• 한국농공학회논문집
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• 제51권3호
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• pp.53-62
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• 2009

This study was carried out to select optimal probability distribution based on design accumulated monthly mean inflow from the viewpoint of drought by Gamma (GAM), Generalized extreme value (GEV), Generalized logistic (GLO), Generalized normal (GNO), Generalized pareto (GPA), Gumbel (GUM), Normal (NOR), Pearson type 3 (PT3), Wakeby (WAK) and Kappa (KAP) distributions for the observed accumulative monthly mean inflow of Chungjudam. L-moment ratio was calculated using observed accumulative monthly mean inflow. Parameters of 10 probability distributions were estimated by the method of L-moments with the observed accumulated monthly mean inflow. Design accumulated monthly mean inflows obtained by the method of L-moments using different methods for plotting positions formulas in the 10 probability distributions were compared by relative mean error (RME) and relative absolute error (RAE) respectively. It has shown that the design accumulative monthly mean inflow derived by the method of L-moments using Weibull plotting position formula in WAK and KAP distributions were much closer to those of the observed accumulative monthly mean inflow in comparison with those obtained by the method of L-moment with the different formulas for plotting positions in other distributions from the viewpoint of RME and RAE.

• Nuclear Engineering and Technology
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• 제55권3호
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• pp.1071-1083
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• 2023

The on-the-fly energy release per fission (OTFK) model is implemented in STREAM to continuously update the Kappa values during the depletion calculation. The explicit neutron and photon energy distribution, which has not been considered in previous STREAM versions, is incorporated into the existing on-the-fly model. The impacts of the modified OTFK model with explicit neutron and photon heating in STREAM on the power distribution, fuel temperature, and other core parameters during depletion with feedback calculations are studied using several problems from the VERA benchmark suit. Overall, the explicit heating calculation provides a better power map for the feedback calculations particularly when strong gamma emitters are present. Generally, the fuel temperature decreases when neutron and photon heating is employed because fission neutrons and gamma rays are transported away from their points of generation. This energy release model in STREAM indicates that gamma energy accounts for approximately 9.5%-10% of the total energy released, and approximately 2.4%-2.6% of the total energy released will be deposited in the coolant for the VERA 5, NuScale, and Yonggwang Unit 3 2D cores.

• 대한조선학회논문집
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• 제37권1호
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• pp.26-39
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• 2000

예인수조와 캐비테이션 터널에서 레이놀즈 수가 프로펠러 단독 특성시험에 미치는 영향을 씨리즈 모형 프로펠러(날개수=4, $0.3{\leq}A_E/A_O{\leq}0.75,\;0.5{\leq}P/D{\leq}1.1$)에 대하여 실험적인 방법으로 조사하였다. 예인수조에서 프로펠러 단독 특성시험을 위한 시험조건으로 제15차와 17차 ITTC에서 추천한 레이놀즈 수($R_n{\geq}3.0{\times}10^5$)는 시험조건으로써 불충분함을 보였으며 적합한 시험조건 선정방법을 제안하였다. 예인수조와 캐비테이션 터널에서 프로펠러 단독특성들의 상호관계를 나타내는 상관계수($\kappa$)를 도출하였다. 프로펠러 축 주위에서 형성된 경계층 유동이 프로펠러 특성에 미치는 영향을 레이저 유속계를 이용한 계측에 의해 조사하였으며, 그 영향이 작지 않다는 것을 보였다.

• 대한기계학회논문집B
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• 제39권7호
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• pp.617-624
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• 2015

용존공기부상법이란 오염물에 미세기포를 부착하여 수표면으로 부상시킴으로써 이를 제거하는 수처리 방법이다. 본 연구에서는 난류모델에 따른 용존공기부상조 내부 유동해석의 변화를 고찰하기 위해 물과 기포의 혼합물에 대한 2상 유동을 모사하였다. 이때, 주어진 용존공기부상조 형상 및 조건에 대하여 다양한 난류모델에 따른 용존공기부상법 내부의 미세기포 분포량, 계산시간 및 수렴성 등을 비교하였으며, 그 결과 기존에 주로 사용되었던 표준 ${\kappa}-{\varepsilon}$ 모델이 타 난류모델과는 다른 거동을 예측하는 것으로 확인되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6463-6468
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• 2012

