• 대한한방내과학회지
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• 제39권3호
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• pp.372-388
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• 2018

Objective: This study evaluates the effectiveness and safety of moxibustion for benign prostatic hyperplasia (BPH). Methods: Using the keywords "benign prostatic hyperplasia", "benign prostatic hypertrophy", "benign prostatic enlargement", "prostatic hyperplasia", and "moxibustion", we searched papers in numerous databases, including National Discovery for Science Leaders (NDSL), Korean Traditional Knowledge Portal (KTKP), Oriental Medicine Advanced Searching Integrated System (OASIS), Research Information Sharing Service (RISS), PubMed, Embase, and CENTRAL. The search range included randomized controlled trials (RCTs). Papers not matched with inclusion criteria were excluded. The methodological quality of each RCT was assessed using the Cochrane risk-of-bias tool. Where appropriate, meta-analyses were performed. Results: Initially, 77 studies were found. Of these, 11 duplicate studies were removed and 27 were excluded following title and abstract screening. After the remaining 39 papers were scanned, 13 RCTs were selected and analyzed. Among these 13 RCTs, five compared moxibustion therapy and oral medication, seven compared moxibustion plus acupuncture therapy and oral medication, and one compared moxibustion plus acupuncture therapy and sham-moxibustion. The meta-analysis showed positive results for the use of moxibustion therapy in terms of International Prostate Symptom Score (IPSS), Quality Of Life (QOL), Maximum Flow Rate (Qmax), Prostate Volume (PV), and the efficacy rate. The meta-analysis showed positive results for the use of moxibustion plus acupuncture therapy in terms of IPSS, QOL, and the efficacy rate. Conclusions: This meta-analysis of clinical trials suggests that moxibustion is effective intreating BPH patients. The results of this study could be applied to clinical treatment of BPH. However, additional large-scale clinical researches should be conducted.

• 식물병연구
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• 제21권1호
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• pp.36-39
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• 2015

2012년과 2013년 6월 하순 강원도 횡성과 평창의 곰취(Ligularia fischeri) 재배포장에서 포기가 서서히 시들어 말라 죽는 이상 증상이 발생하였다. 발병정도는 30-80%로 병든 식물체를 조사한 결과, 줄기가 수침상으로 물러지고 썩으면서 흰색의 곰팡이와 갈색의 작고 둥근 균핵이 관찰되었다. 병원균을 순수 분리하여 병원균의 균학적 특징을 조사한 결과, 감자한천배지에서 균총은 흰색으로 잘 자라며 갈색의 작고 둥근 균핵을 많이 형성하였다. 균핵의 크기는 1-3 mm이며, 균사의 폭은 $4-10{\mu}m$였다. 균사생육과 균핵 형성 적온은 $25-30^{\circ}C$이었으며, 균사특유의 clamp connection이 관찰되었다. 또한, 병원균의 염기서열 분석결과 695 bp로 Sclerotium rolfsii와 같은 계통군으로 확인되었으며, 99% 이상의 상동성을 보였다. 이와 같이 곰취에 발생한 병징, 병원균의 균학적 특징 및 염기서열 분석 등을 종합한 결과 S. rolfsii Saccardo로 동정되어 곰취 흰비단병으로 명명하고자 한다.

• 인터넷정보학회논문지
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• 제13권3호
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• pp.115-126
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• 2012

최근에 매쉬업은 미래 IT 융합 서비스의 효과적인 구현 방법으로써 그 관심도가 점점 높아지고 있으며 그들의 활용도 매우 다양하다. 그렇지만 이러한 높은 관심에도 불구하고 Open API들을 매쉬업 속으로 결합할 때 여러 가지 이슈들이 있을 수 있다. 첫째, 포털사이트들은 매쉬업에서 사용 가능한 수많은 API들을 제공하고 있는데, 이들에 대한 적합한 API들을 수동으로 탐색하고 발견하는 것은 매우 힘들고 많은 시간이 소비되는 작업이다. 둘째, 현존하는 어떠한 매쉬업 포털 사이트들도 전통적인 SOAP 기반 웹 서비스 분야에서 보였던 것처럼 API들을 찾고 통합하는데 시맨틱 기법을 활용하는 사이트는 없다. 세째, 적합한 API들을 발견하였더라도 특별한 기술적 훈련 없이 값어치 있는 매쉬업을 생성하기란 현실적으로 어려운 일이다. 본 논문에서는 위와 같은 이슈들을 해결하기 위해 먼저 기존의 SOAP 기반 웹 서비스 분야에서 사용된 시맨틱 기반 기술 및 알고리즘들을 최소의 수정만으로 재사용할 수 있음을 보인다. 다음으로, 조합 가능한 API들을 발견하기 위해 어떻게 API 특성들이 신택틱하게 정의되고 시맨틱하게 묘사될 수 있는지 보인다. 그러고 이러한 신택틱/시맨틱 정보들이 어떻게 Open API들의 발견과 조합에 도움을 줄 수 있는지 보인다. 마지막으로, 동적 Open API 조합을 위한 대화형 목표 지향 접근 방법을 제안한다. 여기서 최종 매쉬업은 API들의 순차적 접근 방법에 의해 점차적으로 각 단계에서 하나씩 새로운 API가 조합에 첨가된다.

