• 한국항해학회지
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• 제20권3호
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• pp.1-11
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• 1996

The accuracy for determining fishing ground and for setting fishing gear location, and the repeatability of ship position vary depending on fishing methods. Especially, Loran-C has been served to give fisherman highly accurate ship's position, and a number of fishing vessel are equipped with it's receivers. In this paper, in order to evaluate the accuracy of Loran-C fix of Korean chain in Korean southeast coast, the authors examined and analyzed the data of the receiver of Loran-C(LC 90, Furuno) and GPS(AccNav $Sport^{TM}$, Eagle) measured automatically and continuously for 2 seconds at interval of 5minutes during 2hours from $11^{th}$ to $21^{st}$, July, 1996 at six observed points, that is, Pusan, Wolnae, Pangojin, Chongja, Kampo and Kuryongpo in Korean southeast coast. As the result obtained, Loran-C signals showed little fluctuation with good reprodutibility. Good stability of Loran-C signals was indicated by the small value of the standard deviation 0.064~0.094$\mu\textrm{s}$. Although determination of the observed position could not be completely accurate, the extent of the error was estimated smaller than 0.35 nautical mile.

• 약학회지
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• 제43권6호
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• pp.729-735
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• 1999

Scopolia rhizome is mistaken as an atractylodes rhizome because of their similarities in shape. That is why atractylodes rhizome imported from China sometimes contain scopolia rhizome, which is very toxic. 8 persons were intoxicated atractylodes after taking imported atractylodes rhizome which is tainted. In kampo medicine prepared with such imported atractylodes rhizome, the level of tropane alkaloids ranged from 1.12∼4.34 mg/dose. In this study, we tried to investigate the tissue distribution of scopolia rhizome in rats. The extracts of scopolia was administered orally to rats (a single dose of 10mg/kg, 20mg/kg and 7 days repeated dose of 10mg/kg). Their blood was collected at 0.5, 1, 2, 4, 6 hrs, and liver, kidney, lung and spleen were collected after 6 hrs. The tissue homogenate was applied to solid phase extraction column for the determination of tropane alkaloids. After the oral administration of 20mg/kg scopolia extracts, l-hyoscyamine was detected in rat blood to 2 hrs after dosing. The concentration of tropane alkaloids was the highest in liver followed by lung, kidney and spleen. However, lung, kidney and spleen were similar in amount.

• 대한한방소아과학회지
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• 제33권3호
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• pp.1-14
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• 2019

Objectives The purpose of this study is to analyze clinical studies on effectiveness of herbal medicine in influenza compared with Oseltamivir. Methods We searched the randomized controlled trials (RCTs) with herbal medicine treatment on influenza compared to Oseltamivir from the Pubmed, CNKI, OASIS, NDSL, J-stage, and CiNii. Results 14 out of 717 studies were selected and analyzed. The herbal medicine treatment had a significant effects on the alleviation of fever, cough, sore throat than the Oseltamivir control treatment. Herbal medicine had same therapeutic effectiveness like Oseltamivir on duration of influenza-like symptoms and viral shedding. No serious adverse reactions were reported from the herbal medicine treatment. Conclusions The results of these trials showed that the herbal medicine may be more effective than the Oseltamivir in the treatment of influenza. Well-designed RCTs for domestic herbal medicine treatment on influenza are needed to prove its efficacy clearly.

• Journal of Ginseng Research
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• 제27권3호
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• pp.98-102
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• 2003

The aim of this study is to evaluate clinical usefulness of Korean red ginseng (RG) on various postmenopausal syndromes. Total plasminogen inhibitor-l (tPAI-l) in peripheral blood from 9 postmenopausal women with climacteric syndromes (CS) was measured before and 3 months after treatment with daily oral administration of 6 g RG and that from 8 postmenopausal women without any CS was also measured as healthy controls. Blood samples were collected in the early morning on the bed-rest. Psychological conditions of postmenopausal women with CS were measured before and 3 months after treatment with RG using simplified menopausal index (SMI). In addition, OKETSU (blood stagnation) syndrome scores and KI deficiency (generalized energy stagnation) scores proposed by Terasawa et al., were recorded before and 3 months after treatment with RG in postmenopausal women with CS and in healthy postmenopausal women. OKETSU syndrome scores and tPAI-l levels in postmenopausal patients with CS were significantly (P<0.001 and P<0.01) higher than those in healthy postmenopausal women without CS. Similarly, SMI scores and KI deficiency scores in postmenopausal patients with CS were about three-fold higher than those without any CS. When RG was administered for 3 months, KI deficiency scores and OKETSU scores as well as SMI scores declined around the levels of healthy postmenopausal women. Although tPAI-1 levels significantly (P<0.05) decreased after treatment with RG, those did not reach the levels of healthy postmenopausal women. Clinical usefulness of administration of RG to postmenopausal women with CS was confirmed from evaluation not only by modem medicine but also by traditional KAMPO medicine.

