• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.2
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• pp.486-492
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• 2003

To certify the protective effect of herbal medicine on myocardial damage against oxygen free radical-induced myocardiotoxicity, cytotoxicity was measured using by MTT assay, LDH activity and thiobarbituric acid reactive substances(TBARS) assay in the presence of Guaruhaebaekbaekju-tang(GHBT) extracts or single constituents of this prescription, Myocardial toxicity was evaluated in neonatal rat myocardiocytes in cultures. In the present study, xanthine oxidase/hypoxanthine (XO/HX) resulted in a decrease in cell viability, an increase in LDH activity in culture medium and lipid peroxidation in cultured myocardial cells, In the effect of GHBT extract, it showed the prevention from the XO/HX-induced cardiotoxicity such as the decrease of LDH activity and lipid peroxidation. In the protective effect of Fructus Trichosanthis (FT) and Bulbus Allii Macrostemi (BAM), all the extracts were significantly effective in the protection of XO/HX-induced cardiotoxocity in cultured myocardial cells. From these results, they show that XO/HX is cardiotoxic in cultured myocardial cells derived from neonatal rats, and it suggests that GHBT, FT and BAM extracts are positively effective in the blocking XO/HX-induced cardiotoxicity.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.1
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• pp.215-223
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• 2006

This research surveyed oriental medicine therapies currently used in oriental medicine circles by referring to oriental medicine books-based existing traditional authentic therapies, as well as market-sold supplementary therapy-related ordinary health books and Internet information, and supplementary therapy-related dissertations, reviewed the fundamental operating significance of these therapies, and pursued their clinical operating measures based on their clinical information as follows Various therapies currently used in oriental medicine circles are categorized into authentic therapies and supplementary therapies in oriental medicine. Authentic therapies in Oriental medicine are based on bodily self-vitality abilities, pursue positive methods of treating diseases, and include medication therapies, acupuncture therapies, and external therapies. Supplementary therapies in oriental medicine are based on bodily self-vitality abilities, pursue indirect methods of treating diseases, and consist of lifestyle therapy and body management therapy. Authentic and supplementary therapies in Oriental medicine are used either separately or together according to clinical treatment methods. In treating diseases, clinical operating methods exclusively based on traditional authentic therapies and supplementary therapies include Donguibogam (anthology of ancient oriental medicine), Uihakipmun (introduction to medicine), Somun school, and bodily acupuncture according to diagnoses of symptoms, as well as sasangbang (prescription based on four types of bodily constitution), myeongribang prescription, hyeongsangbang prescription, and bodily constitution-based acupuncture according to diagnoses of bodily constitutions. In clinical operation of Oriental medicine, supplementary therapies are parity duplicated dy alternative medicine. However, given patients' needs and clinical practicality, Oriental medicine circles should establish a system based on the fundamental viewpoint of Oriental medicine theories, and corresponding policies should also be researched.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.5
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• pp.1154-1161
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• 2005

Yin Yang theory is the first and the last one to interpret diseases apply to treatment in oriental medicine. So it is regarded as the way of heaven and earth, the discipline of all things, the origin of change, the beginning of giving birth and death, the source of spirit. These regulatory passages are needed to compare with western medical physiology and analyzed whether it has scientific bases or not. The Yin Yang theory of traditional oriental medicine are summerized from the descriptions of Scripture of Documents, Ying Wei theory of Huangdi Neijing. Meanwhile up-to-date neurobiological and molecular genetic theories on circadian physiology are reviewed in western medicine. Sunshine is transferred through RGC to SCN, herein the central circadian rhythm is made by zeitgeber and interaction of melatonin secreted from pineal body and orexin from mp pan of hypothalamus. So HPA axis is activated and controlled under the circadian rhythm and affects peripheral tissues and cells of whole body through glucocorticoid hormones. First of all, the circadian rhythm makes the basic patterns of human life in biological and sociological meaning. It is almost same context with the record of the Scripture of Documents. Also the Ying Qi and Wei Qi is basically same with the sleep-awake mechanism, that is melatonin/orexin signal or per/clk/bmal/cry genes with circadian activation and activity of each organ's physiological function. Conclusively it can be said that Yin Yang is a priori principle of living things and the beginning of giving birth and death for activation of them biologically, as is described in Huangdi Neijing.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.5
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• pp.1112-1119
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• 2005

The dream is a well-known experience in the routine life. It is necessary to consider the dream to modality of diagnosis because many evidences that the dream represents the physiologic and pathologic changes in the human have been proved in recent days. The oneironosus(病夢) was caused by three factors, which are the external stresses of the body, malfunction of Jang-Bu(臟腑) and irregular of Yin-Yang(陰陽) and Gi-blood(氣血). The oneironosus(病夢) reflects the location, characteristics, progression and prognosis of the disease. In addition, it predicts the development of disease. The principle of treatment for the oneironosus(病夢) is making an effort for the stabilization of mind by eradicating the internal and external factors that make the spirit(神) been unstable.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.3
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• pp.595-604
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• 2003

