• Journal of Periodontal and Implant Science
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• v.44 no.1
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• pp.25-32
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• 2014

Purpose: Periodontitis is an infectious disease caused predominantly by gram-negative anerobes. The host inflammatory response to these bacteria causes alveolar bone loss that is characterized as periodontitis. Omega-3 fatty acids (${\omega}$-3 FAs) have anti-inflammatory properties, thus have been used to treat some chronic inflammatory diseases such as cardiovascular disease and rheumatoid arthritis. We aimed to evaluate the effect of dietary supplementation with ${\omega}$-3 FAs as a host modulating agent in patients with chronic periodontitis. Methods: Sixty otherwise healthy subjects with moderate and severe chronic periodontitis were enrolled in our randomised, double-blind, placebo-controlled trial. The control group (CG, n=30) was treated with scaling and root planing (SRP) and given a placebo; the treatment group (TG, n=30) was treated with SRP and dietary supplementation of ${\omega}$-3 FAs (one 300 mg tablet daily for 12 weeks). Periodontal clinical parameters and serum C-reactive protein (CRP) levels were evaluated in all patients at baseline, a 6-week and 12-week period after treatment. Results: A significant reduction in the gingival index, sulcus bleeding index, pocket depth, and clinical attachment level was found in the TG compared to the CG at a 12-week period. However, no statistically significant changes in serum CRP levels were found. Conclusions: Our findings suggest that ${\omega}$-3 FAs can successfully reduce gingival inflammation, pocket depth, and attachment level gain. Dietary supplementation with ${\omega}$-3 FAs may have potential benefits as a host modulatory agent in the prevention and/or C management of chronic periodontitis.

• Journal of Gastric Cancer
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• v.2 no.3
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• pp.163-167
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• 2002

Purpose: Interleukin 1$\beta$ (IL-1$\beta$) polymorphisms are associated with hypochlorhydria, atrophic gastritis, and increased risk of gastric cancer in Caucasians. We tried to determine whether the IL-1.. and IL-1 receptor antagonist (IL-1 RN) genetic polymorphisms contribute to the development of gastric cancer and the specific type of gastritis in Korean. Materials and Methods: The study population was comprised of 128 gastric cancer patients with histologically proven carcinoma and 63 normal healthy individuals. Sixty-eight carcinomas were of intestinal-type and sixty tumors were of diffuse-type. No patient had a familial gastric cancer history. The 511 bp and 31 bp polymorphisms in the IL-1.. were genotyped by polymerase chain reaction (PCR)-restriction fragment length polymorphism. The polymorphism of the IL-1 RN was analyzed with variable number tandem repeat after PCR. Results: The genotype of 511C/-31T of IL-1$\beta$ and allele 1 of IL-1 RN was dominant in the present subjects. The allelic frequencies of the C allele IL-1$\beta$, which is a high risk genotype for gastric cancer, were 0.551 and 0.429 in gastric cancer and normal controls, respectively. Statistically, significant difference in allelic frequencies of three polymorphic sites between gastric cancer patients and normal controls, and between intestinal-type and diffuse-type was not observed. Conclusions: These results suggest that the polymorphisms of IL-1$\beta$ and IL-1 RN may not contribute to the development of Korean gastric caner and that other endogenous or exogenous factors will be important for gastric carcinogenesis.

• Advances in aircraft and spacecraft science
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• v.7 no.5
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• pp.405-423
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• 2020

Non-linear energy sink (NES) is an emerging passive absorber able to mitigate the dynamic response of structures without any external energy supply, resonating with all the modes of the primary structure to control. However, its inherent non-linearities hinder its large-scale use and leads to complicated design procedures. For this purpose, an approximate design approach is herein proposed in a stochastic framework. Since loads are random in nature, the stochastic analysis of non-linear systems may be performed by means of computational intensive techniques such as Monte Carlo simulations (MCS). Alternatively, the Stochastic Linearisation (SL) technique has proven to be an effective tool to investigate the performance of different passive control systems under random loads. Since controlled systems are generally non-classically damped and most of SL algorithms operate recursively, the computational burden required is still large for those problems that make intensive use of SL technique, as optimal design procedures. Herein, a procedure to speed up the Stochastic Linearisation technique is proposed by avoiding or strongly reducing numerical evaluations of response statistics. The ability of the proposed procedure to effectively reduce the computational effort and to reliably design the NES is showed through an application on a well-known case study related to the vibrations mitigation of an aircraft wing.

