• 대한기계학회논문집 C: 기술과 교육
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• 제4권1호
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• pp.27-34
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• 2016

지열 시스템을 대상으로 데이터 마이닝 기반 성능 예측 모델을 구축하였다. 지열 시스템의 실시간 성능 분석과 예측에 필요한 데이터의 기본 조건을 검토한 후, 데이터베이스의 구조를 설계하였다. 먼저 시스템 성능계수(COP)와 전력 소비량을 분석 대상으로 설정한 후, 이들 물리량의 추출 주기(1분 5분 10분 30분 60분 간격)가 예측 결과에 미치는 영향을 분석하였다. 이어서 범주형과 수치형 의사결정나무 모델을 적용하여 시스템의 성능을 예측하였다. 범주형 의사결정나무 모델을 적용했을 때, 10분 주기의 예측 결과의 정확도는 97.7%로 가장 높았다. 또한 수치형 의사결정나무 분석 결과를 통해 COP가 변하는 순간의 임계값을 찾을 수 있었다. 본 논문에서 제안한 방법은 지열 시스템의 실시간 성능 분석과 운전 상태 등에 적용할 수 있을 것으로 판단된다.

• Journal of the Korean Data and Information Science Society
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• 제27권2호
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• pp.353-362
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• 2016

데이터 마이닝은 빅 데이터에 내재되어 있는 새로운 법칙이나 잠재되어 있는 지식을 탐색한 후, 이를 근거로 하여 의사결정에 활용하고자 하는 것이다. 위키 백과사전에 의하면 데이터 마이닝 기법 중의 하나인 연관성 규칙은 연관성 평가 기준에 의해 관심 있는 항목들 간에 관련성을 찾아내는 기법으로 많은 연구자들에 의해 연관성 평가를 위한 흥미도 측도들이 개발되어 왔다. 이들 중에서 헬링거 측도는 여러 가지 흥미도 측도들에 비해 많은 장점이 있으나 연관성의 방향을 판단하기가 곤란한 문제를 내포하고 있다. 이 문제를 해결하기 위해 본 논문에서는 부호를 가지는 헬링거 측도를 제안하고 몇 가지 예제를 통하여 유용성을 고찰하였다. 그 결과, 본 논문에서 제안하는 부호 헬링거 측도는 양의 연관성을 가지는 경우에는 양의 값으로 나타나고 음의 연관성을 가지는 경우에는 음의 값을 갖는 것으로 나타났다. 또한 동시발생빈도, 동시 비 발생빈도, 그리고 불일치 빈도가 증가함에 따라 기본적인 연관성 평가 기준들과 부호 헬링거 측도는 증감 여부가 동일한 것을 알 수 있었다.

• Mass Spectrometry Letters
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• 제8권4호
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• pp.114-118
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• 2017

While saliva can be considered as good biological fluid for monitoring biomarkers due to many advantages including its communication with blood and the non-invasive nature during its sampling, its applications to that purpose is still limited. As a part of efforts to expand the applications of saliva to the protein biomarker research, we carried out global absolute quantitation of proteins in human whole saliva (WS) by bottom-up proteomics techniques mainly based on nLC-Q-IMS-TOF employing $MS^E$. From the analyses of a pooled WS sample collected from 22 healthy Korean volunteers, 93 proteins ranging from $5.89{\times}10^1ng/mL$ (immunoglobulin heavy chain) to $1.59{\times}10^4ng/mL$ (${\alpha}-amylase$ 1) were confirmed. For the validation of the present results, human serum albumin in the same sample was quantitated by ELISA and its result was compared with that from the nLC-Q-IMS-TOF study. As a result, there was no significant difference between two results from individual approaches ($1.18{\times}10^4{\pm}0.03{\times}10^4 ng/mL$ from nLC-Q-IMS-TOF experiments vs. $1.23{\times}10^4{\pm}0.07{\times}10^4ng/mL$ from ELISA experiments, n=3, p=0.309). To our knowledge, this is the first global absolute quantitation of proteins in human whole saliva and information from the present study can be widely used as the first level reference for the discovery of new protein biomarkers from human whole saliva as well as for quantitative applications of human whole saliva proteins.

