Toxicological Research

  • 제11권1호
  • /
  • Pages.43-49
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  • 1995
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

Metallothionein이 지질과산화반응과 Aldehyde Oxidase활성에 미치는 영향

Effect of Metallothionein on the Lipid Peroxidation and Aldehyde Oxidase Activity

  • 허근 (영남대학교 약학대학) ;
  • 신억섭 (영남대학교 약학대학) ;
  • 박종민 (영남대학교 의료원 약제부)
  • Huh, Keun (Department of Pharmacology and Toxicology, College of Pharmacy, Yeungnam University) ;
  • Shin, Uk-Seob (Department of Pharmacology and Toxicology, College of Pharmacy, Yeungnam University) ;
  • Park, Jong-Min (Department of Pharmacy, Yeungnam Medical Center)
  • 발행 : 1995.06.01
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초록

The effects of metallothionein and cadmium ion on the hepatic aldehyde oxidase activity and brain lipid peroxidation were tested in vitro. The content of brain lipid peroxide at the condition of normal or $300{\mu}M$ Fe(II)-induced was remarkably reduced by the addition of metallothionein in the incubation mixture. The induced content of lipid peroxide by cadmium $(30{\mu}g/ml)$ ion was reduced by metallothionein $(100{\mu}g/ml)$. The activity of aldehyde oxidase was not affected by metallothionein, but cadmium ion $(8.38{\mu}g/ml)$ increased the activity of aldehyde oxidase about 80% compared to the control. The cadmium-induced activity of aldehyde oxidase was restored to the control level by metallothionein or penicillamine.

키워드

참고문헌

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