• Title/Summary/Keyword: Kim Dong-hwan

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Autoimmune Regulator Gene (Aire) is Expressed in Lymph Node Fibroblastic Reticular Cell, BLS4 (Autoimmune regulator gene (Aire)의 마우스 림프절 FRC세포, BLS4에서 발현)

  • Moon, Kyoung-Mi;Seo, Hee-Ju;Oh, Ji-Youn;Lee, Jae-Seol;Kim, Hae-Young;Kim, Jeong-Hwan;Choi, Woo-Bong;Kim, Byung-Woo;Kim, Kwang-Hyeon;Lee, Jong-Hwan
    • Journal of Life Science
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    • v.20 no.5
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    • pp.670-675
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    • 2010

  • Autoimmune regulator gene (Aire) is expressed in the thymus and controls the expression of peripheral self-antigens, known as promiscuous genes. Aire and promiscuous genes are involved in T cell tolerance and autoimmunity in the thymus. Here, we identified Aire-expressing fibroblastic reticular cell (FRC), which was derived from mouse lymph node and also expressed in insulin promiscuous antigen. The expression of insulin was increased in cultured FRC over-expressed with Aire. These data suggest that Aire regulates promiscuous gene expression in FRC, and that this function might be under peripheral selection control.

  • https://doi.org/10.5352/JLS.2010.20.5.670 인용 PDF KSCI