• 한국콘텐츠학회논문지
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• 제4권4호
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• pp.45-51
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• 2004

현재의 교육 소프트웨어가 기존의 전통적인 하이퍼미디어 기법이나 계층적 기법에 의존하고 있기 때문에, 컴퓨터 기술의 발전에도 불구하고 교육 소프트웨어 개발 수는 점점 감소하고 있다. 따라서, 기존 방식들의 장점을 살리면서 그 한계를 극복하기 위해서는 기존 방식들의 하이브리드형인 구조화된 하이퍼미디어 링크기법이 최근 문헌들에서 제안되고 있다. 이 기법은 기존 기법들과 비교하여 학습자의 성취도와 학습 능력에 따른 다양한 수준의 개별화 학습이 가능하기 때문에 교육적 효과가 높은 것으로 나타나고 있다. 임상미생물 검사실에서 수행하는 그람 염색(Gram-stain) 검사와 같은 세균 성상에 관한 교육은 체계적인 방법에 의존하는 것이 아니라 기존의 병리사가 업무수행 과정 중 간헐적으로 신규 병리사에게 자신이 교육에 적당하다고 판단되는 현미경시야를 보여주는 방식으로 행해져 왔으며 이 때문에 신규 병리사의 교육에 상당한 기간이 필요했다. 본 연구에서는 학습 화면간의 의미론적 연관성에 따라 링크의 존재여부가 결정되는 논리적으로 구조화된 기법을 사용하여 임상미생물 검사실에서 보다 객관적이고 체계적인 데이터를 기반으로 많은 병리사들이 그람 염색검사에 관해 학습하고 신규 병리사들을 교육할 수 있도록 Web환경에서 멀티미디어 저작도구를 사용한 임상미생물 화상CAI 시스템을 구현하였다. 구현된 CAI 프로그램은 그람 염색 검사를 기반으로 하여 다른 여러 검사 방법에도 적용함으로써 임상 병리사들에게 유용한 프로그램으로 자리잡게 될 것이다.

• 한국항해학회지
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• 제17권4호
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• pp.1-21
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• 1993

The purpose of this paper is to search for reasonable and fair principles applicable to the delimitation of the Exclusive Economic Zone(which is called the EEZ, hereinafter) around the Korean Peninsula th-rought the comprehensive study of maritime boundary, which is one of the most important issues in the law of the Sea. So far, the sea has been exploited for activities such as fishery, transport and military stratedy, and en-vironmental policy and so on. From this time on, however, it becomes important to us as the major trea-sure-house of various resources which will be developed and used for diversified purposes. For these rea-sons, nowadays, more and more countries of the world are competing to secure waters as much as possible within their jurisdiction. And the regime of the EEZ was created as a result of this international trend. At last, it has been institutionalized as the 200-mile EEZ of a legal notion in the Convention on the Law of the Sea, which was adopted at the Third United Nations Conference on the Law of the Sea, in Jamaica on December 10, 1982. In adapting to this EEZ institution, Korea is faced with several complicated problems as it is bounded on three sides by the sea and all of its neighboring countries such as the PRC, the DPRK, Japan, Russia etc are less than 400 miles away between opposite countries. Therefore, when trying to delimit the boun-dary for the EEZ, it appears necessary to analyze applicable principles and rules of international law for delimitation mainly through the Convention on the Law of the Sea, and studies the trends of actual State practices and recent international precedents. It is hoped that such knowledge will enable Korea to secure sufficient resources and other sovereign rights without conflicting with the neighboring countries concer-ned. For the achievement of the above mentioned object. I analyzed the necessities of the establishment of the EEZ in Korea, the difficulties and practices of Korea's neighbors, and the changes and forthcoming trends in Korea's relations with its neighbors concerned on the basis of the general explanation of the EEZ regime. In conclusion, it is my opinion that for the establishment of the EEZ delimitation which neighbors around the Korean Peninsula should be applied reasonable and equitable principles considering the rele-vant circumstances which characterize the area definitely as well as the UN Convention on the Law of the Sea, 1982.

