• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 1995년도 추계학술대회 논문집
• /
• pp.199-203
• /
• 1995

The technology of Semi-Solid Forging (SSF) has been actively developed to fabricate near-net- shape products using light and hardly formable materials, the SSF process is composed of slug heating, forming, compression holding and ejecting step. After forming step in SSF, the slug is compressed during a certain holding time in order to be completely filled in the die cavity and be accelerated in solidification rate. The compression holding time that can affect mechanical properties and shape of products is important to make decision, where it is necessary to find overall hert transfer coefficeient properly which has large effect on heat transfer between slug and die. This paper presents the procedure to predict compression holding time of octaining the final shaped part with information of temperature and solid fraction for a cylindrical slug at compression hoiding step in closed-die compression process using heat transfer analysis considering latent heat by means of finite element method. The influence of the predicted compression hoiding time on mechanical properties of products is finally investigated by experiment.

• 한국소성가공학회:학술대회논문집
• /
• 한국소성가공학회 1997년도 고액공존금속의 성형기술 심포지엄
• /
• pp.174-182
• /
• 1997

The technology of Semi-Solid Forging (SSF) has been actively developed to fabricate near-net-shape products using light and hardly formable materials. Generally, the SSF process is composed of slug heating, forming, compression -holding and ejecting step. After forming step in SSF, the slug is compressed during a certain holding time in order to be completely filled in the die cavity and be accelerated in solidification rate. The compression holding time that can affect microstructural characteristics and shape of products is important to make decision, where it is necessary to find overall heat transfer coefficient properly which has large effect on heat transfer between slug and die. This paper presents the procedure to predict compression holding time of obtaining the final shaped part with information of temperature and solid fraction for a cylindrical slug at compression holding step in closed-die compression process using heat transfer analysis considering latent heat by means of finite element method. The influence of the predicted compression holding time on microstructural characteristics of products is finally investigated by experiment.

• 한국응용곤충학회지
• /
• 제46권2호
• /
• pp.325-330
• /
• 2007

다양한 엽채류에 발생하며 특히 상추에 피해가 큰 민달팽이는 여러 가지 식품자재 중 맥주와 오이즙액에 가장 효과적으로 유인되었다. 하지만, 이들 재료는 민달팽이를 유인할 뿐 살충효과는 전혀 없었다. 민달팽이 유인재료에 살충효과를 나타내는 물질들을 첨가하였을 때 맥주와 담배가루 혼합액의 민달팽이 유인 포살효과가 가장 높았다. 맥주 50ml에 담배 1개비 가루를 혼합하여 작은 플라스틱 용기에 담고 지표면에 매몰한 결과 하룻밤 사이에 평균 25 마리의 민달팽이가 유인 포살되는 것으로 나타났다. 하지만, 민달팽이 유인효과가 높았던 오이즙액에 담배가루를 혼합한 처리구에서는 평균 4.3마리만 유살되었다. 맥주와 담배 혼합액을 민달팽이가 심하게 발생된 상추 재배하우스에 3일간 연속으로 처리한 결과 68.4%의 방제효과를 나타내었으며, 상추 육묘상에서는 58.3%의 방제효과를 보였다. 본 연구에서 개발된 트랩은 매일 작업을 해야 하는 번거로움이 있으나 민달팽이의 피해가 큰 친환경 유기농 채소 생산농가의 육묘장이나 본포장 등 제한된 면적에서는 활용가치가 높을 것으로 기대된다.

• 대한기계학회논문집B
• /
• 제26권11호
• /
• pp.1559-1569
• /
• 2002

In order to investigate the characteristics of electromagnetic flowmeter in two -phase flow, an AC electromagnetic flowmeter was designed and manufactured. In various flow conditions, the signals and noises from the flowmeter were obtained and analyzed by comparison with the observed flow patterns with a high speed CCD camera. The experiment with the void simulators in which rod shaped non-conducting material was used was carried out to investigate the effect of the bubble position and the void fraction on the flowmeter. Based on the results from the void simulator, two -phase flow experiments encompassed from bubbly to slug flow regime were conducted. The simple relation $\Delta$ $U_{TP}$ = $\Delta$ $U_{SP}$ (l-$\alpha$) was verified with measurements of the potential difference and the void fraction. Due to the lack of homogeneity in a rent two -phase flow, the discrepancy between the relation and the present measurement was slightly increased with void fraction and also liquid volumetric flux jf. Whereas there is no difference in the shape of the raw signal between single-phase flow and bubbly flow, the signal amplitude for bubbly flow is higher than that for single -phase flow at the same water flow rate, since the passage area of the water flow is reduced. In the case of slug flow, the phase and the amplitude of the flowmeter output show dramatically the flow characteristics around each slug bubble and the position of a slug bubble itself. Therefore, the electromagnetic flowmeter shows a good possibility of being useful for identifying the flow regimes.ul for identifying the flow regimes.

• 대한기계학회논문집B
• /
• 제39권7호
• /
• pp.557-566
• /
• 2015

본 논문에서는 $600{\times}600{\mu}m$ 사각 마이크로 채널에서의 기-액체 테일러(슬러그) 흐름의 특성을 실험을 통해 살펴보았다. 실험 유체로는 질소와 물을 사용하였으며, 액체 및 기체 겉보기 속도는 각각 0.01 ~ 3 m/s, 0.1 ~ 3 m/s 의 범위에서 테일러 흐름이 나타나는 구간에서만 데이터를 얻었다. 기포 길이, 액체 슬러그 길이, 기포 속도 그리고 기포 생성 주파수를 고속 카메라를 사용하여 이미지 분석을 통해 측정하였다. 제시된 측정값(기포 길이, 액체 슬러그 길이, 기포 속도)과 이전 문헌에서 제안된 경험적 모델의 비교결과 대부분 오차가 50% 이상으로 나타났다. 따라서 기포와 액체 슬러그 길이 그리고 기포 속도에 대한 개선된 모델을 제시하였고, ${\pm}20%$ 이내의 비교적 우수한 결과를 볼 수 있었다. 또한 기포 생성 주파수는 기포 길이, 액체슬러그 길이 그리고 기포 속도의 관계를 이용하여 ${\pm}20%$ 이내에서 예측가능함을 알 수 있었다.