• 인지과학
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• 제28권4호
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• pp.299-314
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• 2017

In-silico 기반의 약물-표적 단백질 연관관계 예측은 신약 탐색 단계에서 매우 중요하다. 그러나 기존의 예측모델은 입력 값이 고정적이며 표적 단백질의 특질 값이 가공된 데이터로 한정됨으로써 예측 모델의 확장성과 유연성이 부족하다. 본 논문에서는 약물-표적 단백질 연관관계를 예측하는 확장 가능한 형태의 머신러닝 모델을 소개한다. 확장 가능한 머신러닝 모델의 핵심 아이디어는 쌍기반의 뉴럴 네트워크로써, 약물과 단백질의 미가공 데이터를 사용하여 특질을 추출하고 특질 값을 각각의 뉴럴 네트워크 레이어에 입력한다. 이 방법은 추가적인 지식없이 자동적으로 약물과 단백질의 특질을 추출한다. 또한 쌍기반 레이어는 특질 값을 풍부한 저차원의 벡터로 향상 시킴으로써 입력 값의 차이로 인한 편향 학습을 방지한다. PubChem BioAssay(PCBA) 데이터 셋에 기반한 5-폴드 교차 검증법을 통하여 제안한 모델의 성능을 평가했으며, 이전의 모델보다 우월한 성능을 보였다.

• 한국수학사학회지
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• 제2권1호
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• pp.9-27
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• 1985

Islam toot a great interest in the utility sciences such as mathematics and astronomy as it needed them for the religious reasons. It needeed geometry to determine the direction toward Mecca, its holiest place: arithmetic and algebra to settle the dates of the festivals and to calculate the accounts lot the inheritance; astronomy to settle the dates of Ramadan and other festivals. Islam expanded and developed mathematics and sciences which it needed at first for the religious reasons to the benefit of all mankind. This thesis focuses upon the golden age of Islamic culture between 7th to 13th century, the age in which Islam came to possess the spirit of discovery and learning that opened the Islamic Renaissance and provided, in turn, Europeans with the setting for the Renaissance in 14th century. While Europe was still in the midst of the dark age of the feudal society based upon the agricultural economy and its mathematics was barey alive with the efforts of a few scholars in churches, the. Arabs played the important role of bridge between civilizations of the ancient and modern times. In the history of mathematics, the Arabian mathematics formed the orthodox, not collateral, school uniting into one the Indo-Arab and the Greco-Arab mathematics. The Islam scholars made a great contribution toward the development of civilization with their advanced the development of civilization with their advanced knowledge of algebra, arithmetic and trigonometry. the Islam mathematicians demonstrated the value of numerals by using arithmetic in the every day life. They replaced the cumbersome Roman numerals with the convenient Arabic numerals. They used Algebraic methods to solve the geometric problems and vice versa. They proved the correlation between these two branches of mathematics and established the foundation of analytic geometry. This thesis examines the historical background against which Islam united and developed the Indian and Greek mathematics; the reason why the Arabic numerals replaced the Roman numerals in the whole world: and the influence of the Arabic mathematics upon the development of the modern mathematics.

• 대한암한의학회지
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• 제25권1호
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• pp.11-24
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• 2020

Objective : Radiodermatitis is a common sequelae in 95% of patients receiving radiation therapy, which is important to be well managed as it can affect the patient's quality of life as well as the cancer treatment schedule. The aim of this study is to review and summarize the interventions available for the treatment of acute radiodermatitis, including traditional Korean medicine, and to propose treatment algorithms for clinicians. Methods : To collect studies about managements for radiodermatitis, domestic and foreign database were used such as Korean journal of traditional knowledge portal (KTKP), Korean studies information service system (KISS), national discovery or science leaders (NDSL), and oriental medicine advance searching integrated system (OASIS), Pubmed, Google scholar and Scopus. Results : Thirty-two studies were selected. There were nine studies on usual care and dressing, eleven studies on chemical agents, two studies on biological preparations, and ten studies on herbal medicines. Conclusion : Hygienic options and dressings have proved to be useful in the management of radiodermatitis. Chemical agents such as corticosteroid, statin, and topical antibiotic agent have proved to alleviate symptoms and severity, regenerate damaged skin, and prevent secondary infection. In biological preparations, EGF (epidermal growth factor) and GM-CSF (granulocyte-macrophage colony-stimulating factor) could be used to protect skin and prevent radiodermatitis. For herbal medicines, Calendula, catechin, β-sitosterol, and Jaungo (紫雲膏) may be effective for symptoms including pain, itching, and burning sensation induced by radiation therapy. Because of some research with conflicting results, further studies are needed to propose an algorithm for more optimal treatments.

