• 한국지구물리탐사학회:학술대회논문집
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• 2003.11a
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• pp.398-401
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• 2003

This paper deals with the recent achievements in AMT data acquisition and processing, which have improved the quality of the collected data,. Comparing AMT with VES, IP and logging data, it is concluded through some case histories that qualified results can be achieved in probing the karst water with AMT technique.

• Journal of the Korean GEO-environmental Society
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• v.14 no.9
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• pp.13-19
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• 2013

The Chongok karst cave which is located in Donghae-city, has high tourist and educational value due to existence of many doline(sink hole). Whereas this cave is easy to approach for the tourists, because this cave is located near the downtown, a high environmental riskiness such as sewage flowing has been also involved. In study, we observed the variation of water quality with long-term monitoring and investigated the possibility of existence of impact factor to water eco-system and determined the proper long-term monitoring factor among many monitoring criteria. The groundwater quality was maintained in the range of about $14^{\circ}C$ in temperature, over 10mg/l in dissolved oxygen and 7-8 in pH, so the impact factor in water eco-system was not observed. The guide line to make sure of tourist safety was determined to 60mm/d as daily rainfall. The conductivity was suggested to main factor for long-term monitoring main factor and pH/turbidity was suitable for the supplementary factor. For the seasonal variation monitoring, ORP was recommended.

• Geomechanics and Engineering
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• v.29 no.4
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• pp.391-405
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• 2022

A newly proposed grouting simulation method, the sequential diffusion solidification method was introduced into the numerical simulation of combined bi-borehole grouting. The traditional, critical and difficult numerical problem for the temporal and spatial variation simulation of the slurry is solved. Thus, numerical simulation of grouting and blocking of flowing water in karst conduits is realized and the mechanism understanding of the combined bi-borehole technology is promoted. The sensitivity analysis of the influence factors of combined bi-borehole grouting was investigated. Through orthogonal experiment, the influences of proximal and distal slurry properties, the initial flow velocity of the conduit and the proximal and distal slurry injection rate on the blocking efficiency are compared. The velocity variation, pressure variation and slurry deposition phenomenon were monitored, and the flow field characteristics and slurry outflow behavior were analyzed. The interaction mechanism between the proximal and distal slurries in the combined bi-borehole grouting is revealed. The results show that, under the orthogonal experiment conditions, the slurry injection rate has the greatest impact on blocking. With a constant slurry injection rate, the blocking efficiency can be increased by more than 30% when using slurry with weak time-dependent viscosity behavior in the distal borehole and slurry with strong time-dependent viscosity behavior in the proximal borehole respectively. According to the results of numerical simulation, the grouting scheme of "intercept the flow from the proximal borehole by quick-setting slurry, and grout cement slurry from the distal borehole" is put forward and successfully applied to the water inflow treatment project of China Resources Cement (Pingnan) Limestone Mine.

• Journal of The Geomorphological Association of Korea
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• v.20 no.1
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• pp.1-9
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• 2013

This study aims to provide fundamental data for further shape-factor research on karst by measuring and classifying the shape of surface topography in Hogye, Mungyeong. First, in the research area, there are 35 dolines and uvalas. Second, large uvalas are found in three places, including Gulnomjae in Bugokri, and Teotgol and Denjimigol in Urori. Third, there are 13 round dolines and 22 oval dolines. Next examining the cross section of dolines, there are 27 bowl shaped dolines, 2 plate shaped dolines, and 6 funnel shaped dolines. Fourth, most dolines lay over 200m elevation, which is ridge and top of mountain. Fifth, development direction of dolines resembles the strike direction of limestone in Hogye, suggesting that the development direction of limestone affects doline corrosion. From this situation, we can guess sinkholes of the doline would be linked with limestone caves by the underground water pipe. Three limestone caves, karren and dry valley etc. appear in the research area.

• YAKHAK HOEJI
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• v.43 no.4
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• pp.464-468
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• 1999

In order to find less toxic antiviral agents from basidiomycetes, EA, the water soluble substance, was isolated from the carpophores of Elfvingia applanata (Pers.) Karst. Anti-encephalomyocarditis (EMC) virus activity of EA was examined in Vero cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with interferon (IFN) alpha and gamma were examined on the multiplication of EMC virus. EA exhibited a concentration-dependent reduction in the plaque formation of EMC virus with 50% effective concentration ($EC_{50}$) of 2.12 mg/ml. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha showed potent synergism with CI values of 0.40~0.60 for 50%, 70% and 90% effective levels, but that with IFN gamma showed antagonism with CI values of 2.16~2.83.

