• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.683-687
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• 2015

Aloe vera gel exhibits protective effects against insulin resistance as well as lipid-lowering and anti-diabetic effects. The anti-diabetic compounds in this gel were identified as Aloe-sterols. Aloe vera gel extract (AVGE) containing Aloe-sterols has recently been produced using a new procedure. We previously reported that AVGE reduced large-sized intestinal polyps in Apc-deficient Min mice fed a high fat diet (HFD), suggesting that Aloe vera gel may protect against colorectal cancer. In the present study, we examined the effects of Aloe vera gel powder (AVGP) and AVGE on azoxymethane-induced colorectal preneoplastic aberrant crypt foci (ACF) in mice fed a HFD. Male C57BL/6J mice were given a normal diet (ND), HFD, HFD containing 0.5% carboxymethyl cellulose solution, which was used as a solvent for AVGE (HFDC), HFD containing 3% or 1% AVGP, and HFDC containing 0.0125% (H-) or 0.00375% (L-) AVGE. The number of ACF was significantly lower in mice given 3% AVGP and H-AVGE than in those given HFD or HFDC alone. Moreover, 3% AVGP, H-AVGE and L-AVGE significantly decreased the mean Ki-67 labeling index, assessed as a measure of cell proliferation in the colonic mucosa. In addition, hepatic phase II enzyme glutathione S-transferase mRNA levels were higher in the H-AVGE group than in the HFDC group. These results suggest that both AVGP and AVGE may have chemopreventive effects on colorectal carcinogenesis under the HFD condition. Furthermore, the concentration of Aloe-sterols was similar between 3% AVGP and H-AVGE, suggesting that Aloe-sterols were the main active ingredients in this experiment.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1725-1729
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• 2013

Background: Breast cancer is the second leading cancer causing death in women. Circulating tumor cells are among the prognostic factors while tumor markers are of diagnostic value and can be used for follow-up. The aim of this study was to investigate the correlation between the prognostic significance of the serum CA15-3 levels, number of circulating tumor cells and histopathological tumor factors. Materials and Methods: Thirty patients recently diagnosed with breast cancer were included in the study. Number of circulating tumor cells and serum CA15-3 level were assessed when metastasis was detected and diagnostic value was assessed. Presence of associations with estrogen and progesterone receptors, c-erbB2, Ki-67 proliferation index and histological grade were also evaluated. Results: Median overall survival of the patients with serum CA15-3 levels of >108 ng/dl was 19 months whereas for those with a low serum level it was 62 months. Median overall survival for CTC ${\geq}5$ vs CTC<5 patients was 19 months and 40 months respectively. The difference between the two groups was statistically significant. Conclusions: Prognostic significance of the CTC count and CA15-3 levels in metastatic breast cancer patients was demonstrated.

• Journal of Veterinary Clinics
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• v.19 no.2
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• pp.186-190
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• 2002

This crossover study was performed in order to compare the effects of cetirizine, loratadine, and terfenadine in canine skin. Five healthy dogs were used. Cetirizine 0.5 mg/kg, loratadine 5 mg/kg and terfenadine 5 mg/kg were administered orally 4 hours before the experiment. Erythema indices and wheal size were assessed by Hexameter ($MX^{\circledR}$ 18, CK, Germany) and skin reaction guide, respectively. Cetirizine-induced erythema inhibition was generally higher than other drugs and was significantly different from placebo. Cetirizine was superior to placebo at 3, 4, 5, 6, 7, and 8 minutes (p< 0.01). Cetirizine also was superior to placebo at 9 minutes (p< 0.05). Loratadine and terfenadine erythema inhibition were better than after placebo treatment from 4 to 9 minutes, but erythema index of terfenadine at 7 minutes was not observed probability of 95% and 99%. At 10 minutes, intradermal injection of the histamine caused a mean wheal dimension for placebo, cetirizine, loratadine and terfenadine, which were 13.25$\pm$0.75 mm,7.5$\pm$ 1.02 mm (53% reduction, p<0.007),6.2$\pm$0.58 mm(43% reduction, p <0.01), and 8.4 $\pm$0.67 mm(37% reduction, p< 0.05), respectively, comparing with placebo. Loratadine and cetirizine were good antihistamines for clinical therapy for atopic dermatitis in dog.

