• 제목/요약/키워드: Keun Seob

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Preventive Agents against Sepsis and New Phenylpropanoid Glucosides from the Fruits of Illicium verum

  • Lee, Sung-Won;Li, Gao;Lee, Kyong-Sun;Jung, Jun-Sub;Xu, Ming-Lu;Seo, Chang-Seob;Song, Dong-Keun;Son, Jong-Keun
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.257.1-257.1
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    • 2003
  • The bioassay-guided fractionation of preventive agents against lethality due to septic shock from the fruits of Illicium verum lead to the isolation of two known racemic mixtures of phenylpropanoids (1 and 2), along with two known phenylpropanoid glucosides (3 and 5) and two new phenylpropanoid glucosides (4 and 6). Their chemical structures were elucidated on the basis of spectroscopic studies. (omitted)

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Protective agents against sepsis from the root bark of Paeonia suffruticosa

  • Li-Gao;Xu , Ming-Lu;Seo, Chang-Seob;Kim, Hyo-Jin;Lee, You-Jeong;Lee, Yeun-Koung;Son, Jong-Keun;Song, Dong-Keun
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.199.2-199.2
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    • 2003
  • The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root bark of Paeonia suffruticosa led to the isolation of ten known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2) methyl 3-hydroxy-4- methoxybenzoate (3), acetovanillone (4), benzoic acid (5), benzoylpaeoniflorin (6), paeonoside (7), paeoniflorin (8), oxypaeoniflorin (9) and apiopaeonoside (10). Among them, 4 exhibited the highest survival rate in a dose-dependent manner (100% with a dose of 30 mg/kg versus 16.7% for the control experiment) and showed reduction of plasma alanine aminotransferase (ALT) value on the in vivo assay model of sepsis induced by LPS/GalN.

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Meteorological Mechanisms Associated with Long-range Transport of Asian Dust Observed at the West Coast of North America in April 2001

  • Song Sang-Keun;Kim Yoo-Keun;Moon Yun-Seob
    • Journal of Korean Society for Atmospheric Environment
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    • 제20권E1호
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    • pp.1-14
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    • 2004
  • Meteorological mechanisms in association with long-range transport of Asian dust in April 2001 have been investigated using weather maps, satellite images, TOMS and surface $PM_{10}$ data, backward trajectories, plus modeling output results (geopotential heights, horizontal wind vectors, potential temperatures, and streamlines). The results indicated that long -range transport of Asian dust to the west coast of North America was associated with strong westerlies between the Aleutian low and the Pacific high acting as a conveyor belt. Accelerating westerly flows due to cyclogenesis at the source regions over East Asia transported pollution from the continent to the central Pacific. When the system reached the Aleutian Islands, the intensity of troughs and the westerlies were amplified in the North Pacific. Thereafter the winds between the Aleutian Islands and the Pacific Ocean were more intensified from the air flow transport of the conveyor belt. Consequently, the strong wind in the conveyor belt enhanced the dust transport from the Pacific Ocean to the west coast of North America. This was evidenced by $PM_{10}$ concentration (maximum of about $100{\mu}g\;m^{-3}$) observed In California. Further evidence of the dust transport was found through the observation of satellite images, the distribution of TOMS aerosol index, and the analyses of streamlines and backward trajectories.

불완전하게 결찰된 뇌동맥류의 혈관내치료 - 증 례 보 고 - (Endovascular Treatment of Incompletely Clipped Cerebral Aneurysm - Case Report -)

  • 임동준;정용구;조태형;이훈갑;김세훈;김근회;권택현;정흥섭;박정율;박윤관;이기찬;서중근
    • Journal of Korean Neurosurgical Society
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    • 제30권4호
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    • pp.533-536
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    • 2001
  • Residual aneurysm is a challenging problem after clipping procedure for the aneurysms. The anthors describe one patient in whom endovascular treatment was sucessfully done to treat residual aneurysm after surgical clipping. We discussed the role of endovascular coil occlusion in case of incomplete surgical obliteration of aneurysms.

