• 한국언어정보학회지:언어와정보
• /
• 제19권2호
• /
• pp.37-53
• /
• 2015

It has been widely accepted that Korean -i/ka, known as the nominative marker, can give rise to exhaustivity effect. However, it has been rarely discussed and still remains unclear how and why the particle can convey exhaustivity. The purpose of this paper is to shed light on this issue, based on Kim's (2014) analysis of the function of -i/ka. The main claim is that the exhaustivity expressed by -i/ka is a pragmatic effect derived from the interaction of the function of -i/ka, namely, unique specification, and the existence of alternatives to the denotation of an -i/ka-marked phrase in discourse context. Thus, the nature of the exhaustive implicature induced by -i/ka is not conventional but conversational.

• 한국언어정보학회지:언어와정보
• /
• 제19권2호
• /
• pp.19-36
• /
• 2015

The aim of this paper is to investigate the usage of Korean markers -(n)un and -i/ka in editorial texts focusing on information structure. Noun phrases ending with the markers -(n)un and -i/ka were annotated semi-automatically using a corpus obtained from an online newspaper. Two important factors to determine the choice of markers were examined with the annotated data: referential givenness/newness and position in a sentence. Referential givenness and newness were adopted as indicators of information structure, topic and focus respectively. In addition to quantitative analysis, qualitative analysis was conducted on the selected data. The results suggest that both the marker -(n)un and -i/ka could carry a topic and a focus reading. Sentence position also played a crucial role in determining the marker, and the marker -i/ka was used more frequently in a later position of a sentence than the marker -(n)un.

• Natural Product Sciences
• /
• 제16권2호
• /
• pp.99-106
• /
• 2010

This experiment was undertaken to investigate whether methanol extract of fruit peel of Dimocarpus longan Lour. (MEFL) protects against kainic acid (KA)-induced seizure. Oral administration of MEFL (1, 2 and 4 mg/kg) increased KA (50 mg/kg)-induced survival rate and latency of convulsion onset, and deceased seizure scores and weight loss induced by intraperitoneal (i.p) injection of KA in mice. In addition, MEFL protected against cell death in the hippocampus of rat brain after KA-administration as analyzed by using TUNEL assay in rats. MEFL also significantly blocked seizure-form of electroencephalogram (EEG) power spectra induced by KA in rats. MEFL also inhibited elevation of [$Ca^{2+}$]i and increased [$Cl^-$]i induced by KA in cultured neuronal cells. Therefore, it is suggested that MEFL protects against seizure induced by KA, decreasing [$Ca^{2+}$]i.

• The Korean Journal of Physiology and Pharmacology
• /
• 제13권4호
• /
• pp.265-271
• /
• 2009

Nitric oxide (NO) has both neuroprotective and neurotoxic effects depending on its concentration and the experimental model. We tested the effects of NG-nitro-L-arginine methyl ester (L-NAME), a nonselective nitric oxide synthase (NOS) inhibitor, and aminoguanidine, a selective inducible NOS (iNOS) inhibitor, on kainic acid (KA)-induced seizures and hippocampal CA3 neuronal death. L-NAME (50 mg/kg, i.p.) and/or aminoguanidine (200 mg/kg, i.p.) were administered 1 h prior to the intracerebroventricular (i.c.v.) injection of KA. Pretreatment with L-NAME significantly increased KA-induced CA3 neuronal death, iNOS expression, and activation of microglia. However, pretreatment with aminoguanidine significantly suppressed both the KA-induced and L-NAME-aggravated hippocampal CA3 neuronal death with concomitant decreases in iNOS expression and microglial activation. The protective effect of aminoguanidine was maintained for up to 2 weeks. Furthermore, iNOS knockout mice ($iNOS^{-1-}$) were resistant to KA-induced neuronal death. The present study demonstrates that aminoguanidine attenuates KA-induced neuronal death, whereas L-NAME aggravates neuronal death, in the CA3 region of the hippocampus, suggesting that NOS isoforms play different roles in KA-induced excitotoxicity.

• 대한가정학회지
• /
• 제36권3호
• /
• pp.77-86
• /
• 1998

The aims of this study show the purpose of writing[Ka-ryae] and its transmission and operation from the end of Koryo to Chosun dynasty. And Studying of a traditional marriage ceremony as shown in [Ka-ryae], We intend to find a mental meaning and value in it. The major findings this study are as follows. 1. Though [Ka-ryae] was written by Chu-Ja who lived in the period of South-Song of China, it had greatly influenced the thought, system and life of Korean society from the end of Koryo to Chosun dynasty. 2. Studying the content of [Ka-ryae], we learned the respect, discretion and reghtness as the mental meaning and value of a marriage ceremony.

