• Title/Summary/Keyword: Knock-in

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Preservice teacher's understanding of the intention to use the artificial intelligence program 'Knock-Knock! Mathematics Expedition' in mathematics lesson: Focusing on self-efficacy, artificial intelligence anxiety, and technology acceptance model (수학 수업에서 예비교사의 인공지능 프로그램 '똑똑! 수학 탐험대' 사용 의도 이해: 자기효능감과 인공지능 불안, 기술수용모델을 중심으로)

  • Son, Taekwon
    • The Mathematical Education
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    • v.62 no.3
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    • pp.401-416
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    • 2023
  • This study systematically examined the influence of preservice teachers' self-efficacy and AI anxiety, on the intention to use AI programs 'knock-knock! mathematics expedition' in mathematics lessons based on a technology acceptance model. The research model was established with variables including self-efficacy, AI anxiety, perceived ease of use, perceived usefulness, and intention of use from 254 pre-service teachers. The structural relationships and direct and indirect effects between these variables were examined through structural equation modeling. The results indicated that self-efficacy significantly affected perceived ease of use, perceived usefulness, and intention to use. In contrast, AI anxiety did not significantly influence perceived ease of use and perceived usefulness. Perceived ease of use significantly affected perceived usefulness and intention to use and perceived usefulness significantly affected intention to use. The findings offer insights and strategies for encouraging the use of 'knock-knock! mathematics expedition' by preservice teachers in mathematics lessons.

A Study of Easy Knock-down Hanger Design (조립이 간편한 넉다운(knock down) 행거 개발)

  • Im, Kwang-Soon;Kim, Jong-Seo;Cho, Sook-Kyung
    • Journal of the Korea Furniture Society
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    • v.18 no.3
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    • pp.234-242
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    • 2007
  • This study purpose is to design the stand-hangers that can be fabricated conveniently and effectly for manufacture and the market situation of Piwoori Furniture. The study scope is from the research to design prototype in a design process. This study explored the development of knock-down hanger which can be easily assembled and be newly oriented to hanger style. The hangers were made into two main parts with lower part composed as legs, drawers, and containers, and with lower part composed as a shelf and hanger-bear As they are emphasized by the function and usefulness, small sized clothing, underwear, and socks can be stored, and a lot of pants and jackets can be hanged by adjusting the height Therefore, it is not difficult for them to be packed, stored, and transported by being easily assembled and disassembled from the adaption of the knock-down system. Furthermore, the hangers made of the natural wood show the quality of texture and appearance.

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Elevated expression of exogenous RAD51 enhances the CRISPR/Cas9-mediated genome editing efficiency

  • Seo Jung Park;Seobin Yoon;Eui-Hwan Choi;Hana Hyeon;Kangseok Lee;Keun Pil Kim
    • BMB Reports
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    • v.56 no.2
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    • pp.102-107
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    • 2023
  • Genome editing using CRISPR-associated technology is widely used to modify the genomes rapidly and efficiently on specific DNA double-strand breaks (DSBs) induced by Cas9 endonuclease. However, despite swift advance in Cas9 engineering, structural basis of Cas9-recognition and cleavage complex remains unclear. Proper assembly of this complex correlates to effective Cas9 activity, leading to high efficacy of genome editing events. Here, we develop a CRISPR/Cas9-RAD51 plasmid constitutively expressing RAD51, which can bind to single-stranded DNA for DSB repair. We show that the efficiency of CRISPR-mediated genome editing can be significantly improved by expressing RAD51, responsible for DSB repair via homologous recombination (HR), in both gene knock-out and knock-in processes. In cells with CRISPR/Cas9-RAD51 plasmid, expression of the target genes (cohesin SMC3 and GAPDH) was reduced by more than 1.9-fold compared to the CRISPR/Cas9 plasmid for knock-out of genes. Furthermore, CRISPR/Cas9-RAD51 enhanced the knock-in efficiency of DsRed donor DNA. Thus, the CRISPR/Cas9-RAD51 system is useful for applications requiring precise and efficient genome edits not accessible to HR-deficient cell genome editing and for developing CRISPR/Cas9-mediated knockout technology.