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정상 골조직과 경계가 불명확한 요추 골연골종 - 증례보고 - (Osteochondroma of the Lumbar Spines without Clear Demarcation from Surrounding Normal bone Tissues - Report of A Case -)

  • 김주한;오우석;정흥섭;이기찬;서중근
    • Journal of Korean Neurosurgical Society
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    • 제30권6호
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    • pp.790-794
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    • 2001
  • Spinal osteochondroms are very rare, and are thought to arise through a process of progressive endochondral ossification of aberrant cartilage of a growth plate, as a consequence of congenital defect or trauma. A case of diffuse type osteochondroma involving the posterior elements of L1-L5 that progressed after laminectomy in a 33-year-old man is reported. Usually, the spinal osteochondroma shows clear demarcation between tumor margin and normal spine elements, and can be exised completely. However, there was no clear demarcation between tumor and normal spine element in our case and therefore it was not possible to removal completely.

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Metallothionein이 지질과산화반응과 Aldehyde Oxidase활성에 미치는 영향 (Effect of Metallothionein on the Lipid Peroxidation and Aldehyde Oxidase Activity)

  • 허근;신억섭;박종민
    • Toxicological Research
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    • 제11권1호
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    • pp.43-49
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    • 1995
  • The effects of metallothionein and cadmium ion on the hepatic aldehyde oxidase activity and brain lipid peroxidation were tested in vitro. The content of brain lipid peroxide at the condition of normal or $300{\mu}M$ Fe(II)-induced was remarkably reduced by the addition of metallothionein in the incubation mixture. The induced content of lipid peroxide by cadmium $(30{\mu}g/ml)$ ion was reduced by metallothionein $(100{\mu}g/ml)$. The activity of aldehyde oxidase was not affected by metallothionein, but cadmium ion $(8.38{\mu}g/ml)$ increased the activity of aldehyde oxidase about 80% compared to the control. The cadmium-induced activity of aldehyde oxidase was restored to the control level by metallothionein or penicillamine.

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EPDM 및 실리콘 애자의 가속실험에 대한 와이블 분포해석 (The Analysis of Weibull Distribution on the Accelerated Aging Test in Polymer Insulation)

  • 임장섭;김진국;박범수;송일근;이재봉
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2003년도 추계학술대회 논문집 전기물성,응용부문
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    • pp.25-28
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    • 2003
  • Fractal mathematics is being highlighted as a research method for classification of image. But the application of Fractal dimension(FB) has been required the complicated calculation method because of its complex repetition progressing. In this paper, it has been developed the new approach method to express the Fractal Dimension(FB) for aging level calculation and estimation system of outside insulator using special image processing algorithm. As a result after FD testing, the recognized aging estimation of FD has a very characteristics compared to the conventional visual inspection.

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차수형 케이블의 수트리 가속실험후 와이블분포 해석 (The Analysis of Weibull Distribution after an Accelerated Aging Test of MV Cable)

  • 김진국;임장섭;송일관;이재봉
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2003년도 추계학술대회 논문집 전기물성,응용부문
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    • pp.178-181
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    • 2003
  • For many years, testing laboratories, research institutes and manufactures try to find a reliable water tree accelerated ageing test that is able to show whether a polymer Medium Voltage cable os susceptible to water treeing or not. Test on laboratory samples, model cable designs, and fell size cable are presented Apart form aging, another important aspect of any accelerated aging test is the right choice of th preconditioning method. This paper is the analysis of weibull distribution method after an accelerated aging test of MV(Medium Voltage) cable.

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작업시간과 육체적인 작업부하를 고려한 혼합모델 조립공정의 라인밸런싱 (Line Balancing for the Mixed Model Assembly Line Considering Processing Time and Physical Workloads)

  • 문성민;권금섭;최경현
    • 산업공학
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    • 제17권3호
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    • pp.282-293
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    • 2004
  • Line Balancing is the problem to assign tasks to stations while satisfying some managerial viewpoints. Most researches about the Mixed-Model Line Balancing problems are focused on the minimizing the total processing time or the number of workstations. Independently, some research reports consider the balance issues of the physical workloads on the assembly line. In this paper, we are presenting a new mathematical model to accomplish the line balance considering both the processing time and the workloads at the same time. To this, end, we propose an zero-one integer program problem, and we use the Chebyshev Goal Programming approach as the solution method. Some computational test runs are performed to compare the pay-offs between the processing time and the workloads. And, the test results show us that the reliable balanced work schedules can be obtained through the proposed model.