• 대한수의학회지
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• 제56권4호
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• pp.241-247
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• 2016

This study was conducted to evaluate the hangover relieving effect of Sanghwang mushroom mycelium extract (SME). The extract showed 1,1-diphenyl-2-picrylhydrazyl radical scavenging effect in a concentration-dependent manner and high antioxidant capacity ($56.67{\pm}1.77%$) when administered at $120{\mu}g/mL$. In addition, SME significantly increased (p < 0.005) the aldehyde dehydronase (ALDH) activity ($126.03{\pm}9.11%$) when applied at 8 or $16{\mu}L/mL$. A locomotor activity test showed that the alcohol-water treated group showed significantly decreased motor activity at 90 min post-administration. However, the alcohol-SME treated group showed a 20-fold higher motor activity than that observed in the alcohol-water treated group at 90 min post-administration. Blood was harvested from each mouse at 90 min post-administration, and both alcohol and aldehyde concentrations were measured. The alcohol-SME treated group showed significantly lower (p < 0.5) alcohol ($120.13{\pm}12.83{\mu}g/mL$) and aldehyde ($7.26{\pm}1.22{\mu}g/mL$) concentrations than the values observed in the alcohol-water treated group. These results suggest that the hangover relieving effect of SME results from increased ALDH activity, which reduces the aldehyde concentration in the blood.

• 한국수산과학회지
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• 제54권1호
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• pp.1-8
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• 2021

In order to develop value-added low-salt fermented seafood with a long shelf-life, we prepared seasoned low-salt fermented Mideoduck (Styela clava) supplemented with fermentation alcohol (SME). The SME was produced by washing and dewatering shelled Mideoduck, followed by cutting and salting for 24 h at 0℃. The salted Mideoduck was seasoned and fermented with ingredients, including garlic, ginger, monosodium glutamate, red pepper, sesame, sorbitol and sugar, for 7-8 days at 0℃. After adding 3-5% fermentation alcohol, the Mideoduck was packed in a polyester container. The salinity, volatile basic nitrogen, and amino nitrogen content of the SME was 4.5%, 20.9 mg/100 g and 92.0 mg/100 g, respectively. In comparison with the control, the addition of 3-5% fermentation alcohol showed inhibitory effects of decreased freshness, texture degradation, and growth of residual bacteria. Additionally, the SME had good storage stability and organoleptic qualities when stored at 4±1℃ for 40 days. Therefore, it is suitable for commercialization as a seasoned low-salt fermented product with a long shelf-life. The total amino acid content of the SME was 11,774.5 mg/100 g, majorly comprising glutamic acid, aspartic acid, lysine, arginine, and leucine, and the free amino acid content was 506.4 mg/100 g, majorly comprising hydroxyproline, taurine, and glutamic acid.

• 중소기업연구
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• 제42권4호
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• pp.235-250
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• 2020

본 연구는 대학생의 중소기업 취업에 대한 인식을 확인하고 개선방안을 마련하고자 충북지역 대학생을 대상으로 조사를 진행하였다. 특히 기존 설문 중심의 일자리 인식 조사에 그치지 않고 서술형 문항에 대한 비정형 데이터를 수집하여 텍스트마이닝을 통해 중소기업 일자리에 대한 인식을 파악하였다. 분석 결과 중소기업 일자리에 대해서 다양한 업무경험, 낮은 취업 경쟁률 등에 대해서는 긍정적 평가가 있는 반면 급여, 업무, 복지 등에서 대체로 부정적 인식이 여전히 있다는 것을 확인할 수 있었다. 이와 같은 상황에서 대학생의 중소기업 취업에 대한 인식을 개선하기 위해서는 '정보'가 필요하다는 것을 중심어 도출을 통해 확인할 수 있었는데, 이는 대학생들이 중소기업 취업 관련 정보를 충분히 제공 받지 못하는 현실이 반영된 것으로 판단된다. 따라서 향후 예산 지원 중심의 중소기업일자리 정책에서 정보 미스매치 해소하는 해결 방안을 우선적으로 마련할 필요가 있다.

• 한국벤처창업학회:학술대회논문집
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• 한국벤처창업학회 2021년도 추계학술대회
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• pp.113-117
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• 2021

Due to the recent COVID-19 pandemic, SMEs are forced to converge themselves into online business to cope with the rapidly changing business environment. However, due to various difficulties of becoming an online business, most SMEs choose to use services provided by the online sales platform. These platforms offer valuable support such as DSS in return for the high amount of commission fee. We analyze a novel data set from Naver Corporation's 'Smart Store' platform with the quasi-experimental method (propensity score matching technique combined with the difference in differences analysis) to analyze DSS usage and SME's performance empirically. Our results suggest that DSS usage leads to an increase in SME's sales performance in means of sales frequency and sales amount. Additionally, we have found weak support that DSS usage enables SMEs to attract customers better than those not using DSS.

