• The Korean Journal of Cytopathology
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• v.14 no.2
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• pp.86-90
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• 2003

Kimura's disease is a chronic inflammatory disorder of unknown cause and is most prevalent among Asians. The cytologic findings of Kimura's disease are significant numbers of eosinophils in a background of lymphoid cells, occasional fragments of collagenous tissue, proliferation oi vessels, and Warthin-Finkeldey polykaryocytes. Among these features, the most important cytologic feature of Kimura's disease is a significant numbers of eosinophils. We experienced a case of Kimura's disease in the parotid gland which we fatted to recognize on cytology due to the apparent paucity of eosinophils. On careful retrograde reviewing of the cytologic findings, a few scattered leukocytes, previously interpreted as polymorphous leukocytes, had bilobed nuclei and coarse green but granular cytoplasm on Papanicolaou preparation. These leukocytes showed obvious orange-red intracyloplasmic granules as in eosionophils on Giemsa stain. The paucity of eosinophils may be due to the thick fibrosis around lymphoid follicles or any technical error during aspiration. Whereas the Warthin-Finkeldey type giant cell is not a sensitive cytologic marker of Kimura's disease, it may be a helpful cytologic feature. To reach a correct cytologic diagnosis of Kimura's disease, It is important to keep in mind that searching for Warthin-Finkeldey type giant cells and evaluation of Giemsa stain for detection of eosinophils would be helpful.

• Investigative Magnetic Resonance Imaging
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• v.12 no.1
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• pp.55-59
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• 2008

We present a case of a 37-year-old woman who had Kimura's disease involving the lower extremity mimicking malignant soft tissue mass. The diagnosis of Kimura's disease would be considered if there is a subcutaneous solid mass showing the preservation of the nodal architecture with perinodal infiltrations and the laboratory examinations for peripheral eosinophilia and serum IgE level should be recommended although it occurs at the lower extremity.

• Korean Journal of Bronchoesophagology
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• v.3 no.2
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• pp.323-326
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• 1997

Kimura's disease is a chronic inflammatory disease which often presents as a tumor like swelling in the head and neck region. This lesion is benign but it may easily be mistaken for a malignant tumor. Kimura's disease has been confused with angiolymphoid hyperplasia with eosinophilia(ALHE). The cause is unknown, but theories include autoimmune, allergic, neoplastic, and infectious cause by insect bites and parasites. The treatment of choice is surgical removal. Recently we experienced a case of Kimura's disease occuring in the both side of posterior neck triangle area of a 37 year old male patient who was treated with surgical excision and systemic corticosteroid administration.

• Archives of Plastic Surgery
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• v.36 no.2
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• pp.229-232
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• 2009

Purpose: Kimura's disease is a relatively rare head and neck tumor that frequently occurs in young orientals accompanied with eosinophila. We shared our experience of two cases of Kimura's disease, treated by radical resection and post operative steroid therapy, so we report the correlation of eosinophil counts and disease progression. Methods: A 25 years old male came to the clinic with a mass localized to the right cheek inferior to the right auricle. We could not resect the mass totally. During the follow up period, we checked the eosinophil counts, and steroid therapy was started 7 months after the surgery. A 34 year old female came to the clinic with a mass localized inferior to the left auricle reaching from the posterior portion of the auricle to the left temporal portion. We tried to remove as much tumor as possible, save the temporal region, in regard to the impairment of blood supply to the auricle. After operation, steroid therapy was started. Results: In the first case, the tumor was easily approachable, and radical resection of the tumor with post operative steroid therapy was an effective treatment. In tumors located at difficult regions to remove, as in the second case, optimal debulking and post operative steroid therapy was also effective in treating Kimura's. There were no recurrences in both cases. Eosinophil counts were always reduced after surgery and steroid therapy, and during the period with low eosinophil counts, there was no recurrence of Kimura's disease. Conclusion: Surgery and post operative steroid therapy were effective in treatment of Kimura's disease, and we could assume eosinophil counts as a good indicator for evaluation of the prognosis of Kimura's disease during the follow up period.

