• 한국컴퓨터정보학회논문지
• /
• 제17권10호
• /
• pp.25-33
• /
• 2012

본 논문에서는 모바일 환경에서 음성인식한 결과에 포함된 오류를 교정하는 규칙기반 접근방법을 제안한다. 제안하는 방법은 처리시간이나 메모리에 제약을 받는 모바일 환경을 고려하여 다음과 같이 구성된다. 오류 교정 속도를 최소화하기 위해서, 음절 해체 및 조합 과정이나 형태소 분석 등의 처리를 줄이고, 최장일치 규칙 선택기준을 바탕으로 오류 발생 추정 지점에서 교정 후보도 하나만 생성한다. 제안하는 방법은 메모리를 효율적으로 사용하기 위해서, 어절사전이나 형태소분석기를 사용하지 않고, 규칙도 유형별로 따로 구분하지 않고 통합하여 저장한다. 제안하는 방법은 모델의 수정 및 유지보수가 용이하도록, 오류교정규칙을 학습말뭉치에서 자동으로 추출하여 구축한다. 실험결과 제안하는 방법은 음성인식 결과에 대하여 정확률을 5.27% 정도 재현율을 5.60% 정도 개선하였다.

• Clinical and Experimental Reproductive Medicine
• /
• 제26권2호
• /
• pp.219-223
• /
• 1999

Ovarian development of the vitrified neonatal ovaries after orthotopical transplantation into the ovariectomized adult recipient mouse were observed. Ovaries were collected from the neonatal females on day of birth and grouped for fresh, vitrification for 1-minute, and 3-minute. Vitrified and thawed neonatal ovaries were orthotopically transplanted into ovarian bursa of the adult mice from which endogenous ovaries have removed just prior to the transplantation (1 minute: n=25; 3 minutes n=23). Fresh ovarian tissue transplanted (n=25) mice were included as control groups. Returning of the estrus cycles and the survival and development of the transplanted ovaries were evaluated. Intact ovaries from neonatal, and four weeks old mice were used for comparison of the ovarian development as in vivo-developed control. From 2 weeks after transplantation, 64%, 36%, and 75% of the transplanted mice showed return of the estrus cycles in fresh, 1-minute, and 3-minute groups, respectively. Four weeks after transplantation, all mice were sacrificed and ovarian tissues were recovered for histological analysis. 57.1%, 33.3%, and 64.7% mice in fresh, 1-minute, and 3-minute groups, respectively, had survived ovaries with follicles at various stages of growth from primordial to preovulatory follicles. Corpus lutea were also observed. Results of the present study suggest that 1) normal folliculogenesis has initiated in vivo after vitrification, and 2) the vitrification may be used as a preservation method for ovarian tissues for establishment of ovarian tissue bank.

• 한국발생생물학회지:발생과생식
• /
• 제20권2호
• /
• pp.91-99
• /
• 2016

Lipopolysaccharide (LPS), an endotoxin, elicits strong immune responses in mammals. Several lines of evidence demonstrate that LPS challenge profoundly affects female reproductive function. For example, LPS exposure affects steroidogenesis and folliculogenesis, resulting in delayed puberty onset. The present study was conducted to clarify the mechanism underlying the adverse effect of LPS on the delayed puberty in female rats. LPS was daily injected for 5 days ($50{\mu}g/kg$, PND 25-29) to treated animals and the date at VO was evaluated through daily visual examination. At PND 39, animals were sacrificed, and the tissues were immediately removed and weighed. Among the reproductive organs, the weights of the ovaries and oviduct from LPS-treated animals were significantly lower than those of control animals. There were no changes in the weights of uterus and vagina between the LPS-treated and their control animals. immunological challenge by LPS delayed VO. Multiple corpora lutea were found in the control ovaries, indicating ovulations were occurred. However, none of corpus luteum was present in the LPS-treated ovary. The transcription level of steroidogenic acute regulatory protein (StAR), CYP11A1, CYP17A1 and CYP19 were significantly increased by LPS treatment. On the other hand, the levels of $3{\beta}$-HSD, $17{\beta}$-HSD and LH receptor were not changed by LPS challenge. In conclusion, the present study demonstrated that the repeated LPS exposure during the prepubertal period could induce multiple alterations in the steroidogenic machinery in ovary, and in turn, delayed puberty onset. The prepubertal LPS challenge model used in our study is useful to understand the reciprocal regulation of immune (stress) - reproductive function in early life.