• 대한화학회지
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• 제30권5호
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• pp.488-492
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• 1986

경북 원성군 감포 78에서 산출되는 벤토나이 중 몬모리노나이트를 분리하여 Ca, Mg-형을 NaCl용액으로 처리하여 Na-형 몬모리노나이트를 만들었다. 이때 가장 적당한 조건은 0.05M NaCl용액으로 80${\circ}C$에서 24시간 반응시켜 치환되는 $Ca^{2+}$, $Mg^{2+}$량을 EDTA로 적정하여 양이온 교환 용량을 구하였다. Na-형에 $Ln^{3+}$이온용액과 같은 조건하에서 반응시켜 $Ln^{3+}$-형 몬모리노나이트를 만들었다. 치환되는 량은 $Ln^{3+}$이온들의 이온 크기에는 무관함을 알 수 있었고, X-선 회절 실험결과 순수한 몬모리노나이트를 얻을 수 있음을 밝혔고, 또한 $Ln^{3+}$형은 새로운 결정모양이 되는 것을 알 수 있었다. 이는 단순한 틈새끼우기 반응이 아니 새로운 결정형이 생성됨을 알 수 있다.

• 대한한방내과학회지
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• 제33권4호
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• pp.347-366
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• 2012

The aim of this new statement is to provide comprehensive and timely evidence-based recommendations on stroke management for clinical practitioners. Many countries are already well engaged in developing and releasing their own clinical practice guidelines, whereas Korean Medicine (KM) is still beginning. It will take time and effort to develop evidence-based guidelines and recommendations of KM or other traditional medicine because they are weak in the area of scientific evidence. The clinical practice guideline of Korean medicine for stroke was formulated through extensive review of published literature and consensus meeting of Korean medicine specialists. This project was supported by a grant of the Oriental Medicine R&D Project, the Ministry of Health and Welfare. Referring to guidelines developed in other countries, the experts in the subject tried to organize and develop guidelines and recommendations adequate for domestic medical circumstances. In December, 2008, a multi-disciplinary team called the Evidence Based Clinical Practice Guidelines Development Group (EBCPGsDG) for Stroke was organized. The writing committee was comprised of experts in internal medicine, acupuncture, rehabilitation, and Sasang constitution. Outside specialists and associated panels were invited for consultation. The scope of the guideline encompasses acupuncture, moxibustion and herbal medicine (including Korean medicine, traditional Chinese medicine, Kampo medicine) as interventions for stroke patients. It includes statements about ischemic stroke (I63), stroke not specified as hemorrhage or infarction (I64), and sequelae of cerebrovascular disease (I69) according to the International Classification of Disease (ICD). The committee subdivided the description of herbal medications into acute stroke management, subacute stroke management, post-stroke management, and secondary prevention of stroke. Guidelines on the practice of acupuncture and moxibustion were described in order for acute stroke management, subacute stroke management, chronic stroke management, and post-stroke rehabilitation. Clinicians who are working in the field of stroke care can adopt this guideline for their practice.

• 대한한의학회지
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• 제39권3호
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• pp.17-27
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• 2018

Objectives: Ukgan-san does not appear in Traditional Korean Medicine classics. However, it has been used in research and clinical applications in Korea. In this paper, we are aiming to examine the records concerned with Ukgan-san to the present, and announce the present usage state in Korea. Methods: We searched and summarized the contents of previous medical books about Ukgan-san. In order to investigate the current status of utilization of Ukgan-san in Korea, a bibliographic database of Korea, a database of clinical researches, and a database of pharmaceuticals of the Korea Food and Drug Administration were searched. Results: As a result of searching Ukgan-san related documents, Ukgan-san has been developed in China (Ming dynasty). However, its clinical application has been expanded by modern Japanese kampo medicine doctors. In Korea, cases of Parkinson's disease, other movement disorders, and psychiatric disorders have been reported, and randomized controlled trials had been done and planned. In addition, some extracts which are consisted of Ukgan-san are also available. Conclusions: In Korea, Ukgan-san has been influenced by Japan and has been used for clinical and research purposes. The utilization rate in Korea is still small, but the utilization rate will increase according to the results of clinical studies.

