• 제목/요약/키워드: Kaplan-Meier survival analysis

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경쟁적 위험하에서의 신뢰성 분석 (Reliability Analysis under the Competing Risks)

  • 백재욱
    • 한국신뢰성학회지:신뢰성응용연구
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    • 제16권1호
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    • pp.56-63
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    • 2016
  • Purpose: The purpose of this study is to point out that the Kaplan-Meier method is not valid to calculate the survival probability or failure probability (risk) in the presence of competing risks and to introduce more valid method of cumulative incidence function. Methods: Survival analysis methods have been widely used in biostatistics division. However the same methods have not been utilized in reliability division. Especially competing risks cases, where several causes of failure occur and the occurrence of one event precludes the occurrence of the other events, are scattered in reliability field. But they are not noticed in the realm of reliability expertism or they are analysed in the wrong way. Specifically Kaplan-Meier method which assumes that the censoring times and failure times are independent is used to calculate the probability of failure in the presence of competing risks, thereby overestimating the real probability of failure. Hence, cumulative incidence function is introduced and sample competing risks data are analysed using cumulative incidence function and some graphs. Finally comparison of cumulative incidence functions and regression type analysis are mentioned briefly. Results: Cumulative incidence function is used to calculate the survival probability or failure probability (risk) in the presence of competing risks and some useful graphs depicting the failure trend over the lifetime are introduced. Conclusion: This paper shows that Kaplan-Meier method is not appropriate for the evaluation of survival or failure over the course of lifetime. In stead, cumulative incidence function is shown to be useful. Some graphs using the cumulative incidence functions are also shown to be informative.

기술평가 자료를 이용한 중소기업의 생존율 추정 및 생존요인 분석 (A Study on the Survival Probability and Survival Factors of Small and Medium-sized Enterprises Using Technology Rating Data)

  • 이영찬
    • 지식경영연구
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    • 제11권2호
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    • pp.95-109
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    • 2010
  • The objectives of this study are to identify the survival function (hazard function) of small and medium enterprises by using technology rating data for the companies guaranteed by Korea Technology Finance Corporation (KOTEC), and to figure out the factors that affects their survival. To serve the purposes, this study uses Kaplan-Meier Analysis as a non-parametric method and Cox proportional hazards model as a semi-parametric one. The 17,396 guaranteed companies that assessed from July 1st in 2005 to December 31st in 2009 are selected as samples (16,504 censored data and 829 accident data). The survival time is computed with random censoring (Type III) from July in 2005 as a starting point. The results of the analysis show that Kaplan-Meier Analysis and Cox proportional hazards model are able to readily estimate survival and hazard function and to perform comparative study among group variables such as industry and technology rating level. In particular, Cox proportional hazards model is recognized that it is useful to understand which technology rating items are meaningful to company's survival and how much they affect it. It is considered that these results will provide valuable knowledge for practitioners to find and manage the significant items for survival of the guaranteed companies through future technology rating.

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중소기업 전용 B2B 전자상거래 보증 이용기업의 생존특성에 관한 실증연구 (An Empirical Study on Survival Characteristics of Enterprises Using B2B e-commerce Guarantee for SMEs)

  • 강명수;한창희
    • 한국IT서비스학회지
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    • 제18권4호
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    • pp.151-170
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    • 2019
  • This study conducted an empirical analysis through the Kaplan-Meier method, which is mainly used for clinical experiment analysis, on the survival rate and the survival duration of small and medium-sized enterprises using B2B e-commerce guarantee provided by credit guarantee institutions for activating B2B e-commerce transactions. The variables presented in this study are analyzed by the subdivision of the survival characteristics of enterprises using B2B e-commerce guaranteee by year, enterprises attribute, representative attribute, and guarantee use amount based on the variables tested through previous studies. According to the empirical analysis, SMEs using B2B e-commerce guarantees have a higher survival rate compared to general enterprises Simply by year and have a variety of survival characteristics, and most of the variables have a significant effect except for some variables. The implication of this study is that the researches conducted on enterprises participating in B2B e-commerce for a long period of time to support the establishment of stable business environment of SMEs and the results of empirical analysis on the survival characteristics are useful information to the stakeholders of B2B e-commerce And it can contribute to enhance the survival rate of related enterprises.

Survival analysis of bank loan repayment rate for customers of Hawassa commercial bank of Ethiopaia

  • Kitabo, Cheru Atsmegiorgis;Kim, Jong Tae
    • Journal of the Korean Data and Information Science Society
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    • 제25권6호
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    • pp.1591-1598
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    • 2014
  • The reviews of the balance sheet of commercial banks showed that loan item constitutes the largest portion of bank's assets. Although the sector has highest rate of profit, it possesses the greatest risk. Identifying factors that can contribute in lifting-up the loan repayment rate of customers of Hawassa district commercial bank is the major goal of this study. A sample of 183 customers who took loan from October, 2005 to April, 2012 was taken from the bank record. Kaplan-Meier estimation method and univariate Cox proportional hazard model were applied to identify factors affecting bank loan repayment rate. The result from Kaplan-Meier survival estimation revealed that the loan repayment rate is significantly related with loan type, and previous loan experience, educational level and mode of repayment. The log-rank test indicates that the survival probability of loan customers is not statistically different in repaying the loan among groups classified by sex. Moreover, the univariate Cox proportional hazard model result portrayed that educational level, having previous loan experience, mode of repayment, collateral type and purpose of loan are significantly related with loan repayment rate of customers commercial bank. Hence, banks should design loan strategies giving special emphasis on the significant factors while they are giving loans to their customers.