• 한국발생생물학회지:발생과생식
• /
• 제21권2호
• /
• pp.151-156
• /
• 2017

High-fructose corn syrup (HFCS) is widely used as sweetener, and its overconsumption is become a major health problem. In the present study, we used adult female rats and applied a 28 days HFCS feeding model to monitor the estrous cycle and changes in tissue weights and histology. Adult female rats were divided into three groups. Animals were fed with ad libitum normal chow and (1) 24 hours tap water (Control group), (2) 12 hours HFCS access during dark period and 12 hours tap water (12H group), and (3) 24 hours HFCS only access (24H group). Total exposure period was 28 days. There is no significant change in body weight between control and HFCS-fed animals. Both absolute and relative weights of ovary in 24H animals were significantly heavier than those in control or 12H animals. The absolute and relative weights of the kidney and liver in 24H groups were significantly heavier than those in control or 12H animals. The estrous cycles of the 24H animals were significantly longer. Histological analyses revealed that 24H ovaries were relatively bigger and possessed more corpus lutea than control ovaries. Uterine sections of 12H and 24H animals showed a well-developed stratum vasculare between inner and outer myometrial layers. The number of endometrial glands were decreased in 12H uteri, and recovered in 24H uteri compared to control. Numbers of convoluted tubule in distal region increased in 12H and 24H kidney samples. Liver specimens of 12H and 24H showed the increased number of fat containing vacuoles. In conclusion, our study demonstrated that HFCS treatment for 28 days could induce (1) changes in length of estrous cycle with extended estrous and diestrous stages, (2) altered ovarian and uterine histology, and (3) liver and renal lipid accumulation. These findings reveal the adverse effects of HFCS drinking on the reproductive function and lipid metabolism of female rats.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제21권3호
• /
• pp.163-169
• /
• 2018

Purpose: The aim of this study is to determine the involvement of the upper gastrointestinal system (GIS) in patients diagnosed with Crohn's disease (CD), ulcerative colitis (UC), and non-inflammatory bowel disease (IBD) and to compare their differences. Methods: This study included patients aged between 2 and 18 years who underwent colonoscopy and esophagogastroduodenoscopy (EGD) for the first time due to the prediagnosis of IBD. In EGD, samples were taken from duodenum, antrum, corpus, and esophagus; and gastritis, duodenitis, and esophagitis were identified through histopathologic examination. The data gathered the ends of the research were compared between IBD with non-IBD groups and between CD-UC with non-IBD groups, and the presence of significant differences between groups were determined. Results: In our study, 16 patients were diagnosed with CD, 13 with UC, 3 with undeterminate colitis, and 13 with non-IBD. In the histopathological examination of the groups, GIS involvement was found in 94.1% of patients diagnosed with IBD and in 38.5% of non-IBD patients. Moreover, the difference was found to be statistically significant (p=0.032). No significant difference was found between the CD and UC groups. Gastritis was mostly observed in 93.8% of CD-diagnosed patients, 76.8% of UC-diagnosed patients, 81.2% of IBD-diagnosed patients, and 38.5% of non-IBD-diagnosed patients. On the other hand, significant differences were found between CD and non-IBD groups (p=0.03), UC and non-IBD groups (p=0.047), and IBD and non-IBD groups (p=0.03). Conclusion: The results of the study show that gastritis was highly observed in UC- and CD-diagnosed patients than in non-IBD-diagnosed patients.

• Preventive Nutrition and Food Science
• /
• 제19권3호
• /
• pp.145-155
• /
• 2014

Vascular dementia is characterized by white matter lesions involving the demyelination and activation of astrocytes and microglia. In a previous study, we showed that the supernatant of a laboratory-scale, hot water extract of ground whole wheat (TALE) attenuated white matter injury and astrocytic activation in a rat model of bilateral common carotid artery occlusion (BCCAO). In the present study, we made several modifications to the hot water extraction process to remove starch and enable large-scale production. We used wheat bran (WB), which contains less starch, instead of ground whole wheat. In addition, we removed starch granules with a decanter before hot water extraction. The final product, wheat bran extract (WBE), contained 2.42% arabinose, a surrogate marker of arabinoxylan, which is an active constituent of WBE. Supplementation of the rat model of BCCAO with WBE (400 mg/kg/day) for 33 days attenuated white matter injury, which was assessed by Luxol Fast Blue staining, in the corpus callosum (cc) and optic tract (opt) regions. Attenuation of white matter injury in the opt region was accompanied by improvement of the pupillary light reflex. Immunochemical staining revealed that supplementation with WBE reduced astrocytic activation in the cc and opt regions and reduced microglial activation in the opt region. These findings indicate that supplementation with WBE is effective at attenuating white matter injury accompanied by the inhibition of astrocytic and microglial activation. Therefore, extracts from WB, a cheap by-product of wheat milling, can be developed as a nutraceutical to prevent vascular dementia, a disease for which there is no approved pharmaceutical treatment.

