• 한국임상수의학회지
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• 제15권1호
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• pp.41-45
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• 1998

This study was performed to investigate the serum creative kinase(CK) activity and CK isoenzyme in Jindo dog. Serum CK activity and CK-isoenzyme were analyzed in 53 Jindo dogs of both sexes. The mean value and normal range of serum CK activity were 24.1 lu/$\ell$ and 7-91 lu/$\ell$, respectively, in 29 female dogs, 24.8 lu/$\ell$ and 8-89 lu/$\ell$ in 24 male dogs. The CK activity of the Puppy showed a tendency to be higher than that of the adult. There was no significance between Puppy and adult. Three isoenzymes (CK-MM, CK- BB, and CK-MB) were recognized in serum. The mean percentages of female and male were as follows: 48.31fp and 48.1% for CK-MM, 35.49) and 33.61fp for CK-BB, and 8.2% and 10.1% for CK-MB in the puppy and 46.21% and 46.1 % for CK-MM, 36.3% and 37.6% for CK-BB and 10.5% and 9.5% for CK-MB in the adult.

• 한국임상수의학회지
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• 제30권6호
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• pp.496-498
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• 2013

본 증례는 충남대학교 수의과대학 부속동물병원에 내원한 심장사상충에 중감염된 2세, 암컷의 진도견에서 혈장 NT-pro BNP농도를 측정하였다. 심장사상충 감염은 신체검사, 혈액검사, ELISA 키트검사 및 영상진단검사 등으로 진단하였다. 본 증례 진도견의 혈장 NT-pro BNP농도는 심장사상충에 감염되지 않고, 다른 질병도 없는 5마리(모두2세, 모두 암컷)의 정상견과 비교하였을 때, 상대적으로 매우 높은 수치를 나타내었다 (정상견 평균: 373 pmol/L, 본 증례: 2,950 pmol/L). 본 연구는 우리가 아는 한 심장사상충에 감염된 진도견에서 혈장 NT-pro BNP농도를 측정하여 보고한 최초의 증례보고이다.

• 대한수의학회지
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• 제36권3호
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• pp.531-539
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• 1996

The lectin-binding patterns in the testis of the sexually matured Jindo dog were investigated to study the distribution of glycoconjugates in the seminiferous tubule under light and transmission electron microscopy. Positive reactions to Wheat germ agglutinin(WGA) and Dolichos biflorus agglutinin (DBA) were observed in the Sertoli cell and in the residual body of spermatid with a stronger reaction in the Sertoli cell to the lectins than in the residual body. Strong reactions to Soybean agglutinin(SBA) and Peanut agglutinin(PNA) were observed in the acrosome vesicles of the Golgi- and cap-phase spermatid, while a moderate reaction was observed in the acrosome-phase, maturation-phase spermatid and the residual body. The acrosome area of the spermatid reacted intensively to Griffonia simplicifolia agglutinin( GS-I) when the cell was in the acrosome-phase and maturation-phase, and the same reaction to the GS-I was observed in the residual body. However, the seminiferous tubule did not react to Ulex europeus agglutinin I(UEA-I). The gold-labelling of the Sertoli cells with DBA resulted in positive reactions of the Sertoli cell column and processes when observed under the electron microscopy, while the Golgi-, cap- and acrosome-phase spermatids reacted positively to SBA in the peripheral low-dense area of the acrosome vesicle of spermatid. Based on these results, we concluded that differences in the lectin-binding pattern of the seminiferous tubules were recognized in the Jindo dog compared to other animals.

• Journal of Animal Science and Technology
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• 제50권2호
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• pp.273-278
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• 2008

개의 성격형질의 연구는 애견가들이 자신의 애견을 잘 이해할 수 있도록 하고, 나아가 만약 탐지견이나 안내견 같은 인간의 생활에 도움을 주는 우수견 선발에 활용될 수 있다. 본 연구에서 우리는 진도개가 가지는 성격적인 형질을 54두의 진도개를 대상으로 조사하였다. 진도개의 공격성과 사교성에 관련하는 10개의 성격문항이 견주들에 의해 채점되었으며, 점수들을 주성분분석법(Principle Component Analysis)을 통해 분석하였다. 나이, 성별, 거주지(진도군 내 또는 외) 그리고 모색(황색 또는 백색)들이 성격특성에 영향을 미칠 수 있는 변수라 판단되어, 진도개 성격 설문문항들에 대해 주성분분석 결과, 세 개의 인자가 추출되었다. 세 개의 인자는 각각 ‘공격성’, ‘unknown factor’, 그리고 ‘사교성’에 관련하는 문항들을 포함 하고 있었다. 위에서 언급한 네 가지 변수와 공격성 간에 상관성은 관찰되지 않았으나(Ps> 0.05), 모색과 사교성 사이에는 황구가 백구에 비해서 사교성이 높은 경향을 보여주었다 (F1,52 =3.213, p=0.079). 공격성이 다른 변수들과는 상관성이 적은 것으로 보아 이후 진도개의 공격성에 대한 유전학적인 연구가 가능할 것으로 사료된다.

