmospheric temperature, the rate of human injury showed the increase by the increased temperature. But there were not significant. Also it was the highest as 3.7 cases in less than 31% of humidity and the rate of human injury as the highest at 41-50%, but not significant. And it was the increasing tendency as wind speed increase, and the rate of human injury was the highest at 6.1-7.0 m/sec, but it was not significant. In relation to precipitation, and visibility, were the highest as 5.4 cases at 5.1-10.0 mm of rainfall, the rate of human injury was increased by the increased precipitation and showed statistically significant. And it was highest within 6 Km of visibility, but the rate of the human injury was the lowest within same distance, and also showed significance. The accidents were higher with snow on the road, but the rate of human injury was comparatively lower, but no significance.