• Korean Journal of Head & Neck Oncology
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• v.29 no.1
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• pp.22-25
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• 2013

Angiolymphoid hyperplasia with eosinophilia(Kimura's disease) is a relatively uncommon chronic benign disorder of unknown etiology, predominantly in the head and neck region and associated with lymphadenopathy or salivary gland enlargement. The treatment options are still controversial including medical therapy, surgery, and radiation. Kimura's disease of bilateral postauricular involvement has rarely been reported. We report a male patient with sequentially developed Kimura's disease involving the bilateral postauricular region and was treated by combined surgical excision and steroid therapy.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.13 no.3
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• pp.332-337
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• 1991

Kimura's disease is a chronic inflammatory condition producing subcutaneous tumor-like nodules mainly head and neck regions. Elevated serum Ig E levels and peripheral blood eosinophilia are common. Kimura's disease represents and aberrant immune reaction to an as yet unknown stimulus. This case presented is 27 year old female whose chief complaint were painful swelling on Rt cheek and temporal area and diagnosed as Kimura's disease. We preformed surgical excision of the mass on Rt. cheek and temporal area and reconstructed with temporal flap and about 100 cc of free fat graft on the defect of Rt. cheek.

• Journal of Yeungnam Medical Science
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• v.26 no.1
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• pp.38-43
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• 2009

Kimura's disease is an idiopathic chronic condition, associated with a high-titer of IgE and peripheral eosinophilia. It frequently presents as a solitary or multiple lesions in the head and neck area. During the perioperative period, anesthesiologists should understand the anatomical structures of the patient who has Kimura's disease involvement of the head and neck, especially the airway. It is important to pay attention to the occurrence of signs and symptoms of acute allergic reactions related to a high-titer of IgE and eosinophilia. We report our experience with anesthetic management in an 18-year-old patient with multiple neck masses due to Kimura's disease.

• Radiation Oncology Journal
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• v.12 no.1
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• pp.67-71
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• 1994

Kimura's disease is a rare disorder which predominantly involves the head and neck region can cause eosinophilia in peripheral blood. It has been treated with steroids, surgical excision, irradiation, cryotherapy, and laser. The lesions have a tendency to recur after steroid and surgery. We reviewed 2 patients with Kimura's disease who recurred. because they were resistant steroid therapy and surgery, and treated succesfully conventional radiation therapy.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.18 no.4
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• pp.636-646
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• 1996

Angiolymphoid hyperplasia with eosinophilia(ALHE) is a benign subcutaneous lesion that primarily affects head and neck region. It is characterized by single or multiple nodules in the subcutaneous tissue associated with eosinophilia in the peripheral blood. Kimura's disease, originally reported by Kimura et al., is similar lesion with ALHE in the clinical and histopathological aspects. There has been considerable controversy about the relation between Kimura's disease and ALHE. In Korea, 26 cases of Kimura's disease and ALHE have been reported since 1975. We present a case of recurred ALHE occurring on the left cheek in a 58-year-old woman. Including this case, we summarized all cases that were reported as Kimura's disease or ALHE in Korea through literature review. We also give an outline of clinical and histopathological characteristics of cases reported in Korea.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.33 no.5
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• pp.554-558
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• 2007

Kimura's disease is a chronic inflammatory disorder presenting regional lymphadenopathy with painless soft tissue mass. Clinically, peripheral eosinophilia and elevated serum IgE levels are observed, and proteinuria associated with renal disease can also be present. Although its etiology is not clearly understood, it occurs predominantly in young Asian males and presents as a deep, subcutaneous mass involving salivary glands of the preauricular and submandibular regions. Spontaneous remission is very rare, and although treatments such as steroid, cytotoxic therapy and irradiation are available, chronic recurrence is very common. As such, surgical excision is regarded as the mainstay of therapy for localized lesions. Histopathologically, Kimura's disease features eosinophilic abscsesses and dense lymphoid aggregates with germinal center. Clinical differential diagnosis of Kimura's disease from other parotid diseases with accompanying lymphadenopathy is often very challenging prior to biopsy. The authors report a case of a 19-year-old male diagnosed with Kimura's disease in the parotid region who underwent surgical excision and was followed up for 6 years, along with a review of related literature.