We study on the HYUN-GOG's main principles of Differentiation of Syndromes. HYUN-GOG insisted upon the main principles of Differentiation of Syndromes based on the individual-physiology. The system of Differentiation of Syndromes was composed of the Korean oriental medicine's physiological system. The main principles of Differentiation of Syndromes was mutually explained for the standpoint of eight principal syndromes(differentiation of pathological conditions in accordance with the eight principal syndromes) and the system of Syndrome-complexes based on the physiological system. BON-HER(original deficiency-syndrome), BON-HAN(original cold excess-syndrome), BON-YEOL(original heat excess-syndrome), the three representative syndrome-complexes is previously carried out the details of Differentiation of Syndromes. And the oriental medicine history was rearranged centering around the theory of Differentiation of Syndromes by HYUN-GOG. The theory of Syndrome-complexes was closely connected with prescription by the presentation of the basic organical prescription for the three representative syndrome-complexes.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.3
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• pp.585-594
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• 2003

Clinical observation on the diseases of Jang(臟) and Bu(腑) comes to the conclusions as follows: Variation in Jang(臟) and Bu(腑) exists diversely with every man because man is a microcosmos resembling the great universe, 'Mother Nature'. If the patient has a distinctive features of Jang(臟) and Bu(腑) in configuration, the diseas must be caused by the problems of Jang(臟) and Bu(腑). Distinctive features of Jang(臟) and Bu(腑) can be recognized by the shape and color of face, ear, eye, mouth and nose. Distinctive features of Jang(臟) and Bu(腑) should be examined preferentially when it comes to old people, children and persons who have past record of surgical operation on Jang(臟) and Bu(腑) organs.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.1
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• pp.179-186
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• 2004

In order to search for the ways of use in distilled liquid of Shogunjung-tang, an oriental medical prescription, the study examined the differences in the activated degree of cells and immunological effects, which are supplied by restoratives such as the existing extracted liquid and distilled liquid of Shogunjung-tang. As seen from the above results, both the extracted liquid of Shogunjung-tang and distilled liquid have remarkable efficiency in the increase of cells, the efficient condition of immunity activation degree possibly formed by these two and activation of cells and organism, in which distilled liquid in the beginning and the extracted liquid later tend to show its efficiency.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.1
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• pp.19-28
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• 2005

According to each developing type, we study a concept, contents and a consideration about in oriental medicine industry. The divisions of each developing speciality are followings: Urban industry type - The development of urban industry type has difficulties; The lack of technical development and social adaptation, etc. If it overcomes these difficulties, it will be activated in the oriental medicine industry. Rural industry type - The oriental medicine industry of rural type needs the model of rural oriental medicine industry which leads an activity and an independence of the rural region. Within the industrialization of the oriental medicine industry, if rural resource makes a specialized brand, it can have great effects in the future industry. Resort industry type - When The resort type is related the characters of natural circumstances, cultural industry and health management, it has many effects. If we gain the clear direction which is activated the regional specialities, the oriental medicine industry of resort type can estabilishs the high value industry. Event industry type - The event type is a festival, an exhibition, etc. Within this event, the promoter must provide visitors the specialized sights, the food things, the enjoyable things. And using traditional image, we have the regional resource is recognized good things and the nomination of open place can inform.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.923-929
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• 2003

The purpose of this study is to examine various Oriental Medical approaches to uterine myoma treatments which have been previously proposed, and find out an appropriate method with the verification of its clinical acceptance. The treatment with GGT(Gami-gwichulikyeong-tang) and JGD (Jagungdan) has been applied to uterine myoma patients visiting Sangdang Oriental medical clinic. After the treatment, 81 cases showing significant results are selected and analyzed in terms of patients' age, social environment, previous history of treatment, condition of uterine myoma, chief complaint, and the comparison between menstrual phases before the treatment and those after it. As for the size change, no-change is dominant. For the change chief complaint take a favorable turn is better after the treatment. Color of menstruation, pathologic blood drainage, hypermenorrhea or menorrhagia. dysmentorrhea show high percentage of improvement. The results above show GGT and JGD are effective treatments for uterine myoma patients. These two are also similar to the typical prescription of Jingga, which is Gwichulpajing-tang. Thus GGT and JGD are effective to the treatment for Jingga and Jingga is one of the most valid Oriental Medical approaches to uterine myoma.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.1
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• pp.27-33
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• 2009

Nowadays we can take a physical examination during pregnancy by various and advanced technology instruments. But there were no instruments in old times, so the ancient doctors examined symptoms and pulse of a pregnant woman. Therefore it is very important to comprehend the pulse in Oriental medicine. Fetus and mother are connected with the umbilical cord, and they interact with each other. Especially, symptoms and pulse of mother change during the formation of fetus. On account of being easy to study the changes of pulse from pregnant woman, it is important to know the formation of fetus. In Western medicine, the Buddhist scriptures and Oriental medicine mentioned about the formation of fetus. Because of different viewpoints, the choice of words and formative methods are differ from field to field. Western medicine calls the formation of fetus 'development', the Buddhist scriptures call it 'Ru-tai', and oriental medicine calls it 'Yang-tai'. In spite of the different viewpoints, they have supplementary explanations to study fetus. As a result, we can understand the reasons why pregnancy pulse cannot help changing from month to month.