• 대한본초학회지
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• 제33권4호
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• pp.9-18
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• 2018

Objectives : This study aimed to investigate the anti-ulcer effect of an standardized herbal extracts mixture of Inulae Flos and Paeoniae Radix (HT074) on acidified ethanol induced gastric injury and its potential mechanisms. Methods : Antioxidant activities of HT074 and its constituents were measured by DPPH (2,2-Diphenyl-1-picrylhydrazyl) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging capacity. After the oral administration of HT074 at doses of 100, 300 mg/kg twice per day for 14 days, Gastric lesions were induced by oral administration of acidified ethanol in Sprague Dawley rats. Oxidative stress markers, such as super oxide dismutase (SOD) activity, concentrations of catalase (CAT) and glutathione (GSH) were measured in gastric mucosal tissues. Additionally, the expression of human mucin gene, Mucin 5AC (MUC5AC) mRNA in gastric mucosal tissues was measured. Results : HT074 showed dose dependent radical scavenging activities against DPPH and ABTS radicals. Oral administration of HT074 300 mg/kg for 14 consecutive days significantly decreased gastric lesions and histological damages induced by HCl/EtOH in rats. HT074 treatment significantly increased the activity of SOD (300 mg/kg) and concentration of GSH (100 and 300 mg/kg), however catalase concentration was not significantly increased. MUC5AC mRNA expression was significantly increased by HT074 100, 300 mg/kg treatment. Conclusions : HT074 protects the gastric mucosa from oxidative stress caused by acidified ethanol by increasing the activity of SOD, concentration of GSH and mucin biosynthesis. These findings suggest that HT074 could be an effective candidate for prevention and treatment of gastritis and gastric ulcer.

• 대한본초학회지
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• 제24권4호
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• pp.197-204
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• 2009

Objectives : This study was conducted to investigate the effect of HT008, a multi-herbal mixture consisting of 3 herbs, Eleutherococcus senticosus, Angelica sinensis, and Scutellaria baicaleinsis on arthritic model in rats. Methods : The anti-inflammatory and analgesic activities were observed by utilizing the following models: carrageenan-induced edema of the hind paw of rats, acetic acid-induced writhing response in mice. The perimeter of the paw was measured before injection and then at 1, 2, 4, 6 h after injection of 1% $\lambda$-carrageenan. The HT008 at five dose levels (10, 30, 100, and 300 mg/kg) and distilled water given 30 min to treatment groups and control group, before $\lambda$-carrageenan injection. In the writhing test, the mice received 0.7% acetic acid solution in normal saline injected intraperitoneally at a dose of 10 ml/kg. The number of writhes was counted staring 10 min after injection. Results : HT008 at four dose levels (30, 100, and 300 mg/kg) significantly decreased the carrageenan-induced rat paw edema perimeter. E. senticosus and S. baicaleinsis extracts reduced acetic acid-induced writhing response in mice. Also A. sinensis extracts significantly decreased the carrageenan-induced rat paw edema perimeter. Conclusions : These results show that HT008, a multi-herbal mixture has both anti-inflammatory activity and analgesic effects in vivo arthritic model, and suggest that HT008 could be a good therapy to treat human osteoarthritis.

• 대한간호학회지
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• 제3권1호
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• pp.41-51
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• 1972

