• 제목/요약/키워드: Korean Medical school

검색결과 16,505건 처리시간 0.05초

Ginsenosides Rg1 regulate lipid metabolism and temperature adaptation in Caenorhabditis elegans

  • Hao Shi ;Jiamin Zhao ;Yiwen Li ;Junjie Li ;Yunjia Li;Jia Zhang ;Zhantu Qiu ;Chaofeng Wu ;Mengchen Qin ;Chang Liu ;Zhiyun Zeng ;Chao Zhang ;Lei Gao
    • Journal of Ginseng Research
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    • 제47권4호
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    • pp.524-533
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    • 2023

  • Background: Obesity is a risk factor for aging and many diseases, and the disorder of lipid metabolism makes it prominent. This study aims to investigate the effect of ginsenoside Rg1 on aging, lipid metabolism and stress resistance Methods: Rg1 was administered to Caenorhabditis elegans (C. elegans) cultured in NGM or GNGM. The lifespan, locomotory activity, lipid accumulation, cold and heat stress resistance and related mRNA expression of the worms were examined. Gene knockout mutants were used to clarify the effect on lipid metabolism of Rg1. GFP-binding mutants were used to observe the changes in protein expression Results: We reported that Rg1 reduced lipid accumulation and improved stress resistance in C. elegans. Rg1 significantly reduced the expression of fatty acid synthesis-related genes and lipid metabolism-related genes in C. elegans. However, Rg1 did not affect the fat storage in fat-5/fat-6 double mutant or nhr-49 mutant. Combined with network pharmacology, we clarified the possible pathways and targets of Rg1 in lipid metabolism. In addition, Rg1-treated C. elegans showed a higher expression of anti-oxidative genes and heat shock proteins, which might contribute to stress resistance Conclusion: Rg1 reduced fat accumulation by regulating lipid metabolism via nhr-49 and enhanced stress resistance by its antioxidant effect in C. elegans.

  • https://doi.org/10.1016/j.jgr.2022.11.005 인용 PDF

Acute-onset chronic inflammatory demyelinating polyneuropathy following hepatitis A virus infection

  • Jung, Eui Sung;Kim, Ye Sel;Min, Ju-Hong;Kang, Kyusik;Lee, Jung Ju;Park, Jong-Moo;Kim, Byung-Kun;Kwon, Ohyun
    • Annals of Clinical Neurophysiology
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    • 제19권1호
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    • pp.50-53
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    • 2017

  • An infection is less likely to elicit chronic inflammatory demyelinating polyneuropathy (CIDP) than Guillain-$Barr{\acute{e}}$ syndrome. We here report a case of acute-onset CIDP following hepatitis A virus infection and briefly comment on the potential mechanisms regarding the induction and chronicity of autoimmunity after a viral infection.

  • https://doi.org/10.14253/acn.2017.19.1.50 인용 PDF KSCI