• Nutrition Research and Practice
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• 제8권4호
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• pp.377-385
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• 2014

BACKGROUND/OBJECTIVES: Abundant consumption of seaweeds in the diet is epidemiologically linked to the reduction in risk of developing cancer. In larger cases, however, identification of particular seaweeds that are accountable for these effects is still lacking, hindering the recognition of competent dietary-based chemo preventive approaches. The aim of this research was to establish the antiproliferative potency and angiosuppressive mode of action of Stoechospermum marginatum seaweed methanolic extract using various experimental models. MATERIALS/METHODS: Among the 15 seaweeds screened for antiproliferative activity against Ehrlich ascites tumor (EAT) cell line, Stoechospermum marginatum extract (SME) was found to be the most promising. Therefore, it was further investigated for its anti-proliferative activity in-vitro against choriocarcinoma (BeWo) and non-transformed Human embryonic kidney (HEK 293) cells, and for its anti-migratory/tube formation activity against HUVEC cells in-vitro. Subsequently, the angiosuppressive activity of S. marginatum was established by inhibition of angiogenesis in in-vivo (peritoneal angiogenesis and chorioallantoic membrane assay) and ex-vivo (rat cornea assay) models. RESULTS: Most brown seaweed extracts inhibited the proliferation of EAT cells, while green and red seaweed extracts were much less effective. According to the results, SME selectively inhibited proliferation of BeWo cells in-vitro in a dose-dependent manner, but had a lesser effect on HEK 293 cells. SME also suppressed the migration and tube formation of HUVEC cells in-vitro. In addition, SME was able to suppress VEGF-induced angiogenesis in the chorio allantoic membrane, rat cornea, and tumor induced angiogenesis in the peritoneum of EAT bearing mice. A decrease in the microvessel density count and CD31 antigen staining of treated mice peritoneum provided further evidence of its angiosuppressive activity. CONCLUSIONS: Altogether, the data underline that VEGF mediated angiogenesis is the target for the angiosuppressive action of SME and could potentially be useful in cancer prevention or treatment involving stimulated angiogenesis.

• Archives of Plastic Surgery
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• 제50권6호
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• pp.573-577
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• 2023

Pachyonychia congenita is a rare genetic disorder characterized by hypertrophic nail plates, hyperkeratotic nail beds, and thickened hyponychium of the fingers and toes, impairing manual dexterity and resulting in poor aesthetics. The current body of literature describes various treatment modalities, but no singular approach has been defined as the gold standard. In this case, the authors employed different surgical techniques for treating pachyonychia congenita to evaluate the most effective approach. A 3-year-old boy presented with hypertrophic nail growth involving all digits of both hands and feet. Three surgical procedures were performed on the patient's fingers and toes using germinal matrix excision (GME) alone, GME plus partial sterile matrix excision (pSME), or GME plus complete sterile matrix excision (cSME). The digits treated with GME + cSME exhibited no recurrence of nail growth. Those treated with GME alone exhibited recurrence of hypertrophic nail growth, although their growth slowed. Excision of GME + cSME prevented recurrence of hypertrophic nails, while GME alone or with pSME led to slower-growing hypertrophic nails. Complete excision of the germinal and sterile matrices with skin graft closure may be a definitive treatment for pachyonychia congenita, but further studies are needed to validate these findings.

• 한국해양공학회지
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• 제6권1호
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• pp.87-95
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• 1992

Recently, the robot actuator worked by the driving recovery-force of the thermo elastic martensitic transformation of shape memory alloys(SMA) has been studied. In general, such a SMA actuator necessitates a number of cyclic repeated motion, so that the investigation of gradual decrease of recovery force with repeated motion cycle as well as the prevention of such a degradation of shape memory effect(SME) are very important for the actual use of a robot actuator. However, such research and discussions about the degradation of SME are very few up to the present. Therefore, in this study, the characteristics of the cyclic deformation and degradation of SME of Ti-Ni alloy would be investigated and discussed in detail by current heat type fatigue tester, which is a newly designed fatigue tester by author. In addition, we will establish a new design concept for robot actuator from these result.

• 수산해양교육연구
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• 제29권1호
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• pp.118-127
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• 2017

The aim of the present study is to research how the main factors for the export of SMEs affect SME's Export possibility in structural method. 62 SMEs in Busan Region were participated in this study. For the empirical analysis, a multiple regression analysis and a path analysis were used with Spss18 and Amos 5v to figure out the relationship between the main factors and SME's Export possibility(SEP). The main factors as variances are "Manpower Needs(MN)", "Technology Innovation Needs(TIN)", "Education Needs for Export(ENE)" and "Intention of Decision-Maker(IDM)". The result indicated that ENE and TIN with IDM could structurally affect SEP through path analysis and implies that the main factors have to be considered with the intention of decision-maker as CEO for the successful export of SMEs.

• 디지털융복합연구
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• 제7권4호
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• pp.117-125
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• 2009

Information and computer technology(ICT) readiness in SME(small and medium enterprises) in globalized digital world get much attention due to its capability to reach broader customers and to personalized the products to the clients. The purpose of this study is to compare the readiness of ICT capabilities in SME between Korean firms operated in Qingdao China and Incheon, South Korea. The results of the study are presented and the implication of this comparative research is discussed. It is hoped that the finding of the research would be beneficial to academian and practitioners in China and South Korea.

• 한국정밀공학회지
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• 제17권1호
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• pp.11-20
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• 2000

본 글은 1999년 5월 CASA/SME Blue Book에 Jim Jordan 그리고 Fred Michel이 “Next Generation Manufacturing”라는 제목으로 게재한 자료를 편자의 의도에 따라 재편집한 것입니다. CASA(Computer and Automated Systems Association)는 SME(Society of Manufacturing Engineers)에서 활동하고 있는 하나의 분과로서 CIM Enterprise Wheel을 만들어 내 유명한 곳이기도 합니다. 저자는 본 글에서 앞으로 10여년 간 펼쳐질 차세대 제조 시스템에서는 지식경영이 가장 중요한 요소라고 정의하고 있습니다. 그리고 차세대 제조 시스템의 운영전략으로는 기업통합, 인간자원의 지적이용, 지식의 개발 및 유지, NGM 프로세스 장비 및 기술의 채용을 들고 있습니다.