Purpose: To evaluated the effect of the gambogic acid (GA), one of the effective components of Garcinia, in combination with a new multi-targeted oral medication, sunitinib (SU) on renal cancer cell proliferation in vitro and on tumor growth in vivo. Methods: After treatment with GA or SU, either alone or in combination, MTT and FACS analysis were used to examine cell viability and cycle distribution of the renal carcinoma cell lines 786-0 and Caki-1. Western blotting was employed to examine the expression of proteins related to the cell cycle and vascular formation. Furthermore, a xenograft model was applied to study the antitumor efficacy of SU or GA alone or in combination, with immunohistochemistry to detect expression of proteins related to xenograft growth and angiogenesis. Western blotting was used to examine NF-${\kappa}B$ signaling pathway elements in xenografts. Results: Treatment of 786-0 and Caki-1 cells with GA or SU resulted in decreased tumor cell proliferation, especially with joint use. Cells accumulated more strongly in the sub-G1 phase after joint treatment with GA and SU than treatment of GA and SU alone. Western blotting arrays showed 1 protein significantly upregulated, 2 proteins downregulated, and 2 proteins unchanged. Moreover, combined use of GA and SU inhibited the growth and angiogenesis of xenografts generated from Caki-1 significantly. Immunohistochemistry arrays showed downregulation of the expression of proteins promoting xenograft growth and angiogenesis, and Western blotting showed inhibition of the NF-${\kappa}B$ signaling pathway after treatment by GA alone and in combination with SU in xenografts. Conclusions: Our results show that the joint use of GA and SU can provide greater antitumor efficacy compared to either drug alone and thus may offer a new treatment strategy for renal cell carcinoma.

• IMMUNE NETWORK
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• 제6권1호
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• pp.20-26
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• 2006

Background: Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease that is characterized by invasive synovial hyperplasia, leading to progressive joint destruction. Recent studies have described that RA is caused by virus, bacteria or outside material. Approximately 2 to 20% of RA cases arc reported to be associated with infected hepatitis C virus (HCV). However, the mechanisms underlying virus-induced RA are still unknown. Moreover, few molecular studies have addressed the inflammatory aspects of HCV-associated autoimmune RA. In this study, we aimed to determine whe ther or not another HCV core protein transactivates the IL-8 gene expression, prototypic chemokine, in synovial cell. Methods: To establish the HCV core expressing stable synovial cell line, pCI-neo-core, a plasmid encoding HCV core protein, were transfected to HIG-82 cell line that is an established cell line from rabbit periaricular soft tissue. We examined the morphological changes and cell cycle distribution of HIG-82 cells with expression of HCV core protein by inverted microscopy and flow cytometry analysis, respectively. Also, we determined the mRNA levels of Interleukin (IL)-6 and IL-8 related to the inflammation by RT-PCR and then analyzed regulation of IL-8 expression by the NF-${\kappa}B$ pathway. Results: Our study showed no significant differences in morphology and cell cycle between HIG-82 control cell line and HIG-82 expressing HCV core protein. However, expression of HCV core protein induces the IL-8 mRNA expression in HIG-82 core cells via activated NF-${\kappa}B$ pathway. Conclusion: These results suggest that HCV core protein can lead to enhanced IL-8 expression. Such a proinflammatory role may contribute to the etiologic pathogenesis in RA patients with HCV infection.

• 한국컴퓨터정보학회논문지
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• 제12권4호
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• pp.33-42
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• 2007

소프트웨어 제품의 정확한 인도시기를 예측하거나 효용성 및 신뢰성을 예측하기 위해서는 소프트웨어 테스팅 과정에서 중요한 요소인 테스트 커버리지를 이용하면 보다 효율적인 테스팅 작업을 할 수 있다. 이런 모형을 ENHPP모형이라고 한다. 본 논문에서는 기존의 소프트웨어 신뢰성 모형인 지수 커버리지 모형과 S-커버리지 모형을 재조명하고 이 분야에 적용될 수 있는 Burr 분포에 기초한 Burr 커버리지 모형을 제안하였다. 고장 간격 시간으로 구성된 자료를 이용한 모수추정 방법은 최우추정법 과 일반적인 수치해석 방법인 이분법을 사용하여 모수 추정을 실시하고 효율적인 모형 선택은 편차자승합(SSE) 및 콜모고로프 거리를 적용하여 모형들에 대한 효율적인 모형선택도 시도하였다. NTDS 자료를 사용한 임무시간 비교 분석한 결과 Burr 커버리지 모형 시행이 지수나 S-형 모형보다 우수함을 보이고 있다. 이 자료들에서 기존의 모형과 Burr 커버리지 모형의 비교를 위하여 산술적 및 라플라스 검정, 편의 검정등을 이용하였다.