• 한국정보과학회논문지:소프트웨어및응용
• /
• 제35권5호
• /
• pp.335-346
• /
• 2008

온톨로지의 인과관계는 특정 응용을 위한 추론에서 중요한 역할을 하므로, 인과관계는 응용에서 쓰이는 추론의 형태에 근거하여 정의되어야 한다. 본 논문에서는, 전자장비의 고장진단 질의응답을 위한 온톨로지에서의 인과관계를 정의하고 추출하는 모델을 제시한다. 질의응답의 패턴을 분석하여 인과범주를 정의하고, 질의응답에서 나타나는 개념들 사이의 관계들 중 인과범주에 속하는 경우를 인과관계로 정의한다. 인과관계 인스턴스는 응용분야의 정의문으로부터 어휘 패턴을 이용하여 추출되고 시소러스 정보를 이용하여 점진적으로 확장된다. 분야 전문가들의 평가 결과, 본 모델은 관계분류에 있어서 92.3%의 평균 정확률과 추출 단계의 인과관계 인식에 있어서 80.7%의 정확률을 보인다.

• Mycobiology
• /
• 제35권4호
• /
• pp.215-218
• /
• 2007

The caterpillar-shaped Chinese medicinal mushroom (DongChongXiaCao) looks like a worm in the winter and like a grass in the summer. The fruiting body has been regarded as popular folk or effective medicines used to treat human diseases such as asthma, bronchial and lung inflammation, and kidney disease. The fruiting bodies of Paecilomyces tenuipes that formed on the living silkworm (Bombyx mon) host were used in this examination. This study was carried out to investigate the proximate composition, soluble sugar, amino acid and fatty acid profiles, and contents of the bioactive ingredient including adenosine and D-mannitol in the fruiting-bodies. The moisture content was 57.56%. Soluble sugars found were glycerol, glucose, mannitol and sucrose, and the contents exceeded $24\;mgg^{-1}dry$ weight. Total free amino acid content was $17.09\;mgg^{-1}dry$ weight. Arginine, glycine, proline and tyrosine were main amino acids. The content of oleic acid in fatty acids was high. Adenosine was more abundant in fruiting bodies than corpus.

• 한국정보과학회논문지:소프트웨어및응용
• /
• 제32권5호
• /
• pp.385-395
• /
• 2005

긴 문장 분석은 높은 분석 복잡도로 인해 기계 번역에서 매우 어려운 문제이다. 구문 분석의 복잡도를 줄이기 위하여 문장 분할 방법이 제안되었으며 본 논문에서는 문장 분할의 적용률과 정확도를 높이기 위한 최대 엔트로피 확률 모델 기반의 문장 분할 방법을 제시한다. 분할 위치의 어휘 문맥적 특징을 추출하여 후보 분할 위치를 선정하는 규칙을 학습을 통해 자동적으로 획득하고 각 후보 분할 위치에 분할 확률 값을 제공하는 확률 모델을 생성한다. 어휘 문맥은 문장 분할 위치가 표시된 말뭉치로부터 추출되며 최대 엔트로피 원리에 기반하여 확률 모델에 결합된다. Wall Street Journal의 문장을 추출하여 학습 데이타를 생성하는 말뭉치를 구축하고 네 개의 서로 다른 영역으로부터 문장을 추출하여 문장 분할 실험을 하였다. 실험을 통해 약 $88\%$의 문장 분할의 정확도와 약 $98\%$의 적용률을 보였다. 또한 문장 분할이 효율적인 파싱에 기여하는 정도를 측정하여 분석 시간 면에서 약 4.8배, 공간 면에서 약 3.6배의 분석 효율이 향상되었음을 확인하였다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
• /
• 제9권4호
• /
• pp.145-152
• /
• 2020

기계독해는(Machine reading comprehension) 사용자 질의와 관련된 문서를 기계가 이해한 후 정답을 추론하는 인공지능 자연어처리 태스크를 말하며, 이러한 기계독해는 챗봇과 같은 자동상담 서비스에 활용될 수 있다. 최근 자연어처리 분야에서 가장 높은 성능을 보이고 있는 BERT 언어모델은 대용량의 데이터를 pre-training 한 후에 각 자연어처리 태스크에 대해 fine-tuning하여 학습된 모델로 추론함으로써 문제를 해결하는 방식이다. 본 논문에서는 BERT기반 특허상담 기계독해 태스크를 위해 특허상담 데이터 셋을 구축하고 그 구축 방법을 소개하며, patent 코퍼스를 pre-training한 Patent-BERT 모델과 특허상담 모델학습에 적합한 언어처리 알고리즘을 추가함으로써 특허상담 기계독해 태스크의 성능을 향상시킬 수 있는 방안을 제안한다. 본 논문에서 제안한 방법을 사용하여 특허상담 질의에 대한 정답 결정에서 성능이 향상됨을 보였다.