• YAKHAK HOEJI
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• v.43 no.4
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• pp.469-473
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• 1999

EA, the water soluble substance, was prepared from the carpophores of Elfvingia applanata (Pers). Karst. Anti-influenza A virus (anti-Flu A) activity of EA was examined of Vero cells by plaque reduction assay in vitro. And the combined antiviral effects fo EA with interferon (IFN) alpha and gamma were examined on the multiplication of Flu A with 50% effective concentration ($EC_50$) of 1.50 mg/ml. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha on Flu A showed more potent synergism with CI values of 0.50~0.52 of 50%, 70%, 90% effective levels than that with IFN gamma with CI values of 0.82~0.99.

• Proceedings of the Korean Geotechical Society Conference
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• 2002.03a
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• pp.165-172
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• 2002

We presents an hazard zonation mapping technique in karst terrain and its assessment. From the detailed engineering geological mapping. Controlling factors of sink hole and limestone cave formation were discussed and 4 main hazard factors affecting hazard potential are identified as follows: prerequisite hazard factor(distributions of pre-existing sink holes and cavities), geomorphological hazard factors(slope gradient, vegetation, and drainage pattern etc.) geological hazard factors(lithology, fracture patterns and geological structures etc.) and hydraulic conditions(hydraulic head, annual fluctuation of ground water table and composition of g/w water). From the construction of hazard zonation map along the Jecheon-Maepo area, and vertical cross-sectional hazard zonations specific tunnel site we suggest hazard zonation rating systems.

• Natural Product Sciences
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• v.5 no.2
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• pp.107-111
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• 1999

To investigate less toxic antiviral agents from Basidiomycetes, EA, the water soluble substance, was isolated from the carpophores of Elfvingia applanata (pers.) Karst. Anti-varicella zoster virus (Oka strain; anti-VZV/Oka) activity of EA was examined in MRC-5 cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with nucleoside anti-VZV agents, acyclovir and vidarabine, were examined on the multiplication of VZV/Oka. EA exhibited a concentration-dependent reduction in the plaque formation of VZV/Oka with a 50% effective concentration $(EC_{50})$ of $464.14\;{\mu}g/ml$. The results of combination assay were evaluated by the combination index (CI) that was calculated by the multiple drug effect analysis. The combination of EA with acyclovir showed more potent synergism with CI values of $0.18{\sim}0.62$ for $50{\sim}90%$ effective levels than that of EA with vidarabine with CI values of $0.67{\sim}1.04$.

• Korean Journal of Pharmacognosy
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• v.30 no.1
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• pp.25-33
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• 1999

In order to find less toxic antiviral agents from basidiomycetes, EA, the water soluble substance, was prepared from the carpophores of Elfvingia applanata (Pers.) Karst. EA was examined for antiviral activity against five strains of pathogenic viruses such as encephalomyocarditis virus (EMCV), vesicular stomatitis virus (VSV) Indiana and New Jersey strains, influenza A virus (Flu A), and varicella zoster virus (VZV) in vitro. Antiviral activity was evaluated by plaque reduction assay. Among five strains of viruses tested, EA exhibited the most potent antiviral activity against VSV Indiana strain with 50% effective concentration $(EC_{50})$ of 0.104 mg/ml in Vero cells, and its selectivity index (SI) was 36.5. EA was also examined for the virucidal activity, antiviral activity in preincubation on VSV Indiana strain in order to examine possible mode of antiviral activity. Preincubation of Vero cells with EA did not confer protection against VSV, however, prolonged exposure of cells to EA inhibited the replication of virus dose-dependently. In virucidal activity, the titer of infectious virus did not decrease significantly.

• Mycobiology
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• v.29 no.1
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• pp.11-14
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• 2001

A preparation of water soluble components(EA) was made from carpophores of Elfvingia applanata(Pers.) Karst and its in vitro antibacterial activity on a number of bacterial species was examined by macrobroth dilution assay. Among 16 species of bacteria tested, the most potent antibacterial activity was observed against Staphylococcus epiderrnidis and Proteus vulgaris, of which MICs were 1.25 mg/ml. To investigate the antibacterial effects in combinations of EA with quinolone antibiotics, such as ciprofloxacin, enoxacin, lomefloxacin, norfloxacin, and ofloxacin, the fractional inhibitory concentrations(FICs) and the fractional inhibitory concentration indices(FICIs) for four bacterial strains were determined by macrobroth dilution checkerboard assay. Combinations of EA and quinolones exhibited either additive or indifferent effects of antibacterial activity in most instances. However, both synergistic and antagonistic effects were not observed in any cases.