• 대한수의학회지
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• 제37권4호
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• pp.855-862
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• 1997

Ivermectin is a synthetic derivative of the naturally occurring avermectin $B_{1a}$ (22, 23-dihydroavermectin $B_{1a}$) and $B_{1b}$ (22, 23-dihydroavermectin $B_{1b}$), It is widely used as antiparasitic and pesticidal agents because of its remarkably potent and broad spectrum of antiparasitic activity. Although the drug has shown excellent anthelmintic effects, development of toxicosis in some animals such as the Collie species of dog is well documented. However, no studies have been reported on the toxic effects of the drug in Korean native animals such as the Jindo dog. The toxic effect of ivermectin was evaluated in 25 Jindo dogs divided into five groups which were orally administered with ivermectin at dosage levels of $200{\mu}g/kg$, $300{\mu}g/kg$, $600{\mu}g/kg$ and $2,500{\mu}g/kg$ of body weight, respectively. Toxic signs were not observed in the groups receiving $200{\mu}g/kg$ and $300{\mu}g/kg$ B.W. ivermectin. One dog developed mild clinical signs of toxicosis in the group receiving $600{\mu}g/kg$ dosage of ivermectin. In the group with $2,500{\mu}g/kg$ dosage, all dogs developed mild (salivation, drooling, vomiting, mydriasis, and/or confusion) and/or moderate (ataxia and tremors) clinical signs of toxicosis. Hematologic changes were not observed in the groups receiving $200{\mu}g/kg$, $300{\mu}g/kg$ and $600{\mu}g/kg$ B.W. ivermectin. In the groups receiving $2,500{\mu}g/kg$ B.W., total erythrocyte counts, total and differential leukocyte counts and hemoglobin levels were not affected by drug. Aspartate aminotransferase levels were increased after administration of ivermectin, while serum cholesterol and blood glucose levels were decreased.

• 한국임상수의학회지
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• 제21권4호
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• pp.369-373
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• 2004

The pelvic distraction-stress radiographs of 50 clinically normal Korean Jindo which confirmed to have non-dysplastic hip joints on the ventrodorsal extension view, were investigated to evaluate the passive coxofemoral joint laxity as quantified by the distraction index. The synovial fluid cavitation of the unilateral coxofemoral joint was detected in 8 dogs, and distraction index was not measured in theses cavitated joints. The distraction index measured minimally 0.20, and maximally 0.74. The medial distraction index for the dog examined was 0.42, and 75th percentile distraction index was below 0.50.

• 한국임상수의학회지
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• 제21권4호
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• pp.416-419
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• 2004

A 9-month-old castrated male Korean Jindo was presented for evaluation of a progressive left forelimb lameness of 4 weeks' duration. On physical examination, the dog showed moderate weight bearing lameness on the left forelimb. Firm and mild swelling was palpated, and range of motion was decreased in the left elbow. Signs of pain were elicited by gentle flection and hyperextension of the left elbow. On radiographs, fragmentation of the medial coronoid process with moderate secondary degenerative joint disease was found. The bone fragments could be seen more clearly on stress radiograph of the left elbow joint which was taken while flexing the elbow and inwardly rotating the antebrachium. A medial elbow arthrotomy was performed, and the loose fragments were removed from the coronoid region. Left forelimb lameness improved markedly after surgery.

• 대한수의학회지
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• 제14권2호
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• pp.191-200
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• 1974

