• 제목/요약/키워드: Kang Il-sun

검색결과 712건 처리시간 0.065초

Suppressive Effects of Triterpenoids on CINC-1 Induction in Interleukin-1{\betha}-stimulated rat fibroblast NRK-49F cells

  • Ha, Joo-Young;Min, Kyung-Rak;Kang, She-Hoon;Kim, Ju-Sun;Lee, Gyeong-Im;Kang, Sam-Sik;Kim, Youngsoo
    • Archives of Pharmacal Research
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    • 제20권3호
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    • pp.234-238
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    • 1997
  • CINC-1 is a member of chemokine family with chemotactic and activating properties to neutrophils. CINC-1 induction in IL-$1{\beta}$-stimulated rat fibroblast NRK-49F cells was quantitated by a sensitive ELISA. CINC-1 production was increased up to 135 ng/ml from basal 2-6 ng/ml by stimulation with IL-$1{\beta}$.Steroidal anti-inflammatory drugs including dexamethasone and prednisolone exhibited potent suppressive effects on IL-$1{\beta}$-induced CINC-1 production. Among 39 kinds of natural triterpenoids tested, acacigenin B exhibited the highest suppressive effects with about $10{\mu}M$ to be 50% of inhibition on the CINC-1 induction. The suppressive potency of acacigenin B on IL-$1{\beta}$induced CINC-1 production was about 10-fold less than that of the steroidal anti-inflammatory drugs.

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