• 한방안이비인후피부과학회지
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• 제31권3호
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• pp.12-25
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• 2018

Objectives : The purpose of this study is to analyze the use of herbal medicine for the treatment of urticaria in case studies and to find the general tendency of herbal medicine treatment and to establish the primary treatment direction of urticaria. Methods : In the domestic databases, Oriental medicine Advanced Searching Integrated System (OASIS), Korean Traditional Knowledge Portal (KTKP), National Discovery for Science Leader (NDSL), Research Information Sharing Service (RISS), we selected among the case study papers published in the last 20 years using search terms related to "urticaria". Reports related to Sasang Constitutional medicine were excluded and total of 15 papers were finally selected. Results : 23 prescriptions were retrieved from 15 papers. The most commonly used prescription was Seungmagalgeun-tang (升麻葛根湯), and Bangpoongtongsung-san (防風通聖散) and Pyeongwi-san (平胃散) were presented twice. Commonly used herbs are Glycyrrhizae Radix et Rhizoma (甘草), Zingiberis Rhizoma Recens (生薑), and Scutellariae Radix (黃芩). 18 out of 78 herbs are belonging to heat-clearing medicinal (淸熱藥) and 16 out of 78 herbs are belonging to exterior-releasing medicinal (解表藥). Concurrent therapies such as acupuncture, pharmacoacupuncture, moxibustion, cupping therapy, ice pack applying therapy were performed and several evaluation methods were used, patient's subjective remission rate was the most used. Conclusions : Through this study, we were able to discover the tendency of herbal medicine prescription for the treatment of urticaria.

• 응용통계연구
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• 제21권4호
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• pp.639-647
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• 2008

본 연구는 국민건강보험공단의 건강검진데이터, 자격 및 보험료 그리고 진료비 데이터를 활용하여 고혈압 관리를 위한 맞춤형 고혈압 사후관리모형(고혈압 진료예측모형 및 고혈압 진료순응도세분화모형)을 개발하고자 하였다. 모형 개발에는 데이터마이닝의 로지스틱 회귀모형, 의사결정나무 그리고 앙상블 모형을 활용하였다. 고혈압 진료예측모형에서는 3가지 모형 중 로지스틱 회귀모형이 가장 우수한 모형으로 채택되었으며, 고혈압 진료순응도세분화모형은 의사결정나무모형을 통해 개발되었다. 본 연구는 전국 규모의 수년간 축적된 자료를 데이터마이닝을 활용함으로써 고혈압의 진료 및 진료순응도에 이르는 고혈압 사후관리 프로세스 전반에 걸친 결과를 도출함으로써 우리나라 고혈압 사후관리체계 구축에 기여할 것으로 사료된다.

• 한국간호교육학회지
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• 제4권1호
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• pp.15-27
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• 1998

In order to help students through their initial clinical experience, faculty must understand more fully the moaning of this experience for nursing students. This study was performed to understand and to explain what is the essential structure of nursing students' initial clinical experience. A grounded theory approach was conducted to explore the actual experience of nursing students' first clinical experience. Each of the nursing students' descriptions about their initial clinical experience was analyzed using Strauss & Corbin's method. The results of the study were as follows : From the 172 written descriptions and 7 in-depth individual interviews, 128 concepts were extracted. After identifying the concepts' formulated meaning, they were organized into 29 subcategories and the following 12 categories . burden, encountering difficulties, self-discovery, grasping actuality, acquirement of nurse's nature, special character of experience, special character of relationship, external effect, problem oriented coping, emotional oriented coping, affection for nursing, skeptical view of nursing. Five hypotheses were derived from the analysis. 1) Burden is an obstacle to grasp nursing actuality. 2) Special character of experience and external effect have an effect on grasping nursing actuality, 3) Encouragement, a part of external effects, will increase nursing student's affection for nursing. 4) Affection for nursing through first clinical experience facilitates positive nursing view and scholarly zest. 5) Disappointment with the difference be tween theory and reality will cause the student to take a skeptical view of nursing. It is hoped that the knowledge gained from this qualitative study will enable faculty to enter more fully Into the world of nursing students as they embark on their initial clinical experience.

• 성인간호학회지
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• 제20권6호
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• pp.852-865
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• 2008

Purpose: This study was designed to explore what experiences nurses had while caring and providing emotional support for patients. Methods: Participants were eight nurses working at hospitals for more than one year. Data were collected from June, 2006 to January, 2007 through in-depth interview by using tape-recordings. Data were analysed with the phenomenological method proposed by Colazzi(1978). Results: From significant statements, 4 clustered themes, 7 themes and 23 sub-themes were extracted from the essential meaning of the emotional experience of hospital nurses. The 4 clustered themes were 'movement of mind', 'affection and service for patients', 'worthwhile and conflict' and 'control oneself'. The 7 themes were 'special feeling', 'rapport formation', 'consideration', 'human interaction', 'value discovery', 'loss of volition', and 'keep to balance'. Conclusion: Although nurses had tough experiences for providing care for patients' emotional support, they had also experienced spiritual maturity from its experience. The result of this study would contribute for nurses not only to care for patients who need emotional support but also to develop knowledge in nursing.