• Korean Journal of Plant Resources
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• v.28 no.3
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• pp.297-304
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• 2015

The flower buds of Sophora japonica L (SF), as a well-known traditional Chinese medicinal herb, have been used to treat bleeding-related disorders such as hematochezia, hemorrhoidal bleeding, dysfunctional uterine bleeding, and diarrhea. However, no specific anti-cancer effect and its molecular mechanism of SF have been described. Thus, we performed in vitro study to investigate if treatment of SF affects activating transcription factor 3 (ATF3) expression and ATF3-mediated apoptosis in human colorectal cancer cells. The effects of SF on cell viability and apoptosis were measured by MTT assay and Western blot analysis against cleaved poly (ADP-ribose) polymerase (PARP). ATF3 activation induced by SF was evaluated using Western blot analysis, RT-PCR and ATF3 promoter assay. SF treatment caused decrease of cell viability and increase of apoptosis in a dose-dependent manner in HCT116 and SW480 cells. Exposure of SF activated the levels of ATF3 protein and mRNA via transcriptional regulation in HCT116 and SW480 cells. Inhibition of extracellular signal-regulated kinases (ERK) 1/2 by PD98059 and p38 by SB203580 attenuated SF-induced ATF3 expression and transcriptional activation. Ectopic ATF3 overexpression accelerated SF-induced cleavage of PARP. These findings suggest that SF-mediated apoptosis may be the result of ATF3 expression through ERK1/2 and p38-mediated transcriptional activation.

• Korean Journal of Materials Research
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• v.18 no.2
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• pp.73-76
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• 2008

[ $SF_6$ ] gas has been widely used as an insulating, cleaning and covering gas due to its outstanding insulating feature and because of its inert properties. However, the global warming potential of $SF_6$ gas is extremely high relative to typical global warming gases such as $CO_2$, CFCs, and $CH_4$. For these reasons, it is necessary to separate and collect waste $SF_6$ gas. In this study, the effects of a surfactant (Tween) on the formation rate of $SF_6$ gas hydrates were investigated. The $SF_6$ gas hydrate formation rate increased with the addition of Tween and showed a nearly 6.5 times faster hydrate formation rate with an addition of 0.2 wt.% Tween compared to an addition of pure water. This is believed to be due to the increased solubility of $SF_6$ gas with the addition of the surfactant. It was also found that $SF_6$ gas hydrate in the surfactant solution showed two-stage hydrate formation rates with a formation rate that increased rapidly in the 2nd stage.

• Korean Journal of Food Science and Technology
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• v.50 no.6
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• pp.688-696
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• 2018

This study aimed to investigate the effects of red ginseng-derived saponin fraction (SF) on lipid accumulation, reactive oxygen species (ROS) production, and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) signaling during adipocyte differentiation. SF effectively inhibited lipid accumulation, with the downregulation of adipogenic factors such as peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$) and CCAAT/enhancer-binding protein alpha ($C/EBP{\alpha}$). A high dose of SF decreased the protein levels of $PPAR{\gamma}$ and $C/EBP{\alpha}$ by over 90% compared to the control. SF-mediated downregulation of adipogenic factors was due to the regulation of early adipogenic factors including $C/EBP{\beta}$ and $Kr{\ddot{u}}ppel$-like Factor 2 (KLF2). In addition, SF ($200{\mu}g/mg$) decreased intracellular ROS generation by 40% during adipocyte differentiation. However, the SF significantly upregulated Nrf2 and its target proteins, hemoxygenase-1 (HO-1) and NADPH dehydrogenase quinone 1 (NQO1). Furthermore, SF ($200{\mu}g/mg$) promoted the nuclear translocation of Nrf2. The SF-mediated reduction of lipid accumulation was associated with the regulation of the Nrf2/Keap1 pathway.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.61 no.4
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• pp.601-605
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• 2012

The non-controlled closing of High-voltage SF6 gas circuit breaker can cause transient current and overvoltage in the field. The controlled closing technology is an effective way to reduce transient current and voltage, prevent equipment failures, and improve power quality. For the development of controlled closing, it is obviously necessary to determine the withstand voltage between arc contacts of High-voltage SF6 gas circuit breaker in making operation. This paper focuses on decrease of pressure and density of SF6 gas that can affect withstand voltage between arc contacts in making operation. The dielectric strength between arc contacts could be improved by minimizing the decrement of pressure and density of SF6 gas obtained by simulation and test and moreover the rate of decrease of dielectric strength (RDDS) of arc contacts could be foreseen.