• 공업화학
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• 제5권6호
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• pp.1024-1029
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• 1994

경북 감포지역에서 산출되는 천연 제올라이트를 각기 다른 농도의 HCl과 NaOH로 화학처리한 시료와 금속양이온 교환한 시료를 제조 하였다. 이들 시료에 대한 질소의 흡착특성을 $25^{\circ}C$, 100~760 torr의 범위에서 조사하였다. 산처리한 시료의 질소 흡착량은 처리하기 전보다 감소하였으며, 알칼리 처리한 시료는 많이 증가하였다. 0.5N-HCl 처리 후 0.5N-NaOH로 연속처리한 경우 약 200% 정도 흡착량이 개선되었으나, 알칼리 처리 후 산으로 연속처리한 경우에는 오히려 감소하였다. $Na^+$, $K^+$, $Cs^+$를 이온교환한 경우 이온의 크기가 증가할수록 흡착량은 감소했으며, $Mg^{2+}$, $Ca^{2+}$, $Ba^{2+}$를 이온교환한 경우는 이온의 크기가 증가할수록 흡착량이 증가하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6351-6356
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• 2013

Background: Goshajinkigan (GJG) is used for the treatment of several neurological symptoms. We investigated the efficacy of GJG and mecobalamin (B12) against neurotoxicity associated with docetaxel (DOC) in breast cancer patients. Materials and Methods: Sixty breast cancer patients were treated with DOC. Thirty-three patients (GJG group) received oral administration of 7.5 g/day GJG and 27 patients (B12 group) received oral administration of 1500 ${\mu}g/day$ B12. Neuropathy was evaluated according to DEB-NTC (Neurotoxicity Criteria of Debiopharm), Common Terminology Criteria for Adverse Events (NCI-CTC) ver. 3.0, and a visual analogue scale (VAS). This study employed a randomized open design. Results: The incidence of neuropathy was 39.3% in the GJG group, and 88.9% in the B12 group (p<0.01). In the GJG group, grade 1 DEB-NTC was observed in 2 cases, grade 2 in 5 cases and grade 3 in 5 cases. Grade 1 NCI-CTC was observed in 7 cases, grade 2 in 6 cases, and VAS was $2.7{\pm}2.2$. In the B12 group, grades 1, 2 and 3 DEB-NTC were observed in one case, 12 cases and 12 cases, respectively; and grades 1, 2 and 3 NCI-CTC were observed in 11 cases, 12 cases and one case, and VAS was $4.9{\pm}2.4$. Conclusions: Concomitant administration of GJG is useful in preventing neuropathy in breast cancer patients treated with a DOC regimen.

• 동의생리병리학회지
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• 제26권4호
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• pp.418-426
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• 2012

Murai Kinzan was a disciple of the great Ko-bang scholar, Yoshimasu Todo(吉益東洞). He was born in a family of doctors, he helped his father's medical works and together made an institution of medical education. He wrote many medical books such as "Yakuchozokuhen(藥徵續編)", "Idonisen'nenganmokuhen(醫道二千年眼目編)" and "Hogyokusantei(方極刪定)". He followed Yoshimasu Todo's theories that "All disease comes from a single poison" and criticized scholars such as Yoshimasu Nangai(吉益南涯) for modifying the theories of his teacher, Yoshimasu Todo. He was also influenced by Kagawa Shuuan(香川修庵) through his father, and learned medicine from Yamawaki Touyou(山脇東洋) through letters. Under the influence of these great scholars, he pursued empirical and practical medicine based on his own experience using "Shanghanlun(傷寒論)" and "Jinguiyaolue(金匱要略)" for reference. In "Yakuchozokuhen" and "Yakuchozokuhenhuroku", Murai Kinzan maintained the main frame of "Yakucho(藥徵)", Yoshimasu Todo's work, discussing in 5 categories. Medicines that are used popularly were written in "Yakucho" and "Yakuchozokuhen", therefore those books were discussed in 5 categories. However, "Yakuchozokuhenhuroku" were discussed only in 1 ~ 3 categories.