Hemoglobin, albumin and transferrin phenetypes observed in a population of 255 dogs of various breeds by agar gel electrophoresis for hemoglobin and albumin, and by starch gel electrophoresis, for transferrin. The results obtained were as follows: 1. The hemoglobin phenotypes were classified as HbAA, HbAB and HbBB and the frequencies of appearence were 91.77, 6.27 and 1.96%, respectively. Gene frequency studies of $Hb^A$ and $Hb^B$ showed the $Hb^A$ gene to have a frequency of 94.9% and $Hb^B$ gene to have a frequency of 5.1. The frequency of hemoglobin phenotypes of the Korean Jindo dog (ylelow) was HbAA 76.19%, HbAB 17.46% and HbBB 6.35% and HbBB was recognized only in the Korean Jindo dogs. 2. The albumin phenotypes were calssified as AlbAA, AlbAB and AlbBB and the frequencies of appearence were 28.71, 43.57 and 27.72% respectively. Gene frequency stduies of $Alb^A$ and $Alb^B$ showed the $Alb^A$ gene to hate a frequency of 50.50% and $Alb^B$ gene to have a frequency of 49.50. The frequency of albumin phenotypes of the Korean Jindo dog was 26.32% for AlbAA, 34.21% for AlbAB and 39.47% for AlbBB. The frequency of albumin phenotypes of the Korean Jindo dog was slightly different from others and gene frequency of $Alb^B$ was 56.58. 3. Transferrin studies resulted in findings of 10 different phenotypes and frequencies of transferrin phenotype were 30.08% for $TfA_1A_1$, 8.02 for $TfA_2A_2$, 2.11 for TfBB, 4.64 for $TfC_1C_1$, 1.69 for $TfA_1B$, 41.35 for $TfA_1C_1$, 5.49 for $TfA_2C_1$, 0.84 for $TfA_2C_2$ and 3.79 for $TfBC_1$. Gene frequency studies of $Tf^A$, $Tf^B$ and $Tf^C$ showed the gene to have a frequency of 63.08% for $Tf^A$, 4.85 for $Tf^B$ and 32.07 for $Tf^C$ 4. Transferrin studies revealed two different band patterns on starch gels with a strong and weaker stained one. The $TfC_2C_2$ and $TfA_2A_2$ which were found in the Korean Jindo dog only showed a weaker stained band and the gene frequency of $TfA_1A_1$ was highly recognized in this dog.

• 대한수의학회지
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• 제41권1호
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• pp.21-28
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• 2001

The protein of the bovine, horse and dog erythrocyte membrane were analyzed by polyacrylamide gel eletrophoresis in sodium dodecyl sulfate and their relation to the sedimentation rate of animal erythrocytes were investigated by treating the erythrocytes with proteinases such as trypsin and chymotrypsin. Protein content in erythrocyte membrane was in human, in Jindo dog, in cattle and in horse, showing similar in among. The erythrocyte sedimentation rates bovine erythrocytes from Hostein and Korean native cattle were very slow compared with the human one(1/7 as slow as the human one) as reported previously. Although the general protein profiles of the bovine erythrocyte membranes were almost similar to that of human, bovine erythrocyte membranes showed one additional protein band, called band Q in this study, which migrated electrophoretically to the mid-position between band 2 and band 3 in human erythrocyte membranes. The erythrocyte sedimentation of race horse were very fast compared with the human one are reported previously. Although the general protein profiles of the race horse erythrocyte membranes were almost similar to that of human, band 3 content was showing higher in race horse(34.7%) than in human(25.3%). The general protein profile of the Jindo dog erythrocyte membrane was almost similar to the human patterns, Jindo dog erythrocyte membranes showed one absent protein band. It was band 7. The glycoprotein profiles of the bovine erythrocyte membranes revealed by periodic acid-Schiff(PAS) stain showed a marked difference from that of human. The PAS-1(glycophorin) and PAS-2(sialoglycoprotein) present in human erythrocyte membrane were almost absent from the bovine erythrocyte membranes showed a strong PAS-positive band near the origin of the electraphorograms, which is named as PAS-B in this study. The PAS-1 and PAS-2 present in human erythrocyte membrane were almost absent from race horse erythrocyte membranes, but PAS-2 was more in only race horse from that of human. The PAS-1 and PAS-2 were absolutely absent from the Jindo dog erythrocyte membrane. These results suggest the slow sedimentation rate of bovine erythrocytes is due in part to the presence of band Q protein fraction and PAS-B glycoprotein in the bovine erythrocytes, and that the fast sedimentation rate of race horse erythrocyte is due in part to the presence of more band 3 protein fraction and PAS-E glycoproteins in the race horse erythrocytes.

• 한국임상수의학회지
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• 제17권1호
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• pp.270-274
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• 2000

A seven-year-old female Jindo-dog was presented with a history of progressive abdominal distension. Except for severe bilateral abdominal swelling, other abnormal signs were not detected. The patient showed normal appetite and defecation. In the radiographic examination, the abdomen was filled with large masses. Suspected a certain neoplastic disease, laparotomy was taken through the cranial abdominal midline. Large pale-yellow masses were proliferated to fill the abdomen. In the masses, grey-brown or black portion presumed hemorrhagic or necrotic spots were found. Even though neoplastic tissues were not detected in the right kidney, they were infiltrated in the left kidney except for a part of the cortex. Obtaining the owner's consent, the patient was euthanized and samples were collecte for further study. In microscopic examination, the parenchyma of the medulla was substituted with tumor cells and the cortex was impressed by the expansive proliferation of the neoplastic tissues. This neoplasm was estimated as renal carcinoma originated from tubular epithelium, being based upon that tumor cells were largely cuboidal cells and they had obscure tubular forms.