• 자원환경지질
• /
• 제39권1호
• /
• pp.53-61
• /
• 2006

Geochemical and sedimentological analyses of sediment piston core were used to trace paleoceanographic environmental changes in the East China Sea. The analytical results revealed three lithostratigraphic units (I, II, and III) corresponding to a highstand stage, a transgressive stage, and a lowstand stage, respectively. Accelerator mass spectrometry (AMS) $^{14}C$ dated the boundaries between the units as 7 ka and II ka. That is, Unit I extended from the present to 7 ka, Unit II occupied a transitional episode from 7 to 11 ka, and Unit III was older than 11 ka. The transitional episode was characterized by sudden fluctuations in various geochemical proxies. Most strikingly, there was a gradual upward increase in both carbonate and total organic carbon (TOe) contents post-7 ka, during which time the ${\delta}^{l3}C$ values of organic material increased to a constant value. The gradual upward increase in the TOC and $CaCO_3$ contents in Unit I were accompanied by slight variations in grain size that probably reflect a stable modern oceanographic environment. Within Unit II (7 to 11 ka), the geochemical signals were characterized by abrupt and steep fluctuations, typical of a transgressive stage. Vertical mixing may have provoked an increase in productivity during this interval, with large amounts of terrigenous organic matter and/or freshwater being supplied by neighboring rivers. The geochemical signals remained stable throughout Unit III but exhibited different patterns than signals in Unit I. The high terrigenous organic matter content of Unit III suggests correspondence to a lowstand stage.

• 한국어학
• /
• 제62권
• /
• pp.171-194
• /
• 2014

In this paper, I seek to differentiate the meaning of the auxiliary verb '-e ka-' from imperfective aspect in Korean. The progressive in imperfective is expressed by the 'be+V-ing' in English and '-ko iss-' in Korean. However the '-e ka-' in Korean can express the gradual progress meaning. This is similar to the progressive of some state verbs. These verbs cannot express the progressive aspect but it is possible if they can express the change of state in sentence. It is more corresponding to the '-e ka-' than '-ko iss-' in Korean.

• Journal of Ginseng Research
• /
• 제47권3호
• /
• pp.390-399
• /
• 2023

Background: Gintonin (GT), a Panax ginseng-derived lysophosphatidic acid receptor (LPAR) ligand, has positive effects in cultured or animal models for Parkinson's disease, Huntington's disease, and so on. However, the potential therapeutic value of GT in treating epilepsy has not yet been reported. Methods: Effects of GT on epileptic seizure (seizure) in kainic acid [KA, 55mg/kg, intraperitoneal (i.p.)]-induced model of mice, excitotoxic (hippocampal) cell death in KA [0.2 ㎍, intracerebroventricular (i.c.v.)]-induced model of mice, and levels of proinflammatory mediators in lipopolysaccharide (LPS)-induced BV2 cells were investigated. Results: An i.p. injection of KA into mice produced typical seizure. However, it was significantly alleviated by oral administration of GT in a dose-dependent manner. An i.c.v. injection of KA produced typical hippocampal cell death, whereas it was significantly ameliorated by administration of GT, which was related to reduced levels of neuroglial (microglia and astrocyte) activation and proinflammatory cytokines/enzymes expression as well as increased level of the Nrf2-antioxidant response via the upregulation of LPAR 1/3 in the hippocampus. However, these positive effects of GT were neutralized by an i.p. injection of Ki16425, an antagonist of LPA1-3. GT also reduced protein expression level of inducible nitric-oxide synthase, a representative proinflammatory enzyme, in LPS-induced BV2 cells. Treatment with conditioned medium clearly reduced cultured HT-22 cell death. Conclusion: Taken together, these results suggest that GT may suppress KA-induced seizures and excitotoxic events in the hippocampus through its anti-inflammatory and antioxidant activities by activating LPA signaling. Thus, GT has a therapeutic potential to treat epilepsy.

• 한국통신학회논문지
• /
• 제36권11A호
• /
• pp.933-940
• /
• 2011

본 논문에서는 도로 장애물 감시 레이더용 Ka 대역 송수신기를 설계 및 제작하였다. 도로 장애물 감시 레이더용 송수신기는 파형발생기, 주파수발생기, IF 송수신기, RF 상하향 변환기로 구성되어 있다. 송수신기는 탐지 거리별로 모드를 3가지로 구분하여 운용되며 이 때 Ka 대역에서 150MHz의 대역폭을 유지한다. 송신 출력은 22dBm 이상이며, 수신 이득은 30dB, 잡음 지수는 6dB인 성능을 얻었다. 수신 동적 범위는 63.28dB 이며, 수신 I/Q 채널 간 진폭 오차는 0.3dB, 위상 오차는 1.74도를 보였다. 시험 결과, 송수신기는 펄스 도플러 형태의 도로 감시 레이더에서 요구되는 전기적인 성능을 만족하였음을 확인하였다.

• 전자공학회논문지A
• /
• 제32A권1호
• /
• pp.45-52
• /
• 1995

A new Kirchhoff approximation(KA) method was proposed for microwave scttering from randomly rough surfaces. Using the spectral representation of delta function and its sifting theorem, a new KA was formulated directly without any further approximation, and this formulated was used to compute exact backscttering coefficients. The validity of the KA was verified by a numerical method, and this new KA technique was used to evaluate the existing approximated KkA methods; i.t., the zeroth-order and the first-order approximated physical optics(PO) models. It was shown that the first-order approximated PO model has small error than the zeroth-order approximated PO model at low incidence angles and the opposite happens at higher incidence angles. This new KA model can be used to compute exact scattering coefficients in the validity regions of KA and to evaluate other theoretical and numerical models for scattering from randomly rough surfaces.