• 한국대기환경학회지
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• 제2권1호
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• pp.55-72
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• 1986

This study was made to determine the factors involving personal exposure levels of nitrogen dioxide for housewives living in urban area in two seasons, winter and summer. Nitrogen dioxide was measured with a small passive sampler containing triethanolamine. The samplers were set for 24 hours at three points. They were places: on the collar of the housewife to investigate the personal exposure level, near the TV in the living room (indoor level), and near the porch of their house (outdoor level). The subjects recorded the times of cooking using a gas range, using a kitchen ventilator, passive smoking, kerosene heater, total number of minutes at an open window, going out of home, etc.$\ldots. There was an apparent increase in personal exposure level in the case of the unvented heater and also an increase by cooking on a gas range. There was no marked increase in the other situations. There was an increase in the indoor level by cooking on a gas range, only in western style cooking in the winter season. Through these observations, we concluded that personal exposure level of nitrogen dioxide was strongly related to indoor nitrogen dioxide level, and factors involving indoor nitrogen dioxide level seemed different between winter and summer. The most significant difference in nitrogen dioxide level was indoor pollution in the winter and the outdoor environment in the summer. The maximum personal exposure level appeared in the western and tenement house in the winter and the traditional korean house in the summer.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2005년도 춘계학술발표대회 논문집
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• pp.261-264
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• 2005

Since the first discovery of carbon nanotube (CNT) in 1991, a window to new technological areas has been opened. One of the emerging applications of CNTs is the reinforcement of composite materials to overcome the performance limits of conventional materials. However, because of the difficulties in distributing CNTs homogeneously in metal or ceramic matrix by means of traditional composite processes, it has been doubted whether CNTs can really reinforce metals or ceramics. In this study, CNT reinforced Cu matrix nanocomposite is fabricated by a novel fabrication process named molecular level mixing process. This process produces CNT/Cu composite powders whereby the CNTs are homogeneously implanted within Cu powders. The CNT/Cu nanocomposite, consolidated by spark plasma sintering of CNT/Cu composite powders, shows to be 3 times higher strength and 2 times higher Young’s modulus than Cu matrix. This extra-ordinary strengthening effect of carbon nanotubes in metal is higher than that of any other reinforcement ever used for metal matrix composites.

• 대한산업공학회지
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• 제32권3호
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• pp.236-241
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• 2006

Monitor height is one of the key factors in the VDT workstation design. Most of the previous studies have focused on traditional VDT workplace where the operators performed data entry or word processing tasks using single monitor. This study aimed to suggest proper monitor height when the main task was monitoring information from different number of information sources. Twelve male students participated in three experiments: single information source (one monitor), two information sources (one monitor and one CCTV), and three information sources (one monitor, one CCTV and a window). Subjects performed monitoring tasks for 10 minutes with 3 different monitor center heights : 89.0 cm (Low), 111.3 cm (Middle), and 124.8 cm (High). Surface EMG signals of five neck muscles, subjective discomfort ratings, preference, and working postures were recorded. Results indicated that the middle height was proper for one monitor condition, but the low monitor height was recommended for more than two information sources.

• 건축역사연구
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• 제19권4호
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• pp.7-19
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• 2010

'Lu' is one of the Korean traditional building structure. The architectural characteristics of the 'Lu' can be classified two types with its use. One is single building type and the other is a part of building type within building complex. This study is about the two-storied 'Lu' that was built on part of building complex. 'Lu' built in building complex such like Sa-chal, Hyang-gyo, Seo-won, Jae-sil, has the similar characters. 1. It is built by taking slope site. 2. Ii is one of four buildings that forms court yard. 3. It uses simple building structure on the purpose of openness 4. It can control view with using window. The column type of 'Lu' can be classified with 3 style. These are $5{\times}2$ Kan style, $3{\times}2$ Kan style and $5{\times}3$ Kan style. It would be assumed with the result of study that $5{\times}2$ Kan style has its origin in Hoe-Rang structure, $3{\times}2$ Kan style is originated from Joong-Moon(middle gate) structure, and $5{\times}3$ Kan is originated from Kang-Dang structure.