In this article, the writer attempted to study the followings: (1) mother's knowledge of milk feeding (including method of sterilization, formula and feeding) (2) reasons of artificial feeding (3) how much mothers are concerned about their artificial feeding infants (4) condition of growth and development of artificial feeding infants. As the object of study, 96 mothers with artificial feeding infants, who had consulted dep't of pediatrics of two Hospitals in Seoul (Korea Hospital and Med. College Woo Suk Hospital, Korea Uni.) and well baby clinic of the two Health Centers (Sung Dong and Dongdaemoon), were randomly sampled. The data were treated by the statistic method of chi-square and percentage, and come to the following conclusion. 1. Knowledge of milk feeding Sterilization: 70 percentages of mothers know about the milk sterilization (including bottle, nipple and instrument), but 55 percentages of them do not know the nipple sterilization correctly. Formula: 69 percentages of mothers follow the indicator or in accordance with doctor's directions, but 31 percentages do at their option by reasons that the baby often coughs up the milk, the baby is too small, the baby often has digestive troubles, or the baby grow fleshy heavily etc, except family economic problems. Feeding: only half of mothers know the correct feeding method, especially they do not know how to determine the heat degree of milk and how to bubble up the baby correctly. They just do feeding according to the accepted usages. 2. Reasons of artificial feeding Of the reasons of artificial feeding, 18 percentages were caused by infants and 82 percentages by mothers. Most of the reasons are mainly due to the lack of breast milk and sufficient supply of nourishments rather than mother's deficiency or mother's abnormality. 3. Mother's concern for artificial feeding infants Mothers who are sharply concerned for their artificial feeding baby's growth and development: 63%, mothers who made the baby (artificial feeding infant) routine vaccinated: 81%, mothers who ear anxious about the baby's future personality forming : 68%, mothers who care about the baby's condition of nourishment; 60%, mothers who are anxious about tile selection of baby's food; 54%. 4. The growth and development of artificial feeding infants compared with Korean average infants. The artificial feeding infants are above the Korean average infants in stature by 1.21 centimeters and in weight by 0.3 kilograms. Conclusion: It has been said that there is no better food for infant than the breast milk. However, the artificial feeding has been used for the supplement of nourishments and as substitute food for the breast milk. And this artificial feeding could give the married women the chance to act in society and more opportunity to develop themselves and to work for others at home and other fields. Considering these advantages, artificial feeding should not be exclusive, but preferably should be more improved and inquired positively. And even in artificial feeding, what is most important is that mothers should recognize the requirement and need of artificial feeding clearly and correctly, and they should be accustomed to the correct knowledge and skills of artificial feeding in order to practice it appropriately. In some degree, they should be properly trained in school education process.

• 한국한의학연구원논문집
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• 제16권3호
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• pp.85-93
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• 2010

The aim of this review is to investigate clinical studies on oriental medicine treatment for obesity in Korean literature and to propose for the better method of clinical studies in order to seek more effective treatment. Electric searches were performed with NDSL, National assembly library, RISS4U, DBPIA, KISS, KMBASE, KoreaMed, Korean traditional knowledge portal and Oasis. Also, 21 major journals associated with oriental medicine in Korea were searched manually. Eighty three studies were included and analyzed in terms of study design, subjects, interventions, results and evaluation of safety. The numbers of controlled, non-controlled and case studies are respectively 26(31%), 43(52%) and 14(17%). Studies using sample size less than 30 accounts for 49% and studies using subjects diagnosed as obese or overweight by specific criteria were 35(42%). Studies which used more than 2 interventions or co-interventions were 76%. Clinical studies which used single herbal medicine were few and clinically studied single herbal medicine were limited to ephedra. More than half of 83 studies were studied for 8 weeks and less. 12% of 69 studies(except case studies) were not statistically analyzed and studies which evaluated safety of intervention were 22(27%) and reported adverse events were 9(11%). To improve the quality of clinical studies on oriental medicine treatment for obesity, studies need to use restricted number of interventions and subjects need to specifically diagnosed as overweight or obese. In addition, various kinds of single herbs need to be clinically studied based on experimental studies and herbalogy.

• 한국산학기술학회논문지
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• 제19권1호
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• pp.517-526
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• 2018