• 영어어문교육
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• 제5호
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• pp.49-62
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• 1999

Education systems throughout the world encourage their students to learn languages other than their native one. In Australia, our Education Boards provide students with the opportunity to learn European and Asian languages. French, German, Chinese and Japanese are the most popular languages studied in elementary and high schools. This choice is a reflection of Australias European heritage and its geographical position near Asia. In most non-English speaking countries, English is the foreign language most readily available to students. In Korea, the English language is actively promoted by the Education Department and, in less official ways, by companies and the public. It is impossible to be anywhere in Korea without seeing the English language alongside or intermingled with Korean. When I ask students why they are learning English, I receive answers that include the word globalization and the importance of English throughout the world. When I press further and ask why they personally are learning English, the students mention passing exams, usually high school tests or TOEIC, and the necessity of passing the latter to obtain a good job. Seldom do I ever hear anything about communication: about the desire to talk with other people in English, to read novels or poetry in English, to understand movies or pop-songs in English, to chat on the Internet in English, to search for information on the Internet in English, or to email pen-pals in English. Yet isnt communication the only valid reason for learning a language? We learn our native language to communicate with those around us. Shouldnt we set the same goal for learning a foreign language? In my opinion communication, whether it is reading and writing or speaking and listening, must be central to language learning. Learning a language to pass examinations is meaningless unless those examinations are a reliable indicator of the ability of the student to communicate. In previous eras, most communication in a foreign language was through reading novels or formal letters. This required a thorough knowledge of grammar and a large vocabulary. Todays communication is much less formal. Telephone conversations, tele-conferences, faxes and emails allow people to communicate regularly and informally. Reading materials are also less formal as popular novels and newspapers are available world-wide. Movies and popular songs have added to the range of informal communication available. Finally travel has ensured that people from different cultures will meet easily and regularly. This informal communication requires less emphasis on grammar and vocabulary and more emphasis on comprehension and confidence to speak. Placing communication central to language learning has important implications for the Education system and for teachers.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4597-4601
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• 2015

Background: Macrophage migration inhibitory factor (MIF) -173G/C (rs755622) gene polymorphism has been associated with cancer risk. Previous studies have revealed that MIF -173G/C gene polymorphism may increase cancer in the Chinese population, while results of individual published studies remain inconsistent and inconclusive.We performed this meta-analysis to derive a more precise estimation of the relationship. Materials and Methods: We conducted a search on PubMed, Embase, MEDLINE, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Wanfang, Weipu on Dec 31, 2014.Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the association. A total of eight studies including 2,186 cases and 2,285 controls were involved in this meta-analysis. Results: The pooled results indicated the significant association between MIF -173G/C polymorphism and the risk of cancer for Chinese population (CC + CG vs GG: OR=1.14, 95%CI=1.02-127, pheterogeneity<0.01; P=0.023; CC vs CG+GG: OR=1.12, 95%CI=1.02-1.23, pheterogeneity<001; P=0.017;CC vs GG: OR=1.18, 95%CI=1.04-1.33, pheterogeneity<001; P=0.008; CG vs GG:OR=1.03, 95%CI=0.91-1.15, pheterogeneity<001; P=0.656; C vs G:OR=1.24, 95%CI=1.14-1.25, pheterogeneity<001; P<001). Subgroup analysis showed that in patients with "solid tumors", heterogeneity was very large (OR=0.94,95%CI=0.83-1.06,pheterogeneity=0.044; p=0.297). Within "non-solid tumors", the association became even stronger (OR=6.62, 95 % CI=4.32-10.14, pheterogeneity<0.001; p<0.001). Conclusions: This study suggested that MIF -173G/C gene polymorphism may increase increase cancer in the Chinese population.Furthermore, more larger sample and representative population-based casees and well-matched controls are needed to validate our results.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.515-521
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• 2013

