• 대한핵의학회지
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• 제16권2호
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• pp.85-89
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• 1982

Patients with diffusely increased uptake in both kindeys("hot kidney") on the $^{99m}Tc-MDP$ bone imagings were evaluated. Total incidence of the "hot kidney" was 2.7% (56/2053). Among 56 patients with "hot kidney", the most common diseases were malignancies (30), and the remainders were composed of renal diseases(11) and other disease group(16). We report the possible factors for the "hot kidney" with brief review of some literatures.

• 대한한의학방제학회지
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• 제16권2호
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• pp.163-169
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• 2008

The kidney toxicities of BDR-29 used for improvement of the vascular diseases, was examined using male and female Sprague-Dawley rats. The male and female rats were divided into 4 groups for intragastrical treatment with doses of 0, 5, 50, and 500 mg/kg/day for 13 weeks, respectively. In all male and female rats treated with BDR-29, no mortality and gross pathological findings were shown for 13 weeks. There substantially was no change in body weight in all rats with treatment of BDR-29. The renal functional parameters including urinary volume, urine osmolality, electrolytes excretory rate, creatinine clearance, and solute-free water reabsorption were not exchanged in all rats treated with BDR-29. Taken together, these results suggest that BDR-29 has no toxicity on kidney in all male and female rats.

• Childhood Kidney Diseases
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• 제18권2호
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• pp.57-63
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• 2014

소아들의 여러 신장 질환 특히 만성신장병은 초기에는 뚜렷한 증세나 징후를 나타내지 않고 단독 단백뇨 또는 현미경적 혈뇨로만 나타나는 경우가 많다. 이런 신장 질환을 발견하기 위하여 소변검사는 여러 장단점에도 불구하고 간단하고 비용이 적게 드는 검사로서 선별검사에 이용하게 되었다. 우리나라에서는 신장 질환의 조기 발견을 위한 학교 집단소변검사가 1998년에 개정된 학교신체검사규칙에 근거하여 전체 초 중 고등학생을 대상으로 실시되었다. 그 이후에 많은 연구와 보고들이 학교 집단소변검사가 만성신질환의 조기 발견에 유용할 것이라고 하였지만 아직도 여기에 대한 이견이 있을 뿐만 아니라 비용 효과 등에 대하여서도 충분한 의견 일치를 얻지 못하였기에 코호트 연구 등의 장기적인 관찰적 역학 연구가 반드시 필요하다. 이를 위하여서는 신장학자들의 지속적인 연구뿐만 아니라 제도 개선 및 개발들이 반드시 동반되어야 할 것이다.

• 한방안이비인후피부과학회지
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• 제5권1호
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• pp.27-44
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• 1992

The cause and mechanism of eye diseases are follow in biblography. The etiological factor of eye diseases are nearly caused by heat. It is important to distinguish deficiency and substance. In external etiologic factors wind-fever is most of all in six exogenous factors. In internal etiologic factors xu(deficiency) of kidney, blood and fire of seven emotions are lots. In factors other than the internal and external, eating greasy food and hyper-caloric food are a lot of case. In relation with the yin-yang andxu-shi, ther are a lot of eye diseases symptom as dark-dizziness due to the yin-xu of hepatic-kidney. According to eight principles of differentiation of syndromes, syndromes of exterior, heat, shi, almost fall into the category of yang and syndromes of interior, cold, xu, nearly fall into the category of yin. In interior treatment, inducing wind and clearing heat, using Qi and tonifying blood, tonifying and suing of hepatic-kid ney are useful and often used treatment.

• Childhood Kidney Diseases
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• 제27권2호
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• pp.133-138
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• 2023

Nutcracker syndrome (NCS) is a disease caused by compression of the left renal vein between the superior mesenteric artery and the abdominal aorta. Immunoglobulin A (IgA) nephropathy (IgAN) is characterized by the predominance of IgA deposits in the glomerular mesangial area. Hematuria and proteinuria can be present in both diseases, and some patients can be concurrently diagnosed with NCS and IgAN; however, a causal relationship between the two diseases has not yet been clarified. Here, we report two pediatric cases of NCS combined with IgAN. The first patient presenting with microscopic hematuria and proteinuria was diagnosed with NCS at the initial visit, and the second patient was later diagnosed with NCS when proteinuria worsened. Both patients were diagnosed with IgAN based on kidney biopsy findings and treated with angiotensin-converting enzyme inhibitors and immunosuppressants. A high index of suspicion and timely imaging or biopsy are essential for the proper management of NCS combined with glomerulopathy.

• 동의생리병리학회지
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• 제20권4호
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• pp.1057-1062
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• 2006

In order to research the interrelationship of symptoms of 5 visceral diseases through Pearson's correlative coefficient and to understand the diagnostic importances of each symptom and sexual differences in the main symptoms of each visceral diseases using Cronbach alpha. For this 500 female and 120 male cases of questionnaire were collected and analyzed. In the main symptoms of 5 visceral diseases, there were a little differences between this results and existing symptom-complex system. And in the comparison of most frequently manifesting symptoms to male and female subject, Heart and Pancreas and Kidney disease were almost same, but Liver disease was different and Lung disease was slightly different. Conclusively, the diagnostic reliability of the abstracted symptom-complex of 5 viscera was graded from Kidney(Cronbach alpha 0.8771555), Pancreas(0.865978), Liver(0.815013), Heart(0.78653) to Lung disease(0.6294695) sequentially. And the each Cronbach alpha was valuable to be permitted as diagnostic criteria of 5 visceral diseases.