본 연구는 최근 10년간 해외 학술지에 게재된 복지관 이용 노인의 생활만족도에 영향을 미치는 요인들의 체계적 문헌 고찰 및 메타분석을 통해 노인의 생활만족도를 증진하기 위한 한국형 노인 생활만족도 도구 개발 및 복지관 운영 및 정책 개발 시 기초 자료로 제시하고자 한다. 분석에 사용된 문헌은 2017년 11월 1일까지 게제 된 국외 논문을 Medline complete, Pubmed central, Scopus를 통해 검색하였다. 검색 용어는 "Elderly. OR aged/) AND Personal Satisfaction/ or life satisfaction. mp"를 사용하였고, 검색된 595편의 초록을 통해 최종 6편의 연구를 분석 대상으로 선정하였다. 각 연구의 내용을 정성적으로 분석한 후 3편 이상의 정량값이 있는 요인들은 메타분석을 시행하였다. 연구 결과 노인 생활 만족도에 영향을 주는 요인으로는 신체적 건강(통합효과크기 0.582, p=.000), 정신적 건강(통합효과크기 0.423, p=.000), 경제적인 문제(r=.51, p=.001), 사회활동, 일상생활정도가 영향요인을 분석되었다. 본 연구를 통해 노인의 생활 만족도의 폭넓은 이해뿐만 아니라 초고령화 사회를 대비한 고령자 취업의 사회적인 함의 및 체계적인 건강관리를 통해 생활만족도를 높이는데 기여할 수 있을 것이다.

• 한국정보통신학회논문지
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• 제15권10호
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• pp.2149-2156
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• 2011

본 논문에서는 디지털통신을 위한 새로운 3차원 16진 신호성상도의 설계방법을 제시하고 그 성능을 분석한다. 기존의 성상도와는 달리 새로운 성상도는 모든 신호점들이 구의 표면에 균일하게 분포하므로 상진폭과 대칭적 구조 특성을 동시에 만족한다. 신호성상도의 평균전력을 정규화시킨 경우 제시된 16진 신호성상도는 기존의 비상진폭(non-constant envelope) 성상도들에 비하여 최대 11.4% 가량 증가된 최소 유클리드 거리를 가지는 것으로 나타났다. 이로 인하여 가산성 백색 가우시안잡음 환경에서 제안된 신호성상도가 적용된 디지털 통신시스템의 심볼오율은 기존 성상도를 이용하는 시스템에 비하여 1.2dB 가량 향상됨을 확인할 수 있다. 유클리드 거리 측면에서 최적화된 기존 상진폭 신호성상도에서는 신호점들이 구의 표면에 균일하게 분포하지 않는 반면 새로운 성상도는 3차원 신호공간에서 완전 대칭인 신호점 분포를 가진다. 이와 함께 기존의 성상도에 비하여 제안된 성상도에서는 설계에 요구되는 연산복잡도가 거의 없는 장점도 있다. 따라서 제안된 3차원 16진 신호성상도는 편광편이키잉과 같이 상진폭 특성이 요구되는 디지털 통신시스템에 적합한 것으로 판단된다.

• 대한한방부인과학회지
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• 제19권2호
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• pp.240-260
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• 2006

Purpose : The objective of this study is to serve guidelines for the investigation and management of uterine myomas with KM therapies. Methods : English-language articles from PubMed and Korean-language articles from the database of the journal of oriental gynecology were reviewed from 2000 to 2005, using the key words 'uterine myoma', 'uterine leiomyoma', 'fibroid', 'uterine artery embolization', 'endometrial ablation', 'myomectomy', and jagungguenjong(子宮筋腫)'. Results and Limits : The areas of clinical practices considered in formulating this guideline are assessment, KM therapies, medical treatments, myolysis, selective artery occlusion, endometrial ablation and surgical therapies including myomectomy and hysterectomy. Implementation of this guideline would optimize the decision-making process of women with uterine myomas and further investigation or therapy of their KM doctors. But we don't have abundant evidences of clinical trials of uterine myoma treated with KM therapy, though we treat or manage that with every-day clinical practices. Moreover cultural gaps between Korea and other western countries make many differences in the attitude to surgical therapies, especially hysterectomy. So it is very difficult to compare W therapies with other therapies. Moreover it is much difficult to estimate cost-effectiveness and benefit of those therapies in QOL. Conclusions : The majority of uterine myoma is asymptomatic and will not require any intervention or further investigation. But unmarried women who wish to marry and get pregnant want to find safe therapy for their asymptomatic uterine myomas. In that case, most of the patients prefer non-surgical therapy to surgical therapy. So KM herbal medicinal therapy is a good alternative method for those patients. For the symptomatic myomas, hysterectomy offers a definitive solution. However, it is not the best solution for women who wish to preserve their uterus. So KM therapy is a good alternative for them. But the predicted benefits of alternative therapies including KM therapy must be carefully weighed against the Possible risks of these therapies. To improve the quality of life of both women with asymptomatic and symptomatic myomas, selecting and treating patients should be done carefully. Moreover, the effect of KM therapy has to evaluated, comparing the possible situation without treatment and the benefit of constant treatment as a health-care system.