• 한국주거학회논문집
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• 제25권3호
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• pp.165-179
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• 2014

The purpose of this study was to draw application elements of housing interior design according to user-oriented sensibility types. The sensibility evaluation experiments were conducted to target the general user 118 people using the sensibility evaluation tool for housing interior space. The results of the analysis were as: To produce the 'cozy' space, the colors and materials giving soft and natural feeling should be used. For the 'practical' space, type of ceiling and window that give the visually open feeling, the user-oriented furniture arrangement that allows using the space efficiently. For the 'cheerful' space, the simple and natural effects should be produced by using closed space that stable. For the 'traditional' space, the natural fishing material having rough texture should be used. For the 'unique' space, the space contained the dynamic feeling by the diagonal or vertical line and the graphic expression in the wall. For the 'congenial' emotional space, basic is the symmetric, stable and simple space. On the other hand, for the material, small size, natural texture or typical and soft materials should be used. For the 'sensuous' space, the dynamic and vertical sense of space should be expressed by the type of ceiling. The most important elements for the space of 'gorgeous' sensibility, is the color.

• Bulletin of the Korean Chemical Society
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• 제34권10호
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• pp.2937-2941
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• 2013

Fluorescence imaging is considered as one of the most powerful techniques for monitoring biomolecule activities in living systems. Near-infrared (NIR) light is advantageous for minimum photodamage, deep tissue penetration, and minimum background autofluorescence interference. Herein, we have developed a new NIR fluorescent dye, namely, RB-1, based on the Rhodamine B scaffold. RB-1 exhibits excellent photophysical properties including large absorption extinction coefficients, high fluorescence quantum yields, and high photostability. In particular, RB-1 displays both absorption and emission in the NIR region of the "biological window" (650-900 nm) for imaging in biological samples. RB-1 shows absorption maximum at 614 nm (500-725 nm) and emission maximum at 712 nm (650-825 nm) in ethanol, which is superior to those of traditional rhodamine B in the selected spectral region. Furthermore, applications of RB-1 for fluorescence imaging in living cells and small animals were investigated using confocal fluorescence microscopy and in vivo imaging system with a high signal-to-noise ratio (SNR = 10.1).

• Korean Circulation Journal
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• 제52권4호
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• pp.251-264
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• 2022

Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of all heart failure (HF) cases. The prevalence of HFpEF is increasing due to an aging population with hypertension, diabetes mellitus, and obesity. HFpEF remains a challenging clinical entity due to a lack of effective treatment options. Traditional HF medications have not been shown to reduce mortality of patients with HFpEF, and an implantable cardioverter-defibrillator is not indicated due to normal ejection fraction. Sudden death is the most common mode of death in patients with HFpEF; however, the underlying mechanisms of sudden death are not fully elucidated. Although ventricular arrhythmias are responsible for the majority of sudden deaths in general, their contribution to sudden deaths in HFpEF patients is likely less significant. The mechanisms of ventricular arrhythmias in HFpEF are 1) reduced conduction velocity due to ventricular hypertrophy, 2) delayed repolarization due to potassium current down-regulation, 3) calcium leakage due to altered excitation-contraction coupling, and 4) increased ventricular fibrosis caused by systemic inflammation. Hypertension and subsequent ventricular hypertrophy reduce the conduction velocity in HFpEF hearts via heterogeneous distribution of connexin 43. Delayed repolarization caused by potassium current down-regulation in HFpEF hearts provides a window for early afterdepolarization to trigger ventricular arrhythmias. Altered excitation-contraction coupling in HFpEF can cause calcium to leak and trigger delayed afterdepolarization. Increased systemic inflammation and subsequent ventricular fibrosis provide substrates for re-entry. Further research is warranted to investigate the detailed mechanisms of ventricular arrhythmias in HFpEF.