• 대한한방소아과학회지
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• 제32권4호
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• pp.1-12
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• 2018

Objectives Bangpungtongsungsan is an herbal medicine that treats obesity and dampness-phlegm. The aim of this study was to investigate the efficacy of Bangpungtongsungsan on insulin resistance induced by non-alcoholic fatty liver disease. Methods Male 6-week-old C57BL/6 male mice were divided into four groups: control group (Ctrl), high fat diet group (HFF), high fat diet with Bangpungtongsungsan extract administration group (BT1), and high fat diet with double concentration of Bangpungtongsungsan extract administration group (BT2). Each 10 mice were allocated to each group (total of 40 mice). All mice were allowed to eat fat rich diet freely throughout the experiment. To examine the effect of Bangpungtongsungsan, we observed weight changes, lipid blot distributions, PGC-1, $p-I{\kappa}B$, 8-OHdG, p-JNK, total cholesterol and glucose levels. Results Comparing of body weight measurements between 4 groups, weight gain was significantly lower in BT1 and BT2 group than the HFF group. The distribution of lipid blots and positive reaction of PGC-1 were significantly lower in BT1 and BT2 group. The positive reaction of $p-I{\kappa}B$ and 8-OHdG in hepatic tissues was significantly lower in BT1 and BT2 group. The positive reaction of p-JNK in hepatic tissues was significantly lower in BT1 and BT2 group. Total cholesterol and glucose levels were significantly lower in BT1 and BT2 group. Conclusions Bangpungtongsungsan has the effect of improving non-alcoholic fatty liver induced insulin resistance through regulation of lipid metabolism.

• 대한한방소아과학회지
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• 제33권2호
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• pp.12-21
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• 2019

Objectives Coptidis Rhizoma and Glycyrrhiza Uralensis are herbs that treat obesity and dampness-phlegm. The aim of this study is to investigate the efficacy of Coptidis Rhizoma and Glycyrrhiza Uralensis on lipid deposition with nonalcoholic fatty liver disease (NAFLD). Methods Male 6-week-old C57BL/6 male mice were divided into three groups: control group (Ctrl), high fat diet group (HFF), and high fat diet with Coptidis Rhizoma and Glycyrrhiza Uralensis extract administration group (CGT). Each 10 mice were allocated to each group (total of 30 mice). All mice were allowed to eat fat rich diet freely throughout the experiment. To examine the effect of Coptidis Rhizoma and Glycyrrhiza Uralensis, we observed weight changes, total cholesterol and glucose levels, lipid blot distributions, PGC-1, p-$I{\kappa}B$, and p-JNK. Results Body weights for all mice were measured and analyzed the difference between the groups. Weight gain was significantly lower in CGT group than the HFF group. Total cholesterol and glucose levels were significantly lower in CGT group. The distribution of lipid blots and positive reaction of PGC-1 were significantly lower in CGT group. The positive reaction of p-$I{\kappa}B$ in hepatic tissues was significantly lower in CGT group. The positive reaction of p-JNK in hepatic tissues was significantly lower in CGT group. Conclusions Coptidis Rhizoma and Glycyrrhiza Uralensis have the effect of improving non - alcoholic fatty liver induced insulin resistance through regulation of lipid metabolism.

• 대한한방소아과학회지
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• 제33권2호
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• pp.22-31
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• 2019

Objective This study is to learn the effects of Hataedock method using Coptidis rhizoma and Glycyrrhiza uralensis mixed extract on inflammatory response in allergic rhinitis-induced obese NC/Nga mice. Materials and Methods The mice were fed with high fat-diet to be obese, and were divided into 3 groups as follows; allergic rhinitis-induced obese mice group with Hataedock method (CGT, n=10), no treatment group (Ctrl), allergic rhinitis elicited obese mice group (ARE). To induce allergic rhinitis, NC/Nga mice of 3 weeks age were sensitized on 7, 8 and 9 weeks by ovalbumin antigen in intraperitoneal space. After 7 days of final sensitization, allergic rhinitis was initially induced in mice through nasal cavities for 5 days. After 1-week, allergic rhinitis was induced again by the same method. Histological examination was used to identify distribution of IL-4, CD40, STAT6, $Fc{\varepsilon}RI$, substance P, MMP-9, NF-${\kappa}B$ p65, iNOS and COX-2. Results Hataedock method significantly reduced IL-4, STAT6 and CD40 response (p<0.05). In CGT, the inhibition of Th2 differentiation decreased inflammatory mediators such as $Fc{\varepsilon}RI$, substance P, MMP-9, NF-${\kappa}B$ p65, iNOS and COX-2 (all p<0.05). The immunological improvement led reduction of respiratory epithelial damage and mucin secretion in goblet cell. Conclusion The results of this study show that the Hataedock method suppresses the expression of allergic rhinitis by decreasing the inflammatory mediators through the regulation of Th2 differentiation even when the inflammation reaction is increased by obesity. Therefore, Hataedock may have potential preventive measure of allergic rhinitis accompanied by obese.