• BMB Reports
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• 제51권5호
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• pp.207-208
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• 2018

Chitinase-Like Proteins (CLPs) are an evolutionarily conserved protein which lose their enzymatic activity for degrading chitin macromolecules. Chitinase-3-like-1 (Chi3l1) is a type of CLP that is highly expressed in epithelial cells, macrophages, etc., and is known to have correlations with type 2 inflammation and cancer. Although the increased level of Chi3l1 in the blood was reported in various disease patients, the function of Chi3l1 in adaptive immunity has been totally unknown. Recently, we found that Chi3l1 is expressed in T cells and has a negative regulatory role in T-cell activation and proliferation. A genetic ablation study of Chi3l1 in T cells showed hyperresponsiveness to TcR stimulation, which increased proliferation and Th1 differentiation. A significant increase of $IFN{\gamma}$ signaling in Chi3l1-deficient T cells synergistically increased Th1 and CTL functions against melanoma cells in vitro and in vivo. In addition, targeted knockdown by Chi3l1 siRNA complexed with the cell-penetrating peptide dNP2, which showed decreased pulmonary melanoma metastasis with increased infiltration of Th1 and CTL in the lung. This study first suggests that Chi3l1 is a novel regulator of Th1/CTL responses and could be a target for treating cancer to increase tumor immunity.

• 근관절건강학회지
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• 제15권1호
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• pp.5-23
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• 2008

Purpose: This study aims to conduct a systematic review of the physical, psychosocial and physiological effects of Tai Chi exercise in elderly. Method: 37 articles from Medline search of foreign journals (1966-2006) were surveyed by the key words 'Tai Chi', 'Tai-chi program' and 'Tai-chi and elderly' limiting the range to age 65 or older, choosing clinical trial and randomized controlled trial research in English articles. Four articles were excluded due to methodological study, pilot study and review. The research was analyzed according to health status of the subjects, styles and forms of Tai Chi exercises, factors for physical, psychosocial and physiological measures. Result: A short forming Yang style was commonly used in chronic diseases and health for elderly. Variable outcome measures were used in Tai Chi studies relating to balance, muscle strength, walking and mobility, flexibility and cardiorespiratory function in physical measure, quality of life, depression, self-efficacy, health status, cognition and impact questionnaire in psychosocial measure, lipids, insulin resistance and hormone in physiological measure. Conclusion: Tai Chi exercise appears to have physical and psychosocial benefits and also appears to be safe for elderly and chronic diseases. It is suggested that future studies analyze statistical part of systematic reviews through meta analysis.

• 한국수학사학회지
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• 제29권5호
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• pp.279-294
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• 2016

In this study, Bumwoo KIM Chi Young's (1916.12.24~1995.4.22) papers, essays and books on mathematics education were collected and classified. Bumwoo KIM Chi Young was the most important person on the New Math Movement (Modernization for Mathematics Education), and in 1973, he led the Third Reformation of National School Mathematics Curriculum in Korea. Bumwoo emphasized mathematical structure in mathematics education, and he was a strong advocate of importance of set theory, creativity and the type of spiral learning.

• 척추신경추나의학회지
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• 제13권1호
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• pp.35-44
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• 2018

Objectives: To determine the effectiveness of Tai-chi in treatinglow back pain. Methods: We searched 9 electronic databases(Pubmed, CAJ, EMBASE, Cochrane Library, Web of Science, KISS, KISTI, NDSL, and RISS) till April 2018 and included randomized controlled trials(RCTs) that used Tai-chi for lower back pain treatment. The methodological quality of each RCT was assessed usingthe Cochrane risk of bias tool. Results: As per the inclusion criteria, 5 RCTswere found to be eligible for our review. These studies were divided into 4 groups and meta-analysis was performed. The meta-analysis of 1 study showed favorable results regardingthe use of Tai-chi. Twostudies showed favorable results regardingthe use of Tai-chi with Tuina rather than Tuina alone. All studies were observed to have a high risk of bias. Conclusions: There is limited evidence available to support the effectiveness of Tai-chi in relieving low back pain;hence, additionalwell-designed RCTs should be encouraged for better evidence.