Effects of the General Coordinative Manipulation Joint Intervention Model in Correcting Distort Leg with Imbalance of the Lower Extremity Joint, Pelvic and Shoulder Girdles, and Lumbar Spine (다리관절, 다리-팔 이음뼈, 허리뼈의 불균형을 가진 휜다리에 대한 전신조정술 관절중재모형의 교정효과)

  • Moon, Sangeun
    • Journal of The Korean Society of Integrative Medicine
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    • v.8 no.3
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    • pp.1-10
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    • 2020
  • Purpose : The purpose of this study is to analyze the corrective effect of the general coordinative manipulation (GCM) joint intervention model on distort leg with imbalance of the lower extremity joints, pelvic and shoulder girdles, and lumbar spine. Methods : The study used a comparative analysis of the size of the distort leg and the imbalance of the lower extremity joints, pelvic and shoulder girdles, and lumbar spine before and after the application of the GCM joint intervention model. A total of 31 subjects from movement center G and the department of physical therapy at university M were selected as research subjects, and they were divided into two groups. The GCM joint intervention model was applied to 18 subjects in the bow knee group and 13 subjects in the knock knee group. The two groups received daily intervention three times a week for four weeks. The corrective effect of the GCM joint intervention model for each type of distort leg was compared and analyzed. Results : The effects of the GCM joint intervention model in correcting bow knee and knock knee with knee deformation and imbalance of the lower extremity joints, pelvic and shoulder girdles, and lumbar spine were significant in most domains (p<.05). The correlation between the bow knee and knock knee groups showed significance in most domains (p<.05). Conclusion : The GCM joint intervention model showed significant corrective effect in the bow knee and knock knee groups in terms of knee deformation, lower extremity joints, pelvic and shoulder girdles, and lumbar spine (p<.05).

The Limit Compression Ratio of Knock Occurring by $R_{dH2}$ in the Heavy Duty Hydrogen-CNG Fueled Engine (대형 수소-천연가스 기관의 수소첨가율에 따른 노크발생 한계압축비)

  • Kim, Yong-Tae;Lee, Jong-Tai
    • Transactions of the Korean Society of Automotive Engineers
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    • v.14 no.2
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    • pp.84-91
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    • 2006
  • A heavy duty hydrogen-natural gas fueled engine can obtain stable operation at ultra lean conditions and reduce emissions extremely. Reduction of $CO_2$ in its engine is one of the most benefit. In this study, rate of hydrogen addition($R_{dH2}$) and compression ratio($\varepsilon$) were investigated including performance of this engine. As results, it was found that phenomenon of pressure oscillation when increasing $R_{dH2}$ and $\varepsilon$, it means occurring knock. It consider that pressure oscillation was increased due to fast burning speed of hydrogen. Even if same compression ratio, pressure oscillation was remarkable increased according to increasing $R_{dH2}$. Therefore, limit compression ratio of knock occurring was reduced by increasing $R_{dH2}$.

Some Calculated (p,α) Cross-Sections Using the Alpha Particle Knock-On and Triton Pick-Up Reaction Mechanisms: An Optimisation of the Single-Step Feshbache-Kermane-Koonin (FKK) Theory

