• Title/Summary/Keyword: Kim Chun-su

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The Antifungal Activity of Bee Venom against Dermatophytes

  • Yu, A-Reum;Kim, Jum-Ji;Park, Gil-Sun;Oh, Su-Mi;Han, Chung-Sub;Lee, Mi-Young
    • Journal of Applied Biological Chemistry
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    • v.55 no.1
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    • pp.7-11
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    • 2012
  • The antifungal activities of the bee venom against Trichophyton mentagrophytes and Trichophyton rubrum were determined by using modified broth dilution assay. The most common dermatophytes, named T. mentagrophytes and T. rubrum, were known to cause a variety of cutaneous infections in humans and animals. The bee venom exhibited prominent antifungal activities against the two dermatophytes tested in this investigation. Moreover, the antifungal activities of the bee venom were much stronger than that of fluconazole, one of the commercial antifungal drugs used in the treatment and prevention of superficial and systemic fungal infections. The result suggests that bee venom could be developed as a natural antifungal drug.

A study on improvement method of historic cultural street. - Focusing on DongChun-Dang street - (역사문화가로 활성화 방법에 대한 고찰 - 대전광역시 대덕구 동춘당 가로를 실제사례로 하여 -)

  • Yoon, Hwon;Kim, Duk-Su;Kill, Seong-Ho
    • Journal of The Korean Digital Architecture Interior Association
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    • v.8 no.1
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    • pp.23-30
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    • 2008
  • In order to improve the atmosphere within Historic and Culturally Symbolic Street- DongChun-Dang street which represents the historical characteristics of Daejeon- this study aims to derive improvement methods by analyzing preceding studies, identify problems and offer the directions that could make historic cultural street, and propose the guidelines could apply to new district development at historic cultural area. The research results are as follows : First, method for improvement of historic cultural street is not fragmentary but integrated. Second, we suggested plans for improvement of DongChun-Dang street. Third, to make historic cultural images of streets, it is considered that guidelines include volumes, colors of surrounding buildings and designs of street furnitures have to be provided on the new urban or district development at historic cultural area.

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Cardamonin Inhibits the Expression of Inducible Nitric Oxide Synthase Induced by TLR2, 4, and 6 Agonists

  • Kim, Ah-Yeon;Shim, Hyun-Jin;Kim, Su-Yeon;Heo, Sung-Hye;Youn, Hyung-Sun
    • Biomedical Science Letters
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    • v.24 no.2
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    • pp.102-107
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    • 2018
  • Toll-like receptors (TLRs) play an important role for host defense against invading pathogens. The activation of TLRs signaling leads to the activation of $NF-{\kappa}B$ and the expression of pro-inflammatory gene products such as cytokines and inducible nitric oxide synthase (iNOS). To evaluate the therapeutic potential of cardamonin, which is a naturally occurring chalcone from Alpinia species (zingiberaceous plant species), $NF-{\kappa}B$ activation and iNOS expression induced by MALP-2 (TLR2 and TLR6 agonist) or LPS (TLR4 agonist) were examined. Cardamonin inhibited the activation of $NF-{\kappa}B$ induced by MALP-2 or LPS. Cardamonin also suppressed the iNOS expression induced by MALP-2 or LPS. These results suggest that cardamonin has the specific mechanism for anti-inflammatory responses by regulating of TLRs signaling pathway.