• Biomolecules & Therapeutics
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• 제18권2호
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• pp.152-158
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• 2010

Melanin concentrating hormone is a neuropeptide highly expressed in the brain that regulates several physiological functions mediated by receptors in the G-protein coupled receptor family, especially plays an important role in the complex regulation of energy balance and body weight mediated by the melanin concentrating hormone receptor subtype 1 (MCH1). Compelling pharmacological evidence implicating MCH1 signaling in the regulation of food intake and energy expenditure has generated a great deal of interest by pharmaceutical companies as MCH1 antagonists may have potential therapeutic benefit in the treatment of obesity and metabolic syndrome. Although fluorescence-based calcium mobilization assay platform has been one of the most widely accepted tools for receptor research and drug discovery, fluorescence interference and shallow assay window limit their application in high throughput screening and have led to a growing interest in alternative, luminescence-based technologies. Herein, a luminescence-based functional assay system for the MCH1 receptor was developed and validated with the mitochondrial targeted aequorin. Aequorin based functional assay system for MCH1 presented excellent Z' factor (0.8983) and high signal-to-noise ratio (141.9). The nonpeptide MCH1 receptor antagonist, SNAP 7941 and GSK 803430, exhibited $IC_{50}$ values of 0.62 ${\pm}$ 0.11 and 12.29 ${\pm}$ 2.31 nM with excellent correlation coefficient. These results suggest that the aequorin based assay system for MCH1 is a strong alternative to the traditional GPCR related tools such as radioligand binding experiments and fluorescence functional determinations for the compound screening and receptor research.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권7호
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• pp.3446-3464
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• 2017

Backoff mechanism serves as one of the key technologies in the MAC-layer of wireless mobile networks. The traditional Binary Exponential Backoff (BEB) mechanism in IEEE 802.11 Distributed Coordination Function (DCF) and other existing backoff mechanisms poses several performance issues. For instance, the Contention Window (CW) oscillations occur frequently; a low delay QoS guarantee cannot be provided for real-time transmission, and services with different priorities are not differentiated. For these problems, we present a novel Multi-Priority service differentiated and Adaptive Backoff (MPAB) algorithm over IEEE 802.11 DCF for wireless mobile networks in this paper. In this algorithm, the backoff stage is chosen adaptively according to the channel status and traffic priority, and the forwarding and receding transition probability between the adjacent backoff stages for different priority traffic can be controlled and adjusted for demands at any time. We further employ the 2-dimensional Markov chain model to analyze the algorithm, and derive the analytical expressions of the saturation throughput and average medium access delay. Both the accuracy of the expressions and the algorithm performance are verified through simulations. The results show that the performance of the MPAB algorithm can offer a higher throughput and lower delay than the BEB algorithm.

• Biomolecules & Therapeutics
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• 제19권4호
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• pp.371-389
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• 2011

A new strategy for cancer therapy has emerged during the past decade based on molecular targets that are less likely to be essential in all cells in the body, therefore confer a wider therapeutic window than traditional cytotoxic drugs which mechanism of action is to inhibit essential cellular functions. Exceptional heterogeneity and adaptability of cancer impose significant challenges in oncology drug discovery, and the concept of complex tumor biology has led the framework of developing many anticancer therapeutics. Protein kinases are the most pursued targets in oncology drug discovery. To date, 12 small molecule kinase inhibitors have been approved by US Food and Drug Administration, and many more are in clinical development. With demonstrated clinical efficacy of bortezomib, ubiquitin proteasome and ubiquitin-like protein conjugation systems are also emerging as new therapeutic targets in cancer therapy. In this review, strategies of targeted cancer therapies with inhibitors of kinases and proteasome systems are discussed. Combinational cancer therapy to overcome drug resistance and to achieve greater treatment benefit through the additive or synergistic effects of each individual agent is also discussed. Finally, the opportunities in the future cancer therapy with molecularly targeted anticancer therapeutics are addressed.