• The Journal of Pediatrics of Korean Medicine
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• v.34 no.3
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• pp.76-80
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• 2020

Objectives The purpose of this study is to report the effectiveness of topical application of Korean medicine on treating neonatal seborrheic dermatitis. Methods We treated a 22-days-old patient who was diagnosed with neonatal seborrheic dermatitis by topical application of Korean medicine. Results After 2 weeks of the treating by topical application of Korean medicine, patient's seborrheic dermatitis on the face was disappeared. Conclusions Topical application of Korean medicine can be effective in treating neonatal seborrheic dermatitis.

• 대한핵의학회:학술대회논문집
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• 2003.11a
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• pp.11.1-11.1
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• 2003

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.3
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• pp.1-13
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• 2016

Objectives : We conducted a survey aimed at developing a personal health record application for the treatment of atopic dermatitis in Korean medicine .Methods : We conducted a survey on Korean medicine doctors who attended the Korean Medicine Ophthalmology and Otolaryngology and Dermatology conference 2016. The questionnaire was based on priority of usage of the diagnostic indices and tools, and intention to use the personal health record application for treatment of atopic dermatitis in the clinic.Results : Data were collected from 50 Korean medicine doctors. Ninety-six per cent of respondents replied that they were willing to use the personal health record application for treating atopic dermatitis. Among the diagnostic indices related to atopic dermatitis, Korean medicine doctors regarded the following as important in the order of priority, i.e., condition of skin, lifestyle, risk factors, symptoms other than those of skin, past history, family history and medical history, results of tongue, pulse, and abdomen investigation, and constitution. These results did not vary with the purpose of diagnosis, and the results were consistent with those obtained with the intention to use diagnostic. Over 50% of respondents replied that they use immunoglobulin E, scoring atopic dermatitis, and visual analogue scale among the diagnostic tools.Conclusions : Our survey was conducted on clinicians who are the intended users of the personal health record application for the treatment of atopic dermatitis; hence, the results of this study can be helpful for developing a useful personal health record application for atopic dermatitis in the clinic.

• The Journal of Pediatrics of Korean Medicine
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• v.29 no.2
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• pp.49-58
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• 2015

Objectives Asthma is an allergic disease that frequently occurs in children. This study aims to research acupuncture and acupoint-application treatment of pediatric asthma. Methods We got 53,653 search results with searching word 'child' 'children' 'pediatric' 'juvenile' 'adolescence' 'baby' 'infant' 'asthma' in Pubmed and got 147 results among them with searching word 'acupuncture' 'acupoint application'. We selected 13 articles among them which were seem to be related to this study. We classified these studies according to the type of study, the treatment methods and treatment outcomes. Results There were few studies about acupuncture and acupoint application on pediatric asthma. According to current research, conducting acupuncture and acupoint application treatment on pediatric asthma patient is recommended. Especially, acupoint application and laser acupuncture treatment were important to consider as treatment options on pediatric asthma patients for non-invasive way and less painful to children. Conclusions For the study on acupuncture and acupoint application treatment in pediatric asthma, it is necessary that we conduct research on various merit of acupuncture. More clinical data would be needed to prove the effects of acupuncture and acupoint application treatment in pediatric asthma.

• Journal of Ginseng Research
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• v.48 no.4
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• pp.384-394
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• 2024

Background: Herpes simplex virus type 1 (HSV-1), known to latently infect the host's trigeminal ganglion, can lead to severe herpes encephalitis or asymptomatic infection, potentially contributing to neurodegenerative diseases like Alzheimer's. The virus generates reactive oxygen species (ROS) that significantly impact viral replication and induce chronic inflammation through NF-κB activation. Nuclear factor E2-related factor 2 (Nrf2), an oxidative stress regulator, can prevent and treat HSV-1 infection by activating the passive defense response in the early stages of infection. Methods and results: Our study investigated the antiviral effects of ginsenoside Rg5, an Nrf2 activator, on HSV-1 replication and several host cell signaling pathways. We found that HSV-1 infection inhibited Nrf2 activity in host cells, induced ROS/NF-κB signaling, and triggered inflammatory cytokines. However, treatment with ginsenoside Rg5 inhibited ROS/NF-κB signaling and reduced inflammatory cytokines through NRF2 induction. Interestingly, the Nrf2 inhibitor ML385 suppressed the expression of NAD(P)H quinone oxidoreductase 1(NQO1) and enhanced the expression of KEAP1 in HSV-1 infected cells. This led to the reversal of VP16 expression inhibition, a protein factor associated with HSV-1 infection, thereby promoting HSV-1 replication. Conclusion: These findings suggest for the first time that ginsenoside Rg5 may serve as an antiviral against HSV-1 infection and could be a novel therapeutic agent for HSV-1-induced neuroinflammation.

• Journal of Sasang Constitutional Medicine
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• v.30 no.1
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• pp.66-73
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• 2018

Objectives The purpose of this study was to develop mobile a application that evaluate the Mibyeong(deterioration of the health) in daily life and provide optimal Yangseng(養生) interventions according to the Korean medicine types. Methods The evaluation of Mibyeong utilized questionnaire or objective informations including Facial photographs and hemodynamic information. The Korean medicine type classification was reconstructed based on the concept of Sasang constitution and cold-heat pattern identification. Yangseng interventions were recommended based on Mibyeong symptoms, Korean medicine types, and demographic information. And we have developed tracking and ranking functions for user motivations. We used a Korean medicine database that focused on healthy people as a reference data, and used Yangseng interventions database that reinterpreted classical Yangseng in a modern way. Results and Conclusions We have developed a mobile application that evaluates the user's Mibyeong state and provides optimal Yangseng interventions based on Korean medicine types. This study are expected to improve the quality of health and contribute to the prevention of diseases.

