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http://dx.doi.org/10.20307/nps.2020.26.4.279

A New Cytotoxic Compound from Methanol Extract of Koordersiodendron pinnatum Merr. Leaves  

Fajriah, Sofa (Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK)
Megawati, Megawati (Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK)
Darmawan, Akhmad (Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK)
Lotulung, Puspa Dewi N. (Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK)
Salahuddin, Salahuddin (Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK)
Hanafi, Muhammad (Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK)
Publication Information
Natural Product Sciences / v.26, no.4, 2020 , pp. 279-282 More about this Journal
Abstract
Chemical investigation of the methanol extract of Koordersiodendron pinnatum Merr. leaves resulted a new naphthalene derivative, (Z)-4-(tetradec-3-enyl)naphthalene-1,2,7-triol (1), together with three known compounds, ��-sitosterol (2), 20-epibryonolic acid (3), and scopoletin (4). The structure of the new compound was elucidated based on spectroscopic evidence. The isolated compounds (1-4) were tested their cytotoxic activities against the P-388 murine leukemia cell line and compound 1 has highest activity with IC50 1.94 μM.
Keywords
Naphthalene derivative; Koordersiodendron pinnatum Merr.; cytotoxic activities; P-388 murine leukemia cell lines;
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