• 한국조경학회지
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• 제32권5호
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• pp.129-138
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• 2004

Cherishing the dead is based in sadness. Designing a memorial space therefore has an inherent challenge to evoke the feeling that is so personal and varied by providing a physical space. The tendency of memorials, especially in the US after the mid 20th century, has been to emphasis each dead individual, as seen at the Vietnam Veterans Memorial in Washington, D. C., the Oklahoma City National Memorial in Oklahoma City, and so forth. In the process of designing the memorial of the Taiwanese Chi-chi earth-quake, Cheng Kim Park Robidoux tried to set up a series of spaces through which not only the relatives of the dead but also unrelated visitors could have their own spatial experiences, private rituals and public events, so that they can finally build up a collective memory. Sky-Well consists of a large bamboo forest enclosing a void. Without a particular entrance and guiding system, visitors stroll and get lost in the bamboo forest before they find the central void. The horror they experienced during the earthquake is melted down into the motion and phenomenology of the bamboo forest whereas the central void is reinterpreted as an empty mind, where people find solace from the sky. Details, such as the bamboo wall to place commemorative flowers and lotus blossom paving, are echoing the theme of rebirth.

• 근관절건강학회지
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• 제13권2호
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• pp.83-93
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• 2006

Purpose: The purpose of the study was to compare the effects of Tai Chi self-help program and Tai Chi exercise in patients with osteoarthritis. Methods: quasi experimental design was utilized for the study to compare the effects after implementing tai chi self-help program and Tai Chi exercise for 6 weeks. The subjects of the study was osteoarthritis patients who visited to two Public Health Centers in Gyunggi-do from August to December, 2005. Total of 25 OA patients agreed to participate in the study, and 10 tai chi self-help program group and 9 Tai Chi exercise group were included for the final analysis after 6 weeks. Tai Chi self-help program was provided twice a week, 2 hours per session (one hour for tai chi exercise, one hour for self help program) for 6 weeks, and Tai Chi exercise group was provided once a week, 2 hours per session for 6 weeks. Outcome measures include flexibility, 6 m walking, and balance. Mann-Whitney U test of SPSS WIN 11.0 was utilized to compare the group differences. Results: The subjects of both program participants were not improved in their arm flexibility, and the difference was not significant. Tai chi self-help group improved more in their 6 m walking ability than Tai Chi exercise group, but the difference was not significant (F=.000, p>.05). Tai chi self-help group improved more in their balance than Tai Chi exercise group, but the difference was not significant (Rt: U=.24, p>.05; Lt: F=2.60, p>.05). Conclusion: The provision of both Tai Chi self-help program and Tai Chi exercise can lead improvement of 6 m walking, and balance, but the group difference was not significant. A rigorous research design should be further utilized to identify the potential benefits for this population.

• 대한간호학회지
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• 제39권1호
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• pp.136-144
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• 2009

Purpose: Natural menopause resulting in the decline in endogenous estrogen concentrations is responsible for an increased risk of coronary heart disease in postmenopausal women. The purpose of the study was to examine the effects of a 6-month Tai Chi exercise program on cardiovascular risk factors and quality of life in post-menopausal women. Methods: A quasi-experimental design with pretest and posttest measures was used. The participants in the study, 29 women in the Tai Chi group and 31 in the control group, were enrolled for 6 months. Results: After 6 months of Tai Chi exercise, total cholesterol (M=213 to 185), LDL-cholesterol (M=135 to 128), and their 10 yr cardiovascular disease risk (M=2.62 to 2.27) had improved significantly for the Tai Chi participants compared to the control group. Total scores for quality of life along with the sub-dimensions of health perception and mental functioning were also significantly higher in the Tai Chi participants. Conclusion: Tai Chi exercise favorably affected cardiovascular health and quality of life in post-menopausal women after 6 months. Additional rigorous studies are needed to examine long term effects on the prevention of cardiovascular disease in this population.