• 대한화장품학회지
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• 제39권2호
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• pp.141-148
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• 2013

자외선 노출 증가로 인한 자외선의 유해성을 방지하기 위해 자외선차단제의 사용이 보편화되었다. 이러한 추세에 맞게 화장품 업계에서는 서로 다른 성분을 혼합하거나 천연물에서 유효성분을 추출하는 연구를 활발하게 진행하고 있다. 본 연구에서는 황금에서 추출한 천연성분인 황금추출물을 함유하는 자외선차단제품의 자외선 차단효과를 확인해보고자 하였다. 총 10명의 지원자를 대상으로 각 제품의 최소홍반량을 측정하였고 자외선차단지수를 구하였다. 그 결과 황금추출물을 함유하는 자외선차단제품과 함유하지 않는 자외선차단제품의 자외선차단지수는 각각 $34.52{\pm}2.13$, $32.67{\pm}1.44$였다. 두 제품 간의 자외선차단지수 차이는 통계적으로 유의하지는 않았지만, 인체를 대상으로 천연물 자외선차단제의 임상적 효과를 평가하였고 제품도포로 인한 이상반응이 없었다는 점에서 의미 있는 시도였다고 생각된다.

• 한국육종학회지
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• 제41권4호
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• pp.645-648
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• 2009

"드래찬" 품종은 국립식량과학원 벼맥류부에서 2008년도에 육성한 중만생 양질 내병성 품종으로 주요특성과 수량성을 요약하면 다음과 같다. 1. 출수기는 보통기 보비재배에서 8월 17일로 한마음보다 2일 늦은 중만생종이다. 2. 쌀은 복백이 약간 있으나 아밀로스 함량이 낮고 밥맛이 좋은 편이다. 3. 도열병, 흰잎마름병 레이스K1-3 및 줄무늬잎마름병에는 저항성 반응을 보였으나 멸구 및 매미충류에는 약한 반응을 보였다. 4. 유묘 내냉성은 한마음과 비슷하나 임실율은 약간 낮다. 5. 쌀수량은 보통기 다비재배에서 6.52 MT/ha로 한마음보다 2% 증수되었다. 6. "드래찬"은 중부이남 평야지 1모작지에 알맞은 품종이다.

• 한국육종학회지
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• 제40권3호
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• pp.314-317
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• 2008

"다미" 품종은 작물과학원 호남농업연구소에서 2006년도에 육성한 중만생 고품질 내병성 품종으로 주요특성과 수량성을 요약하면 다음과 같다. 1. 출수기는 보통기 보비재배에서 8월 15일로 남평벼와 같은 중만생종이다. 2. 쌀은 심백이 약간 있으나 단백질 함량이 낮고 밥맛이 매우 좋은 편이다. 3. 도열병, 흰잎마름병 레이스$K_{1-3}$에는 저항성 반응을 보였으나 줄무늬잎마름병 멸구 및 매미충류에는 약한 반응을 보였다. 4. 유묘내냉성은 남평벼와 비슷하나 임실율은 약간 낮다. 5. 쌀수량은 보통기 보비재배에서 5.92 MT/ha로 남평벼보다 9% 증수되었으나 이모작재배에서는 4.91 MT/ha로 남평보다 9% 적었고, 만식재배에서는 5.48 MT/ha로 남평벼 보다 5% 증수되었다. 6. 다미는 충남이남 평야지 1모작 답에 알맞은 품종이다.