• Korean Journal of Community Nutrition
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• v.18 no.5
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• pp.442-456
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• 2013

This study was performed to investigate the dietary habits, body satisfaction and nutritional knowledge according to body image of middle school girl students (n = 284). The subjects were classified as lean, normal and fat groups according to body image. The weight, body mass index (BMI) and the score of body image were significantly higher in the students who recognized their body image as 'fat'. The satisfaction of present body image was significantly lower in students who recognized their body image as 'lean'. The interest in weight control and experience of weight control were significantly higher in students who recognized their body image as 'fat'. The necessity of nutrition education was higher in all groups (lean 67.2%, normal 59.0% and fat 52.8%). The products used to feel sweetened were sweetened ice (68.7%), processed milk (68.3%), confectionery (62.3%), carbonated beverage (55.3%), fermented milk (38.0%) and none (6.0%). The frequency of consumption of fruit juices and fried food was significantly higher in 'normal' compared to 'fat'. There was no significant difference in the frequency of consumption of snack and nutritional knowledge among the three groups. In the multiple regression analysis, the score of body image was negatively associated with the frequency of snack consumption in the 'lean'. The score of body image was positively associated with identification of nutrition labels and an interest in weight control but was negatively associated with satisfaction of present body image in the 'fat'. Based on these results, we conclude that, the middle school girl students need correct recognition of body image and continuous and practical nutrition education in order to maintain healthy dietary habits.

• Economic and Environmental Geology
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• v.26 no.1
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• pp.67-81
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• 1993

This dissertation is a basic research on the degradation of rocks and aims at clarifying the relations between the progression of degree of weathering and the variation of chemical composition. The author wants to make clear the degradation of rocks and the process of formation of sedimentary rocks from a standpoint of elucidation of migration of elements. This study is considered to be significant not only as a part of research on the distribution of earth crust materials but as the petrogenesis of rocks. The chemical studies on the weathered rocks have been started relatively early and there are not a few researches on them: Goldich, 1938; Harris, et al., 1966; Ruxton, 1968; Berner, et al., 1982; Kanuss, 1983; Lasaga, 1984; Siagel, 1984. The degree of migration of elements in weathering is the composite result of various factors. Because, at the present time, it is difficult to clarify the individual and composite effects of each factor theoretically and quanititatively, we must accumulate empirical data and use them relatively. In such consideration the author acquired some data of chemical weathering from the chemical analysis of granitic and basaltic rocks in and around Fukuoka city, Japan and granitic rocks in and around Chonju and Iri cities, Korea. Because both rock types studied can be considered as representative materials of acidic and basic rocks compsing the earth crust, it is significant to examine the phenomena of weathering of both rock types. The following results are obtained from the analysis and examinations of chemical compositions of the original and weathered rocks. The loss rate of major elements has no uniformity, but the following relation holds in general; Ca, Na> K, Si> Mg> Fe, Al. As weathering proceeds, the ratio of $Al_2O_3/CaO$ shows increasing phenomena, and that of $Na_2O/CaO$ decreasing. The range of migration of composition is broad in basaltic rocks but narrow in granitic rocks. The reason is that the chemical weathering of basaltic rocks progresses more easily than that of granitic rocks. The chemical weathering potenitial index of basaltic rocks in larger than that of granitic rocks. The reason is that the chemical weathering of basaltic rocks proceeds more easily than that of granitic rocks. In weathering, the decrease of mobile cations such as $Ca^{2+}$, $Na^{2+}$, $Mg^{2+}$ and the increase of $H_2O$ in basaltic rocks are more obvious than in granitic rocks.

• Physical Therapy Korea
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• v.5 no.3
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• pp.72-87
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• 1998

This study examined the rates of spinal abnormal curvature and the correlation of the Body Mass Index (BMI), Low Back Pain (LBP) and spinal curvature by measuring scoliosis, kyphosis, and lordosis in university students. The study population included 67 male, 92 female university students, making a total of 159, in Wonju City. Spinal curvature was measured by an electrogoniometer in a computerized skeletal analysis system. Lateral curvature of spine of more than 10 degrees was considered as nonspostural scoliosis. The correlation of BMI, LBP and the spinal curvature was analysed by Pearson's correlation coefficient and t-test. The following results were obtained: 1. The overall incidence and rate of scoliosis in cases with a greater than 10 degree curve in males was an incidence of 8 and a rate of 11%. In females the incidence was 36 and the rate 39.2%. 2. The overall incidence and rate of kyphosis of less than 20 degrees in males was a rate of 9 and an incidence of 11.9%. In females, the rate was 5 and the incidence 5.4%. In kyphosis cases of more than 40 degrees, the male rate was 5 and the incidence 7.7%. For female the rate was 13 and the incidence 14.2%. 3. The overall incidence and rate of lordosis with curves of less than 20 degrees was a rate of 6 for males and an incidence of 9.0%. For females, the rate was 5 and the incidence 5.4%. In cases of more than 50 degrees lordosis, the female rate was 2 and the incidence 2.2%. There were no males in this category. 4. There was a negative correlation between kyphosis and BMI. The greater the kyphotic curve, the less the BMI in males (p<0.05). There was no significant BMI difference by gender in either scoliosis or lordosis. There was, however, a significantly decreased sacral angle in the female group with LBP. The results of this study cannot be generalized to the general population because the subjects were all from one university. The measurements were quite reliable because the angles determined by the Metrocom System were highly correlated with radiologic findings. This study shows the need for a regular screening system for spinal curvatures in university health examination procedures.