• Herbal Formula Science
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• v.25 no.4
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• pp.527-536
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• 2017

Objectives : The present study, to confirm the osteoblast differentiation effects of Acer tegmentosum Maxim. (AT) extract. Methods : In this experiment, cell viability, Alizarin red S assay, and Alkaline phosphatase (ALP) activity with AT extract (50, $100{\mu}g/m{\ell}$). Also, we studied the expression of differentiation regulator with AT extract in primary calvarial osteoblasts cells (pOB). Results : As a result of AT treatment, we determined that AT extract stimulates ALP activity and alizarin red activities in the pOB cells for mineralization for 18 days. Moreover, these factors increasing osteogenic markers such as Runt-related transcription factor2 ($Run{\times}2$), osteocalcin (OC), osteopontin, osterix, smad1, smad5, activating transcription factor4 (ATF4) and collagen type I alpha 1. Conclusions : These results indicate that AT extract have effect on bone through the promotion of osteoblastic differentiation, suggesting that it could be used for the treatment of bone diseases.

• The Journal of Korean Medicine
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• v.38 no.1
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• pp.21-33
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• 2017

Objectives: The purpose of this study is to present the needs for New Health Technology in Korean medicine field and suggest the strategy to raise the application and selection rate. Methods: In this study, we reviewed the application status of New Health Technology application from April 27, 2007 to June 30, 2016. And we analyzed the assessment methods, procedures, and failure factors through the two Research stage technologies reports in Korean medicine field. Results: In Korean medicine field, the application status of New Health Technology is very small as 2% of the whole applications. Moreover, 62.9% of the applied technology were either an existing technology or an early technology, so did not enter the assessment process. Two technologies categorized as Research stage technology also had failed to adopt New Health Technology because they were lacking evidences or need more research to prove effectiveness. Conclusions: In order to develop New Health Technology in Korean medicine, more efforts should be made to activate research that can prove the safety and effectiveness of medical technology, and to create a quantitative or qualitative basis for the results of the research. Also, it is necessary to increase researchers' awareness of New Health Technology. And the strategy to positively utilize the "Limited Approval" to promote clinical studies.

• Annals of Rehabilitation Medicine
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• v.42 no.6
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• pp.833-837
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• 2018

Objective To investigate and demonstrate persistent increase of peak cough flow after mechanical in-exsufflator application, in patients with neuromuscular diseases and pneumonia. Methods A mechanical in-exsufflator was applied with patients in an upright or semi-upright sitting position (pressure setting, +40 and $-40cmH_2O$; in-exsufflation times, 2-3 and 1-2 seconds, respectively). Patients underwent five cycles, with 20-30 second intervals to prevent hyperventilation. Peak cough flow without and with assistive maneuvers, was evaluated before, and 15 and 45 minutes after mechanical in-exsufflator application. Results Peak cough flow was 92.6 L/min at baseline, and 100.4 and 100.7 L/min at 15 and 45 minutes after mechanical in-exsufflator application, respectively. Assisted peak cough flow at baseline, 15 minutes, and 45 minutes after mechanical in-exsufflator application was 170.7, 179.3, and 184.1 L/min, respectively. While peak cough flow and assisted peak cough flow increased significantly at 15 minutes after mechanical in-exsufflator application compared with baseline (p=0.030 and p=0.016), no statistical difference was observed between 15 and 45 minutes. Conclusion Increased peak cough flow after mechanical in-exsufflator application persists for at least 45 minutes.

• Journal of Korean Medical classics
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• v.26 no.3
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• pp.85-98
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• 2013

Subject : The application of eight extra Meridians theory to birth physiology of Korean Medicine. Objective : This study suggests physiological theories in child birth in Korean Medicine. Method : First, the application of eight extra Meridians and extraordinary organs theories to physiology, pathology, pregnancy, postnatal period of women were examined based on major publications and theories of some historical characters. This work provided clues for application of eight extra Meridians theory to birth physiology. Second, the progressing birth physiology of modern medicine based on the importance of the brain function was examined, with which the application of eight extra Meridians and extraordinary organs theories to the birth process showed close relationship. Conclusion : The following conclusions could be drawn. In traditional publications of Korean Medicine, the contents explaining birth physiology with eight extra Meridians theory were scarce, mainly due to the doctor's perception of birth as part of the natural female physiology along with menstruation and pregnancy. However, the contents explaining menstruation, pregnancy, postnatal physiology and pathology through eight extra Meridians theory could be found in classical texts such as Neijing, Jebyeong-wonhuron, Imjeunginameuian. Therefore, it is reasonable to apply the eight extra Meridians theory to the birth process as well. Modern medicine's understanding that pituitary and hypothalamus hormones are in play on womb in the birth process, such as Oxytocin, is in continuous progress. Moreover, the environmental condition that has been traditionally known ideal to the birth process in both the East and West-dark, warm, quiet and secluded-is being confirmed in modern research. The application of eight extra Meridians theory to birth physiology can help to explain these modern information, and thus make them more acceptable.