• Title/Summary/Keyword: Koordersiodendron pinnatum Merr.

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A New Cytotoxic Compound from Methanol Extract of Koordersiodendron pinnatum Merr. Leaves

  • Fajriah, Sofa;Megawati, Megawati;Darmawan, Akhmad;Lotulung, Puspa Dewi N.;Salahuddin, Salahuddin;Hanafi, Muhammad
    • Natural Product Sciences
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    • v.26 no.4
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    • pp.279-282
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    • 2020
  • Chemical investigation of the methanol extract of Koordersiodendron pinnatum Merr. leaves resulted a new naphthalene derivative, (Z)-4-(tetradec-3-enyl)naphthalene-1,2,7-triol (1), together with three known compounds, ��-sitosterol (2), 20-epibryonolic acid (3), and scopoletin (4). The structure of the new compound was elucidated based on spectroscopic evidence. The isolated compounds (1-4) were tested their cytotoxic activities against the P-388 murine leukemia cell line and compound 1 has highest activity with IC50 1.94 μM.