• Journal of Periodontal and Implant Science
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• v.43 no.1
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• pp.37-40
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• 2013

Purpose: The purpose of study was to compare blood glucose in capillary finger-prick blood and gingival crevice blood using a self-monitoring blood glucose device among patients with gingivitis or periodontitis. Methods: Thirty patients with gingivitis or periodontitis and bleeding on probing (BOP) were chosen. The following clinical periodontal parameters were noted: probing depth, BOP, gingival bleeding index, and periodontal disease index. Blood samples were collected from gingival crevicular blood (GCB) and capillary finger-prick blood (CFB). These samples were analyzed using a glucose self-monitoring device. Results: Descriptive statistical analysis has been carried out in the present study. Data were analyzed using a Pearson's correlation coefficient and Student's t-test. A r-value of 0.97 shows very strong correlation between CFB and GCB, which was statistically highly significant (P<0.0001). Conclusions: The authors conclude that GCB may serve as potential source of screening blood glucose during routine periodontal examination in populations with an unknown history of diabetes mellitus.

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2001.05a
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• pp.142-142
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• 2001

A national survey for enteric virus contamination in treated water and its source water was performed from March to November 1999. The water samples were subjected to virus filtration at the major water plants producing over 10$^5$ tons treated water per day. Twenty surveyed sites encompass most of heavily populated residential area except for Seoul and Pusan. (omitted)

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2003.10a
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• pp.11-11
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• 2003

Peroxisome proliferator-activated receptor (PPAR) is nuclear hormone receptors that can be activated by a variety of compounds. Two PPAR gamma isoforms are expressed at the protein level in mouse, gamma 1 and gamma 2. And PPAR gamma is intimately associated with cell differentiation and proliferation[1]. So aim of this study, investigated where express PPAR gamma in mouse gastric cancer tissues, including human gastric cancer cell lines and expression pattern of PPAR gamma. (omitted)

• Proceedings of the KIPE Conference
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• 2019.07a
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• pp.352-353
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• 2019

자기유도 무선전력 전송 (Inductive Power Transfer, IPT) 시스템에서 송 수신패드의 결합계수 k는 송신패드와 수신패드의 이격거리에 따라 가변된다. 송 수신패드의 결합계수에 따라 IPT 컨버터의 동작특성이 바뀌기 때문에, 일반적인 스위칭 주파수 제어 방법으로는 IPT 컨버터의 정상 동작 영역이 제한된다. 본 논문에서는 송 수신패드의 결합계수 계수에 따라 풀브릿지 구조의 IPT 컨버터 1차 측을 풀브릿지 또는 하프브릿지로 제어하여 동작 가능한 결합계수 범위를 확장할 수 있는 제어 방법을 제안하고, LCCL-S 구조의 IPT 컨버터에 적용하여 실험을 통하여 제어 방법의 타당성을 검증한다.

• Proceedings of the Membrane Society of Korea Conference
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• 2004.11a
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• pp.294-297
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• 2004

• Advances in aircraft and spacecraft science
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• v.3 no.2
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• pp.211-224
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• 2016

The present study aims to investigate the shimmy stability behavior of a single wheeled nose landing gear system. The system is supposed to be equipped with an electromechanical actuator capable to control the shimmy vibrations. A Proportional-Integrative-Derivative (PID) controller, tuned by using the Particle Swarm Optimization (PSO) procedure, is here proposed to actively damp the shimmy vibration. Time-history results for some test cases are reported and commented. Stochastic analysis is last presented to assess the robustness of the control system.

• Journal of Periodontal and Implant Science
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• v.43 no.2
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• pp.79-86
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• 2013

Purpose: The purpose of study was to compare glycemic control using glycated hemoglobin levels ($HbA_{1c}$) in diabetic patients with chronic generalized periodontitis (CGP) undergoing scaling and root planing (SRP) with and without systemic doxycycline. Methods: Fifty subjects with type 2 diabetes mellitus ($T_2DM$) and CGP receiving antidiabetic therapy were selected for study. The selected subjects were randomly assigned to two groups (test group [TG] and control group [CG]) comprising 25 patients each. The TG received SRP followed by systemic doxycycline. The CG received treatment with SRP only. The periodontal parameters were recorded at baseline (day zero), and every 1 month for 4 months and included probing depth, clinical attachment level, plaque index, gingival index, and $HbA_{1c}$ level were recorded at baseline (day zero) and at the end of 4 months. Results: A statistically significant effect was demonstrated for the periodontal parameters for both the TG and CG. $HbA_{1c}$ values did not show a statistically significant difference in the treatment group as compared to the CG. Conclusions: The authors concluded that nonsurgical periodontal therapy improved glycemic control in patients with $T_2DM$ in both groups, but no statistical difference was observed with adjunctive systemic doxycycline therapy. A further study with a larger sample size is required.