• Journal of Korean Society for Atmospheric Environment
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• v.33 no.4
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• pp.370-376
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• 2017

This study was performed to investigate whether the decomposition process of $SF_6$ using an electron beam is economically reasonable when applied to the actual field. To do this, electron beam experiment and economic analysis were conducted. The experiment conditions are initial concentration of 1% of $SF_6$, 1 mA of input energy and 15 mA of flow rate with $H_2$ as an additive which were obtained from our previous research. As a result, removal efficiency of $SF_6$ was 90% for 8 hours continuously. In addition, economic analysis shows positive results in terms of using $SF_6$ decomposition process using electron beam. According to the analysis, the revenue is approximately 1.66 billion won in the first year and 3 billion won in the second year.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2003.07b
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• pp.1102-1105
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• 2003

Energy distribution function for electrons in $SF_6$-Ar mixtures gas used by MCS-BEq algorithm has been analysed over the E/N range $30{\sim}300[Td]$ by a two term Boltzmann equation and by a Monte Carlo Simulation using a set of electron cross sections determined by other authors, experimentally the electron swarm parameters for 0.2(%) and 0.5(%) $SF_6$-Ar mixtures were measured by time-of-flight(TOF) method, The results show that the deduced electron drift velocities, Electrons Drift Velocities for a rang of E/N values. As a consequence, it was known that the spatial growth rates and the dielectric behaviors in $SF_6$-Ar mixtures are strongly dependent on the addition rate of $SF_6$ gas but the transport coefficients of electrons are insensitive to the addition rate of $SF_6$ gas. The results obtained from Boltzmann equation method and Monte Carlo simulation have been compared with present and previously obtained data and respective set of electron collision cross sections of the molecules.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.1
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• pp.39.1-39.1
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• 2012

Nuclear rings in barred galaxies are sites of active star formation (SF). We investigate SF and its feedback effects occurring in barred galaxies, for the first time, using high-resolution grid-based hydrodynamic simulations. The gaseous medium is assumed to be infinitesimally thin, isothermal, and unmagnetized. The SF recipes include a density threshold corresponding to the Jeans condition, a SF efficiency of 1%, and momentum feedback via Type II supernova events together with stellar-wind mass loss. To investigate various environments, we vary the gas sound speed as well as the efficiency of momentum injection in the in-plane direction. We find that when the sound speed is small, the surface density of a ring becomes largely independent of the azimuthal angle, resulting in star-forming regions distributed over the whole length of the ring. When the sound speed is large, on the other hand, the ring achieves the largest density at the contact points between the dust lanes and the ring where SF occurs preferentially, leading to a clear age gradient of star clusters in the azimuthal direction. Since rings shrink with time, a radial age gradient of star clusters naturally develop regardless of sound speed, consistent with observations. SF persists over 200 Myr, with an average rate of ${\sim}1.3M_{\odot}/yr$ similar to observed values. Rings gradually become hostile to SF as they lose gas into stars and turbulent motions dominate.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1999.11a
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• pp.29-32
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• 1999

$GaF_3$ films were directly grown on p' and p-type GaAs(100) substrates using a $SF_6$ plasma discharge system. GaAs MIS(Meta1-Insulator-Semiconductor) capacitor was successfully fabricated for about 1 hour at temperature $290^{\circ}C$ using the as-grown $GaF_3$ films. The as-grown films on p'-GaAs exhibited a current density of less than 6.68 $\times$ $1O^{-9}$ A/$cm^2$ at a breakdown field of 500kV/cm and a refractive index of 2.0 ~ 2.3 at a wavelength of 632.8 nm. The dielectric constant was about 5 derived from 1 MHz capacitance-voltage (C-V) measurements. Dielectric dispersion of the fluoridated films on p'-GaAs measured ranged from 100 Hz to 10 MHz was not observed.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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• 2009.05a
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• pp.267-269
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• 2009

In this paper, insulations characteristics by temperature changes($+10{\sim}-60[^{\circ}C]$) of $SF_6$ 9as in the experimental chamber were studied. From this result, The breakdown characteristics classify the gas & liquid coexisted stage of voltage value increases & much deviation and the $V_B$ low stage as the interior of chamber gets filled with mixture of $SF_6$ that are not liquefacted and remaining air which couldn't be ventilated. In addition the ability of insulation of liquid $SF_6$ was higher than that of the highly pressurized $SF_6$ gas. In this research, we want to provide the base data on designing insulation of high-temperature superconductor and the cryogenic equipments by investigating the insulation characteristics of $SF_6$.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.2
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• pp.75.3-75.3
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• 2019

The filament is an interesting structure in the Universe because clusters form at the nodes of filaments and grow through the continuous accretion of individual galaxies and groups from the surrounding filaments. We study the chemical properties of star-forming (SF) galaxies in the five large-scale filamentary structures (Leo II A, Leo II B, Leo Minor, Canes Venatici, and Virgo III) related with the Virgo cluster, with the spectroscopic data taken with the SDSS DR12, and compare them with those of the Virgo cluster and field galaxies. In mass-metallicity relation, most of the SF galaxies in Virgo-related filaments (except Virgo III filament) show lower metallicity on average than the Virgo cluster SF galaxies, but similar to field counterparts. These chemically less evolved feature of SF galaxies in the filaments and field are more pronounced for lower mass galaxies. This is probably because low mass galaxies have low potential wells and are therefore likely to be sensitive to cluster environmental effects. Interestingly, we find that the metallicity enhancement of SF galaxies in the Virgo III filament. In chemical and morphological perspectives, SF galaxies in the Virgo III thought to be transitional objects possibly transformed from SF late-type galaxies and are on the way to red early-type galaxies in the filament environment. This is the first discovery of systematic 'chemical pre-processing' signature for filament galaxies in Local Universe before they fall into the cluster.