Conditional Bootstrap Methods for Censored Survival Data

  • Kim, Ji-Hyun
    • Journal of the Korean Statistical Society
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    • 제24권1호
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    • pp.197-218
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    • 1995
  • We first consider the random censorship model of survival analysis. Efron (1981) introduced two equivalent bootstrap methods for censored data. We propose a new bootstrap scheme, called Method 3, that acts conditionally on the censoring pattern when making inference about aspects of the unknown life-time distribution F. This article contains (a) a motivation for this refined bootstrap scheme ; (b) a proof that the bootstrapped Kaplan-Meier estimatro fo F formed by Method 3 has the same limiting distribution as the one by Efron's approach ; (c) description of and report on simulation studies assessing the small-sample performance of the Method 3 ; (d) an illustration on some Danish data. We also consider the model in which the survival times are censered by death times due to other caused and also by known fixed constants, and propose an appropriate bootstrap method for that model. This bootstrap method is a readily modified version of the Method 3.

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중도절단 회귀모형에서 역절단확률가중 방법 간의 비교연구 (A comparison study of inverse censoring probability weighting in censored regression)

  • 신정민;김형우;신승준
    • 응용통계연구
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    • 제34권6호
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    • pp.957-968
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    • 2021
  • 역중도절단확률가중(inverse censoring probability weighting, ICPW)은 생존분석에서 흔히 사용되는 방법이다. 중도절단 회귀모형과 같은 ICPW 방법의 응용에 있어서 중도절단 확률의 정확한 추정은 핵심적인 요소라고 할 수 있다. 본 논문에서는 중도절단 확률의 추정이 ICPW 기반 중도절단 회귀모형의 성능에 어떠한 영향을 주는지 모의실험을 통하여 알아보았다. 모의실험에서는 Kaplan-Meier 추정량, Cox 비례위험(proportional hazard) 모형 추정량, 그리고 국소 Kaplan-Meier 추정량 세 가지를 비교하였다. 국소 KM 추정량에 대해서는 차원의 저주를 피하기 위해 공변량의 차원축소 방법을 추가적으로 적용하였다. 차원축소 방법으로는 흔히 사용되는 주성분분석(principal component analysis, PCA)과 절단역회귀(sliced inverse regression)방법을 고려하였다. 그 결과 Cox 비례위험 추정량이 평균 및 중위수 중도절단 회귀모형 모두에서 중도절단 확률을 추정하는 데 가장 좋은 성능을 보여주었다.

이종 환경에서 운용되는 부품의 신뢰도 평가 방법 연구 (Study on the Reliability Evaluation Method of Components when Operating in Different Environments)

  • 황정택;김종학;전주연;한재현
    • 한국안전학회지
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    • 제32권5호
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    • pp.115-121
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    • 2017
  • This paper is to introduce the main modeling assumptions and data structures associated with right-censored data to describe the successful methodological ideas for analyzing such a field-failure-data when components operating in different environments. The Kaplan - Meier method is the most popular method used for survival analysis. Together with the log-rank test, it may provide us with an opportunity to estimate survival probabilities and to compare survival between groups. An important advantage of the Kaplan - Meier curve is that the method can take into account some types of censored data, particularly right-censoring. The above non-parametric method was used to verify the equality of parts life used in different environments. After that, we performed the life distribution analysis using the parametric method. We simulated data from three distributions: exponential, normal, and Weibull. This allowed us to compare the results of the estimates to the known true values and to quantify the reliability indices. Here we used the Akaike information criterion to find a suitable life time distribution. If the Akaike information criterion is the smallest, the best model of failure data is presented. In this paper, no-nparametrics and parametrics methods are analyzed using R program which is a popular statistical program.