  • Olise, Felix S.;Ajala, Afis;Olaniyi, Hezekiah B.
    • Nuclear Engineering and Technology
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    • v.48 no.2
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    • pp.482-494
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    • 2016
  • The Feshbache-Kermane-Koonin (FKK) multi-step direct (MSD) theory of pre-equilibrium reactions has been used to compute the single-step cross-sections for some (p,${\alpha}$) reactions using the knock-on and pick-up reaction mechanisms at two incident proton energies. For the knock-on mechanism, the reaction was assumed to have taken place by the direct ejection of a preformed alpha cluster in a shell-model state of the target. But the reaction was assumed to have taken place by the pick-up of a preformed triton cluster (also bound in a shell-model state of the target core) by the incident proton for the pick-up mechanism. The Yukawa forms of potential were used for the proton-alpha (for the knock-on process) and proton-triton (for the pick-up process) interaction and several parameter sets for the proton and alpha-particle optical potentials. The calculated cross-sections for both mechanisms gave satisfactory fits to the experimental data. Furthermore, it has been shown that some combinations of the calculated distorted wave Born approximation cross-sections for the two reaction mechanisms in the FKK MSD theory are able to give better fits to the experimental data, especially in terms of range of agreement. In addition, the theory has been observed to be valid over a wider range of energy.

A Study on the Normal Combustion and Abnormal Combustion in Automotive S.I.Engine (Knocking Phenomena in Quiscent or Swirl Flow Field) (자동차용 가솔린 기관의 정상연소 및 이상연소에 관한 연구)

  • Lee, K.W.;Fujimoto, H.;Park, K.S.
    • Transactions of the Korean Society of Automotive Engineers
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    • v.3 no.6
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    • pp.250-261
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    • 1995
  • In this study, a rapid compression and expansion machine(RCEM) equipped with a swirl generator was designed and developed, in order to clarify normal and abnormal combustion(knocking phenomena). This RCEM is intended to simulate combustion process in actual automotive S.I.engines, having a high reproducibility in the compression stroke. Flame propagation and autoignition processes associated with normal and abnormal combustion were captured by the high speed schlieren photography. And swirl intensity. equivalence ratio and ignition position were varied to investigate the effect of turbulence, concentration in the unburnt gas region and flame propagation length. The knock intensity, knock mass fraction and knock mass fraction after autoignition were calculated by use of history of measured cylinder pressure.

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Physiological Roles of Bacillus subtilis thiol peroxidase gene in response to oxidative stress (산화적 스트레스에 대한 Bacillus subtilis의 thiol peroxidase 유전자의 생리적인 기능)

  • Kim, Ha-Kun;Kim, Sung-Jin
    • The Journal of Natural Sciences
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    • v.15 no.1
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    • pp.57-67
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    • 2005
  • In Order to investigate the physiological role of thiol peroxidase in Bacillus subtilis, a thiol peroxidase (btpx) knock-out mutant was generated by homologous recombination. The growth of btpx knock-out mutant in aerobic condition showed a similar pattern with that of wild type of Bacillus subtilis 168/ But btpx knock-out mutant showed a retarded growht in response to oxidative stress such as $H_2O_2$, cumene hydroperoxide (CHP) treatments.

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Effects of knock-out Pad and Extrusion Ratio on Mechanical Property Changes in Milli-Forward Extrusion of Cylindrical Pin (원형핀의 밀리 전방압출에서 녹아웃패드와 압출비가 기계적 성질 변화에 미치는 영향)

  • 심경섭;김용일;이용신;김종호
    • Transactions of Materials Processing
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    • v.12 no.6
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    • pp.582-587
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    • 2003
  • This paper is concerned with the mechanical property changes of the milli-size products manufactured by forward extrusion processes with square dies. Experiments are carried out with pure aluminum and pure copper billets. Extrusion ratio and knock-out pad are chosen as the important process parameters affecting the changes of mechanical properties such as shear strength and hardness. Shear strength tests with the extruded milli-size pin have shown the strong relation between victors hardness and shear strength in the neck of a stepped pin. As the extrusion ratio increases, the hardness on both the surface and the center line of a pin also increase. It is also noted that the hardness on the surface is a little higher than that on the center. The existence of knock-out pad in extrusion die causes the hardness in the neck of a extruded pin to increase. Finally, the approximated linear relations between shear strength and hardness of a pin are suggested.