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Development of a Cosmetic Ingredient Containing DHA Derivatives for Anti-inflammation, Anti-wrinkle, and Improvement of Skin Barrier Function (DHA 유도체를 이용한 항염, 항노화, 피부장벽 강화용 화장품 원료의 개발)

  • Lee, Miyoung;Lee, Gil-Yong;Suh, Jinyoung;Lee, Kyung min;Lee, Woojung;Cho, Hee Won;Yi, Jong-Jae;Seo, Jeong-Woo;Choi, Heonsik
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.47 no.1
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    • pp.65-73
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    • 2021
  • It is very important to control the inflammation of the skin because it can develop into diseases such as atopy as well as scarring and aging. In this work, we recently identified the in vitro synthesis of specialized pro-resolving mediators (SPMs) known to control inflammation in the human body and the applicability of cosmetics. Using recombinant protein of lipoxygenase from Glycine max, we succeeded to prepare mixtures of mono- or di-hydroxy DHA named as S-SPMs and used them for in vitro efficacy test. To investigate anti-inflammatory effect of S-SPMs, mRNA level of TNF-α and IL-6 were analyzed. Under UVB exposed condition, expression of both were decreased by S-SPMs treatment. And we observed reduced production of nitric oxide (NO) by S-SPMs application under the condition with diesel particulate matter (DPM). At the same experimental condition, malondialdehyde (MDA) production was decreased by S-SPMs, indicating the inhibitory effect of S-SPMs in lipid peroxidation. In addition, S-SPMs treatment resulted in reduction of matrix metalloproteinases-1 (MMP-1) expression and elevation of procollagen type I synthesis. Together with this, mRNA level of filaggrin and loricrin were increased by S-SPMs, indicating enhancement of skin barrier function. These results demonstrate that S-SPMs is a good candidate to develop as a cosmetic ingredient for anti-inflammation, anti-wrinkle, and improvement of skin barrier function.

A Case Study on the Self-Supported Earth Retaining Wall with Different Formations (다양한 형태의 2열 자립식 흙막이 공법 시공사례 연구)

  • Sim, Jae-Uk;Kim, Kyoung-Chul;Son, Sung-Gon;Park, Young-Jin;Im, Jong-Chul
    • Proceedings of the Korean Geotechical Society Conference
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    • 2010.09a
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    • pp.1039-1049
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    • 2010
  • Excavation support systems are the temporary earth retaining structures that can prevent the lateral movement of soils. The systems are initially performed before other construction operations and have a great impact on the entire construction period. The temporary support system in Korea have been carried out generally along with installing supports, which are struts, tiebacks, and rakers. However, most of existing support systems in application relatively have limitations such as cost increase, construction configuration, and displacement occurred with support systems. Thus, a new retaining support system (referred to as the SSR, New Construction Technology No. 533) was developed to solve the aforementioned problems. This study introduces the design, construction, and maintenance of the SSR system under the different construction conditions. The behavior and characteristics of the SSR system were identified based on the case studies.

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A Study on Overbreak Control Methods by Evaluating Drilling Conditions in Tunnel Blasting (터널발파시 천공상태 평가를 통한 여굴 저감방안 연구)

  • Kim, Yang-Kyun;Kim, In-Ho;Yoo, Joung-Hoon;Kim, Seong-Min
    • Proceedings of the Korean Geotechical Society Conference
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    • 2005.10a
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    • pp.198-209
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    • 2005
  • Overbreak or underbreak is one of the most important factors in evaluation the results of a tunnel blasting. Overbreak, which depends on the quality of rock, the type and quantity of explosives, and the method and condition of drilling, has been a target of challenge to many blasting engineers as it is connected with economic directly. Drilling is generally known as a primary one of overbreak producing factors. So, This study presented the practical solution to reduce overbreak, which was caused by drilling, through the analyses of how to make a drilling process accurate and how to evaluate the effect of each drilling method. Thus, this solution would give a quantitative analysis of overbreak and provide the information of how to reduce the quantity of overbreak. Moreover, for verifying this solution, we applied it to a tunnel project and then have found out that the quantity of overbreak decreased to approximately 10-40% compared with the previous way of overbreak control.

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A Study on the Power Performance Measurement of Transparent Thin-film PV Windows of BIPV Depending on the Inclined Angle (건물일체형 투명 PV복층창의 설치조건에 따른 단위출력당 발전특성 분석연구)

  • An, Young-Sub;Song, Jong-Hwa;Kim, Seok-Ge;Lee, Sung-Jin;Yoon, Jong-Ho
    • 한국태양에너지학회:학술대회논문집
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    • 2008.04a
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    • pp.55-60
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    • 2008
  • This study is on the analysis of power output of transparent thin-film PV windows which are integrated into the building envelope instead of traditional windows. 3 installation angles of vertical, horizontal and $30^{\circ}C$ inclination are investigated. To measure power output of PV windows, full scale mock-up house was designed and constructed. The power performance of PV window system was analyzed for horizontal angle, declination angle and vertical angle according to incline angle. Monitoring data are gathered from November 2006 to August 2007 and statistical analysis is performed to analysis a characteristics of power performance of transparent PV windows. Results show that annual power output of PV window with horizontal angle is 844.4kWh/kWp/year, declination angle 1,060kWh/kWp/year and vertical angle 431.6 kWh/kWp/year.

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A Study on the Rapid Construction Method for Ground Excavation (지반굴착을 위한 급속시공 방안 연구)

  • Sim, Jae-Uk;Son, Sung-Gon;An, Hyung-Jun;Kim, In-Ho
    • Proceedings of the Korean Geotechical Society Conference
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    • 2008.10a
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    • pp.1251-1258
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    • 2008
  • The purpose of this research is to introduce the new temporary earth retaining wall system using landslide stabilizing piles. This system is a self-supported retaining wall(SSR) without installing supports such as tiebacks, struts and rakers. The SSR is a kind of gravity structures consisting of twin parallel lines of piles driven below dredge level, tied together at head of soldier piles and landslide stabilizing piles by beams. There are three types of excavation wall structures: standard method for medium retained heights(<8.0m), internal excavation method and slope excavation method for deep-excavation applications(>8.0m). In the present study, the measured data from seven different sites which the SSR was used for excavation were collected and analyzed to investigate the characteristic behavior lateral wall movements associated with urban excavations in Korea.

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