• BMB Reports
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• v.57 no.4
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• pp.182-187
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• 2024

Neural stem cells (NSCs) in the adult hippocampus divide infrequently; the endogenous molecules modulating adult hippocampal neurogenesis (AHN) remain largely unknown. Here, we show that ErbB3 binding protein 1 (Ebp1), which plays important roles in embryonic neurodevelopment, acts as an essential modulator of adult neurogenic factors. In vivo analysis of Ebp1 neuron depletion mice showed impaired AHN with a low number of hippocampal NSCs and neuroblasts. Ebp1 leads to transcriptional repression of Bmp4 and suppression of Ascl1 promoter methylation in the dentate gyrus of the adult hippocampus reflecting an unusually high level of Bmp4 and low Ascl1 level in neurons of Ebp1-deficient mice. Therefore, our findings suggests that Ebp1 could act as an endogenous modulator of the interplay between Bmp4 and Ascl1/Notch signaling, contributing to AHN.

• The Research Journal of the Costume Culture
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• v.7 no.6
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• pp.68-84
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• 1999

The purpose of this study was analyze how korean adult women\`s swimming suit buying behavior varied according to consumer characteristics. Especially, it was intended to provide basic materials for swimming suit product development and quality improvement appropriate to consumer characteristics with a focus on product evaluation criteria. Questionnaire research was conducted for 850 adult women resident in Seoul, to whom questionnaire were distributed and who were asked to complete their questionnaires. 1. As for buying motive, of swimming suit buying behavior, it was shown that the highest proportion of adult women bought their new swimming suit because their old swimming suit was wornout and most adult women tended to buy their new swimming suit or their own will rather than at others\` suggestion. 2. As for the source of information at a time. of swimming suit purchase, adult women collected information from the product on display most and bought their swimming suit in a planned way in relation to the degree of purchase planning. 3. As for product evaluation criteria, adult women showed the high scores in order of the type and quality of material, activity and functionalism, dimensions and fitness. 4. In many cases actual swimming suit purchasers were the adult women who bought their swimming suit, and they used the department store or the large shopping center as the place of purchasing the swimming suit. Its reason was that the department store or the large shopping center had a diverse assortment of products. As for the degree of their travelling companion\`s influence, it was found that most adult women were influenced by their travelling companions when purchasing their swimming suits. 5. As for the level of satisfaction with swimming suit purchase, it was shown that adult women were generally satisfied with their swimming suit purchase. It was found that their level of satisfaction was higher in order of activity and functionalism, the type and quality of swimming suit materials, and ease in washing management while they showed the low level of satisfaction with price, the fastness of color to washing, light and detergents and durability.

• Journal of Fisheries and Marine Sciences Education
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• v.27 no.1
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• pp.160-169
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• 2015

The purpose of this study was to search and analyze the realities and needs of life long education, the necessity and perception of life competencies and the difference of competencies on experiences of education to support life long education system for adult learners in Busan and Ulsan. In this study, we conducted a questionnaire survey of 234 adult learners living in Busan and Ulsan. The results of this study were summarized as follows. First, adult learners perceived that life long education was very important to adults and appreciated an educational institution being managed by government. Second, adult learners thought that basic literacy competency and basic work competency were important and late fifties perceived that professional job is in important. Third, adult learners perceived that self directed learning and capacity of management are poor competencies. And they perceived that the government support adult learners who has economical difficulty. Forth, adult learners perceived that it was normal that 'professional job' and 'job transition abilities', 'women', 'the middle aged and old','the unemployed' and' low incomers' perceived that they have poor level. Fifth, according to the results of ${\chi}^2$ test for determining the statistical significance of differences in experience in lifelong learning among adult learner groups divided by their individual background, significant differences were observed in a few competencies(p<.05, p<.01).