• The Korean Journal of Emergency Medical Services
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• v.14 no.1
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• pp.65-80
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• 2010

Objective : The objective of this study was to survey the job satisfaction and turnover intention of 119 emergency medical technicians who are fire fighters and, at the same time, provide emergency patients with first aid, to examine the correlation between their job satisfaction and turnover intention, and to provide basic materials for the human resource management of 119 emergency medical technicians. Method : The survey was conducted with 152 119 emergency medical technicians working at fire stations in an area of Gyeonggi-do during the period from July 15 to September 14, 2009. Job satisfaction was measured with a tool developed by Kim Sun-sim and Kwon Hye-ran (2002) based on the Index of Work Satisfaction, and turnover intention with the tool developed by Becker (2002) and translated and used by Cho Yeong-sook (2002). The questionnaire was composed of 11 questions on general characteristics, 35 on job satisfaction, and 4 on turnover intention, so a total of 50 questions. The reliability of the questionnaire was Cronbach's ${\alpha}=0.922$ for job satisfaction and Cronbach's ${\alpha}=0.854$ for turnover intention. Using SPSS 14.0, we obtained frequencies, percentages, means, and standard deviations, and performed independent two-sample t-test, one-way ANOVA, and Pearson correlation analysis, and Cronbach's ${\alpha}$. Results : 1) The mean score of the 119 emergency medical technicians' job satisfaction was 2.71, and that of their turnover intention was 2.64. By area of job satisfaction, the mean score was 3.44 for the area of job itself, 2.92 for the interaction area, 2.67 for the organizational demand area, 2.64 for the autonomy area, 2.14 for the wage area, and 1.91 for the working condition area, showing that emergency medical technicians were generally satisfied with their job itself but not with their working condition. 2) As to difference according to the 119 emergency medical technicians' general characteristics, statistically significant difference was observed in job satisfaction according to license type (F = 4.729, p < .010), and in turnover intention according to position (F = 3.768, p < .025). 3) The 119 emergency medical technicians' job satisfaction and turnover intention was in a negative correlation with each other (r = -.44, p < .000) in general, and by the sub-areas of job satisfaction, the correlation with turnover intention was high in order of the autonomy area (r = -.42, p = .000), interaction area (r = -.42, p = .000), job itself (r = -.35, p < .000), organizational demand area (r = -.30, p = .000), wage area (r = -.23, p = .000), and working condition area (r = -.21, p = .008). Conclusion : The 119 emergency medical technicians' job satisfaction showed a negative correlation with their turnover intention. This suggests that turnover intention can be reduced by improving job satisfaction. Furthermore, 119 emergency medical technicians' job satisfaction was high with the job itself, showing their high pride in their job, but was low with working condition and wage. Thus, it is necessary to enhance their job satisfaction by improving the 24-hour work system through supplementing manpower, compensating for overtime works, adjusting work hours per week, etc. These results are expected to be useful in making human resource management plans to lower turnover intention by enhancing 119 emergency medical technicians' job satisfaction.

• Korean Journal of Health Education and Promotion
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• v.20 no.1
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• pp.159-172
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• 2003

Purpose : The purpose of this study was to investigated the dietary habits of students in order to identify risk groups according to their Body Mass Index (BMI), and to compare the eating behavior of students in the normal range (19${\le}$24) and those in risk groups (BMI${\le}$19, 24${\le}$27, BMI>27). Method : 1176 elementary school students, 850 middle school students and 672 high school students in Wonju City, were the participants The instrument for this study was a structured questionnaire that included demographic data as well as dietary habits, and the eating behavior instrument developed by Stunkard & Messick(1985) and revised by Kim & Kim (1997). Result : 1) As students moved up ingrade level their dietary habits became more irregular and the degree that students chewed food was reduced 2) As students moved up in grade level, a greater number of the student did not eat breakfast. The reasons given were that there were not enough time before classes started(40.4%) and a lack of appetite in the morning(10.6%) in high school students. 3) As for supper, from 67.8 to 81.9% of subjects reported having regular supper. However the rest of the subjects did not eat supper because of anorexia and fear of weight gain. 4) The results identified risk groups according to their BMI showed that for elementary school students, 55.9% were in the low weight group, 5.5% in the overweight group, and 0.9% in the obese group. For middle and high school students, 40.6% and 35.5% respectively were in the low weight group, 7.4% and 6.3% in the overweight group, and 4.1% and 2.5% the obese group. 5) Comparisons of the eating behavior of students in the normal weight group with that of those in the three risk groups showed that there significant differences in 'hunger' and cognitive restraint of eating' in elementary school students, and significant differences in 'cognitive restraint of eating' in middle and high school students. Conclusion : The results of this study show that management of diet in school health should be addressed from both the aspect of lack of nutrition and that of excess nutrition. In other words, good diet is as important for students in the low weight group as it is for those in the overweight and obese groups. The establishment of good dietary habits and eating behavior in students, by nurses and dieticians should be done by providing repeated diet education and involvement in diet counseling.