Purpose: To evaluate the efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy (the treatment group) versus concurrent chemoradiotherapy with or without adjuvant chemotherapy (the control group) for locoregionally advanced nasopharyngeal carcinoma. Methods: The search strategy included Pubmed, Embase, the Cochrane Library, China National Knowledge Internet Web, Chinese Biomedical Database and Wanfang Database. We also searched reference lists of articles and the volumes of abstracts of scientific meetings. All randomized controlled trials were included for a meta-analysis performed with RevMan 5.1.0. The Grading of Recommendations Assessment, Development, and Evaluation system (GRADE) was used to rate the level of evidence. Results: Eleven studies were included. Risk ratios of 0.99 (95%CI 0.72-1.36), 0.37 (95%CI 0.20-0.69), 1.08 (95%CI 0.84-1.38), 0.98 (95%CI 0.75-1.27) were observed for 3 years overall survival, 3 years progression-free survival, 2 years loco-regional failure-free survival and 2 years distant metastasis failure-free survival. There were no treatment-related deaths in either group in the 11 studies. Risk ratios of 1.90 (95%CI 1.24-2.92), 2.67 (95%CI 0.64-11.1), 1.04 (95%CI 0.79-1.37), 0.98 (95%CI 0.27-3.52) were found for grade 3-4 leukopenia, grade 3-4 thrombocytopenia, grade 3-4 mucous membrane, and grade 3-4 hepatic hematologic and gastrointestinal toxicity, the most significant toxicities for patients. Conclusion: Compared with the control group, induction chemotherapy followed by concurrent chemoradiotherapy was well tolerated but could not significantly improve prognosis in terms of overall survival, loco-regional failure-free survival or distant metastasis failure-free survival.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.3945-3951
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• 2016

Background: Whether concurrent chemotherapy treatment is superior to radiotherapy alone as an adjuvant regimen for postoperative cervical carcinoma with risk factors remains controversial. Materials and Methods: A literature search strategy examined Pubmed, Embase, the Cochrane Library, the China National Knowledge Internet Web, the Chinese Biomedical Database and the Wanfang Database. Article reference lists and scientific meeting abstracts were also screened. Controlled trials comparing concurrent chemoradiotherapy versus radiotherapy alone in postoperative cervical cancer were included. The methodological quality of non-randomized controlled trials was evaluated using the Newcastle-Ottawa Scale. Randomized controlled studies were evaluated with the Cochrane handbook. A meta-analysis was performed with RevMan 5.3. Results: A total of 1,073 patients from 11 clinical trials were analysed, with 582 patients in the concurrent chemoradiotherapy group and 491 patients in the radiotherapy group. Hazard ratios (HR) of 0.47 (95% CI 0.31-0.72) and 0.50 (95% CI 0.35-0.72) were observed for overall survival and progression-free survival, indicating a benefit from the additional use of concurrent chemotherapy. Subgroup analyses demonstrated that cervical cancer with high risk factors significantly benefitted from concurrent chemotherapy when examining overall survival (HR 0.44, 95% CI 0.28-0.67) and progression-free survival (HR 0.48, 95% CI 0.33-0.70), but patients with intermediate risk factors showed no benefit from concurrent chemotherapy in overall survival (HR 1.72, 95% CI 0.28-10.41) and progression-free survival (HR 1.09, 95% CI 0.19-6.14). No significant differences were observed for grade 3-4 anaemia (risk ratio (RR) 3.87, 95% CI 0.69-21.84), grade 3-4 thrombocytopenia (RR 3.04, 95% CI 0.88-10.58), grade 3-4 vomiting or nausea (RR 1.71, 95% CI 0.27-10.96), or grade 3-4 diarrhoea (RR 1.40, 95% CI 0.69-2.83). Significant differences were observed for grade 3-4 neutropenia in favour of the radiotherapy group (RR 7.23, 95% CI 3.94-13.26). Conclusions: In conclusion, concurrent chemoradiotherapy improves survival in postoperative cervical cancer with high risk factors but not in those with intermediate risk factors.

• 기본간호학회지
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• 제15권1호
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• pp.34-44
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• 2008

Purpose: The purpose of this study was to develop an eye care protocol for intensive care unit (ICU) patients. Method: A systematic review was conducted to develop an eye care protocol for ICU patients. Searches were performed using computerized databases (CINAHL, MEDLINE, EBM Review) and citation search from 1996 to January 2007. For the keywords, "eye care", and "randomized controlled trial" were used to identify experimental studies regarding eye care for ICU patients. After reviewing the collected studies, a preliminary eye care protocol algorithm was created. Then, content validity was examined with ophthalmologists and ICU nurses. Results: Six studies were included to serve as a basis for framing of the preliminary algorithm. The final eye care protocol was completed after verifying the preliminary algorithm's content validity. The final eye care protocol was organized in the following manner: 3 items in the assessment stage, 7 items in the no-risk stage, 4 items in the low-risk stage, and 5 items in the high-risk stage. Conclusion: The results indicate that, for ICU patients, nurses can broaden their knowledge regarding ocular diseases, as well as improve their practice-based eye care nursing performance.