• Journal of Families and Better Life
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• v.35 no.1
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• pp.139-158
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• 2017

Following the global trend of the delayed transition to adulthood, the number of unmarried middle aged adult children living with, or economically dependent on their parents has increased in Korea. Middle aged adult children in Korea are traditionally expected to satisfy their duty to support their elderly parents both in economic and emotional needs. This study aims to explore group differences in unmarried adult children in their mid 30s or older and in parents having unmarried middle aged child(ren) depending on co-residency and the children's eonomic dependency in Korea. Using quota sampling in terms of living arrangements (living together vs. living apart), 500 unmarried adult children 35 years of age or older and 500 elderly parents, having at least one unmarried child in the mid of 30s or over, were selected in Seoul, Korea in June 2016. First, the findings show that unmarried adult children living together with their parents and depending on their parents economically were in the lowest level of educational achievement and the lowest level of monthly average income among the respondents. Second, both unmarried adult children and parents from the group of co-residency and economically dependent showed the lowest level of psychological well-being. Third, parents from the group of co-residency and economically independent had mostly positive relationships with children, whereas, parents from the group of living apart and economically dependent reported the most negative relationships. Finally, respondents included in the group of co-residency had positive attitudes toward marriage and the support for their elderly parents regardless of the child's economic dependency. This study has implications for the increasing number of unmarried middle aged adult children and their elderly parents.

• Physical Therapy Korea
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• v.3 no.2
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• pp.19-28
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• 1996

The purpose of this study was to asses and compare the effects of superficial heating on the pain threshold at limbs in healthy adult and adult hemiplegia. We used hot pack for superficial heat and applied to healthy adult(n=12) and adult hemiplegia(n=12) on lumbar region. Pain treshold was quantatively measured by an electrical stimulator and measured before hot pack application, immediatly and post 30 minutes after hot pack application on the distal parts of limbs(styloid process of radius, medial malleoulus of tibia). The results were as follows 1) A statically significant defference in pain treshold were not found at limbs of healthy adult and adult hemiplegia that have an affected side and a non-affected side before hot pack application, immediatly and post 30 minutes after hot pack apllication(p>0.05). 2) In comparance of pain threshold of upper and lower limbs in the all subjects, pain threshold was significantly increase at lower limbs(p<0.01). 3) In comparance of pain threshold of limbs between healthy adult and adult hemiplegia, pain threshold was showed a significant defferance at the upper and lower limbs of affected side before hot pack application(p<0.05, p<0.01).

• Journal of Fashion Business
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• v.10 no.4
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• pp.95-113
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• 2006

This study was conducted comparative analysis of juvenile brassiere and adult brassiere to identify the problems of brassieres on the market. The raw data for this study was processed by SPSS 10.1 version(statistical software) and the results of this study can be summarized as follows. 1) The result of comparative analysis of juvenile brassiere and adult brassiere pattern is that each pattern showed no difference. 2) The results of the comparative analysis of juvenile and adult brassiere pattern in wing's length and angle is that even though there are some difference between juvenile and adult in side line inclination of brassiere. there is no setting difference but size of that brassiere. 3) The result of a comparative analysis pattern and cup size measurement of juvenile brassiere and adult brassiere is that even though the adult cup girth and angle is bigger than the juvenile because adults have more protrusive and bigger volume and well developed breast, some case rather the adult's cup angle is smaller than the juvenile as brand. And as we grow up to be a woman, difference of lower breast girth and breast girth are become big while difference of upper breast girth and breast girth are become small for that reason upper cup must be lower and lower cup must be higher but there is almost no difference between adult and juvenile. 4) The result of a comparative analysis of juvenile brassiere and adult brassiere bust point of the pattern is that adult brassiere's distance between bust points 6.12cm, and juvenile's 5.6cm, there are only 0.52cm difference between two products and just 0.4cm, size grading. These results are explained that even though when grow up to be a woman the distance between two bust points become to be long and breast toward out side but brassiere size don't vary with body characteristic.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.1
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• pp.41-51
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• 2016

Adult hippocampal dentate granule neurons are generated from neural stem cells (NSCs) in the mammalian brain, and the fate specification of adult NSCs is precisely controlled by the local niches and environment, such as the subventricular zone (SVZ), dentate gyrus (DG), and Toll-like receptors (TLRs). Epigallocatechin-3-gallate (EGCG) is the main polyphenolic flavonoid in green tea that has neuroprotective activities, but there is no clear understanding of the role of EGCG in adult neurogenesis in the DG after neuroinflammation. Here, we investigate the effect and the mechanism of EGCG on adult neurogenesis impaired by lipopolysaccharides (LPS). LPS-induced neuroinflammation inhibited adult neurogenesis by suppressing the proliferation and differentiation of neural stem cells in the DG, which was indicated by the decreased number of Bromodeoxyuridine (BrdU)-, Doublecortin (DCX)- and Neuronal Nuclei (NeuN)-positive cells. In addition, microglia were recruited with activating TLR4-NF-${\kappa}B$ signaling in the adult hippocampus by LPS injection. Treating LPS-injured mice with EGCG restored the proliferation and differentiation of NSCs in the DG, which were decreased by LPS, and EGCG treatment also ameliorated the apoptosis of NSCs. Moreover, pro-inflammatory cytokine production induced by LPS was attenuated by EGCG treatment through modulating the TLR4-NF-${\kappa}B$ pathway. These results illustrate that EGCG has a beneficial effect on impaired adult neurogenesis caused by LPS-induced neuroinflammation, and it may be applicable as a therapeutic agent against neurodegenerative disorders caused by inflammation.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.15 no.1
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• pp.140-150
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• 2002

