• Title/Summary/Keyword: Kim Sung-ok

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A Design Study of the Mountainous Contemporary Han-ok based on Regional Tradition in Gangwon-do (지역적 전통에 기반을 둔 강원도 산간형 현대한옥 계획 연구)

  • Kim, Do-Kyoung;Choi, Sung-Woo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.6
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    • pp.2789-2796
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    • 2012

  • The purpose of this study was to develope the Contemporary Han-ok based on the natural environment characteristics of mountainous territory in Gangwon-do. According to the result of this study, Eco-friendly Contemporary Han-ok adaptable to the natural environment feature focused on the local climate was proposed based on the tradition of mountainous territory housing in Gangwon-do. In addition, proposed Mountainous Han-ok in Gangwon-do planned to keep the out feature of traditional Korean Han-ok and have the environmental control system same as traditional Korean Han-ok. Despite of several limits, this study has the meaning in terms of propose the prototype of adaptable contemporary han-ok based on the Natural Environment Characteristics of Mountainous Territory and regional tradition in Gangwon-do in cognition of local natural environment difference. the proposal of contemporary han-ok as the result of this study will give a support to the wide planning of Han-ok and the development plan of contemporary Han-ok.

  • https://doi.org/10.5762/KAIS.2012.13.6.2789 인용 PDF KSCI

Inhibitory Effect of Extract from Ostericum koreanum on LPS-induced Proinflammatory Cytokines Production in RAW264.7 Cells (LPS로 자극한 RAW264.7 세포에서 강활 추출물의 염증성세포활성물질의 억제효과)

  • Park, Hee-Je;Bae, Gi-Sang;Kim, Do-Yun;Seo, Sang-Wan;Park, Kyung-Bae;Kim, Byung-Jin;Song, Je-Moon;Lee, Kyung-Yong;Na, Chul;Shin, Byung-Chul;Park, Sung-Joo;Song, Ho-Joon;Hwang, Sung-Yeon
    • The Korea Journal of Herbology
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    • v.23 no.3
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    • pp.127-134
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    • 2008

  • Objectives : The present study was designed to investigate whether Ostericum koreanum (OK) could regulate lipopolysaccharide (LPS)-induced inflammatory response in vitro and in vivo. Methods : To evaluate of anti-inflammatory effect of OK, we examined Nitric oxide (NO), proinflammatory cytokines production in LPS-stimulated RAW264.7 cells. Furthermore, we checked molecular mechanism especially in the phosphorylation of mitogen-activated protein kinases (MAPKs) and the degradation of inhibitory kappa B a ($Ik-B{\alpha}$) using western blot and also investigated survival of mice in LPS-mediated endotoxin shock. Results : 1. Extract from OK itself have weak cytotoxic effect on RAW264.7 cells. Extract from OK inhibited LPS-induced NO, tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$), interleukin $(IL)-1{\beta}$, IL-6 and IL-10 production in RAW264.7 cells. 2. OK inhibited the phosphorylation of MAPKs, such as p38, extracelluar signal-regulated kinase (ERK1/2) and c-Jun NH2-terminal kinase (JNK) and also the degradation of $I{\kappa}-B{\alpha}$ in the LPS-stimulated RAW264.7 cells 3. OK did not inhibit LPS-induced endotoxin shock. Conclusions : OK down-regulated LPS-induced NO and cytokines production through suppressing activation of MAPKs and degradation of $I{\kappa}-B{\alpha}$. Our results suggested that OK may be a beneficial drug against inflammatory diseases.

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A New Epoxynaphthoquinol from Rumex japonicus

  • Zee, Ok-Pyo;Kim, Dae-Keun;Kwon, Hak-Cheol;Lee, Kang-Ro
    • Archives of Pharmacal Research
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    • v.21 no.4
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    • pp.485-486
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    • 1998

  • A new epoxynaphthoquinol derivative, 3-acetyl-2-methyl-1, 5-dihydroxy-2,3-epoxynaphthoquinol (I), was isolated from the root of Rumex japonicus. The structure was elucidated by high field 1D and 2D NMR techniques.

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