Black Hispanic and Black Non-Hispanic Breast Cancer Survival Data Analysis with Half-normal Model Application

  • Khan, Hafiz Mohammad Rafiqullah;Saxena, Anshul;Vera, Veronica;Abdool-Ghany, Faheema;Gabbidon, Kemesha;Perea, Nancy;Stewart, Tiffanie Shauna-Jeanne;Ramamoorthy, Venkataraghavan
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권21호
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    • pp.9453-9458
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    • 2014
  • Background: Breast cancer is the second leading cause of cancer death for women in the United States. Differences in survival of breast cancer have been noted among racial and ethnic groups, but the reasons for these disparities remain unclear. This study presents the characteristics and the survival curve of two racial and ethnic groups and evaluates the effects of race on survival times by measuring the lifetime data-based half-normal model. Materials and Methods: The distributions among racial and ethnic groups are compared using female breast cancer patients from nine states in the country all taken from the National Cancer Institute's Surveillance, Epidemiology, and End Results cancer registry. The main end points observed are: age at diagnosis, survival time in months, and marital status. The right skewed half-normal statistical probability model is used to show the differences in the survival times between black Hispanic (BH) and black non-Hispanic (BNH) female breast cancer patients. The Kaplan-Meier and Cox proportional hazard ratio are used to estimate and compare the relative risk of death in two minority groups, BH and BNH. Results: A probability random sample method was used to select representative samples from BNH and BH female breast cancer patients, who were diagnosed during the years of 1973-2009 in the United States. The sample contained 1,000 BNH and 298 BH female breast cancer patients. The median age at diagnosis was 57.75 years among BNH and 54.11 years among BH. The results of the half-normal model showed that the survival times formed positive skewed models with higher variability in BNH compared with BH. The Kaplan-Meir estimate was used to plot the survival curves for cancer patients; this test was positively skewed. The Kaplan-Meier and Cox proportional hazard ratio for survival analysis showed that BNH had a significantly longer survival time as compared to BH which is consistent with the results of the half-normal model. Conclusions: The findings with the proposed model strategy will assist in the healthcare field to measure future outcomes for BH and BNH, given their past history and conditions. These findings may provide an enhanced and improved outlook for the diagnosis and treatment of breast cancer patients in the United States.

비재무정보를 이용한 사회적기업의 생존에 영향을 미치는 요인에 관한 실증연구 (An Empirical Study on Factors Affecting the Survival of Social Enterprises Using Non-Financial Information)

  • 김혁;이동명;남기정
    • 산업융합연구
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    • 제21권1호
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    • pp.111-122
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    • 2023
  • 본 연구의 목적은 신용보증기관에서 신용보증을 이용한 사회적기업의 비재무정보를 사용하여 생존율과 생존시간을 추정하고 생존시간에 영향을 주는 요인들을 검증하여 이해관계자에게 정보를 제공하고 생존율을 향상시켜 기업의 고용을 유지·확대하여 사회·경제적 비용을 감소시키는데 기여하고자 한다. 연구방법은 비모수적 분석방법인 카플란마이어 분석법(Kaplan-Meier Analysis)으로 생존분석을 실시하였다. 연구대상 기업은 2009년부터 2018년 사이에 설립된 621개(정상기업 577개, 부실기업 44개) 기업을 표본으로 선정하였다. 사회적기업의 대표자정보와 기업정보로 구분하여 생존시간에 영향을 주는 요인들을 검증한 결과 대표자 신용등급, 대표자 주택보유여부, 여신거래기간, 기업 신용등급이 생존시간에 영향을 주는 유의미한 변수로 도출되었다. 향후 금융기관들은 사회적기업 대출심사시 생존에 영향을 미치는 요인들을 반영하여 기업의 건전성을 유인하고, 고용유지와 사회적비용 감소에 기여할 수 있을 것이다. 정부나 민간단체 등 지원기관들은 사회적기업의 성장과 지속가능성을 위한 정책수립, 교육훈련 등에도 다양하게 활용이 가능할 것이다. 본 연구를 계기로 사회적기업의 성과와 더불어 기업의 부실과 관련하여 영향을 미치는 요인들에 대하여 더욱 관심을 갖고 연구가 지속되길 바란다.

One-year Survival Rate of Patients with Primary Malignant Central Nervous System Tumors after Surgery in Kazakhstan

  • Akshulakov, Serik;Igissinov, Nurbek;Aldiyarova, Nurgul;Akhmetzhanova, Zauresh;Ryskeldiyev, Nurzhan;Auezova, Raushan;Zhukov, Yevgeniy
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권16호
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    • pp.6973-6976
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    • 2014
  • This study was conducted to evaluate the one-year survival rate of patients with primary malignant central nervous system (CNS) tumors after surgical treatment in Kazakhstan. Retrospective data of patients undergoing operations in the Department of Central Nervous System Pathology in the JSC National Centre for Neurosurgery in the period from 2009 to 2011 were used as the research material. Kaplan-Meier survival analysis was performed with the following information: gender, date of birth, place of residence, diagnosis according to ICD-10, the date of the operation, the morphological type of tumor, clinical stage, state at the end of the first year of observation, and the date of death. The study was approved by the ethical committee of the JSC National Centre for Neurosurgery. The overall one-year overall survival rate (n=152) was 56.5% (95% confidence interval (CI): 50.2-62.7), and 79.5% (95% CI 72.2-86.8) and 33.1% (95% CI: 21.0-42.3) for Grades I-II (n=76) and Grades III-IV (n=76), respectively. Significant prognostic factors which affected the survival rate were age and higher tumor grade (Grades III-IV), corresponding with results described elsewhere in the world.