• 조명전기설비학회논문지
• /
• 제28권7호
• /
• pp.1-12
• /
• 2014

This paper is proposed to design the new heat-sink apparatus for improving the heat transfer characteristics in the power LED chip, and results of the operation characteristics were discussed. The core design is that the soldering through-hole on the FR-4 PCB board is formed to the effective heat transfer. That is directly filled with Ag-nano materials, which shows the high thermal conductivity. The heat transfer medium consisting of Ag-nano materials is classified into two structures. Mediums are called as the heat slug and the multi-pin in this work. The heat of the high temperature generated from the LED chip was directly transferred to the heat slug of the one large size. And the accumulated heat from the heat slug was quickly dissipated by the medium of the multi-pin, which is the same body with the heat slug. This multi-pin was designed for the multi-dissipation of heat by increasing the surface areas with a little pins. Subsequently, the speed of the heat transfer with this new heat-sink apparatus is three times faster than the conventional heat-sink. Therefore, the efficiency of the illuminating light will be improved by adapting this new heat-sink apparatus in the large area's LED.

• 소성∙가공
• /
• 제7권2호
• /
• pp.139-149
• /
• 1998

The technology of Semi-Solid Forging(SSF) has been actively developed to fabricate near net shape products using light and hardly formable materials. Generally the SSF process is composed of slug is compressed during a certain holding time in order to completely fill the die cavity and accelerate the solidification rate. The decision of compression time is important since it can affect microstructural characteristics, mechanical properties and shape of products.. In order to determine it proper overall heat transfer coefficient between the slug and dies should be investigated. This paper presents the procedure to find the overall heat transfer coefficient between the slug and dies by nonlinear optimization of temperature and solid fraction for a cylindrical slug at compression step in closed-die semi-solid forging. In finite ele-ment heat transfer analysis release of latent heat during solidification was considered. The influence of the predicted compression time on miscrostructural characteristics mechanimcal properties and shape of products is finally investigated by experiment.

• Journal of Applied Biological Chemistry
• /
• 제59권1호
• /
• pp.25-29
• /
• 2016

B형 간염 바이러스는 간경변증과 간세포암의 원인이 되는 간섬유화를 유발한다. 하지만 현재까지 그와 관련한 자세한 메커니즘은 밝혀지지 않았기에 본 연구에서 이를 알아보고자 하였다. 실험 결과, B형 간염 바이러스에서 발현되는 HBx 단백질에 의해 vimentin, fibronectin, slug, snail, NOX4가 증가되는 것을 확인하였다. NOX4에 의한 활성산소가 snail, slug 발현을 유도하고 섬유화 과정을 촉진할 수 있기 때문에 NOX4의 발현을 유도하는 HBx가 간섬유화를 조절, 유도하는 것을 확인하였다.

• Molecules and Cells
• /
• 제39권12호
• /
• pp.909-914
• /
• 2016

Epithelial-mesenchymal transition (EMT) is a critical step in the acquisition of the migratory and invasive capabilities associated with metastatic competence. Cysteine-rich protein 61 (CCN1/Cyr61) has been implicated as an important mediator in the proliferation and metastasis of breast cancer. Hence, Cyr61 and associated pathways are attractive targets for therapeutic interventions directed against the EMT. In the present study, we report that baicalein significantly inhibits the expression of Cyr61 and migration and invasion of MDA-MB231 human breast cancer cells. Exposure to baicalein led to increased E-cadherin expression, possibly due to the ubiquitination of Snail and Slug, which was mediated by the Cyr61/Akt/glycogen synthase kinase $3{\beta}$ ($GSK3{\beta}$) pathway. Further analysis revealed that baicalein inhibited the expression of lysyl oxidase like-2 (LOXL-2), which is a functional collaborator of Snail and Slug, and subsequently attenuated the direct interaction between LOXL-2 and Snail or Slug, thereby enhancing $GSK3{\beta}$-dependent Snail and Slug degradation. Our findings provide new insights into the antimetastatic mechanism of baicalein and may contribute to its beneficial use in breast cancer therapies.

• BMB Reports
• /
• 제57권6호
• /
• pp.305-310
• /
• 2024

T-plastin (PLST), a member of the actin-bundling protein family, plays crucial roles in cytoskeletal structure, regulation, and motility. Studies have shown that the plastin family is associated with the malignant characteristics of cancer, such as circulating tumor cells and metastasis, by inducing epithelial-mesenchymal transition (EMT) in various cancer cells. However, the role of PLST in the EMT of human lung cancer cells remains unclear. In this study, we observed that PLST overexpression enhanced cell migratory and invasive abilities, whereas its downregulation resulted in their suppression. Moreover, PLST expression levels were associated with the expression patterns of EMT markers, including E-cadherin, vimentin, and Slug. Furthermore, the phosphorylation levels of focal adhesion kinase (FAK) and AKT serine/threonine kinase (AKT) were dependent on PLST expression levels. These findings indicate that PLST induces the migration and invasion of human lung cancer cells by promoting Slug-mediated EMT via the FAK/AKT signaling pathway.