• 대한수의학회지
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• 제53권3호
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• pp.169-174
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• 2013

We demonstrated that a mineral aqueous solution (MAS) administered to mice functionally and histologically protected against cisplatin-induced acute renal failure (ARF) and $CCl_4$-induced acute liver failure (ALF). In ARF model, 0.4 and 0.2% MAS decreased mortality and the serum concentrations of blood urea nitrogen (BUN) and creatine in mice. Additionally, 0.4 and 0.2% MAS reduced contraction of distal convoluted tubules and suppressed expression of the proinflammatory cytokines interlukein-6 (IL-6) and tumor necrosis factor (TNF-${\alpha}$) in the kidney. In ALF model, 0.4 and 0.2% MAS decreased serum concentrations of alanine aminotransferase and aspartate aminotransferase in mice. Additionally, 0.4 and 0.2% MAS reduced necrotic areas and suppressed expression of IL-6 and TNF-${\alpha}$ in the liver. These results indicate that a MAS might have protective effects against ARF and ALF.

• Childhood Kidney Diseases
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• 제21권1호
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• pp.1-7
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• 2017

Mitogen-activated protein kinases (MAPKs) play important roles in various cellular functions including proliferation, differentiation, and apoptosis. We showed that MAPKs are developmentally regulated in the rat kidney. p38 MAPK (p38) and extracellular signal-regulated kinase (ERK) were strongly expressed in the fetal kidney, whereas c-Jun N-terminal kinase (JNK) was detected predominantly in the adult kidney. The inhibition of p38 or ERK in organ culture resulted in reduced nephron formation with or without reduced kidney size. On the other hand, persistent fetal expression pattern of MAPKs, i.e., upregulation of p38 and ERK and downregulation of JNK, was observed in the cyst epithelium of human renal dysplasia, ovine fetal obstructive uropathy, and pcy mice, a model of polycystic kidney disease. Furthermore, activated p38 and ERK induced by cyclic stretch mediated proliferation and $TGF-{\beta}1$ expression in ureteric bud cells, probably leading to cyst formation and dysplastic changes. Inhibition of ERK slowed the disease progression in pcy mice. Finally, ERK and p38 were inactivated in the early embryonic kidney subjected to maternal nutrient restriction, characterized by reduced ureteric branching and nephron number. Thus, MAPKs mediate the development of normal and diseased kidney. Their modulation may result in novel therapeutic strategies against developmental abnormalities of the kidney.

• Yonsei Medical Journal
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• 제59권9호
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• pp.1015-1025
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• 2018

Kidney diseases including acute kidney injury and chronic kidney disease are among the largest health issues worldwide. Dialysis and kidney transplantation can replace a significant portion of renal function, however these treatments still have limitations. To overcome these shortcomings, a variety of innovative efforts have been introduced, including cell-based therapies. During the past decades, advances have been made in the stem cell and developmental biology, and tissue engineering. As part of such efforts, studies on renal cell therapy and artificial kidney developments have been conducted, and multiple therapeutic interventions have shown promise in the pre-clinical and clinical settings. More recently, therapeutic cell-secreting secretomes have emerged as a potential alternative to cell-based approaches. This approach involves the use of renotropic factors, such as growth factors and cytokines, that are produced by cells and these factors have shown effectiveness in facilitating kidney function recovery. This review focuses on the renotropic functions of bioactive compounds that provide protective and regenerative effects for kidney tissue repair, based on the available data in the literature.

• 성인간호학회지
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• 제12권3호
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• pp.452-462
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• 2000

The purpose of this study is to develop and evaluate the Self Efficacy Promotion and Exercise Program to prevent of obesity and cardiovascular diseases for the kidney transplant recipients. The subjects were selected randomly among the patients who underwent kidney transplantations at one major transplantation hospital in Seoul, Korea. This study ws carried out between November 23, 1999 and February 15, 2000. The subjects in this study consisted of 16 patients who had kidney transplantations between 1 month and 12 months ago prior to this study. They were all on steroids therapy and did not take any physical exercise regularly. The subjects received the self efficacy promotion and exercise program for 12 weeks which contained self efficacy promotion education and exercise program. The weight, body fat rate, exercise time and cardiopulmonary function were evaluated before the experiment and after the experiment. The results were as follows: 1. After the experiment, the weight was significantly decreased than that of before the experiment(p=.0001). 2. After the experiment, the body fat rate was significantly decreased than that of before the experiment(p=.0010). 3. After the experiment, the exercise time was significantly increased than that of before the experiment(p=.0002). 4. After the experiment, the absolute VO2 was significantly increased than that of before the experiment(p=.0008). 5. After the experiment, the relative VO2 was significantly increased than that of before the experiment(p=.0002). This study showed that the self efficacy promotion and exercise program was effective. So it would be expected that this self efficacy promotion and exercise program could be applied as an effective independent nursing intervention widely in prevention of obesity and cardiovascular diseases for kidney transplant recipients.