• 제목/요약/키워드: Kangwon National University

검색결과 16,242건 처리시간 0.043초

Improving Medication Adherence in Isolated Patients With Cognitive Impairment Using Automated Telephone Reminders

  • Moon Jeong Kim;Jeong Yun Song;Jae-won Jang;Seo-Young Lee;Jin Hyeong Jhoo;Gi Hwan Byeon;Yeshin Kim
    • 대한치매학회지
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    • 제21권4호
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    • pp.117-125
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    • 2022
  • Background and Purpose: Medication adherence is essential for effective medical treatment. However, it is challenging for cognitively impaired patients. We investigated whether an automated telephone reminder service improves medication adherence and reduces the decline of cognitive function in isolated patients with cognitive impairment. Methods: This was a single-center, randomized clinical trial. We enrolled mild cognitive impairment (MCI) or Alzheimer's disease (AD) patients who lived alone or with a cognitively impaired spouse. We provided an automated telephone reminder service for taking medication to the intervention group for 6 months. The control group was provided with general guidelines for taking the medication every month. The participants underwent neuropsychological assessment at the beginning and end of the study. Statistical significance was tested using nonparametric Wilcoxon rank sum and Wilcoxon matched-pairs signed-rank tests. Results: Thirty participants were allocated randomly to groups, and data for 29 participants were analyzed. The mean age was 79.6 (standard deviation, 6.0) years and 79.3% of the participants were female. There was no significant difference in medication adherence between the 2 groups. However, a subgroup analysis among participants with more than 70% response rates showed better medication adherence compared to the control group (intervention: 94.6%; control: 90.2%, p=0.0478). There was no significant difference in the change in cognitive function between the 2 groups. Conclusions: If a patient's compliance is good, telephone reminders might be effective in improving medication adherence. It is necessary to develop reminder tools that can improve compliance for cognitively impaired patients.

A New Record of Nannizziopsis mirabilis from Field Soil in Korea

  • Adhikari, Mahesh;Gurung, Sun Kumar;Kim, Sang Woo;Lee, Hyun Goo;Ju, Han Jun;Gwon, Byeong Heon;Kosol, San;Bazie, Setu;Lee, Hyang Burm;Lee, Youn Su
    • 한국균학회지
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    • 제46권3호
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    • pp.249-254
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    • 2018
  • Nannizziopsis mirabilis (KNU17-67) was isolated from a field soil sample collected from Jejudo in 2017. This fungal isolate was identified and described by its morphological characters and the internal transcribed spacer rDNA gene sequencing. Potato dextrose agar medium was used to study its macro and micromorphology. In addition, a molecular phylogenetic tree was constructed for its precise confirmation as N. mirabilis. This fungal isolate has not officially been reported previously in Korea.

Aspergillus caninus (Syn: Phialosimplex caninus): a New Isolate from Field Soils in Korea

  • Adhikari, Mahesh;Gurung, Sun Kumar;Kim, Sang Woo;Lee, Hyun Goo;Ju, Han Jun;Gwon, Byeong Heon;Kosol, San;Bazie, Setu;Lee, Hyang Burm;Lee, Youn Su
    • 한국균학회지
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    • 제46권4호
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    • pp.383-392
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    • 2018
  • During the study of indigenous fungal communities in soil samples collected from various field soils in Sancheong, Gyeongsangnam-do, Korea in 2017, several species of Aspergillus were discovered. Aspergillus caninus (KNU17-7) was isolated, identified, and described based on the results from macro and micro morphological characteristics and molecular characterization. Morphologically, it was identified using five different growth media: potato dextrose agar, oatmeal agar, yeast extract sucrose agar, czapek yeast extract agar, and malt extract agar. For the molecular identification, sequencing of internal transcribed spacer, ${\beta}-tubulin$, and calmodulin genes was performed. Based on this characterization, our study isolate was identified as Aspergillus caninus. This fungal species has not been officially reported in Korea before, and we report here with its morphological and molecular phylogenetic characterization.

패혈증 생존 및 사망 환자 혈장에서 단백질 칩을 이용한 분석의 차이 (Difference in Protein Markers According to the Survival of Sepsis Patients using Protein Chips)

  • 박명옥;이희영;손희정;성지현;이승준;이성준;하권수;김우진
    • Tuberculosis and Respiratory Diseases
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    • 제61권1호
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    • pp.41-45
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    • 2006
  • 배 경: 패혈증 환자의 예후를 예측하는 데 현재 사용되고 있는 임상적 채점 방식은 몇가지 제한점이 있다. 그래서 단백질체학(proteomics) 기법을 사용하여 표지자(proteomic biomarkers)를 찾으려 연구를 진행하였다. 방 법: 본 연구에서는 16명의 패혈증환자에게서 중환자실에 입원하자마자 혈장을 채취하였다. 패혈증의 예후를 예측할 수 있는 표지자를 찾기 위해 Surface-enhanced laser desorption/ionization time-of-flight (SELDI -TOF) mass spectrometry를 사용하였다. 결 과: 사망환자와 생존환자 사이에 통계적으로 유의한 차이가 있는 6개의 단백표지자를 발견하였고 이들은 패혈증 환자의 예후 예측과 치료계획수립에 도움이 될 것으로 생각된다. 결 론: 프로테오믹 마커는 패혈증 환자의 예후를 예측하고 치료계획을 세우는 데 있어 유용하게 이용될 가능성이 있을 것으로 사료된다.