• Geophysics and Geophysical Exploration
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• v.19 no.2
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• pp.67-75
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• 2016

To investigate spatial and temporal variations of low-frequency (${\leq}5Hz$) ambient seismic noise, we analyzed the noise data recorded for one whole year of 2014 at surface accelerometer stations in South Korea. After decomposed into low-frequency (LF; < 1 Hz) and high-frequency (HF; ${\geq}1Hz$) components, the root-mean-squared (RMS) amplitudes and power spectral densities (PSD) of the noise data were computed. The RMS amplitudes were larger on islands and near-shore stations, but also large RMS amplitudes were observed at inland stations in large cities only for HF components. The RMS amplitudes of HF components were larger in the daytime than at nighttime and during weekdays than on Sunday and holidays. This indicates the HF components are closely related to human activities. On the contrary, daily and weekly variations were not clear in the LF components while they showed seasonal variations with its maximum during the winter and a good correlation with significant wave height. Therefore, we interpret the mechanism of LF components is closely related to natural phenomena such as sea. The amplitude of LF components decreased as an exponential function of the distance to the center of typhoons. The exponential index of -0.76 suggested that ambient seismic noise included both surface and body waves. Peak frequencies of the PSD curves were near 0.34 Hz indicating the double frequency. No temporal variation in the peak frequency was clearly noticed.

• Journal of Korean Neurosurgical Society
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• v.64 no.1
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• pp.78-87
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• 2021

Objective : Intraoperative neurophysiological monitoring (IONM) has been widely used during spine surgery to reduce or prevent neurologic deficits, however, its application to the surgical management for cervical myelopathy remains controversial. This study aimed to assess the success rate of IONM in patients with cervical myelopathy and to investigate the factors associated with successful baseline monitoring and the effect of increasing the stimulation intensity by focusing on motor evoked potentials (MEPs). Methods : The data of 88 patients who underwent surgery for cervical myelopathy with IONM between January 2016 and June 2018 were retrospectively reviewed. The success rate of baseline MEP monitoring at the initial stimulation of 400 V was investigated. In unmonitorable cases, the stimulation intensity was increased to 999 V, and the success rate final MEP monitoring was reinvestigated. In addition, factors related to the success rate of baseline MEP monitoring were investigated using independent t-test, Wilcoxon rank-sum test, chi-squared test, and Fisher's exact probability test for statistical analysis. The factors included age, sex, body mass index, diabetes mellitus, smoking history, symptom duration, Torg-Pavlov ratio, space available for the cord (SAC), cord compression ratio (CCR), intramedullary increased signal intensity (SI) on magnetic resonance imaging, SI length, SI ratio, the Medical Research Council (MRC) grade, the preoperative modified Nurick grade and Japanese Orthopedic Association (JOA) score. Results : The overall success rate for reliable MEP response was 52.3% after increasing the stimulation intensity. No complications were observed to be associated with increased intensity. The factors related to the success rate of final MEP monitoring were found to be SAC (p<0.001), CCR (p<0.001), MRC grade (p<0.001), preoperative modified Nurick grade (p<0.001), and JOA score (p<0.001). The cut-off score for successful MEP monitoring was 5.67 mm for SAC, 47.33% for the CCR, 3 points for MRC grade, 2 points for the modified Nurick grade, and 12 points for the JOA score. Conclusion : Increasing the stimulation intensity could significantly improve the success rate of baseline MEP monitoring for unmonitorable cases at the initial stimulation in cervical myelopathy. In particular, the SAC, CCR, MRC grade, preoperative Nurick grade and JOA score may be considered as the more important related factors associated with the success rate of MEP monitoring. Therefore, the degree of preoperative neurological functional deficits and the presence of spinal cord compression on imaging could be used as new detailed criteria for the application of IONM in patients with cervical myelopathy.