Introduction: Atopic dermatitis is chronic eczematous dermatosis which is related strongly to a family history of atopic disease and hereditary disposition. Its threshold of itching is low so that severe itching occurs and causes secondary eczema. Adult atopic dermatitis has mostly severe symptoms and progresses to chronic relapsing. Objective: The purpose of this study was to estimate the efficacy of oriental medical treatment and management on chronic adult atopic dermatitis. Subject: We studied 3 patients who visited Dongguk University Gangnam Oriental Hospital Dept. of Dermatol. with chronic adult atopic dermatitis from August 2001 to April 2002 and were observed for over 4 months. Methods: We treated them with herb-medication, acupuncture, negative therapy, aroma therapy, full spectrum visible ray therapy(by carbon arc) and external application(Jaun-go). We used the SCORAD index to assess the severity of atopic dermatitis. Results: There were 3 patients with chronic adult atopic dermatitis we could check for over 4 months by clinical scoring using the SCORAD system. 1. The grades of the severity of atopic dermatitis were lower only by the oriental medical treatments and management. 2. Intensities of relapse cases were lower then before the oriental medical treatments. 3. The secondary treatment term for relapse cases was shorter then the first treatment term after oriental remedies were used. Conclusion: Considering the above results, more study is needed on the chronic relapse cases with adult atopic dermatitis, the factors of increasing seventy of adult atopic dermatitis, the prognostic factors of adult atopic dermatitis, and the clinical interchange of chronic adult atopic dermatitis between oriental medicine and western medicine.

• Korean Journal of Social Welfare
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• v.47
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• pp.206-242
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• 2001

A survey research was conducted for a sample of 306 adult children who have an elderly parent or both parents alive. The purpose of the research was to test a structural equation model which specified the effects of early family relationships on comtemporary relationships and assistance patterns between adult children and their parents. The data were analyzed using EQS for Windows 5.7, utilizing maximum likelihood method. The results showed that early family relationships affected filial concern first, which in turn affected the level of assistance provided by adult children for elderly parents. No direct effect has been found between early family relationships and the level of assistance by adult children for elderly parents. Filial concern was played as an intervening variable. Early family relationships gave no direct effects to adult children's intention to assist their parents. Here again, filial concern was played as an intervening factor. Adult children's intention to assist their parents had not been led directly to provision of actual support to parents by their adult children. Thus, it was identified that intention to support is one thing, and the actual support is another. Controlling for the effects of filial concern, overall, early family relationship patterns gave no differential effects to the different aspects of support provided to parents by their adult children. On the basis of these results, this paper provided both discussions and suggestions for some strategies of intervention in the present family relationships in order for the inter-generational exchange of supports to happen in the future.

• Korean Journal of Child Studies
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• v.23 no.4
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• pp.71-88
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• 2002

Mothers of 113 Korean toddlers completed Toddler Behavior Assessment Questionnaire(TBAQ) and Child Rearing Practice Report(CRPR). Observations of mother-child dyads in novel situations involving unfamiliar settings and adults assessed child's behavioral inhibition. Nonsocial inhibition were measured by the amount of time each child spent in physical contact with his/her mother in free-play episodes. Adult-social inhibition was based on child's behavior when an unfamiliar adult requested that the child approach her as she presented them with toys or activities. Results showed that TBAQ Social Fearfulness was positively associated with nonsocial and adult-social inhibition. TBAQ Pleasure was correlated negatively and TBAQ Anger Proneness positively correlated with adult-social inhibition. An interaction effect showed that child's social fearfulness and mother's overprotective behaviors affected adult-social inhibition. The regression model explained 31% of the variance.