• 대한간호학회지
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• 제49권4호
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• pp.437-448
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• 2019

Purpose: This study was conducted to test a path model for the factors related to undergraduate nursing students' clinical practicum stress, based on Lazarus and Folkman's stress-coping model. Methods: This study utilized a path analysis design. A total of 235 undergraduate nursing students participated in this study. The variables in the hypothetical path model consisted of clinical practicum, emotional intelligence, self-efficacy, Nun-chi, and nursing professionalism. We tested the fit of the hypothetical path model using SPSS/WIN 23.0 and AMOS 22.0. Results: The final model fit demonstrated a satisfactory statistical acceptance level: goodness-of-fit-index=.98, adjusted goodness-of-fit-index=.91, comparative fit index=.98, normed fit index=.95, Tucker-Lewis index=.92, and root mean square error of approximation=.06. Self-efficacy (${\beta}=-.22$, p=.003) and Nun-chi behavior (${\beta}=-.17$, p=.024) were reported as significant factors affecting clinical practicum stress, explaining 10.2% of the variance. Nursing professionalism (${\beta}=.20$, p=.006) and self-efficacy (${\beta}=.45$, p<.001) had direct effects on emotional intelligence, explaining 45.9% of the variance. Self-efficacy had indirect effects on Nun-chi understanding (${\beta}=.20$, p<.001) and Nun-chi behavior (${\beta}=.09$, p=.005) through emotional intelligence. Nursing professionalism had indirect effects on Nun-chi understanding (${\beta}=.09$, p=.005) and Nun-chi behavior (${\beta}=.09$, p=.005) through emotional intelligence. The variables for self-efficacy and nursing professionalism explained 29.1% of the Nun-chi understanding and 18.2% of the Nun-chi behavior, respectively. Conclusion: In undergraduate nursing education, it is important to identify and manage factors that affect clinical practicum stress. The findings of this study emphasize the importance of Nun-chi, self-efficacy, emotional intelligence, and nursing professionalism in the development of an educational strategy for undergraduate nursing students.

• 한국진공학회지
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• 제12권S1호
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• pp.100-103
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• 2003

The magnetoresistance (MR) of $La_{1-\chi}S_{\chi}CoO_{3-\delta}$ films prepared by pulsed-laser deposition were investigated in order to clarify the magnetotransport properties around the metal-insulator transition. For the films in the metallic state ($\chi$ > 0.25), the MR(T) manifests a small peak at the Curie temperature due to the spin-disorder scattering. The transition of the film into the insulating state ($\chi\;\leq$ 0.25) is accompanied by an essential growth of the MR and results in a significant increase in the MR(T) with decreasing temperature, due to a phase separation into the ferromagnetic-metal clusters and the insulating matrix.

• 근관절건강학회지
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• 제18권2호
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• pp.147-157
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• 2011

Purpose: The purpose of this study was to determine the effect of Tai Chi exercise program (Sun style 12 forms) on anxiety, powerlessness, self-esteem in community-dwelling elderly women. Methods: With a quasi-experimental design, a nonequivalent control group pretest-post test was used. Elderly women who agreed to participate in the study were assigned into an experimental group (n=23), or a control group (n=23). The experimental group participated in Tai Chi exercise program for 50 minutes per session, 2 times a week for 11 weeks. Tai Chi exercise program consisted of 10 minutes for warm-up, 35 minutes for main session, and 5 minutes for cooling down exercises. Anxiety, powerlessness, and self-esteem were measured with questionnaires to evaluate the effect of Tai Chi exercise program. The data were analyzed by using Chi-square test, Fisher's exact test, and Mann-Whitney test by a SPSS WIN 12.0 program. Results: The experimental group showed significant improvement for self-esteem (z=-3.130, p=.002), powerlessness(z=-3.267, p=.001), and anxiety (z=-2.932, p=.003) when compared to control group, Conclusions: Tai chi exercise program may be an effective nursing intervention to improve self-esteem and to reduce powerlessness and anxiety in community-dwelling elderly women.